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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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LIU TUNGSHENG 1988:LOESS IN CHINA

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第四纪研究 2007年第6期27卷 905-907页

作者： ian j.Smalley University of Leicester

ian ***是国际著名的黄土研究专家。他对黄土研究的发展历史有独到的见解,对有里程碑式杰出贡献的黄土专家的成果有精辟的分析和论述。本文是他对刘东生先生1988年出版的英文专著"Loess in China"的分析和介绍,以外国学者的视角,对刘东... 详细信息

ian ***是国际著名的黄土研究专家。他对黄土研究的发展历史有独到的见解,对有里程碑式杰出贡献的黄土专家的成果有精辟的分析和论述。本文是他对刘东生先生1988年出版的英文专著"Loess in China"的分析和介绍,以外国学者的视角,对刘东生先生,也包括他所领导的团队,在中国黄土研究先进的学术思想的发展,对国际黄土和第四纪研究的重大贡献做了恰如其分的评估。原文2006年发表在《自然地理学进展》(Progress in Physical Geography)上。在刘东生先生九十华诞之际,本刊征得原作者同意,除了对文中中国科学家姓名拼法做了校准,删除了照片外,原文刊载,以飨读者。在此谨向Smalley教授表示衷心感谢!

关键词：刘东生黄土研究 ian j.Smalley 《Loessin China》书介

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Self-identification of electronically scanned signatures(ESS)and digitally constructed signatures(DCS)

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Forensic Sciences Research 2022年第2期7卷 261-264页

作者： Zuzanna Kazmierczyk ian j.Turner Centre for Excellence in Learning and Teaching University of DerbyDerbyUK

The use of electronic signatures as a form of identification is increasingly common,yet they have been shown to lack the dynamic features found in online *** this study,handwritten signatures were scanned to produce electronically scanned signatures(ESS)which were then digitally altered to produce digitally constructed signatures(DCS).The ESS and DCS were presented back to participants to identify which were *** 1%of participants correctly identified all signatures,with a mean score of 57.6%*** lack of self-recognition of ESS raises questions on their reliability and usefulness as means of personal identification.

关键词： Forensic sciences signature handwriting questioned document analysis electronic signature digital signature simulation

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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Critical interfaces in body armour systems

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Defence Technology（防务技术） 2021年第6期17卷 1887-1894页

作者： ian G.Crouch Ulverston Armour Solutions UlverstonLA127BJCumbriaUK

The ballistic performance,and behaviour,of an armour system is governed by two major sets of variables,geometrical and *** these,the consistency of performance,especially against small arms ammunition,will depend upon the consistency of the properties of the constituent *** a body armour system for example,fibre diameter,areal density of woven fabric,and bulk density of ceramic are examples of critical parameters and monitoring such parameters will form the backbone of associated quality control *** is often overlooked,because it can fall into the User’s domain,are the interfaces that exist between the various products;the carrier,the Soft Armour Insert(SAI),and the one or two hard armour plates(HAP1 and HAP2).This is especially true if the various products are sourced from different suppliers.

关键词： Interfaces Body armour Body armor Ceramic armour UHMWPE Aramids Ballistic fibres Fabrics Interfacial materials Hard armour plates Soft vests

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Apoptosis block as a barrier to effective therapy in non small cell lung cancer

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World journal of Clinical Oncology 2014年第4期5卷 588-594页

作者： ian Paul j Mark jones Department of Cardiothoracic Surgery Royal Victoria Hospital Belfast BT12 6BA Northern Ireland United Kingdom

Lung cancer, is the most common cause of cancer death in men and second only to breast cancer in women. Currently, the first line therapy of choice is platinumbased combination chemotherapy. A therapeutic plateau has been reached with the prognosis for patients with advanced non-small cell lung cancer(NSCLC) remaining poor. New biomarkers of prognosis as well as new therapies focusing on molecular targets are emerging helping to identify patients who are likely to benefit from therapy. Despite this, drug resistance remains the major cause for treatment failure. In this article we review the role of apoptosis in mediating drug resistance in NSCLC. Better understanding of this fundamental biological process may provide a rationale for overcoming the current therapeutic plateau.

关键词： Apoptosis Lung cancer Adjuvant therapy Mitochondria BAX BAK BCL2

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皮革的可塑性 POLENE首尔专卖店

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室内设计与装修 2025年第1期 90-95页

作者：无 Minwoo(ian)Yang Sunho Shin Hyevin Park Yongjoon Choi(摄影) 秋落(编译) WGNB 不详

继巴黎、纽约和东京之后,专注皮革设计的小众品牌Pol$ne于日前在韩国首尔开设首家品牌旗舰店,也是全球第4间专卖店。这个深受时尚迷和年轻一代欢迎的法国小众品牌,将店址选在逛街胜地之一的江南新沙洞,打造了两层的品牌旗舰店。除了延... 详细信息

继巴黎、纽约和东京之后,专注皮革设计的小众品牌Pol$ne于日前在韩国首尔开设首家品牌旗舰店,也是全球第4间专卖店。这个深受时尚迷和年轻一代欢迎的法国小众品牌,将店址选在逛街胜地之一的江南新沙洞,打造了两层的品牌旗舰店。除了延续品牌形象,引进品牌经典包款和人气新作,受到韩国打卡文化的影响,Pol$ne为首尔旗舰店精心规划出拍照空间,凡是走进店内的人,都会忍不住想要拿起手机留下回忆。

关键词：小众品牌旗舰店皮革品牌形象专卖店 Pol

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Body armour-New materials, new systems

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Defence Technology（防务技术） 2019年第3期15卷 241-253页

作者： ian G.Crouch Armour Solutions

This is a very timely review of body armour materials and systems since new test standards are currently being written, or reviewed, and new, innovative products released. Of greatest importance, however, is the recent evolution, and maturity, of the Ultra High Molecular Weight Polyethylene fibres enabling a completely new style of system to evolve e a stackable system of Hard Armour Plates. The science of body armour materials is quickly reviewed with emphasis upon current understanding of relevant energy-absorbing mechanisms in fibres, fabrics, polymeric laminates and ceramics. The trend in ongoing developments in ballistic fibres is then reviewed, analysed and future projections offered. Weaknesses in some of the ceramic grades are highlighted as is the value of using cladding materials to improve the robustness, and multi-strike performance, of Hard Armour Plates. Finally, with the drive for lighter, and therefore smaller, soft armour systems for military personnel the challenges for armour designers are reported, and the importance of the relative size of the Hard Armour Plate to the Soft Armour Insert is strongly emphasised.

关键词： Body armour Body armor Ceramic armour Reaction sintered silicon carbide UHMWPE Fibres Fabrics Strike-face materials Aramids Small-arms ammunition

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