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Effect of arsenic contaminated irrigation water on Lens culinaris *** toxicity assessment using lux marked biosensor

journal of Environmental Sciences 2012年第6期24卷 1106-1116页

作者： F.R.Sadeque Ahmed ian j.alexander Mwinyikione Mwinyihija Ken Killham Department of Environment (Climate Change) E-16 AgargaonDhakaBangladesh School of Biological Sciences Institute of Biological and Environmental SciencesUniversity of AberdeenAberdeenAB24 3UUUK Kenya Leather Development Council P.O.Box 14480NairobiKenya Remedios Limited Balgownie Technology CentreCampus 3 Balgownie DriveAberdeenAB22 8GWUK

Contamination of irrigation water represents a major constraint to Bangladesh agriculture,resulting in elevated levels in the terrestrial *** bacterial biosensor technology has previously been used to measure the toxicity of metals in various environmental *** arbuscular mycorrhizal fungi have their most significant effect on phosphorus uptake,but showed alleviated metal toxicity to the host *** study examined the effects of arsenic and inoculation with an arbuscular mycorrhizal fungus,Glomus mosseae,on lentil （Lens culinaris ***）.Plants were grown with and without arbuscular mycorrhizal inoculum for 9 weeks in a sand and terra-green mixture （50：50,V/V） and watered with five levels of arsenic （0,1,2,5,10 mg As/L arsenate）.The results showed that arsenic addition above 1 mg/L significantly reduced percentage of mycorrhizal root *** further analysis a close relationship was established with the vegetative and reproductive properties of lentil （***） plants compared to the percentage bioluminescence of the soil ***,arbuscular mycorrhizal fungal inoculation reduced arsenic concentration in roots and *** concentrations of arsenic （5,10 mg As/L arsenate） reduced the mycorrhizal efficiency to increase phosphorus content and nitrogen ***,this study showed that increased concentration of arsenic in irrigation water had direct implications to the lentil （***） plants overall *** the use of bioassay demonstrated that mycorrhiza and clay particle reduced arsenic bioavailability in soil.

关键词： bioassay contaminated water lentil trace metals vegetative response

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Muscle, myeloid cells, and complement: a complex interaction

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Cellular & Molecular Immunology 2018年第11期15卷 992-993页

作者： jessy j.alexander Richard j.Quigg Department of Medicine SUNY at BuffaloBuffaloNY14086USA

The complement system is a critical arm of the immune system that plays an important role not only in maintaining health but also contributes to *** activation generates biologically active products C3a and C5a,which are important links between complement and cellular *** studies have revealed that C5a/C5aR signaling is critical in both humoral and inflammatory responses,resulting in functional renal insufficiency in immune complex-mediated glomerulonephritis.1 Consistent with these studies and considering the complexity of complement system interactions based on location and setting,a recent article by Zhang et al.2 has shed light on C3a/C3aR signaling as the link that regulates monocyte function and trafficking and facilitates skeletal muscle *** commentary highlights the important themes originating from the work described,which include the following:(1)complement C3 depletion reduced muscle regeneration,(2)C3a signaling through its G-coupled receptor C3aR facilitated muscle regeneration by regulating monocyte/macrophage infiltration through CCL5,and(3)C5a/C5aR signaling does not affect monocyte/macrophage infiltration in this particular setting.

关键词： complex interaction critical

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Optical coherence tomography in optic disc drusen

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Annals of Eye Science 2020年第1期5卷 22-34页

作者： j.alexander Fraser Lulu L.C.D.Bursztyn Department of Clinical Neurological Sciences Western UniversityLondonONCanada Department of Ophthalmology Western UniversityLondonONCanada

Optic disc drusen (ODD) are hyaline deposits in the optic nerve head, occurring in approximately 2% of the population. ODD may be superficial and visible, or buried and either invisible or seen only as elevation of the optic disc, mimicking optic disc edema. Advanced optic nerve imaging, including optical coherence tomography (OCT) can be used to diagnose and characterize ODD with very high resolution. Enhanced depth imaging (EDI-OCT) in particular has emerged as the optimal modality to directly visualize ODD. This modality has led to a greater ability to differentiate ODD from optic disc edema and prevent misdiagnosis or invasive testing. We review the characteristic findings of ODD on OCT, their distinguishing features, and the use of OCT as a biomarker in the neuro-ophthalmic assessment of ODD.

关键词： Drusen optic disk tomography optical coherence

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Double negative T cells,a potential biomarker for systemic lupus erythematosus

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Precision Clinical Medicine 2020年第1期3卷 34-43页

作者： jessy j.alexander alexander jacob Anthony Chang Richard j.Quigg james N.jarvis Department of Pathology University of ChicagoChicagoIL 60637USA Departments of Medicine PediatricsJacobs School of Medicine and Biomedical Sciences and GeneticsGenomics&Bioinformatics ProgramUniversity at BuffaloBuffaloNY 14203USA

Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and *** is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T cells,the CD3^(+)CD4^(−)CD8^(−)(DNeg)cells,is significantly increased in lupus *** cases(53%)of pediatric SLE patients had elevated DNeg cells in their peripheral blood,which correlated with kidney function(R^(2)=0.54).Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by *** the first time,this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus *** lupus mice,the increase in DNeg cells tracked with worsening disease and correlated with kidney function(R^(2)=0.85).Our results show that DNeg cells per se can cause kidney dysfunction,increase in number with increase in disease pathology,and could serve as a potential biomarker.

关键词： CD3^(+)CD4^(−)CD8^(−)T cells glomerulonephritis inflammation lupus

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A Company Presents Itself to the World

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journal of Literature and Art Studies 2023年第10期13卷 803-811页

作者： Richard j.alexander Vienna University of Business and Economics ViennaAustria

As we all know,environmental breakdown is rooted in capitalism’s quest for perpetual *** to O’Connor(quoted in Büscher et al 2010/2013,p.3)the“environmental crisis has given liberal capitalist society a new lease on life.”He continues:“Now,through purporting to take in hand the saving of the environment,capitalism invents a new legitimation for itself:the sustainable and rational use of nature”.“Those who hold the power and they are not all heads of state,see themselves as saviours of the world,and offer the population the opportunity of becoming their clients”is how john Berger has referred to such cognitive *** discourse analysis and corpus linguistics are employed to scrutinize a powerful corporation’s *** company produces and distributes food *** story it presents to the world maintains that it protects animal welfare,the environment and people,among other things,in all its *** language it employs on its corporate websites will be subjected to close analysis.

关键词： agribusiness discourse analysis ecolinguistics greenwashing sustainability

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Subnanometer localization accuracy in widefield optical microscopy

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Light(Science & Applications) 2018年第1期7卷 740-754页

作者： Craig R.Copeland jon Geist Craig D.McGray Vladimir A.Aksyuk j.alexander Liddle B.Robert Ilic Samuel M.Stavis Center for Nanoscale Science and Technology National Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland NanoCenter University of MarylandCollege ParkMD 20742USA Engineering Physics Division National Institute of Standards and TechnologyGaithersburgMD 20899USA

The common assumption that precision is the limit of accuracy in localization microscopy and the typical absence of comprehensive calibration of optical microscopes lead to a widespread issue—overconfidence in measurement results with nanoscale statistical uncertainties that can be invalid due to microscale systematic *** this article,we report a comprehensive solution to this underappreciated *** develop arrays of subresolution apertures into the first reference materials that enable localization errors approaching the atomic scale across a submillimeter *** present novel methods for calibrating our microscope system using aperture arrays and develop aberration corrections that reach the precision limit of our reference *** correct and register localization data from multiple colors and test different sources of light emission with equal accuracy,indicating the general applicability of our reference materials and calibration *** a first application of our new measurement capability,we introduce the concept of critical-dimension localization microscopy,facilitating tests of nanofabrication processes and quality control of aperture *** a second application,we apply these stable reference materials to answer open questions about the apparent instability of fluorescent nanoparticles that commonly serve as fiducial *** study establishes a foundation for subnanometer localization accuracy in widefield optical microscopy.

关键词： optical limit field

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Fluctuating resources,disturbance and plant strategies:diverse mechanisms underlying plant invasions

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journal of Arid Land 2013年第3期5卷 284-297页

作者： ian j RADFORD CSIRO Sustainable Ecosystems Davies LaboratoryPrivate Mailbag POAitkenvale 4814Australia Botany Department University of OtagoPO Box 56Dunedin 9054New Zealand

This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. （2000）. I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.

关键词： plant invasion plant strategies C-S-R triangle fluctuating resources disturbance

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Ab initio vibrational free energies including anharmonicity for multicomponent alloys

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npj Computational Materials 2019年第1期5卷 454-459页

作者： Blazej Grabowski Yuji Ikeda Prashanth Srinivasan Fritz Körmann Christoph Freysoldt Andrew ian Duff alexander Shapeev jörg Neugebauer Institute of Materials Science University of StuttgartPfaffenwaldring 5570569 StuttgartGermany Department for Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHMax-Planck-Str.140237 DüsseldorfGermany Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628 CD DelftNetherlands Scientific Computing Department STFC Daresbury LaboratoryHartree CentreWarringtonUK Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel St.3Moscow 143026Russia

The unique and unanticipated properties of multiple principal component alloys have reinvigorated the field of alloy design and drawn strong interest across scientific *** vast compositional parameter space makes these alloys a unique area of exploration by means of computational ***,as of now a method to compute efficiently,yet with high accuracy the thermodynamic properties of such alloys has been *** of the underlying reasons is the lack of accurate and efficient approaches to compute vibrational free energies—including anharmonicity—for these chemically complex multicomponent *** this work,a density-functional-theory based approach to overcome this issue is developed based on a combination of thermodynamic integration and a machine-learning *** demonstrate the performance of the approach by computing the anharmonic free energy of the prototypical five-component VNbMoTaW refractory high entropy alloy.

关键词： alloys alloy thermodynamic

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Comparison of visual acuity outcomes between ranibizumab and bevacizumab treatment in neovascular age-related macular degeneration

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International journal of Ophthalmology(English edition) 2011年第1期4卷 85-88页

作者： ian j Constable ian L McAllister Timothy Isaacs Lions Eye Institute Centre for Ophthalmology and Visual ScienceUniversity of Western AustraliaPerthWestern AustraliaAustralia

AIM: To compare visual acuity (VA) outcomes between intravitreal injection of bevacizumab and ranibizumab in the treatment of neovascular age-related macular degeneration (AMD). METHODS: We conducted a consecutive, retrospective case series study in patients with newly diagnosed all type choroidal neovascularization (CNV) secondary to AMD who received an intravitreal injection of bevacizumab (1.25mg) or ranibizumab (0.3mg) at Lions Eye Institute, Western Australia from Mar. 2006 to May 2008. All patients received injection at baseline with additional monthly injections given at the discretion of the treating physician. Main outcome measures were changes in VA. RESULTS: There were 371 consecutive patients received injection at least in one eye with at least 6 months of follow up (median of 12.0 months). Bevacizumab treatment prevented 221 out of 278 (79.5%) patient from losing jection was not associated with VA outcome of benefit after adjusting the covariate (P=0.857). CONCLUSION: There are no difference in treatment efficacy in terms of VA between bevacizumab and ranibizumab in routine clinical condition.

关键词： age-related macular degeneration anti-VEGF bevacizumab ranibizumab choroidal neovascularization

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