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Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients

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World Journal of Gastroenterology 2006年第39期12卷 6299-6304页

作者： Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour ian Spendlove ian O Ellis Poulam M Patel Section of Gastrointestinal Surgery University of Nottingham Queens' Medical Centre Nottingham United Kingdom Academic Department of Clinical Oncology University of Nottingham Institute of Infections Immunity and Inflammation City Hospital Nottingham United Kingdom Academic Department of Clinical Oncology (with LGD ZM DS and PMP) University of Nottingham Institute of Infections Immunity and Inflammation City Hospital Nottingham United Kingdom Department of Histopathology Nottingham City Hospital and University of Nottingham Nottingham United Kingdom

AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome.

关键词： Colorectal cancer Tissue microarray p27^Kip1 Prognostic factor

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低成本全电子安全与解除保险装置研究现状

火工品 2024年第3期 14-21页

作者：汪柯施长军郭莎郑监任新联胡宏伟西安近代化学研究所陕西西安710065

随着全电子引信技术的不断成熟和快速发展,对全电子引信及安保装置的低成本化提出了新的要求,以便进一步扩展其应用领域。本文重点介绍了全电子安保装置高压元器件(高压变压器、高压电容、高压开关、爆炸箔起爆器)的低成本化发展现状,... 详细信息

随着全电子引信技术的不断成熟和快速发展,对全电子引信及安保装置的低成本化提出了新的要求,以便进一步扩展其应用领域。本文重点介绍了全电子安保装置高压元器件(高压变压器、高压电容、高压开关、爆炸箔起爆器)的低成本化发展现状,同时分析了全电子安保装置低成本化发展的影响因素;指出新材料、新工艺、新原理是实现全电子安保装置低成本化发展的根本方法,利用MEMS等先进工艺技术实现全电子高压器件的批量化生产是降低成本的重要手段之一。

关键词：全电子安保装置低成本高压器件 MEMS

Self-identification of electronically scanned signatures(ESS)and digitally constructed signatures(DCS)

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Forensic Sciences Research 2022年第2期7卷 261-264页

作者： Zuzanna Kazmierczyk ian J.Turner Centre for Excellence in Learning and Teaching University of DerbyDerbyUK

The use of electronic signatures as a form of identification is increasingly common,yet they have been shown to lack the dynamic features found in online *** this study,handwritten signatures were scanned to produce electronically scanned signatures(ESS)which were then digitally altered to produce digitally constructed signatures(DCS).The ESS and DCS were presented back to participants to identify which were *** 1%of participants correctly identified all signatures,with a mean score of 57.6%*** lack of self-recognition of ESS raises questions on their reliability and usefulness as means of personal identification.

关键词： Forensic sciences signature handwriting questioned document analysis electronic signature digital signature simulation

Extreme points, support points and the Loewner variation in several complex variables

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Science China Mathematics 2012年第7期55卷 1353-1366页

作者： GRAHAM ian HAMADA Hidetaka KOHR Gabriela KOHR Mirela Department of Mathematics University of Toronto Toronto Ontario M5S 2E4 Canada Faculty of Engineering Kyushu Sangyo University 3-1 Matsukadai 2-Chome Higashi-ku Fukuoka 8138503 Japan Faculty of Mathematics and Computer Science Babe s-Bolyai University 1 M. Koga lniceanu Str. Cluj-Napoca 400084 Romania Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. Cluj-Napoca 400084 Romania

In this paper we consider extreme points and support points for compact subclasses of normalized biholomorphic mappings of the Euclidean unit ball Bn in Cn. We consider the class So（Bn） of biholomorphic mappings on Bn which have parametric representation, i.e., they are the initial elements f（-, O） of a Loewner chain f（x,t） = etz ＋ ... such that {e-tf（.,t）}t≥o is a normal family on Bn. We show that if f（.,O） is an extreme point （respectively a support point） of So（Bn）, then e-t f（., t） is an extreme point of So（Bn） for t≥0 （respectively a support point of So（Bn） for t C [O, t0] and some to〉 0）. This is a generalization to the n-dimensional case of work due to Pell. Also, we prove analogous results for mappings which belong to So（Bn） and which are bounded in the norm by a fixed constant. We relate the study of this class to reachable sets in control theory generalizing work of Roth. Finally we consider extreme points and support points for biholomorphic mappings of Bn generated by using extension operators that preserve Loewner chains.

关键词： biholomorphic mapping Loewner chain parametric representation reachable set starlike map-ping

Convolutional neural network to learn building-shape representations for early-stage energy design

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Energy and AI 2023年第4期14卷 463-478页

作者： Manav Mahan Singh ian F.C.Smith Georg Nemetschek Institute Artificial Intelligence for the Built World Technical University of MunichWalther-von-Dyck-Straße 10Garching bei München 85748Federal Republic of Germany

Machine learning(ML)supports energy-efficient design by quickly predicting the building performance at early ***,existing ML approaches cannot easily learn geometrical representations and their interactions with technical specifications for predicting *** approaches of artificial neural networks(ANN)use either numerical parameters to represent building geometry or component-based ML(CBML)to train trans-ferrable ML ***,both approaches have high generalisation errors for complex *** used a convolutional neural network(CNN)to learn geometrical representations of buildings and an autoencoder to optimise the training *** test existing approaches of ANN and CBML with a proposed approach of CNN for different sizes of training *** the biggest training dataset,ANN,CBML,and CNN have generalisation errors(root-mean-squared errors)of 1.35,1.60,and 0.77 kWh/a.m 2,*** CBML has lower prediction errors on small datasets,CNN is more suitable for large ***,CNN most often has better prediction accuracy than ANN and trains faster on encoded *** CNN captures the effects of building geometry on energy predictions better than ANN and CBML approaches,it is an attractive choice for early-stage energy design.

关键词： Energy performance ANN CNN Component-based ML Deep learning Autoencoders

Spinal Motion Segments-Ⅱ:Tuning and Optimisation for Biofidelic Performance

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Journal of Bionic Engineering 2020年第4期17卷 757-766页

作者： Constantinos Franceskides Emily Arnold ian Horsfall Gianluca Tozzi Michael CGibson Peter Zioupos Musculoskeletal and Medicolegal Research Group Cranfield Forensic InstituteCranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK Centre for Defence Engineering Cranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK School of Engineering University of PortsmouthPortsmouthPO13DJUK Centre for Simulation&Analytics Cranfield UniversityDefence Academy of the UKShrivenhamSN68LAUK

Most commercially available spine analogues are not intended for biomechanical testing,and the few that are suitable for using in conjunction with implants and devices to allow a hands-on practice on operative procedures are very expensive and still none of these offers patient-specific analogues that can be accessed within reasonable time and price ***-made spine analogues would also avoid the ethical restrictions surrounding the use of biological specimens and complications arising from their inherent biological *** we sought to improve the biofidelity and accuracy of a patient-specific motion segment analogue that we presented *** models were made by acrylonitrile butadiene styrene(ABS)in 3D printing of porcine spine segments(T12-L5)from microCT scan data,and were tested in axial loading at 0.6 ***-1(strain rate range 6×10^-4 s^-1-10×10^-4 s^-1).In this paper we have sought to improve the biofidelity of these analogue models by concentrating in improving the two most critical aspects of the mechanical behaviour:the material used for the intervertebral disc and the influence of the facet *** deformations were followed by use of Digital Image Correlation(DIC)and consequently different scanning resolutions and data acquisition techniques were also explored and compared to determine their *** found that the selection of an appropriate intervertebral disc simulant(PT Flex 85)achieved a realistic force/displacement response and also that the facet joints play a key role in achieving a biofidelic behaviour for the entire motion *** have therefore overall confirmed the feasibility of producing,by rapid and inexpensive 3D-printing methods,high-quality patient-specific spine analogue models suitable for biomechanical testing and practice.

关键词： spine bone analogue micro-CT 3D printing Digital Image Correlation(DIC)

Diffusion of Sm-Nd in Scheelite and its Significance to Isotopic Dating and Tracing

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Acta Geologica Sinica(English Edition) 2023年第2期97卷 651-661页

作者： ZHANG Dongliang ian MCOULSON PENG Jiantang LI Shijie WANG Guoqiang Key Laboratory of Metallogenic Prediction of Nonferrous Metals Ministry of EducationSchool of Geosciences and InfophysicsCentral South UniversityChangsha 410083China Solid Earth Studies Laboratory Department of GeologyUniversity of ReginaReginaSaskatchewan S4S OA2Canada Lunar and Planetary Science Research Center Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Xi'an Center of Geological Survey CGSXi'an 710054China

As the principal ore mineral in various tungsten(-gold)deposits,scheelite(CaWO_(4))plays an important role in directly dating the timing of ore formation,and in tracing associated material sources through the study of its Sm-Nd geochronology and Nd isotopic *** the retention of Sm-Nd systematics within scheelite is presently unconstrained,equivocal interpretations for isotopic data resulting from this method have occurred quite often in previous studies that apply these isotopic *** order to better elucidate the closure of Sm-Nd in scheelite,the kinetics of Sm and Nd within this mineral lattice were investigated through calculation of diffusion constants presented *** following Arrhenius relations were obtained:D_(Nd)=4.00exp(-438 kJ·mol^(–1)/RT)cm^(2)/s D_(Sm)=1.85exp(-427 kJ·mol^(–1)/RT)cm^(2)/s showing diffusion rate of Nd is near identical to Sm in scheelite when at the same ***,compared to other rare earth elements(REEs),which have markedly different atomic radii to either Nd or Sm,these are shown to exhibit a great variation in *** observed trends in our data are in excellent agreement with the diffusion characteristics of REEs in other tetragonal ABO4 minerals,indicating that ionic radius is a key constraint to the diffusivity of REEs in the various crystal *** this in mind,the same substitution mechanism and a very slight discrepancy in radii will allow us to infer that significant Sm/Nd diffusional fractionation in scheelite is unlikely to occur during most geological *** upon the diffusion data determined herein,Sm and Nd closure temperatures and retention times in scheelite are discussed in terms of diffusion *** results suggest that closure temperatures for Sm-Nd within this mineral are relatively high in contrast to the temperature ranges of ore-formation responsible for scheelite-related deposits,and any later thermal *** is likely,therefore,that rel

关键词： Sm-Nd system diffusion scheelite closure temperature isotopic dating

Nicotiana attenuata's capacity to interact with arbuscular mycorrhiza alters its competitive ability and elicits major changes in the leaf transcriptome

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Journal of Integrative Plant Biology 2018年第3期60卷 242-261页

作者： Ming Wang Julia Wilde ian T.Baldwin Karin Groten Department of Molecular Ecology Max Planck Institute for Chemical EcologyHans-Knoll-Str.8Jena 07745Germany

To study the local and systemic effects of arbuscular mycorrhizal fungal （AMF） colonization, Nicotiana attenuata plants impaired in their interactions with AMF due to silencing of a calcium- and calmodulin dependent protein kinase （inverted repreat （ir）CCaMK） were grown competitively in pairs with empty vector （EV） plants, with and without two different types of inoculum. When inoculated, EV plants strongly outperformed irCCaMK plants. Foliar transcript profiling revealed that AMF colonization significantly changed gene expression of P-starvation and -transporter genes in irCCaMK plants. The Phtl family phosphate transporter NaPT5 was not only specifically induced in roots after AMF colonization, but also in leaves of AMF-colonized irCCaMK plants, and in plants grown under low Pi conditions in the absence of AMF. The P-starvation signature of inoculated irCCaMK plants corresponded with increases in selected amino acids and phenolic compounds in leaves. We also found a strong AMF-induced increase in amino acids and phenolic metabolites in roots. Plants impaired in their interactions with AMF clearly have a fitness disadvantage when competing for limited soil nutrients with a fully functional isogenic line. The additional role of the AMF-induced Phtl family transporter NaPT5 in leaves under P-starvation conditions will require further experiments to fully resolve.

关键词： William J. Lucas University of California Davis USA

Do mantle plumes exist？

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Episodes 2006年第3期29卷 162-168页

作者： ian H. Campbell Geoffrey F. Davies Research School of Earth Sciences The Australian National University Canberra ACT 0200 Australia

The physics of low Reynolds number plumes is well understood, which allows a number of testable predictions to be made about mantle plumes. They are predicted to originate from the core-mantle boundary and consist of a large head followed by a narrower tail. Millions of cubic kilometers of magma can be produced from a plume head. Rifting over a previously-emplaced plume head should produce a narrow zone of thickened oceanic crust along the rift margin. Initial eruption from a plume head should be preceded by -1,000 m of domal uplift. Picrites are expected to dominate the first eruptive products of a new plume and should be concentrated near the centre of the volcanic province. All of these predictions are confirmed by observations, and so provide strong support for the validity of the mantle plume hypothesis.

关键词：地幔热流柱数值模型俯冲作用深部构造