检索结果-南通市图书馆

Neurocircuit regeneration by extracellular matrix reprogramming

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian N.Levasseur Kimberly M.Alonge Department of Medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Globus Toolkit Version 4： Software for Service-Oriented Systems

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2006年第4期21卷 513-520页

作者： ian Foster Computation Institute Argonne National Laboratory & University of Chicago Argonne IL 60439 U.S.A.

The Globus Toolkit （GT） has been developed since the late 1990s to support the development of serviceoriented distributed computing applications and infrastructures. Core GT components address, within a common framework, fundamental issues relating to security, resource access, resource management, data movement, resource discovery, and so forth. These components enable a broader ＂Globus ecosystem＂ of tools and components that build on, or interoperate with, GT functionality to provide a wide range of useful application-level functions. These tools have in turn been used to develop a wide range of both ＂Grid＂ infrastructures and distributed applications. I summarize here the principal characteristics of the recent Web Services-based GT4 release, which provides significant improvements over previous releases in terms of robustness, performance,, usability, documentation, standards compliance, and functionality. I also introduce the new ＂***＂ community development process, which allows a larger community to contribute to the development of Globus software.

关键词： distributed systems distributed applications Internet applications middleware open source

The changing world under the corona virus threat-from human needs to SDGs and what next?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2021年第1期24卷 50-57,I0008页

作者： Orhan Altan ian Dowman Department of Geomatics Istanbul Technical UniversityIstanbulTurkey Department of Civil Environmental and Geomatic EngineeringUniversity College LondonLondonUK

The COVID-19(coronavirus)disease has affected over 100 countries in a matter of *** way humans live and work on planet Earth has changed profoundly over the last *** lives and livelihoods have been *** of working,shopping,and social interactions are all vastly different for most of *** do not know when the current crisis will end,or how far we will“return”to the way things were before the *** world is experiencing one of the most transformative moments of the last 100 *** social,economic,and political influences of the COVID-19 crisis have already been hugely momentous,we do not utterly understand *** ahead,we have inevitably had to make important public health,economic,governance,and ecological decisions with less information than usual and to reverse recently adopted policies,which can lead to an era of disruptive transformations to *** these historic times,we must understand the hidden reality of the earth system and attempt to transform our needs so that we all have a sustained future on our planet.

关键词： COVID-19 human needs social and scientific response millennium development goals sustainable development goals UN

The blood–brain barrier in systemic infection and inflammation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第11期18卷 2489-2501页

作者： ian Galea Clinical Neurosciences Clinical&Experimental SciencesFaculty of MedicineUniversity of SouthamptonSouthamptonSO166YDUK

The vascular blood-brain barrier is a highly regulated interface between the blood and *** primary function is to protect central neurons while signaling the presence of systemic inflammation and infection to the brain to enable a protective sickness behavior *** increasing degrees and duration of systemic inflammation,the vascular blood-brain barrier becomes more permeable to solutes,undergoes an increase in lymphocyte trafficking,and is infiltrated by innate immune cells;endothelial cell damage may occasionally *** of neuronal function results in the clinical features of ***,the molecular and cellular anatomy of the vascular blood-brain barrier is reviewed,first in a healthy context and second in a systemic inflammatory *** from the molecular and cellular mediators of the blood-brain barrier’s response to inflammation,several moderators influence the direction and magnitude at genetic,system,cellular and molecular *** include sex,genetic background,age,pre-existing brain pathology,systemic comorbidity,and gut *** progress is required to define and measure mediators and moderators of the blood-brain barrier’s response to systemic inflammation in order to explain the heterogeneity observed in animal and human studies.

关键词： blood-brain barrier inflammation infection signaling moderation

Critical interfaces in body armour systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2021年第6期17卷 1887-1894页

作者： ian G.Crouch Ulverston Armour Solutions UlverstonLA127BJCumbriaUK

The ballistic performance,and behaviour,of an armour system is governed by two major sets of variables,geometrical and *** these,the consistency of performance,especially against small arms ammunition,will depend upon the consistency of the properties of the constituent *** a body armour system for example,fibre diameter,areal density of woven fabric,and bulk density of ceramic are examples of critical parameters and monitoring such parameters will form the backbone of associated quality control *** is often overlooked,because it can fall into the User’s domain,are the interfaces that exist between the various products;the carrier,the Soft Armour Insert(SAI),and the one or two hard armour plates(HAP1 and HAP2).This is especially true if the various products are sourced from different suppliers.

关键词： Interfaces Body armour Body armor Ceramic armour UHMWPE Aramids Ballistic fibres Fabrics Interfacial materials Hard armour plates Soft vests

在线全文

学校读者我要写书评

暂无评论

皮革的可塑性 POLENE首尔专卖店

室内设计与装修 2025年第1期 90-95页

作者：无 Minwoo(ian)Yang Sunho Shin Hyevin Park Yongjoon Choi(摄影) 秋落(编译) WGNB 不详

继巴黎、纽约和东京之后,专注皮革设计的小众品牌Pol$ne于日前在韩国首尔开设首家品牌旗舰店,也是全球第4间专卖店。这个深受时尚迷和年轻一代欢迎的法国小众品牌,将店址选在逛街胜地之一的江南新沙洞,打造了两层的品牌旗舰店。除了延... 详细信息

继巴黎、纽约和东京之后,专注皮革设计的小众品牌Pol$ne于日前在韩国首尔开设首家品牌旗舰店,也是全球第4间专卖店。这个深受时尚迷和年轻一代欢迎的法国小众品牌,将店址选在逛街胜地之一的江南新沙洞,打造了两层的品牌旗舰店。除了延续品牌形象,引进品牌经典包款和人气新作,受到韩国打卡文化的影响,Pol$ne为首尔旗舰店精心规划出拍照空间,凡是走进店内的人,都会忍不住想要拿起手机留下回忆。

关键词：小众品牌旗舰店皮革品牌形象专卖店 Pol

Body armour-New materials, new systems

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2019年第3期15卷 241-253页

作者： ian G.Crouch Armour Solutions

This is a very timely review of body armour materials and systems since new test standards are currently being written, or reviewed, and new, innovative products released. Of greatest importance, however, is the recent evolution, and maturity, of the Ultra High Molecular Weight Polyethylene fibres enabling a completely new style of system to evolve e a stackable system of Hard Armour Plates. The science of body armour materials is quickly reviewed with emphasis upon current understanding of relevant energy-absorbing mechanisms in fibres, fabrics, polymeric laminates and ceramics. The trend in ongoing developments in ballistic fibres is then reviewed, analysed and future projections offered. Weaknesses in some of the ceramic grades are highlighted as is the value of using cladding materials to improve the robustness, and multi-strike performance, of Hard Armour Plates. Finally, with the drive for lighter, and therefore smaller, soft armour systems for military personnel the challenges for armour designers are reported, and the importance of the relative size of the Hard Armour Plate to the Soft Armour Insert is strongly emphasised.

关键词： Body armour Body armor Ceramic armour Reaction sintered silicon carbide UHMWPE Fibres Fabrics Strike-face materials Aramids Small-arms ammunition

Blockchain for decentralised rural development and governance

在线全文

学校读者我要写书评

暂无评论

Blockchain(Research and Applications) 2022年第3期3卷 100-108页

作者： ian Merrell National Innovation Centre for Rural Enterprise Centre for Rural EconomyNewcastle UniversityNewcastle-Upon-TyneNE17RUUK

Rural areas are steadily being marginalised in a global economy where‘core/periphery’models of development are *** overcome this,rural areas have experimented with decentralised ***,this process is fraught with political,fiscal,and institutional *** often revolve around transparency and accountability issues and low participation *** technology could act as a social innovation to overcome issues in decentralised governance,and rural areas could even prove to be a fertile environment for future *** this conceptual paper,the potential of blockchain technology is theoretically positioned in regional development *** exploring how blockchain could be applied to rural governance and the barriers it needs to overcome to reach mass adoption,a new distributed model of governance is suggested.

关键词： Rural development Decentralised governance Blockchain Social innovation Regional development Participatory governance

Fluctuating resources,disturbance and plant strategies:diverse mechanisms underlying plant invasions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Arid Land 2013年第3期5卷 284-297页

作者： ian J RADFORD CSIRO Sustainable Ecosystems Davies LaboratoryPrivate Mailbag POAitkenvale 4814Australia Botany Department University of OtagoPO Box 56Dunedin 9054New Zealand

This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. （2000）. I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.

关键词： plant invasion plant strategies C-S-R triangle fluctuating resources disturbance