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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： Sarah Khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar T sims Christine E Koval Aanchal Kapoor Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** To investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,P<0.001).The majority of the fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,P<0.001),and dialysis due to acute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and Chronic Health Evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for End-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).There was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World Journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R Patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B sims Sasha Vukelic Stephen J Forest Jamil F Borgi Daniel J Goldstein Ulrich P Jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

Beyond the SDG 15.3.1 Good Practice Guidance 1.0 using the Google Earth Engine platform: developing a self-adjusting algorithm to detect significant changes in water use efficiency and net primary production

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Big Earth Data 2023年第1期7卷 59-80页

作者： Andrea Markos Neil sims Gregory Giuliani Foundation for the Conservation of the Chiquitano Forest Santa CruzBolivia Bolivian National Academy of Sciences La PazBolivia Centre for Earth Observation Space&AstronomyCSIROClaytonAustralia GEO LDN Initiative Institute for Environmental Sciences EnviroSPACE LabUniversity of GenevaGenevaSwitzerland Institute for Environmental Sciences GRID-GenevaUniversity of GenevaGenevaSwitzerland

Monitoring changes in Annual Net Primary Productivity(ANPP)is required for reporting on UN Sustainable Development Goal(SDG)Indicator 15.3.1:the proportion of land that is degraded over the total land *** time-series observations of ANPP to derive Water Use Efficiency(WUE;a measure of ANPP per unit of evapotranspiration)can minimize the influence of climate factors on ANPP observations and highlight the influence of non-climatic drivers of degradation such as land use *** the ANPP and WUE time series may be useful for identifying the primary drivers of land degradation,which could be used to support the Land Degradation Neutrality objectives of the UN Convention to Combat Desertification(UNCCD).This paper presents an algorithm for the Google Earth Engine(freely and openly available upon request-http://***/10.5281/zenodo.4429773)to calculate and compare ANPP and WUE time series for Santa Cruz,Bolivia,which has recently experienced an intensification in its land *** code builds on the Good Practice Guidance document(ver-sion 1)for monitoring SDG Indicator *** use the MODIS 16-day average,250 m resolution to demonstrate that the Enhanced Vegetation Index(EVI)responds faster to changes in water avail-ability than the Normalized Difference Vegetation Index(NDVI).We also consider the relationships between ANPP and *** and concordant trends may highlight good agricultural practices or increased resilience in ecosystem structure and productivity when they are positive or reducing resilience and functional integrity if *** sign and significance of the correlation between ANPP and WUE may also diverge over *** further analysis,it may be possible to interpret this relationship in terms of the drivers of change in plant productivity and ecosystem resilience.

关键词： Land degradation land productivity water use efficiency Google Earth Engine MODIS Good Practice Guidance SDG 15.3.1

Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer

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Cancer Biology & Medicine 2018年第4期15卷 375-388页

作者： Maria Bonello ANDrew Harvey sims Simon Peter Langdon Cancer Research UK Edinburgh Center and Division of Pathology Laboratory MRC Institute of Genetics and Molecular Medicine University of Edinburgh

Ovarian cancer is the second most lethal gynecological cancer worldwide and while most patients respond to initial therapy, they often relapse with resistant disease. Human epidermal growth factor receptors(especially HER1/EGFR and HER2/ERBB2) are involved in disease progression; hence, strategies to inhibit their action could prove advantageous in ovarian cancer patients,especially in patients resistant to first line therapy. Monoclonal antibodies and tyrosine kinase inhibitors are two classes of drugs that act on these receptors. They have demonstrated valuable antitumor activity in multiple cancers and their possible use in ovarian cancer continues to be studied. In this review, we discuss the human epidermal growth factor receptor family; review emerging clinical studies on monoclonal antibodies and tyrosine kinase inhibitors targeting these receptors in ovarian cancer patients; and propose future research possibilities in this area.

关键词： Tyrosine kinase monoclonal antibodies ovarian cancer inhibitors HER receptors

Risk factors for hamstring injuries in Australian male professional cricket players

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Journal of Sport and Health Science 2017年第3期6卷 271-274页

作者： John W.Orchard Alex Kountouris Kevin sims School of Public Health The University of SydneySydneyNSW 2006Australia Cricket Australia MelbourneVIC 3002Australia

Background:Injuries to the hamstring are relatively common in professional cricketers(as they are in many team sports) and have increased in incidence in the "T20 era"(introduction of 20-over matches) of cricket since ***:This study analyzed incidence of hamstring injury in the various elite male match types over a 20-year period(1995–1996 to 2014–2015seasons).Risk factors for hamstring strain were assessed using a multivariate logistic regression analysis ***:There were 276 match time-loss hamstring injuries recorded over a 20-year period at the Australian state or national player level,of which170 occurred in one of 40,145 player match *** overall rate of match onset rate was 22.5 hamstring injuries per 1000 team *** bowling onset injuries were the highest subcategory at a rate of 10.9 injuries per 1000 team days,although batting onset injuries were particularly common in 50-over(one day) international *** risk factors in logistic regression analysis,in addition to hamstring injury history,were being a fast bowler relative risk(RR) 2.5(95% confidence interval(CI):1.3–4.5) and playing a match in Australia RR 2.3(95%CI:1.3–3.9).Conclusion:Fast bowlers suffer more hamstring injuries than other playing roles in cricket,particularly in First Class(multi-day) *** are more likely to get injured in 50-over(one day) *** in Australia(compared to overseas venues) leads to increased risk of hamstring injury.

关键词： Cricket Fast bowling Fielding Hamstring strains Muscle strains Sprinting

Painful sesamoid of the great toe

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World Journal of Orthopedics 2014年第2期5卷 146-150页

作者： Alex L sims Harish V Kurup Department of Orthopaedics University Hospital of North Tees Cleveland TS19 8PE United Kingdom Department of Orthopaedics Pilgrim Hospital Sibsey Rd Lincolnshire PE21 9QS United Kingdom

The painful sesamoid can be a chronic and disabling problem and isolating the cause can be far from straightforward. There are a number of forefoot pathologies that can present similarly to sesmoid pathologies and likewise identifying the particular cause of sesamoid pain can be challenging. Modern imaging techniques can be helpful. This article reviews the anatomy,development and morphological variability present in the sesamoids of the great toe. We review evidence on approach to history, diagnosis and investigation of sesamoid pain. Differential diagnoses and management strategies, including conservative and operative are outlined. Our recommendations are that early consideration of magnetic resonance imaging and discussion with a specialist musculoskeletal radiologist may help to identify a cause of pain accurately and quickly. Conservative measures should be first line in most *** fracture and avascular necrosis can be ruled out,injection under fluoroscopic guidance may help to avoid operative intervention.

关键词： Sesamoid Pain Great toe Management Forefoot

Does orthotics use improve comfort,speed,and injury rate during running?A randomised control trial

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World Journal of Orthopedics 2023年第5期14卷 348-361页

作者： Alice E Fortune Jonathan M G sims George Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi Ltd.SouthportPR83NSUnited Kingdom School of Medicine University of LiverpoolLiverpool L693GEMerseysideUnited Kingdom

BACKGROUND Running is a hugely popular ***,running-related injury(RRI)rates are high,particularly amongst amateur and recreational *** ways to reduce RRI rates and maximise comfort and performance for runners is *** regarding whether orthotics can successfully improve these parameters is limited and *** research is required to provide runners with clearer guidance on the usefulness of *** To investigate the effect of Aetrex Orthotics on comfort,speed and RRI rates during recreational *** One hundred and six recreational runners were recruited on a voluntary basis via running clubs and social media pages and randomised into either the intervention or control *** in the intervention group ran with Aetrex L700 Speed Orthotics inserted in their usual running shoes,whilst participants in the control group ran in their usual running shoes with no *** study ran for an 8-wk *** provided data relating to running comfort,distance,and time during weeks *** provided data relating to any RRIs they sustained during all 8 *** distance and time were used to calculate running speed in miles per hour(mph).For each outcome variable,95%confidence intervals and P values were calculated to assess the statistical significance between the *** comfort and speed data,univariate multi-level analysis was performed,and for outcome variables with significant between group differences,multi-level multivariate analysis was performed to evaluate any confounding effects of gender and *** Ninety-four participants were included in the final analysis(drop-out rate=11%).Comfort and speed from 940 runs and 978 injury data reports were *** who ran with orthotics reported,on average,speeds 0.30 mph faster(P=0.20)and comfort scores 1.27 points higher(P≤0.001)than participants who ran with no *** were also 2.22 times less

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

Brain-derived neurotrophic factor rs6265(Val66Met)single nucleotide polymorphism as a master modifier of human pathophysiology

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Neural Regeneration Research 2023年第1期18卷 102-106页

作者： Van Thuan Nguyen Braxton Hill Naiya sims Aaron Heck Marcus Negron Claire Lusk Cristi LGalindo Department of Biology Western Kentucky UniversityBowling GreenKYUSA

Brain-derived neurotrophic factor is the most prevalent member of the nerve growth factor *** its discovery in 1978,this enigmatic molecule has spawned more than 27,000 publications,most of which are focused on neurological ***-derived neurotrophic factor is indispensable during embryogenesis and postnatally for the normal development and function of both the central and peripheral nervous *** is becoming increasingly clear,however,that brain-derived neurotrophic factor likewise plays crucial roles in a variety of other biological functions independently of sympathetic or parasympathetic ***-derived neurotrophic factor is also increasingly recognized as a sophisticated environmental sensor and master coordinator of whole organismal *** that point,we recently found that a common nonsynonymous(Val66→Met)single nucleotide polymorphism in the brain-derived neurotrophic factor gene(rs6265)not only substantially alters basal cardiac transcriptomics in mice but subtly influences heart gene expression and function differentially in males and *** addition to a short description of recent results from associative neuropsychiatric studies,this review provides an eclectic assortment of research reports that support a modulatory role for rs6265 including and beyond the central nervous system.

关键词： brain-derived neurotrophic factor neuropsychiatric disorders rs6265 Val66Met

Effect of psychological preparation on anxiety level before colonoscopy in outpatients referred to Golestan Hospital in Ahvaz

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Frontiers in Biology 2017年第3期12卷 235-239页

作者： Hatam Boustani sims Pakseresht Mohammad-Reza Haghdoust Saeid Qanbari Hadis Mehregan-Nasab Department of Psychiatry Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Gastrointestinal disorders are common complaints for which endoscopy and colonoscopy are the most important diagnostic procedures. Anxiety is an unpleasant, ambiguous feeling of apprehension and fear of unknown origin that occurs during stressful situations or injury. Lack of sufficient information and fear of pain can cause anxiety prior to a colonoscopy, reducing the number of patients willing to undergo the procedure and increasing colonoscopy time. The aim of this study was to evaluate the efficacy of psychological preparation on anxiety before colonoscopy in patients presenting to Golestan Hospital during the years 1994 and 1995. MATERIAL and METHODS： This study was a double-blind clinical trial of patients presenting to the colonoscopy unit in Golestan Hospital in 1994 and 1995. A total of 80 patients were divided into two groups： intervention and control. A primary assessment of anxiety was performed using Spielberger＇s State-Trait Anxiety Inventory. Before the colonoscopy, the State-Trait Anxiety Inventory was completed by the patients again. The effectiveness of psychological preparation before colonoscopy and its effect on anxiety were evaluated using statistical software SPSS 20. RESULTS： The mean age of participants was 46.33 ±12.2 years in the intervention group and 44.8±12.26 years in the control group. In this study, there were 41 males （51.3%） and 39 females （48.7%）; 15 patients （18.7%） were single and the rest married. In terms of demographic variables, there were no significant differences between the two groups （p 〉 0.05）. The average scores of state and trait anxiety in the intervention group showed a statistically significant difference before and after the intervention （p = 0.000）. CONCLUSION： Trait and state anxiety levels after psychological preparation showed a statistically significant reduction. This indicates the effectiveness of intervention programs to reduce anxiety before colonoscopy.

关键词： anxiety colonoscopy Spielberger