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Mapping inertial migration in the cross section of a microfluidic channel with high-speed imaging

Microsystems & Nanoengineering 2020年第1期6卷 185-198页

作者： Jian Zhou Zhangli Peng ian papautsky Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

The wide adoption of inertial microfluidics in biomedical research and clinical settings,such as rare cell isolation,has prompted the inquiry of its underlying *** tremendous improvement has been made,the mechanism of inertial migration remains to be further *** observations are not fully reconciled by the existing theory,and details of the inertial migration within channel cross sections are missing in the *** this work,for the first time,we mapped the inertial migration pathways within channel cross section using high-speed imaging at the single-particle *** is in contrast to the conventional method of particle streak velocimetry(PSV),which provides collective *** also applied smoothed particle hydrodynamics(SPH)to simulate the transient motion of particles in 3D and obtained cross-sectional migration trajectories that are in agreement with the high-speed imaging *** found two opposing pathways that explain the contradicting observations in rectangular microchannels,and the force analysis of these pathways revealed two metastable positions near the short walls that can transition into stable positions depending on the flow condition and particle *** new findings significantly improve our understanding of the inertial migration physics,and enhance our ability to precisely control particle and cell behaviors within microchannels for a broad range of applications.

关键词： positions details collective

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Viscoelastic microfluidics: progress and challenges

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Microsystems & Nanoengineering 2020年第1期6卷 63-86页

作者： Jian Zhou ian papautsky Department of Bioengineering University of Illinois at ChicagoChicagoIL 60607USA

The manipulation of cells and particles suspended in viscoelastic fluids in microchannels has drawn increasing attention,in part due to the ability for single-stream three-dimensional focusing in simple channel *** in the understanding of non-Newtonian effects on particle dynamics has led to expanding exploration of focusing and sorting particles and cells using viscoelastic *** factors,such as the driving forces arising from fluid elasticity and inertia,the effect of fluid rheology,the physical properties of particles and cells,and channel geometry,actively interact and compete together to govern the intricate migration behavior of particles and cells in ***,we review the viscoelastic fluid physics and the hydrodynamic forces in such flows and identify three pairs of competing forces/effects that collectively govern viscoelastic *** discuss migration dynamics,focusing positions,numerical simulations,and recent progress in viscoelastic microfluidic applications as well as the remaining ***,we hope that an improved understanding of viscoelastic flows in microfluidics can lead to increased sophistication of microfluidic platforms in clinical diagnostics and biomedical research.

关键词： Viscoelastic flow Elastic and inertial force Microfluidics Numerical modeling Particle separation and cell sorting 3D focusing

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Evolution of focused streams for viscoelastic flow in spiral microchannels

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微系统与纳米工程(英文) 2023年第3期9卷 129-143页

作者： Hua Gao Jian Zhou Mohammad Moein Naderi Zhangli Peng ian papautsky Department of Biomedical Engineering University of Illinois ChicagoChicagoIL 60607USA

Particle migration dynamics in viscoelastic fluids in spiral channels have attracted interest in recent years due to potential applications in the 3D focusing and label-free sorting of particles and *** a number of recent studies,the underlying mechanism of Dean-coupled elasto-inertial migration in spiral microchannels is not fully *** this work,for the first time,we experimentally demonstrate the evolution of particle focusing behavior along a channel downstream length at a high blockage *** found that flow rate,device curvature,and medium viscosity play important roles in particle lateral *** results illustrate the full focusing pattern along the downstream channel length,with side-view imaging yielding observations on the vertical migration of focused ***,we anticipate that these results will offer a useful guide for elasto-inertial microfluidics device design to improve the efficiency of 3D focusing in cell sorting and cytometry applications.

关键词： viscoelastic flow curvature

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Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel

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Microsystems & Nanoengineering 2019年第1期5卷 615-626页

作者： Jian Zhou Arutha Kulasinghe Amanda Bogseth Ken O’Byrne Chamindie Punyadeera ian papautsky Department of Bioengineering University of Illinois at ChicagoChicagoIL 60607USA University of Illinois Cancer Center ChicagoIL 60612USA The School of Biomedical Sciences Institute of Health and Biomedical InnovationQueensland University of TechnologyKelvin GroveQLDAustralia Translational Research Institute BrisbaneQLDAustralia Princess Alexandra Hospital WoolloongabbaQLDAustralia

Circulating tumor cells(CTCs)carry a wealth of information on primary and metastatic tumors critical for precise cancer detection,monitoring,and *** microfluidic platforms have been developed in the past few years to capture these rare cells in patient bloodstream for deciphering the critical information ***,the practical need for a high-quality method of CTC isolation remains to be ***,we demonstrate a novel multi-flow microfluidic device that is able to sensitively provide high purity(>87%)of separation outcome without *** device is constructed and configured based on the phenomenal effect of size-dependent inertial *** recovery rate of>93%has been achieved using spiked cancer cells at clinically relevant concentrations(10 cells per 5 mL and above).We have also successfully detected CTCs from 6 out of 8 non-small-cell-lung-cancer(NSCLC)patients,while none for 5 healthy control *** these results,we envision our approach is a promising alternative for reliable CTC capture,and thus for facilitating the progress of extracting information from CTCs to personalize treatment strategies for solid tumor patients.

关键词： patients fluid flow

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