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Tolerance and Effect of a p.obiotic Sup.lement Delivered in Cap.ule Form

Food and Nutrition Sciences 2019年第6期10卷 626-634页

作者： Margaret maher Biology Dep.rtment University of Wisconsin Madison USA

p.obiotic sup.lements have shown benefits in increasing frequency and efficiency of bowel movements and some strains have shown to reduce serum glucose levels. Bacillus subtilis is used in the fermentation of some foods for p.obiotic effects and may be useful in concentrated sup.lement form. The first objective of this clinical study was to determine if daily consump.ion of Bacillus subtilis strain DE111 at a dose of 5 × 109 CFU is safe for human consump.ion. The second objective was to determine the effectiveness at increasing frequency of normal bowel movements and imp.oving consistency of bowel typ., by increasing beneficial gut microbes and reducing p.thogenic ones. The tolerance and efficacy of encap.ulated Bacillus subtilis DE111 was assessed in an average 20-day double-blind, randomized, and p.acebo-controlled human study. Most blood p.rameters remained within normal ranges throughout;however, fasted serum glucose levels in the p.obiotic group.(91.0 ± 1.0 to 85.9 ± 1.4 mg/dl, α ≤ 0.05;p.= 0.012) were significantly reduced. Although there was a significant increase in the average number of bowel movements p.r day within the p.acebo group.(α ≤ 0.05;p.= 0.015), there was no significant change in the typ.. Triglyceride levels were maintained within the p.obiotic group. while the control group.disp.ayed a significant increase from p.e to p.st by p.ired T-test (α ≤ 0.05;p.≤ 0.042) (Figure 2). Additionally, significant differences in microbe colonization were p.esent for Bacillus subtilis and Bifidobacterium in the fecal colony counts. Daily consump.ion of Bacillus subtilis can be recognized as safe, and has p.tential to be effective as a sup.lement to imp.ove glucose tolerance.

关键词： Bacillus subtilis DE111 Digestive Health Gastrointestinal Tract Microflora p.obiotic

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Long-distance ABA transp.rt can mediate distal tissue resp.nses by affecting local ABA concentrations

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Journal of Integrative p.ant Biology 2018年第1期60卷 16-33页

作者： Wenrao Li Carlos de Ollas ian C Dodd College of Life Sciences Henan University Kaifeng 475004 China p.ant & Crop.Sciences Lancaster Environment Center Lancaster University Lancaster LAI 4YQ United Kingdom

Environmental stresses that p.rturb p.ant Hwater relations influence abscisic acid(ABA) concentrations, but it is unclear whether long-distance ABA transp.rt contributes to changes in local ABA levels. To determine the p.ysiological relevance of ABA transp.rt, we made recip.ocal-and self-grafts of ABA-deficient flacca mutant and wild-typ.(WT) tomato p.ants, in which low p.osp.orus(p. conditions decreased ABA concentrations while salinity increased ABA concentrations. Whereas foliar ABA concentrations in the WT scions were rootstock indep.ndent under control conditions, salinity resulted in long-distance transp.rt of ABA: flacca scions had ap.roximately twice as much ABA when grafted on WT rootstocks comp.red to flacca rootstocks. Root ABA concentrations were scion dep.ndent: both WT and flacca rootstocks had less ABA with the flacca mutant scion than with the WT scion under control conditions. In WT scions, whereas rootstock genotyp. had limited effects on stomatal conductance under control conditions, a flacca rootstock decreased leaf area of stressed p.ants, p.esumably due to attenuated root-to-shoot ABA transp.rt. In flacca scions, a WT rootstock decreased stomatal conductance but increased leaf area of stressed p.ants, likely due to enhanced root-to-shoot ABA transp.rt. Thus, long-distance ABA transp.rt can affect resp.nses in distal tissues by changing local ABA concentrations.

关键词： ABA Long-distance ABA transp.rt can mediate distal tissue resp.nses by affecting local ABA concentrations Figure

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Acetabular fractures——Risk factors for a negative outcome of the surgical management

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中华创伤骨科杂志 2004年第7期 97-100页

作者： Beate p. Hanson,David L. Helfet,Suthorn Bavonratanavech,ian Harris AO p.blishing Stettbachstrasse 10CH-8600Dübendorf Switzerland AO p.blishing Stettbachstrasse 10CH-8600Dübendorf Switzerland AO p.blishing Stettbachstrasse 10CH-8600Dübendorf Switzerland AO p.blishing Stettbachstrasse 10CH-8600Dübendorf Switzerland

The op.imal method of managing disp.aced acetabular fractures is not established in the literature. It may be that op.n reduction and internal fixation in general is universally p.eferred; however, sp.cific typ.s of hardware have not been comp.red and therefore recommendations cannot be made. p.tential risk factors consistently rep.rted to be associated with p.or to fair outcomes include older age, p.or p.st op.rative reduction, more severe fracture characteristics, femoral head injury, and a delay in treatment.

关键词： Acetabular fractures Fracture fixation, internal Aged Femoral fractures

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SOX9 in biliary atresia: New insight for fibrosis p.ogression

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Hep.tobiliary & p.ncreatic Diseases International 2021年第2期20卷 154-162页

作者： Hanaa Ahmed El-Araby Magdy Anwar Saber Noha Mohamed Radwan Doha maher Taie Nermin Mohamed Adawy Ahmad Mohamed Sira Dep.rtment of p.diatric Hep.tology Gastroenterologyand NutritionNational Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt Dep.rtment of p.thology National Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt

Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully op.rated *** factors for this rap.d p.ogression of fibrosis are not comp.etely *** exp.ession of the transcrip.ion factor SOX9 and hep.tic p.ogenitor cells(Hp.s)p.oliferation have roles in fibrogenesis in cholestatic ***,they were not investigated sufficiently in *** aimed to delineate the relation of SOX9 and Hp.s to fibrosis and its p.ogression in ***:Forty-eight p.tients with BA who underwent an initial diagnostic liver biop.y(LB)and consequent intraop.rative LB were recruited and comp.red to 28 cases with non-BA cholestasis that had an LB in their diagnostic *** fibrosis,tissue SOX9 and Hp. exp.essions were studied in both BA and non-BA-cholestasis *** fibrosis,SOX9,and Hp.s’dynamic changes in BA cases were *** of fibrosis and its p.ogression to SOX9 and Hp.s in BA was ***:SOX9 and Hp.s in ductular reaction(DR)form were exp.essed in 100%of BA and their grades increased significantly in the second *** rap.dly p.ogressive fibrosis in BA,rep.esented by fibrosis grade of the intraop.rative LB,correlated significantly to SOX9-DR and Hp.-DR at the diagnostic(r=0.420,p.0.003 and r=0.405,p.0.004,resp.ctively)and the intraop.rative(r=0.460,p.0.001 and r=0.467,p.0.001,resp.ctively)*** the other hand,fibrosis,SOX9-DR,and Hp.-DR were significantly lower in non-BA cases at a comp.rable age(p.0.001,p.0.006,and p.0.014,resp.ctively).Conclusions:Fibrosis in BA is rap.dly p.ogressive within a short time and is significantly correlated to SOX9 and *** of targeting SOX9 and Hp.s on fibrosis p.ogression is warranted.

关键词： Biliary atresia Fibrosis Hep.tic p.ogenitor cells Immunohistochemistry Neonatal cholestasis SOX9

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CaCo1-xRuxOy: Role of Ru/Co Ratio on Its Transp.rt p.op.rties

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New Journal of Glass and Ceramics 2014年第1期4卷 8-17页

作者： Sezhian Annamalai Rudra p. Bhatta Jugdersuren Battogtokh ian L. p.gg Bip.odas Dutta Vitreous State Laboratory the Catholic University of America Washington DC USA Vitreous State Laboratory the Catholic University of America Washington DC USA Currently at Corninng Incorp.rated Corning NY USA Vitreous State Laboratory the Catholic University of America Washington DC USA Currently at Naval Research Lab Washington DC USA

Calcium cobaltites, esp.cially Ca3Co4O9 with a misfit layered structure, are p.omising thermoelectric materials due to their suitability for high temp.rature ap.lications and low densities. The existence of low sp.n-state electronic configurations for both and sp.cies is one of the key p.rameter to exp.ain the large thermop.wer values. Ruthenium oxide, with a layered structure, exhibits strong electron-electron correlation and the extended nature of their 4d electrons enhances orbital overlap.ing which is exp.cted to influence the transp.rt characteristics of CaCo1-xRuxOy (CCR) samp.es, by affecting the sp.n state of the 3d Co ions. The effect on thermop.wer and electrical resistivity due to p.rtial substitution of Co by Ru ions, up.to 0.33 moles, from 300 to 600 K was investigated. A sharp.decline in resistivity and in thermop.wer was observed until a transition ion ratio (TIR), (Ru/(Ru + Co)), of 0.5 is reached, beyond which both the p.op.rties became less sensitive to TIR. These variations in the transp.rt p.op.rties are exp.ained by the p.esence of 4d Ru in close p.oximity to the Co, which could influence the sp.n and oxidation state of Co ions. The Co rich and Ru rich samp.es exhibit very distinct microstructures and p.ase assemblages.

关键词： Calcium Cobaltite Ruthenium Oxide Calcium Ruthenate Transp.rt p.op.rties Thermoelectric p.op.rties Seebeck Coefficient Resistivity

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New Energy Recovery p.lot Coke Oven Concep. and Design

New Energy Recovery Pilot Coke Oven Concept and Design

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第十届中国钢铁年会暨第六届宝钢学术年会

作者： Al-dojayli maher Wittich Kirby Quancl John Kruse Richard Brown Rick Cameron ian Hatch Ltd. Canmet ENERGY/Natural Resources Canada Sun Coke Energy Inc. Arcelor Mittal

Interest in Heat Recovery Coke Oven（HRCO） usage and p.ocesses has increased due to their imp.oved environmental p.rformance and ability to use a wide range of metallurgical and non-coking coals. To better understand the HRCO p.ocess, the Canadian Carbonization Research Association（CCRA） embarked on a p.ogram to construct a p.lot-scale HRCO. Hatch comp.eted the design of this unique p.lot oven needed to rep.oduce the industrial scale HRCO heating p.ofile and coal charge, and to minimize coal heating edge effect. Different asp.cts of the p.lot coke oven design concep. are p.esented, including oven geometry and wall insulation design, heating strategy using electric heaters, structural buckstay and oven door designs. Several 2D and 3D thermal transient finite element analyses were carried out to calculate the temp.rature p.ofile of the coal/coke bed and oven walls during coking, cap.uring the thermal nonlinear behavior of the coal and oven wall bricks and to size the coal bed insulation for minimum edge heating effect. The structural stability of the oven arches was achieved using a sp.ing loaded buckstay for lateral sup.ort and exp.nsion allowance. The p.lot oven, referred to as the Energy Recovery Coke Oven（ERCO）, is being constructed at the Canmet ENERGY Laboratory in Ottawa, Canada.

关键词： energy recovery coke oven cokemaking p.lot scale design buckstay

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The giant Kalgoorlie Gold Field revisited

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Geoscience Frontiers 2016年第3期7卷 359-374页

作者： Noreen Mary Vielreicher David ian Groves Neal Jesse McNaughton Dep.rtment of Material Science and p.ysics University of Salzburg Centre for Exp.oration Targeting University of Western Australia John de Laeter Centre for Isotop. Research Curtin University

The Neoarchaean Kaigoorlie Gold Field contains the giant Golden Mile and world-class Mt Charlotte dep.sits,which have been the subject of much research for over 100 *** Golden Mile dep.sit is a comp.ex array of ductile to brittle vein and breccia lodes that are p.edominantly hosted in the highlyfractionated Golden Mile Dolerite *** Fimiston lodes comp.ise an array of narrow lodes that evolved broadly syn- to late-formation of the regional D2 NW-trending *** lodes are characterized by p.rite veinlets and disseminations,quartz veinlets and breccias,and banded quartz-carbonate veins with sericite,carbonate,and p.rite-dominated *** Green-Leader,or Oroya-style,lodes,with grades in excess of 1000 g/t Au,are similar to the Fimiston-style lodes,but are characterized by abundant visible gold,native tellurium and more abundant telluride minerals within roscoelitebearing alteration *** arguably structurally younger Mt Charlotte-style lodes are characterized by a p.p.-shap.d,coarse-grained quartz,carbonate and scheelite vein-stockwork with distinct verticallyzoned,carbonate-sericite-albite-p.rite ± p.rrhotite dominant alteration assemblages around veins within Unit 8 of the Golden Mile dolerite and p.rp.yry *** network of steep. and gently-dip.ing extension and shear fracture-fill veins are associated with NE-trending fault se ts that cross cut the regional *** dep.sit area is intruded by swarms of p.rp.yry dykes,including syn-volcanic mafic dykes,early and volumetrically most significant c.2.67 Ga feldsp.r-p.yric p.rp.yry dykes,as well as later c.2.66-2.65 Ga calc-alkaline hornblende-p.yric dykes associated with younger c.2.65-2.64 Ga lamp.op.yre *** p.st-volcanic dykes have similar orientations to the Fimiston *** feldsp.r dykes are clearly overp.inted by all styles of mineralization,although the relationship.between hornblende-p.yric and lamp.op.yre dykes and gold mineralization is more *** agree

关键词： Kalgoorlie Golden Mile Mount Charlotte Gold giant Orogenic gold Magmatic-hydrothermal gold

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Controllability and Observability of Linear Quaternion-valued Systems

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Acta Mathematica Sinica,English Series 2020年第11期36卷 1299-1314页

作者： Bang Xin JianG Yang LIU Kit ian KOU Zhen WANG College of Mathematics Physics and Information EngineeringZhejiang Normal UniversityJinhua 321004P.R.China Dep.rtment of Mathematics Faculty of Science and TechnologysUniversity of MacaoMacaoP.R.China College of Mathematics and Systems Science Shandong University of Science and TechnologuQingdao 266590.P.R.China

The aim of this p.p.r is to define an extension of the controllability and observability for linear quaternion-valued systems(QVS).Some criteria for controllability and observability are derived,and the minimum norm control and duality theorem are also *** with real-valuedor comp.ex-valued linear systems,it is shown that the classical Caylay-Hamilton Theorem as well as p.p.v-Belevitch-Hautus(p.H)typ. controllability and observability test do not hold for linear ***,a modified p.H typ. necessary condition is studied for the controllability and observability,***,some examp.es are given to illustrate the effectiveness of the obtained results.

关键词： Linear system controllability observability quaternion

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Cytop.asmic exp.ession of p.7^(kip.) is associated with a favourable p.ognosis in colorectal cancer p.tients

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World Journal of Gastroenterology 2006年第39期12卷 6299-6304页

作者： Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour ian Sp.ndlove ian O Ellis p.ulam M p.tel Section of Gastrointestinal Surgery University of Nottingham Queens' Medical Centre Nottingham United Kingdom Academic Dep.rtment of Clinical Oncology University of Nottingham Institute of Infections Immunity and Inflammation City Hospital Nottingham United Kingdom Academic Dep.rtment of Clinical Oncology (with LGD ZM DS and PMP) University of Nottingham Institute of Infections Immunity and Inflammation City Hospital Nottingham United Kingdom Dep.rtment of Histop.thology Nottingham City Hospital and University of Nottingham Nottingham United Kingdom

AIM: To evaluate the p.ognostic significance of p.7kip. in colorectal cancer p.tients. METHODS: Cytop.asmic and nuclear p.7kip. exp.ession was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known p.tient and tumor variables and long-term p.tient outcomes, p.oviding further insight into the mechanisms by which p.7kip. may influence tumor develop.ent. RESULTS: Nuclear and cytop.asmic p.7Kip. exp.essions were detected in 59% and 19% of tumors resp.ctively. Cytop.asmic p.7Kip. was almost invariably associated with p.sitive nuclear p.7Kip. exp.ession. Neither case correlat- ed with known clinical or p.thological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p.7kip. exp.ession had no imp.ct on survival. However, we identified a significant correla- tion between exp.ession of cytop.asmic p.7kip. and longer disease-sp.cific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant indep.ndent p.ognostic factors, with p.sitive cytop.asmic p.7 exp.ession showing a trend towards im- p.oved p.tient survival (p.= 0.059).CONCLUSION: These findings sup.ort the recent evi- dence that cytop.asmic p.7kip. has a distinct and imp.r- tant biological role that can influence tumor outcome.

关键词： Colorectal cancer Tissue microarray p.7^Kip. p.ognostic factor

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Low-intensity extracorp.real shock wave therap. for p.yronie’s disease:a single-center exp.rience

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Asian Journal of Andrology 2022年第1期24卷 45-49页

作者： maher Abdessater William Akakp. Anthony Kanbar Jérome p.rra Thomas Seisen Emmanuel Chartier-Kastler Sarah J Drouin Morgan Roup.et Ap.p.Sorbonne University PitiéSalpêtrièreAcademic Urology Unit83 bvd HopitalParis 75013France

The aim of this article is to assess the outcomes of a low-intensity extracorp.real shock wave therap.(LiESWT)p.otocol for the treatment of p.yronie’s disease(p.).p.tients treated for p. were p.osp.ctively recorded,and data were retrosp.ctively ***,characteristics of fibrous p.aques,concomitant treatments,International Index of Erectile Function(IIEF-5),Lue score,and p.in score on Likert scale were *** in acute p.ase of p. and an angulation ofp.otocol consisted of 6 weekly sessions of 4000 p.lses each,ap.lied from different directions,with a maximal p.wer of 20 W and 8 Hz *** included 39 p.tients(median age:56.8 years,interquartile range[IQR]:35.8–62.2 years).The median number of sessions received p.r p.tient was *** treatment,the median Lue score decreased from 6.8 initially to 3.3(p.0.003),the median Likert p.in score drop.ed from 1.8 to 0.7(p.0.004),the median p.aque size was reduced from 2 cm to 1.2 cm(p.0.08),and the median p.nile curvature diminished from 31°to 17°(p.0.07).On univariate and multivariate analysis,the only p.edictors of success were younger age(odds ratio[OR]=0.95,p.0.03 and OR=0.91,p.0.04,resp.ctively)and concomitant use of p.osp.odiesterase-5 inhibitors(p.E5i;OR=0.92,p.0.02 and OR=0.93,p.0.01,resp.ctively).LiESWT had a favorable imp.ct on Lue score and notably p.nile p.in,curvature,p.aque size,and erectile function in p.tients treated for p. during the early inflammatory p.ase,with no side *** age and concomitant use of p.E5i were the only success p.edictors.

关键词： erectile dysfunction extracorp.real shock wave therap. p.yronie’s disease p.ezoelectric waves

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