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Sarcomas - the model for multidisciplinary care in cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 399-403页

作者： ian Judson Emeritus Professor of Cancer Pharmacology The Institute of Cancer ResearchSuttonSurrey SM25NGUK

Sarcomas were one of the first cancers for which multidisciplinary clinics and team meetings were set up,acknowledging the need for all the diagnostic and treatment disciplines to be involved in the clinical decision-making *** is amply demonstrated by the papers chosen for this special issue of the Journal of Cancer Metastasis and Treatment,which includes articles on basic biology,translational research,pathology,surgery and survivorship.

关键词： clinical Cancer surgery

Unconventional Bose–Einstein Condensations from Spin-Orbit Coupling

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Chinese Physics Letters 2011年第9期28卷 217-220页

作者： WU Cong-Jun ian Mondragon-Shem ZHOU Xiang-Fa Department of Physics University of CaliforniaSan DiegoCA 92093 Instituto de Física Universidad de AntioquiaAA 1226MedellínColombia Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026

According to the"no-node"theorem,the many-body ground state wavefunctions of conventional Bose–Einstein condensations(BEC)are positive-definite,thus time-reversal symmetry cannot be spontaneously *** find that multi-component bosons with spin-orbit coupling provide an unconventional type of BECs beyond this *** focus on a subtle case of isotropic Rashba spin-orbit coupling and the spin-independent *** the limit of the weak confining potential,the condensate wavefunctions are frustrated at the Hartree–Fock level due to the degeneracy of the Rashba *** zero-point energy selects the spin-spiral type condensate through the"order-from-disorder"*** a strong harmonic confining trap,the condensate spontaneously generates a half-quantum vortex combined with the skyrmion type of spin *** both cases,time-reversal symmetry is spontaneously *** phenomena can be realized in both cold atom systems with artificial spin-orbit couplings generated from atom-laser interactions and exciton condensates in semi-conductor systems.

关键词： interaction mechanism Einstein

盐爪爪根际土壤产IAA菌株分离及促生特性分析

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草业学报 2024年第4期33卷 110-121页

作者：程鑫宇王继莲麦日艳古·亚生李明源喀什大学生命与地理科学学院新疆喀什844006 新疆帕米尔高原生物资源与生态自治区重点实验室新疆喀什844006

为丰富具有产吲哚-3-乙酸(IAA)功能的植物根际促生菌(PGPR),开发高效微生物菌肥,从南疆克孜勒苏柯尔克孜自治州耐盐植物盐爪爪根际土壤中分离产IAA的菌株。结合16S rDNA的限制性片段长度多态性PCR技术(PCR-RFLP)与16S rDNA序列分析进行... 详细信息

为丰富具有产吲哚-3-乙酸(IAA)功能的植物根际促生菌(PGPR),开发高效微生物菌肥,从南疆克孜勒苏柯尔克孜自治州耐盐植物盐爪爪根际土壤中分离产IAA的菌株。结合16S rDNA的限制性片段长度多态性PCR技术(PCR-RFLP)与16S rDNA序列分析进行菌种鉴定,分析高产IAA菌株对玉米和小麦种子发芽的影响,并通过盆栽试验验证其对盐碱胁迫下植株幼苗生长(株高、茎粗、地上干重等)的影响。结果表明,共筛选到67株PGPR菌株,其分泌IAA能力为16.65~71.63 mg·L^(-1),尤以PM14、PM18分泌量较高。PM14和PM18菌株同时兼具解磷、固氮能力。所有菌株分属6个菌属,以肠杆菌属占绝对优势。接种PM14和PM18均促进了玉米和小麦种子萌发,但菌液浓度高低对种子发芽的影响有显著差异(P<0.05)。接种处理增加了玉米株高、鲜重、地上干重、茎粗和根干重,分别增加了4.7%~37.2%、28.8%~94.5%、15.8%~157.9%、4.4%~35.5%和23.5%~82.4%,但叶绿素含量无显著变化。接种处理增加了小麦株高、茎粗、鲜重和地上干重,分别增加了9.5%~33.1%、13.0%~49.6%、57.4%~112.8%和71.4%~114.3%。除接种灭活的PM14导致小麦根干重与对照相比无显著差异,其他处理均有积极作用,提高了52.8%~69.0%,而所有处理对叶绿素含量均无显著影响。综上,本研究筛选的产IAA菌株提高了植株在盐碱胁迫下的抗性,对开发适用于盐碱地区的微生物菌肥有重要意义。

关键词：吲哚-3-乙酸植物根际促生菌盐碱胁迫促生微生物菌肥

Combined extracorporeal shockwave therapy and exercise for the treatment of tendinopathy:A narrative review

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Sports Medicine and Health Science 2022年第1期4卷 8-17页

作者： ian Burton NHS Grampian 172 Market StreetAberdeenAB115PPUnited Kingdom

Tendinopathy is a chronic degenerative musculoskeletal disorder that is common in both athletes and the general *** and extracorporeal shockwave therapy(ESWT)is among the most common treatments used to mediate tendon healing and *** review presents the current understanding of mechanisms of action of ESWT and exercise in isolation and briefly synthesises evidence of their effectiveness for various *** central purpose of the review is to synthesize research findings investigating the combination of ESWT and exercise for five common tendinopathies(plantar heel pain,rotator cuff,lateral elbow,Achilles,and patellar tendinopathy)and provide recommendations on clinical ***,the available evidence indicates that ESWT combined with exercise in the form of eccentric training,tissue-specific stretching,or heavy slow resistance training are effective for specific tendinopathies and can therefore be recommended in *** there are at present a limited number of studies investigating combined EWST and exercise approaches,there is evidence to suggest that the combination improves outcomes in the treatment of plantar heel pain,Achilles,lateral elbow,and rotator cuff ***,despite overall positive outcomes in patellar tendinopathy,the combined treatment has not been shown at present to offer additional benefit over eccentric exercise alone.

关键词： Exercise Muscle stretching exercises High-energy shock waves Tendinopathy Resistance training Extracorporeal shockwave therapy

Power maximization of variable-speed variable-pitch wind turbines using passive adaptive neural fault tolerant control

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Frontiers of Mechanical Engineering 2017年第3期12卷 377-388页

作者： Hamed HABIBI Hamed RAHIMI NOHOOJI ian HOWARD Faculty of Science and Engineering School of Civil and MechanicalEngineering Curtin University Perth Australia

Power maximization has always been a practical consideration in wind turbines. The question of how to address optimal power capture, especially when the system dynamics are nonlinear and the actuators are subject to unknown faults, is significant. This paper studies the control methodology for variable-speed variable-pitch wind turbines including the effects of uncertain nonlinear dynamics, system fault uncertainties, and unknown external disturbances. The nonlinear model of the wind turbine is presented, and the problem of maximizing extracted energy is formulated by designing the optimal desired states. With the known system, a model-based nonlinear controller is designed; then, to handle uncertainties, the unknown nonlinearities of the wind turbine are estimated by utilizing radial basis function neural networks. The adaptive neural fault tolerant control is designed passively to be robust on model uncertainties, disturbances including wind speed and model noises, and completely unknown actuator faults including generator torque and pitch actuator torque. The Lyapunov direct method is employed to prove that the closed-loop system is uniformly bounded. Simulation studies are performed to verify the effectiveness of the proposed method.

关键词： wind turbine nonlinear model maximum power tracking passive fault tolerant control adaptive neural control

Porosity of bimodal and trimodal sediment mixtures

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International Journal of Sediment Research 2022年第2期37卷 258-271页

作者： Chamil Perera Weiming Wu ian Knack Department of Civil and Environmental Engineering Clarkson University

This study focuses on the prediction of the porosity of nonuniform sediment mixtures,considering the effects of particle packing.A random particle packing model has been developed for the porosity of bimodal mixtures by extending the existing random particle filling *** in the developed model are calibrated by fitting the model to measured data for a variety of bimodal mixtures,including spherical glass particles,rounded quarry grains,and natural *** model coefficients are found to be functions of the diameter ratio of coarse and fine particles,separately for spherical glass particles and natural sediments due to differences in particle *** bimodal mixture model is then extended to trimodal particle mixtures in three approaches:two based on serial packing and one based on random *** models are tested against experimental data of six trimodal mixtures with spherical glass *** results show that the random packing model and the fine-medium-coarse particle serial packing model predict well the observed trimodal mixture porosities.

关键词： Porosity Particle filling Particle packing Bimodal mixture Trimodal mixture

Lithological and Si–O–S isotope geochemistry:constraints on the origin and genetic environment of the selenium(Se)-rich siliceous rocks in Enshi,Hubei Province,China

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Acta Geochimica 2021年第1期40卷 89-105页

作者： Caixia Feng Shen Liu ian M.Coulson State Key Laboratory of Continental Dynamics and Department of Geology Northwest UniversityXi'an 710069China Solid Earth Studies Laboratory Department of GeologyUniversity of ReginaReginaSK S4S 0A2Canada

Se-rich black rock series of the Middle and Late Permian system is widely distributed in Enshi Prefecture with an exposed area of 850 km~2,among which the unique Yutangba black rock series independent selenium deposit with industrial mining significance in the world is ***,the source and metallogenic mechanisms of Se are still *** general,terrestrial weathering and submarine hydrothermal processes are the main source end members of Si and Se,and the related siliceous rocks record the deposition process of Si and Se from different *** study of lithofacies and paleogeography shows that western Hubei belongs to the near eastwest turn of the Yangzi platform in the Middle and Late Permian and becomes an inter-platform basin with nearly north-south ***,the comparative study of the Yutangba deposit and the selenium-rich black rock series in the northern Shadi with high selenium content is expected to reveal the provenance evolution of the two sections in space,and further restrict the Se mineralization mechanism in the Enshi *** the element geochemistry study,the black rock series in two study areas may have formed in a transitional position of either the continental margin or continental slope,in the process of sedimentary,more terrigenous clastic materials *** are rich in lithophile elements V and Cr.δU>1.0,U/Th and V/(V+Ni)ratio indicate that the Se-rich strata of black rock series in the Enshi areas occurred in an anoxic reducing environment and formed in an environment between the ocean basin and the continental *** Si-O isotope geochemistry,the original Si source of the study area is thought to relate to a volcanic eruption,which leads to the enrichment of Si in the *** determined values of S isotope in the black rock series of the two study areas both show the characteristics related to organic reduction/biogenic.

关键词： Se-rich siliceous rocks Geochemistry Si–O–S isotope Origin Sedimentary environment

Food Safety and Regulatory Compliance in Europe

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China Standardization 2010年第3期55卷 26-33页

作者： ian Lumley Selvarani Elahi michael Walker Head of Food Science Laboratory of the Government Chemist(LGC) Head of Food Chemistry LGC Consultant Science & Food Law Manager LGC

It is obvious that food and feed should be safe and wholesome in order to protect the consumer and to ensure animal health and welfare. Animal health and welfare are important factors that con- tribute to the maintenance of food quality and safety. All stakeholders require a risk-based, proportionate, integrated and transparent approach to ＇farm to fork＇ official control across all EU member states and between major world trading partners. Also consumers and industry require a consistent EU and global approach to food law implementation and enforcement to prevent differences in food safety and trading conditions developing. To monitor compliance with feed and food law samples have to be analysed by laboratories in EU member states and in other countries who export into the EU. Many analytical methods applied for such official controls are complex. This is particularly the case for methods used for the detection of approved and unapproved additives, veterinary and pesticide residues and natural and process contaminants. How do we ensure consistency and comparability of analytical measurements between laboratories and between countries？ How do we predict and anticipate the target analytes that we may have to detect and determine in samples from the food chain next week, next month, and next year？ As a consequence, how do we prepare analytical methods that will be capable of addressing these challenges and how do we demonstrate that they are robust, validated and provide data that will withstand challenge？ These are problems that are faced by laboratories in all trading nations. This article will review the issues, describe a project that aims to anticipate problems that may affect the food chain in the future and review approaches that enable laboratories to demonstrate the reliability of their methods of analysis via the use of validation protocols, reference ma- terials and proficiency testing schemes.

关键词： food safety laboratory test LGC

Silencing NOA1 Elevates Herbivory-Induced Jasmonic Acid Accumulation and Compromises Most of the Carbon-Based Defense Metabolites in Nicotiana attenuata

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Journal of Integrative Plant Biology 2011年第8期53卷 619-631页

作者： Hendrik Wünsche ian T. Baldwin Department of Molecular Ecology Max Planck Institute for Chemical Ecology

Nitric oxide-associated protein 1 （NOA1） is involved in various abiotic stress responses and is required for plant resistance to pathogen infections. However, the role of NOA1 in plant-herbivore interactions has not been explored. We created NOA1-silenced Nicotiana attenuata plants （irNaNOA1）. Compared with wild-type （WT） plants, irNaNOA1 plants had highly decreased photosynthesis rates. We further examined various traits important for plant defense against its specialist herbivore Manduca sexta by treating WT and irNaNOA1 plants with mechanical wounding and M. sexta oral secretions （OS）. NOA1-silenced plants showed elevated levels of herbivory-induced jasmonic acid （JA）, but decreased JA-isoleucine conjugate （JA-Ile） levels. The decreased JA-Ile levels did not result from compromised JAR （jasmonic acid resistant） activity in irNOA1 plants. Moreover, nitrogen-rich defensive compounds, nicotine and trypsin proteinase inhibitors, did not differ between WT and irNaNOA1 plants. In contrast, concentrations of most carbon-based defensive compounds were lower in these plants than in WT plants, although the levels of chlorogenic acid were not changed. Therefore, silencing NOA1 alters the allocation of carbon resources within the phenylpropanoid pathway. These data suggest the involvement of NOA1 in N. attenuata’s defense against M. sexta attack, and highlight its role in photosynthesis, and biosynthesis of jasmonates and secondary metabolites.

关键词： NOA1 defense herbivory nitric oxide-associated protein 1 secondary metabolites.