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Finding effective combinations of compounds to prevent Alzheimer's disease

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Neural Regeneration Research 2022年第11期17卷 2450-2451页

作者： Sudip Dhakal ian Macreadie School of Science Bundoora CampusRMIT University

Alzheimer's disease AD remains one of the significant causes of death and morbidity in the older population (2021).The cause of AD remains unclear despite there being numerous *** the most widely accepted hypothesis is the amyloid cascade hypothesis which is based on the accumulation of amyloid beta (Aβ) in neurons (Dhakal et al., 2019).

关键词： Alzheimer Aβ death

Biodiversification of Late Ordovician Hirnantia Fauna on the Upper Yangtze Platform,South China

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Science China Earth Sciences 2010年第12期53卷 1800-1810页

作者： ian G.PERCIVAL Geological Survey of New South Wales NSW Department of Primary Industries947-953 Londonderry RoadLondonderryNSW 2753Australia

The Hirnantia Fauna is a globally-represented,cool water brachiopod fauna that originated and flourished in shallow marine environments at intermediate to low latitudes after the first episode of the end-Ordovician mass *** was well-developed,widely distributed,long in stratigraphical range,and complex in palaeoecological differentiation on the Upper Yangtze Platform of the South China paleoplate,where it has been extensively *** and quantitative analyses show that the FAD of the Hirnantia Fauna in South China becomes stratigraphically higher from nearshore to offshore localities on the Yangtze Platform,while the range of the fauna becomes shorter whereas the taxonomic diversity *** its stratigraphical range the diversity of the Hirnantia Fauna at nearshore localities consistently decreases,but trends in the opposite direction at offshore,deeper water *** fauna was represented by different communities,subcommunities or associations with changing environmental factors(such as water depth and substrate) at different localities or horizons.

关键词： Hirnantia Fauna biodiversification Ordovician Hirnantian Upper Yangtze Platform South China

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

Mixed reality emergency management:bringing virtual evacuation simulations into real-world built environments

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International Journal of Digital Earth 2019年第2期12卷 190-208页

作者： ian Lochhead Nick Hedley Department of Geography Simon Fraser UniversityBurnabyCanada

Computer-based evacuation simulations are important tools for emergency *** simulations vary in complexity and include 2D and 3D GIS-based network analyses,agent-based models,and sophisticated models built on documented human behaviour and particle *** the influential role of built environments in determining human movement,a disconnect often exists between the features of the real world and the way they are represented within these simulation *** proliferation of emergency management location-aware mobile devices,along with a recent infatuation for augmented reality(AR),has resulted in new wayfinding and hazard assessment tools that bridge this gap,allowing users to visualize geospatial information superimposed on the real *** this paper,we report research and development that has produced AR geovisual analytical systems,enabling visual analysis of human dynamics in multilevel built environments with complex thoroughfare network *** demonstrate prototypes that show how mixed reality visual analysis of intelligent human movement simulations built in virtual spaces can become part of real *** research introduces a fundamentally new way to view and link simulations of people with the real-world context of the built environment:mixed reality crowd simulation in real space.

关键词： Augmented reality 3D geovisualization situated simulation human movement analysis emergency management

Time averaged consensus in a direct coupled coherent quantum observer network

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Control Theory and Technology 2017年第3期15卷 163-176页

作者： ian R. PETERSEN Research School of Engineering The Australian National University Canberra ACT 2601 Australia

This paper considers the problem of constructing a direct coupling quantum observer for a closed linear quantum system. The proposed distributed observer consists of a network of quantum harmonic oscillators and it is shown that the observer network converges to a consensus in a time averaged sense in which each element of the observer estimates the specified output of the quantum plant. An example and simulations are included to illustrate the properties of the observer network.

关键词： Quantum systems quantum observers quantum networks

The capsid revolution

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Journal of Molecular Cell Biology 2023年第11期15卷 1-11页

作者： ian A.Taylor Ariberto Fassati Macromolecular Structure Laboratory The Francis Crick InstituteLondon NW11ATUK Division of Infection and Immunity University College LondonLondon WC1E 6JFUK Institute of Immunity and Transplantation University College LondonLondon NW32PPUK

Lenacapavir,targeting the human immunodeficiency virus type-1(HIV-1)capsid,is the first-in-class antiretroviral drug recently approved for clinical *** development of Lenacapavir is attributed to the remarkable progress in our understanding of the capsid protein made during the last few *** little more than a component of the virus shell to be shed early during infection,the capsid has been found to be a key player in the HIV-1 life cycle by interacting with multiple host factors,entering the nucleus,and directing ***,we describe the key advances that led to this‘capsid revolution’.

关键词： HIV-1 capsid CPSF6 Lenacapavir integration IP6 nucleus reverse transcription

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自粘绝缘系统

绝缘材料 1986年第4期 47-49页

作者： David a.wilson 谢月珍凌春华

前言电器工业绝缘系统在过去二十余年相对说来未有变化。制造了各种耐热等级的电动机采用了品种繁多的柔软绝缘材料、电磁线、漆、软管、绑扎绳和引线。典型的柔软片材和带材是用做槽衬、相间隔片、槽楔或顶封。所用的电磁线符合NEMA MW... 详细信息

前言电器工业绝缘系统在过去二十余年相对说来未有变化。制造了各种耐热等级的电动机采用了品种繁多的柔软绝缘材料、电磁线、漆、软管、绑扎绳和引线。典型的柔软片材和带材是用做槽衬、相间隔片、槽楔或顶封。所用的电磁线符合NEMA MW24,30,35,73或类似于OEM规范。

关键词：绝缘系统树脂处理电磁线绕组线自粘性电工材料绝缘材料

Real-time calculation of fragment velocity for cylindrical warheads

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Defence Technology（防务技术） 2019年第3期15卷 264-271页

作者： David Felix ian Colwill Elias Stipidis Institution of Engineering and Technology Stevenage England Member of British Computer Society London Institute of Electrical and Electronics Engineers London

To simulate explosion fragments, it is necessary to predict many variables such as fragment velocity, size distribution and projection angle. For active protection systems these predictions need to be made very quickly, before the weapon hits the target. Fast predictions also need to be made in real time simulations when the impact of many different computer models need to be assessed. The research presented in this paper focuses on creating a fast and accurate estimate of one of these variables - the initial fragment velocity. The Gurney equation was the first equation to calculate initial fragment velocity. This equation, sometimes with modifications, is still used today where finite element analysis or complex mathematical approaches are considered too computationally expensive. This paper enhances and improves Breech’s two-dimensional Gurney equation using available empirical data and the principals of conservation of momentum and energy. The results are computationally quick, providing improved accuracy for estimating initial fragment velocity. This will allow the developed model to be available for real-time simulation and fast computation, with improved accuracy when compared to existing approaches.

关键词： Initial fragment velocity Real-time simulation Cylindrical explosion

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer

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Asian Journal of Andrology 2014年第1期16卷 99-100页

作者： Elizabeth M wilson Laboratories for Reproductive Biology Department of Pediatrics Lineberger Comprehensive Cancer Center Department of Biochemistry and Biophysics University of North Carolina

Again-of-function stabilizing somatic mutation in 3β-hydroxysteroiddehydrogenase type 1 （3βHSDI, HSD3B1） was reported in castration-resistant prostate cancer. The A-C nucleotide polymorphism replaced asparagine-367 with threonine （3βHSD1-N367T） as a homozygous somatic mutation in a subset of castration-resistant prostate cancers by loss of heterozygosity of the wild-type allele. Increased stability of 3[HSD I-N367T was associated with decreased ubiquitin-mediated degradation and higher levels of dihydrotestosterone （DHT）. The studies suggest that genetic instability in castration-resistant prostate cancer favors the more stable 313HSD I-N367T mutant that contributes to drug resistance. A somatic mutation in a steroid metabolic enzyme required for DHT synthesis provides further support for intratumoral androgen synthesis contributing to prostate cancer progression.

关键词： 3-BETA-HYDROXYSTEROID DEHYDROGENASE ANDROGEN RECEPTOR STEROIDOGENESIS DIHYDROTESTOSTERONE ABIRATERONE