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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

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First detection of F1534C knockdown resistance mutation in Aedes aegypti(Diptera:Culicidae)from Cameroon

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Infectious Diseases of Poverty 2020年第6期9卷 51-62页

作者： Aurelie P.Yougang Basile Kamgang Theodel a.wilson Bahun Armel N.Tedjou Daniel Nguiffo-Nguete Flobert Njiokou Charles S.Wondji Centre for Research in Infectious Diseases P.O.Box 13591YaoundéCameroon Parasitology and Ecology Laboratory Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaoundé1P.O.Box 812YaoundéCameroon Laboratory of Vertebrate and Invertebrate Bioecology Faculty of Science and TechnologyMarien-Ngouabi UniversityBrazzavilleCongo Laboratory of Biology and Applied Ecology Department of Animal BiologyFaculty of ScienceUniversity of DschangP.O.Box 96DschangCameroon Liverpool School of Tropical Medicine Pembroke placeLiverpoolL35QAUK

Background: Aedes borne viral diseases,notably dengue,are increasingly reported in Cameroon with Aedes aegypti being a major *** on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in ***,we present the nationwide distribution of insecticide resistance in *** and investigate the potential resistance mechanisms ***:: Immature stages of *** were collected between March and July 2017 in 13 locations across Cameroon and reared until G1/G2/G3 ***,adult bioassays,and piperonyl butoxide(PBO)synergist assays were carried out according to World Health Organization guidelines.F1534C mutation was genotyped using allele specific polymerase chain reaction in field collected adults(Go)and the polymorphism of the sodium channel gene was ***χ2 test was used to compare the mortality rate between bioassays with insecticides only and bioassays after preexposure to PBO ***: Larval bioassay revealed that all the three populations tested with temephos were *** bioassays showed a good level of susceptibility toward both pyrethroids tested,0.25%permethrin and 0.05%deltamethrin,with six out of 10 populations ***,two populations(Douala and Edéa)were resistant(deltamethrin[73.2–92.5%mortality],permethrin[2.6–76.3%mortality]).The resistance to 4%dichlorodiphenyltrichloroethane was observed in four out of 10 populations tested(16.8–87.1%mortality).Resistance was also reported to carbamates including 0.1%propoxur(60.8–87.1%mortality)and to 0.1%bendiocarb(82.9%mortality).All populations tested were fully susceptible to 1%fenitrothion.A partial recovery of susceptibility was observed in the pyrethroid resistant population of Douala after pre-exposed to PBO suggesting the implication of cytochrome P450 monoxygenases permethrin *** and sequencing detected the F1534C kdr mutation in the two pyrethroid resistant

关键词： Aedes aegypti Insecticide resistance Kdr mutation Cameroon Arbovirus

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50 years change in urban land use and ecological planning globally in the era of design with nature

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Ecosystem Health and Sustainability 2019年第1期5卷 185-198,I0001页

作者： ian Douglas School of Environment Education and DevelopmentUniversity of ManchesterManchesterUK

ian McHarg’s 1969 book,Design with Nature,was grounded in earlier good practice,especially the European vision of fitting cities into the regional landscape and carrying thorough surveys before planning *** book emerged in the wake of publications that worried about the ability of the earth to support expanding populations and their growing impact on the *** argued that ecological design should follow planning based on detailed site *** McHarg advised many urban authorities in the USA and other countries,especially in Africa,Asia and Europe,and his ideas had influenced some British new towns,they had little attention in the planning of Milton Keynes,England’s largest new urban settlement,where the initial geological surveys were inadequate,but a successful large tree-planting programhas created a“city in the forest.”McHarg was however closely involved in planning the Nigerian Capital city,Abuja,but his sound master plan was ill-equipped to provide for a nation undergoing post-conflict rebuilding and a local population more concerned with access to land than ecological ***,McHarg helped us to promote,protect,and preserve urban green *** teams from different disciplines now work well together,the integrated thinking advocated by McHarg remains sometimes in short supply in local practice.

关键词： Planning design urban nature garden city site investigation

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Scale,Information-Processing,and Complementarities in Old-World Axial Age Societies

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Journal of Social Computing 2022年第2期3卷 119-127页

作者： ian Morris the Department of Classics Stanford UniversityStanfordCA 94305-2145USA

Recent cross-disciplinary work on quantifying historical dynamics has made major contributions to ***,efforts to specify relationships between scale and information-processing always run a risk of shoehorning messy realities into overly rigid *** the case of the first-millennium BCE“Axial Age”in the Old World,networks of collective computing were structured more by cultural systems than by polities,and to understand the relationships between political scale and collective computational abilities,scholars need categories flexible enough to clarify the complementarities between political and cultural systems.

关键词： scale information-processing Axial Age ancient Greece

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A fast and accurate model for the creation of explosion fragments with improved fragment shape and dimensions

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Defence Technology（防务技术） 2022年第2期18卷 159-169页

作者： David Felix ian Colwill Paul Harris School of Computing Engineering&MathematicsUniversity of BrightonBrightonUK Engineering and Design(Alumni) University of SussexBrightonUK

Explosion models based on Finite Element Analysis(FEA)can be used to simulate how a warhead *** their execution times are *** protection systems need to make very fast predictions,before a fast attacking weapon hits the *** execution times are also needed in real time simulations where the impact of many different computer models is being ***,FEA explosion models are not appropriate for these real-time *** research presented in this paper delivers a fast simulation model based on Mott’s equation that calculates the number and weight of fragments created by an *** addition,the size and shape of fragments,unavailable in Mott’s equation,are calculated using photographic evidence and a distribution of a fragment’s length to its *** model also identifies the origin of fragments on the warhead’s *** results are verified against experimental data and a fast execution time is achieved using uncomplicated simulation *** developed model then can be made available for real-time simulation and fast computation.

关键词： Distribution of fragments Fragment shape Real-time simulation Cylindrical explosion

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Lag times in toe-to-heel air injection(THAI)operations explain underlying heavy oil production mechanisms

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Petroleum Science 2022年第3期19卷 1165-1173页

作者： Wei Wei ian D.Gates Department of Chemical and Petroleum Engineering University of CalgaryCalgaryAlbertaCanada

From a time value of revenue point of view,it is preferred that the time between reservoir stimulation and oil production response is *** oil combustion processes have a lag time between air injection and liquid production,but the common practice in production data analysis uses simultaneous injection and production data when seeking a relationship between *** this research,the time scales of production for the Kerrobert toe-to-heel air injection(THAI)heavy oil project in Saskatchewan,Canada,is analyzed by using cross correlation analysis,*** delay analysis between air injection and oil *** results reveal two time scales with respect to production response with two distinctive recovery mechanisms:(1)a short time scale response(nearly instantaneous)where oil production peaks right after air injection(directly after opening production well)reflecting cold heavy oil production mechanisms,and(2)a longer time scale(of order of 100-300 days)response where peak production occurs associated with the collective phenomena of air injection,heat generating reactions,heat transfer,and finally,heated mobilized heavy oil drainage to the production *** understanding of the two time scales and associated production mechanisms provides a basis for improving the performance of THAI.

关键词： Heavy oil In situ combustion Toe-to-heel air injection(THAI) Production analysis Lag time

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The Roper-Suffridge extension operator and classes of biholomorphic mappings Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1539-1552页

作者： GRAHAM ian KOHR Gabriela Department of Mathematics University of Toronto TorontoOntario M5S 2E4Canada Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. 400084 Cluj-NapocaRomania

In this paper we give a survey about the Roper-Suffridge extension operator and the developments in the theory of univalent mappings in several variables to which it has led. We begin with the basic geometric properties (most of which now have a number of different proofs)and discuss relations with the theory of Loewner chains and generalizations and modifications of the operator, some of which are very recent.

关键词： convex mapping, starlike mapping, Roper-Suffridge operator, growth theorem, distortion theorem, covering theorem, Loewner chain, parametric representation,extreme points, linear invariant family.

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The ballistic performance of the bombard Mons Meg

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Defence Technology（防务技术） 2016年第2期12卷 59-68页

作者： ian LEWTAS Rachael MCALISTER Adam WALLIS Clive WOODLEY ian CULLIS QinetiQ Fort Halstead

The bombard Mons Meg, located in Edinburgh Castle, with a diameter of 19 inches(48 cm), was one of the largest calibre cannons ever *** in 1449 and presented to King James II of Scotland in 1454, Mons Meg was used in both military and ceremonial roles in Scotland until its barrel burst in 1680. This paper examines the history, internal, external and terminal ballistics of the cannon and its shot. The likely muzzle velocity was estimated by varying the propellant type and the cannon profile was investigated to identify weak spots in the design that may have led to its failure. Using the muzzle velocity calculated from the internal ballistics, simulations were performed with granite and sandstone shot for varying launch angle and ground temperature. The likely trajectory and range of the cannonballs are described. The internal and external ballistics informed the initial conditions of the terminal ballistic impact scenarios. The performance of the cannonball against both period and modern targets, in the form of a pseudo-castle wall and a monolithic concrete target, respectively, were simulated and are presented and discussed.

关键词：弹道性能 Meg 内弹道计算 19英寸速度估计地面温度弹道冲击苏格兰

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Self-assembly and chemical processing of block copolymers:A roadmap towards a diverse array of block copolymer nanostructures

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Science China Chemistry 2013年第8期56卷 1040-1066页

作者： WYMAN ian LIU GuoJun Department of Chemistry Queen's University

Block copolymers can yield a diverse array of *** assembly structures are influenced by their inherent structures,and the wide variety of structures that can be prepared especially becomes apparent when one considers the number of routes available to prepare block copolymer *** examples include self-assembly,directed assembly,coupling,as well as hierarchical assembly,which can yield assemblies having even higher structural *** assembly routes can also be complemented by processing techniques such as selective crosslinking and etching,the former technique leading to permanent structures,the latter towards sculpted and the combination of the two towards permanent sculpted *** combination of these pathways provides extremely versatile routes towards an exciting variety of *** review will attempt to highlight destinations reached by LIU Guojun and coworkers following these pathways.

关键词： block copolymers self-assembly chemical processing crosslinking

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会计专业数智化人才培养改革演进与意义建构

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红河学院学报 2024年第2期22卷 53-58页

作者：代军邱玉莲武汉科技大学管理学院湖北武汉430065

文章选取浙江大学管理学院为对象,研究了高校会计数智化培养改革演变过程中的意义建构范式。研究发现,案例对象的改革演进先后经历了人才改革培养方案制定、智能财务专业成立起步、产学研贯通协同育人等三个阶段,各阶段的意义建构范式... 详细信息

文章选取浙江大学管理学院为对象,研究了高校会计数智化培养改革演变过程中的意义建构范式。研究发现,案例对象的改革演进先后经历了人才改革培养方案制定、智能财务专业成立起步、产学研贯通协同育人等三个阶段,各阶段的意义建构范式分别是:受限的意义建构、介于受限与导向明确之间的意义建构、导向明确的意义建构。研究认为:意义建构活动能够提升各利益相关方的认知,并以此为指导,调整人才培养实施行为,进而影响到高校会计数智化人才培养改革的实施效果;其中,促发因素表现出由外到内,由被动到主动,由短期到可持续的演变规律;意义建构的控制主体表现出逐步下沉,控制程度逐渐降低,控制作用非线性的变化规律;意义建构的接受主体呈现出活跃度由低向高、由管理层向基层教师、由学校向校外企业逐渐转化的变化规律。

关键词：数智化人才培养意义建构会计专业

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