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第五届中国结构生物学学术讨论会

作者： Heng Zhang Yu-Hui Dong ian a.wilson Beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of Sciences Department of Integrative Structural and Computational Biology The Scripps Research Institute

An outbreak of avian-origin H7N9 influenza virus has occurred in China since March 2013 and caused hundreds of human-infection cases worldwide. The hemagglutinin（HA） of influenza viruses is the major surface glycoprotein facilitating virus entry and infection of host cells and is the major target of neutralizing antibodies. The naturally occurring human monoclonal antibody H7.167 was isolated from the memory B cells of human infected with H7N9 vaccine strain（A/Shanghai/02/2013, Sh2/H7） and exhibited efficient neutralization activity against influenza H7 strains. Here, we report the crystal structure of H7.167 Fab in complex with Sh2/H7 HA and provide the structural basis of H7.167 neutralization specialty for H7 subtype. H7.167 targets a highly conserved epitope adjacent to the receptor-binding site（RBS） using its complementarity-determining regions（CDRs） through a series of hydrogen bonds and van der Waals interactions. The heavy chain appears to bind to the residues including R131, and N157 to N158 B close to 150-loop, 130-loop and 190-helix that constitute the RBS, while the light chain appears to bind additional residues, including F161, S187, K200 and N248, which are distant from the RBS. The contacting residues in H7 HA, including the insertion of residues D158 A and N158 B in the 150-loop, differ remarkably from the corresponding residues in H1/H2/H3/H5 HAs. Moreover, the 150-loop has a unique conformation in H7 HA compared with other subtype HA, where N157 and N158 B are key residues responsible for the neutralization activity of the antibody. These remarkable structural characters are likely associated with the particular specificity of H7.167 neutralization for H7. This identified epitope in the HA RBS may be of use in design of novel immunogens for development of H7 vaccines or small-molecule therapeutics to block transmission of H7 avian flu to humans.

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Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 ? Resolution

Crystal structure of the post-fusion core of the Human coron...

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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Lei Yan Bing Meng Jiangchao Xiang ian a.wilson Bei Yang Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University School of Life Science and Technology ShanghaiTech University Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology The Scripps Research Institute

Human coronavirus 229 E(HCoV-229 E) usually causes mild upper respiratory infections in heathy adults,but may lead to severe complications or mortality in individuals with weakened immune *** entry of HCoV-229 E is mediated by its spike(S) protein,where the S1 domain facilitates attachment to host cells and the S2 domain is involved in subsequent fusion of the virus and host *** the fusion process,two heptad repeats,HR1 and HR2,in the S2 domain assemble into a six-helix membrane-fusion structure termed the fusion ***,the complete fusion-core structure of HCoV-229 E is presented at 1.86 ? resolution,representing the most complete post-fusion conformation thus far among published human alpha-coronavirus(α-HCoV) fusion-core *** overall structure of the HCoV-229 E fusion-core is similar to those of SARS,MERS and HCoV-NL63,but the packing of its 3 HR1 core differs from those of SARS and MERS in that it contains more noncanonical ‘x’ and ‘da’ ***-by-side electrostatic surface comparisons reveal that the electrostatic surface potentials are opposite in α-HCoVs and β-HCoVs at certain positions and that the HCoV-229 E surface also appears to be the most hydrophobic among the various *** addition to the highly conserved hydrophobic interactions between HR1 and HR2,some polar and electrostatic interactions are also well preserved across different *** study adds to the structural profiling of HCoVs to aid in the structure-based design of pan-coronavirus small molecules or peptides to inhibit viral fusion.

关键词： Coronavirus HCoVs-229E spike protein post-fusion core x-ray structure

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Dual PPAR delta/gamma agonist offer therapeutic potential for Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1175-1176页

作者： ian Steinke Meenakshi Singh Rajesh Amin Department of Drug Discovery and Development Auburn UniversityAuburn AlabamaALUSA

The increasing incidence of Alzheimer's disease(AD)in the aging population,indicates the critical need for the development of novel targeted molecular therapies for ameliorating AD ***,clinical and preclinical evidence demonstrates that peroxisomal proliferator activating receptors(PPAR)agonists regulate energy and lipid homeostasis in models of diabetes,as well as improve spatial memory in animal models of AD(Khan et al.,2019).

关键词： Alzheimer clinical homeostasis

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Considerations for exerkine research focusing on the response to exercise training

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Journal of Sport and Health Science 2024年第2期13卷 130-132页

作者： ian A.J.Darragh Brendan Egan School of Health and Human Performance Dublin City UniversityGlasnevinDublin D09 V209Ireland Florida Institute for Human and Machine Cognition PensacolaFL 32502USA

García-Hermoso and colleagues1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2diabetes mellitus patients,providing a contemporary view on how exerkines respond to exercise *** review prompted us to highlight 2 additional considerations that should be taken into account when studying the response of exerkines to exercise ***,whether exerkines can exhibit discordant responses to acute exercise compared to exercise training,and secondly,the need to consider the residual effects of the most recent exercise bout.

关键词： acute exercise prompt

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A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah L.Apostolou ian M.McDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

Loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).Lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

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Impact of interfacial tension on oil-water flow in a narrow gap

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Petroleum Research 2024年第2期9卷 219-227页

作者： Salim Raza ian D.Gates Saira Sherin University of Engineering and Technology PeshawarPakistan Department of Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCanada

Numerous researchers have examined the co-current flow of oil-water and aqueous solutions containing polymers and surfactants in thin gaps for oil *** some have focused on charges and forces at the interfaces of oil-surfactant solutions during *** study of flow structures,interface behavior,and relative permeabilities of oil and aqueous phases of surfactant flow through thin gaps has been less *** the first time,this research aims to comprehensively investigate the flow of oil-water and oil-surfactant solutions through a thin gap(Hele-Shaw cell)with a particular focus on the impact of sodium dodecyl sulfate(SDS).The experiments reveal that SDS forms an emulsion near the oil-water interface,capturing oil droplets and enabling their flow along with the SDS *** studies confirm this,showing that when SDS contacts oil,it creates channels through the oil phase,leading to the accumulation and division of oil into small round-shaped droplets,resulting in an oil-in-water *** addition of SDS to the injecting water significantly enhances relative permeabilities,leading to a remarkable 90%increase in oil recovery from the *** research suggests that the optimal SDS concentration range for maximum oil recovery is between 1.5 and 2 wt%,as it achieves the minimum interfacial tension between oil and water.

关键词： Surfactant Co-current flow Narrow gap Interface interactions Relative permeability

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Multi-Timescale Distributed Approach to Generalized-Nash-Equilibrium Seeking in Noncooperative Nonconvex Games

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 791-793页

作者： Banghua Huang Yang Liu Kit ian Kou Weihua Gui the School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China IEEE the Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province Jinhua 321004China the Faculty of Science and Technology University of MacaoMacaoChina the School of Automation Central South UniversityChangsha 410083China

Dear Editor,The distributed generalized-Nash-equilibrium(GNE)seeking in noncooperative games with nonconvexity is the topic of this *** by the sequential quadratic programming(SQP)method,a multi-timescale multi-agent system(MAS)is developed,and its convergence to a critical point of the game is *** illustrate the qualities and efficacy of the theoretical findings,a numerical example is elaborated.

关键词： letter seeking programming

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Low-thermal-budget electrically active thick polysilicon for CMOS-First MEMS-last integration

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Microsystems & Nanoengineering 2024年第3期10卷 395-407页

作者： Aron Michael ian Yao-Hsiang Chuang Chee Yee Kwok Kazuo Omaki UNSW SydneyNSW 2052Australia

Low-thermal-budget,electrically active,and thick polysilicon films are necessary for building a microelectromechanical system(MEMS)on top of a complementary metal oxide semiconductor(CMOS).However,the formation of these polysilicon films is a challenge in this ***,for the first time,the development of in situ phosphorus-doped silicon films deposited under ultrahigh-vacuum conditions(~10^(−9)Torr)using electron-beam evaporation(UHVEE)is *** process results in electrically active,fully crystallized,low-stress,smooth,and thick polysilicon films with low thermal *** crystallographic,mechanical,and electrical properties of phosphorus-doped UHVEE polysilicon films are *** films are compared with intrinsic and boron-doped UHVEE silicon *** spectroscopy,X-ray diffraction(XRD),transmission electron microscopy(TEM)and atomic force microscopy(AFM)are used for crystallographic and surface morphological *** curvature,cantilever deflection profile and resonance frequency measurements are employed to study the mechanical properties of the ***,resistivity measurements are conducted to investigate the electrical properties of the *** vertical,high-aspectratio micromachining of UHVEE polysilicon has been developed.A comb-drive structure is designed,simulated,fabricated,and characterized as an actuator and inertial sensor comprising 20-μm-thick in situ phosphorus-doped UHVEE films at a temperature less than 500℃.The results demonstrate for the first time that UHVEE polysilicon uniquely allows the realization of mechanically and electrically functional MEMS devices with low thermal budgets.

关键词： budget thick thermal

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Public health importance of light intensity physical activity

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Journal of Sport and Health Science 2024年第5期13卷 674-675页

作者： Robert Ross ian Janssen Mark S.Tremblay School of Kinesiology and Health Studies Queen’s UniversityKingstonON K7L 3N6Canada School of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

*** intensity physical activity(PA)benefits health PA guidelines worldwide recommend that adults accumulate 150 min of moderate intensity or 75 min of vigorous intensity PA(moderate-to-vigorous PA(MVPA))weekly to achieve health benefits.1-3 Absent from these guidelines are recommendations for light intensity PA(LPA,e.g.,walking at a leisurely pace of 3 km/h or less,equivalent to 1.5-2.9 metabolic equivalents).

关键词： intensity light benefits

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Health economics for intra-capsular hip fractures undertaking fixation

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World Journal of Orthopedics 2024年第1期15卷 30-38页

作者： Anatole Wiik Thomas Ashdown ian Holloway Department of Surgery Trauma and OrthopaedicsLondon North West University HealthcareLondon HA13UJUnited Kingdom Department of Surgery Trauma and OrthopaedicsLondon North West University HospitalLondon HA13UJUnited Kingdom

BACKGROUND Hip fracture is a common musculoskeletal injury in the elderly requiring surgery *** operative mainstay of intra-capsular hip fractures is arthroplasty with a smaller proportion for *** To determine the most beneficial method of fixation for patients with intracapsular hip *** A registered audit from 2012-2018 was conducted on all intra-capsular hip fractures treated with 2 commonly used fixation *** notes,electronic records and clinical codes for cost benefit were evaluated.A validated quality of life measure was collected at least 1 year after *** A total of 83 patients were identified with intra-capsular fractures undergoing fixation during the retrospective *** were 47 cannulated cancellous screw and 36 sliding hip screw fixations with the case mix comparable for age,gender,co-morbidities and fracture *** was no significant difference in blood loss,tip apex distance,radiation exposure,length of stay,radiological union time,collapse,avascular necrosis or re-operation between fixation *** regression analysis demonstrated displaced intracapsular hip fractures correlated significantly with an undesirable outcome conferring a relative odds ratio of *** were 9(19%)and 4(11%)patients respectively,who required *** was no significant difference in health resource group tariff and implant cost with comparable EQ-5D and visual CONCLUSION No significant advantage was identified with differing fixation type,but irrespective there were a high number of patients requiring *** was predicted by initial fracture displacement and patient *** may need to be carefully considered for health economics and patient benefit.

关键词： Hip fracture Fixation Patient reported outcome measure Cost

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