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Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice

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international Journal of Oral Science 2019年第3期11卷 201-212页

作者： Jin Sook Suh Sol kim Kristina i.Bostrom Cun-Yu wang Reuben H.kim No-Hee Park The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Oral Biology and Medicine UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Bioengineering UCLA Samueli School of EngineeringLos AngelesCAUSA

Growing evidence suggests close associations between periodontitis and *** further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/***) in Apolipoprotein E knock out mice and studied the atherogenesis process in these *** mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and *** did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/*** showed severe periodontitis,systemic inflammation,and aortic plaque *** aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell *** severity of periodontitis was slightly higher in mice receiving ligature/*** than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/*** observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe *** vitro,*** enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial ***,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial *** together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice.

关键词： via aortic cells TNF-α did had but was

Numerical modelling of a low power non-transferred arc plasma reactor for methane conversion

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Plasma Science and Technology 2019年第6期21卷 29-37页

作者： B i MiN D K DiNH D H LEE T H kim S CHOi institute for Nuclear Science and Technology Jeju National University 102 Jejudaehak-ro Jeju 63243Republic of Korea University of Science and Technology(UST) 217 Gajeong-ro Yuseong-gu Daejeon 34113 Republic of Korea Korea institute of Machinery and Materials 156 Gajeongbuk-ro Yuseong-gu Daejeon 34103 Republic of Korea Department of Nuclear and Energy Engineering Jeju National University 102 Jejudaehak-ro Jeju 63243Republic of Korea

Thermal flow characteristics and the methane conversion reaction in a low power arc plasma reactor for efficient storage and transport of methane,which is the main component of shale gas,were *** temperature and velocity distributions were calculated according to the type of discharge gases and arc current level by a self-developed magnetohydrodynamics (MHD)code and a commercial ANSYS-FLUENT code;the transport of chemical species was analyzed as including the chemical reactions of methane *** simulated results were verified by the comparison of calculated and measured arc voltages with permissible low error as under 4%.Three C2 hydrocarbon gases with ethane (C2H6),ethylene (C2H4),and acetylene (C2H2)were selected as the converted species of methane from experimental *** mass fraction of C2 hydrocarbons and hydrogen as the product of the conversion reaction at the reactor was also *** values show good agreement with the actual experimental results in that the major conversion reaction occurred in C2H2 and hydrogen,and the conversions to C2H6,C2H4,and hydrogen were minor reactions of methane pyrolysis conversion.

关键词： numerical modelling non-transferred arc plasma methane chemical reaction

Closed-loop Control Using High Power Hexapole Magnetic Tweezers for 3D Micromanipulation

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Journal of Bionic Engineering 2020年第1期17卷 113-122页

作者： Xiao Zhang Louis wRogowski Min Jun kim Department of Mechanical Engineering Southern Methodist UniversityDallasTX 75275USA

This paper presents the design,modeling,integration,and application of 3D printed high power hexapole magnetic tweezers for 3D micromanipulation *** sharp-tipped magnetic poles were configured with electromagnetic coils and mounted on 3D printed magnetic yokes to form a tilted Cartesian coordinate system for actuation.A closed loop control algorithm was developed to automatically manipulate external power supplies connected to the magnetic tweezers,by using 3D positional information obtained from real-time image processing *** compared against other designs of magnetic tweezers,our system has a larger working space and can generate higher magnetic field *** allows for more diverse applications regarding small scale manipulation,including cell manipulation and cell *** and analytics explained in this paper demonstrate the closed-loop manipulation of microswimmers can provide a magnetic force as high as 800 pN while maintaining a positional error below 4μm in 3D and 1.6μm in *** the desired location as the control input,the microswimmers investigated were able to achieve arbitrary 2D and 3D *** also show that the implemented hexapole magnetic tweezers have adequate power to control microswimmers in Newtonian fluid *** system will later be optimized and deployed to control microswimmers in non-Newtonian fluid environments.

关键词： magnetic tweezers micromanipulation magnetic gradient control 3D motion control microswimmers

Numerical Method of Fabric Dynamics Using Front Tracking and Spring Model

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Communications in Computational Physics 2013年第10期14卷 1228-1251页

作者： Yan Li i-Liang Chern Joung-Dong kim Xiaolin Li Department of Applied Mathematics and Statistics Stony Brook UniversityStony BrookNY 11794-3600USA Department of Applied Mathematics Center of Mathematical Modeling and Scientific ComputingNational Chiao Tung UniversityHsin Chu300Taiwan Department of Mathematics National Taiwan UniversityTaipei106Taiwan National Center for Theoretical Sciences Taipei OfficeTaipei106Taiwan

we use front tracking data structures and functions to model the dynamic evolution of fabric *** represent the fabric surface by a triangulated mesh with preset equilibrium side *** stretching and wrinkling of the surface are modeled by the mass-spring *** external driving force is added to the fabric motion through the"impulse method"which computes the velocity of the point mass by superposition of *** mass-spring system is a nonlinear ODE *** by the numerical and computational analysis,we show that the spring system has an upper bound of the eigen *** analyzed the system by considering two spring models and we proved in one case that all eigenvalues are imaginary and there exists an upper bound for the *** upper bound plays an important role in determining the numerical stability and accuracy of the ODE *** on this analysis,we analyzed the numerical accuracy and stability of the nonlinear spring mass system for fabric surface and its tangential and normal *** used the fourth order Runge-Kutta method to solve the ODE system and showed that the time step is linearly dependent on the mesh size for the system.

关键词： Front tracking spring model eigen frequency

Effects of weaving Laser on weld Microstructure and Crack for Al 6k21-T4 Alloy

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Journal of Materials Science & Technology 2011年第1期27卷 93-96页

作者： B.H.kim N.H.Kang w.T.Oh C.H.kim J.H.kim Y.S.kim Y.H.Park Department of Materials Science and Engineering Pusan National UniversitySan30Jangjeon-dongGeumjeong-guBusan 609-735Korea Department of Materials and Components Engineering Dong-Eui UniversityBusan 614-714Korea Advanced Joining Technology Team KITECH7-47Songdo-dongYeonsu-guIncheon 406-840Korea Division for Dongnam Area Technology Service KITECHJisa-dongGanseo-guBusan 618-230Korea

For Al 6k21-T4 overlap weld joint,the shear-tensile strength by using the weaving laser was improved as compared to the case of linear *** the specimen of low strength,the porosity was distributed continuously along the intersection between the plates and fusion ***,for the optimized welding condition,large oval-shaped porosities were located only in the advancing track of the concave ***,the continuity of cracks and porosities played a key role to determine the ***,the weaving width was also the important parameter to control the ***,the concave part had more significant hot and cold cracking in the weld and heat-affected zone（HAZ）,respectively,than the convex part.

关键词： weaving laser weld microstructure Void Al alloy

Mg-Al Alloys Manufactured by Casting and Hot working Process

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Journal of Materials Science & Technology 2008年第1期24卷 96-98页

作者： J.M.kim J.H.Jun w.J.Jung Department of Applied Materials Eng. Hanbat National University Daejeon 305-719 Korea Light Materials Team Korea Institute of Industrial Technology Incheon 406-800 Korea

Mechanical properties of Mg-Al based alloys at different fabrication state,namely as-cast,hot rolled,and annealed,were investigated to develop the alloys that are suitable for the casting/hot working ***- imental results indicated that the castability such as hot cracking resistance tends to improve with increasing the aluminum ***,the elongation at elevated temperatures was observed to decrease as the Ai content increases,implying difficulties in hot forming.A small amount of Zr additions could significantly enhance the room temperature mechanical properties of hot-rolled Mg-6%Al-1%Zn *** tendency of remarkable grain coarsening at high temperatures was effectively reduced by the Zr *** analyses suggested that very fine Al-3Zr precipitates formed in the Zr-added alloy are responsible for the obtained results.

关键词： Magnesium Casting Forming Tensile properties

Utilization of the superior properties of highly mesoporous PVP modified NiCo_2O_4 with accessible 3D nanostructure and flower-like morphology towards electrochemical methanol oxidation reaction

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Journal of Energy Chemistry 2019年第2期28卷 136-146页

作者： Gracita M.Tomboc Medhen w.Abebe Anteneh F.Baye Hern kim Department of Energy Science and Technology Smart Living Innovation Technology CenterMyongji University

Up to this date,researchers are still facing difficulties to expand the technology of direct methanol fuel cells(DMFCs) because of the high overpotential required to oxidize the methanol and its relatively poor performance due to CO poisoning of the leading-high cost anode *** line with this,we have successfully modified the morphological structure and composition of low cost cobalt based-metal oxides,MCo_2O_4(M = Zn and Ni),with the simple and noble use of polyvinyl pyrrolidone(PVP) as growth modifier and surface stabilizer during the synthesis of nanoparticles in our previous reports,which shown high electrocatalytic activity and strong *** to the good performance of our PVP modified MCo_2O_4 towards pseudocapacitor and oxygen evolution reaction applications,we decided to extend our research study to methanol oxidation ***,PVP modified Ni Co_2O_4 electrode directly grown on nickel foam substrate via a simple hydrothermal process exhibited better performance compared with PVP modified ZnCo_2O_4 and NiCo_2O_4 without *** had obtained a remarkably low onset potential of 0.285 V and high current density of 280 m A cm^(-2),and shown great stability and high poison tolerance during a continuous CV cycling and Chronoamperometry test,which attained high efficiency of 86.86%and 98.52%,*** positive results of PVP modified Ni Co_2O_4 electrode towards MOR might be attributed to its hierarchical 3 D nanostructures with highly mesoporous surface and large surface area which may have provided numerous electroactive sites,and the exceptional corrosion stability of Ni Co_2O_4 electrode in alkaline solution.

关键词： NiCo2O4 3D nanostructure Electrochemical Methanol oxidation Current density

MOLECULAR DESiGN OF LiGHT EMiTTiNG POLYMERS

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Chinese Journal of Polymer Science 2000年第3期18卷 227-237页

作者： J.w.Yu J.K.kim J.MHong Y.C.kim H.N.Cho D.Y.kim C.Y.kim Polymer Materials Laboratory Korea Institute of Science and TechnologyP.O.Box 131CheongryangSeoul 130-650.Korea

Fluorene-based alternating and statistical copolymers were synthesized by employing reaction methods of wittig,Heck and *** copolymers were classified into three groups with the photoluminescence(PL)emission maxima at420,475 and 500 nm,*** copolymers with two chromophores having PL emission maxima at 420 and475 nm emitted light with the emission maximum at 475 nm on photoexcitation at 365 nm and improved the quantumefficiency by the energy ***,the intramolecular energy transfer was inefficient compared to the intermolecularenergy transfer when the two chromophores were apart from each other in the range of the Forster critical ***-pyridinedivinylene alternating copolymer was synthesized by the wittig reaction and found to have physical,electronic andelectrochemical properties of the individual units *** double-layered light emitting diode(LED)with the statisticalcopolymer as an emitting layer and the pyridine-containing copolymer as an electron transporting-hole blocking layer,whichwere sandwiched between iTO and Al,displayed a quantum efficiency of 0.1%.

关键词： Light emitting polymers

Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

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Nano Research 2018年第7期11卷 3582-3592页

作者： Bong Geun Cha Han-Gil Jeong Dong-wan Kang Myong-Joo Nam Chi Kyung kim Do Yeon kim in-Young Choi Seul Ki Ki Song i kim Ju hee Han Jaeyun kim Seung-Hoon Lee School of Chemical Engineering Sungkyunkwan University Suwon 16419 Republic of Korea Department of Laboratory of innovative Nanobiotechnology Biomedical Research Institute Seoul National University Hospital 101 Daehak-ra Jongno-gu Seou103080 Republic of Korea Department of Neurology Seoul National University Hospital 101 Daehak-ro Jongno-gu Seou103080 Republic of Korea Department of Neurology Korea University Guro Hospital and Korea University College of Medicine Seoul 08308 Republic of Korea Department of Health Sdences and Technology Samsung Advanced Institute for Health Science & Technology (SAIHST) Sungkyunkwan University Suwon 16419 Republic of Korea Biomedical institute for Convergence at SKKU (BiCS) Sungkyunkwan University Suwon 16419 Republic of Korea

intracerebral hemorrhage （iCH）, caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. intense inflammatory reactions that occur in the peri-hematomal area after iCH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles （CeNPs）, abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanopartide-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. in the rodent iCH model, intracerebraUy injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with iCH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in iCH.

关键词： magnetic mesoporous silica nanoparticle ceria nanoparticles intracerebral hemorrhage reactive oxygen species therapeutics imaging