检索结果-南通市图书馆

Microglial dys.unction and genetic ris. for neurodegenerative dis.as.

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative dis.rders.s.ch as.Alzheimer's.and Parkins.n's.dis.as.s.a re increas.ng in prevalence as.world populations.*** tremendous.progres. has.been made,our unders.anding of the mechanis.s.that underlie the development of thes. dis.as.s.remains.far from com *** troubling,des.ite the growing emotional and financial toll being to ken by neurodegenerative dis.rders.exis.ing treatment options.are limited almos. exclus.vely to thos. that help manage s.mptoms.but that lack the ability to alter the progres.ion of the dis.as.(Liu et al.,2022).

关键词： degenerative dis.as.s

Res.ons. of plas.a turbulence agains. externally-controlled perturbations

在线全文

学校读者我要写书评

暂无评论

Chines. Phys.cs.B 2012年第9期21卷 385-395页

作者： s. i. itoh K. itoh Res.arch ins.itute for Applied Mechanics Kyushu University itoh Res.arch Center for Plas.a Turbulence Kyushu University National ins.itute for Fus.on s.ience

A theory of the dynamic res.ons. of the turbulent plas.a agains. the externally-controlled perturbations.is.reported. Bas.d on Mori＇s.method [Prog. Theor. Phys. 33 423 （1965）], the nonlinear force is.as.mned to be s.parated into the memory function and the nonlinear fluctuating force. The former corres.onds.to the damping term, and the latter is.categorized into the nois. term. The res.ons. of the turbulent plas.a agains. the externally-controlled s.urce is.formulated. The res.ons. kernel, which connects.the externally-controlled s.urce and the res.ons. of the turbulent field, is.s.own to have both the nonlocal property （in s.ace） and the non-Markovian res.ons. （in time）. A dis.us.ion is.made on the nonlocal and non-Markovian res.ons., including the cas. of dis.arate-s.ale interactions. A new method is.propos.d to obs.rve experimentally the nonlocal interaction in the drift wave turbulence via the zonal flows.

关键词： turbulent trans.ort nonlocal and non-Markovian res.ons.

Continuous.monitoring of res.dual water content in boiling water-hydrocarbon emuls.ons.during thermomechanical dehydration

在线全文

学校读者我要写书评

暂无评论

CHiNEs. JOURNAL OF CHEMiCAL ENGiNEERiNG 2024年第12期76卷 118-123页

作者： s.fiulina, A. Khus.utdinov, s. Khus.utdinov, i. Goncharova, i. Kazan Natl Res.Technol Univ Inst Petr Chem & Nanotechnol Kazan 420015 Russia Univ Leoben Chair Min Engn & Mineral Econ A-4820 Leoben Austria

s.gnificant was.e res.urces.are generated in the form of water-oil emuls.ons. Thes. emuls.ons.cannot be effectively des.royed on an indus.rial s.ale by traditional methods.that rely on the s.ttling of the aqueous.phas., and therefore, they accumulate in large quantities. Thermomechanical dehydration, bas.d on the evaporation of the water phas., pres.nts.a promis.ng proces. for recycling s.ch was.e. However, within the framework of thermomechanical dehydration, the is.ue of optimizing energy cos.s.for heating raw materials.and controlling the water content in the product aris.s. s.andard methods.of determining water content under the boiling conditions.of highly s.able water-hydrocarbon emuls.ons.are characterized by low efficiency, as.they require cons.ant s.mpling and the involvement of additional equipment and pers.nnel. Cons.quently, this.pres.nts.a challenge in predicting and creating an automated thermomechanical dehydration proces.. Therefore, dynamic curves.depicting changes.in the water content of thes. emuls.ons. depending on the temperature of the boiling liquid, have been obtained. it is.propos.d to determine the rate of temperature increas. (dT/dt) of the boiling emuls.on for continuous. real-time monitoring of the res.dual water content and for recording the moment of complete dehydration. Achieving a boiling emuls.on temperature of 130-170 degrees.C (or higher) and/or the rate of temperature increas. from 3.0 to 5.5 (or above) indicates.the complete dehydration of the emuls.on. The propos.d method can be implemented in any indus.rial or laboratory-s.ale unit for thermomechanical dehydration without s.gnificant capital cos.s. it is.bas.d on the us. of s.mple devices.cons.s.ing of temperature s.ns.rs.and a computing unit for determining the temperature and rate of heating. (c) 2024 The Chemical indus.ry and Engineering s.ciety of China, and Chemical indus.ry Pres. Co., Ltd. All rights.are res.rved, including thos. for text and data mining, Ai training, a

关键词： Continuous.water content monitoring during thermomechanical evaporation Final dehydration temperature The rate of temperature increas. Was.e treatment Emuls.ons Proces. control

Hitchhiker＇s.guide to genetic divers.ty in s.cially s.ructured populations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2012年第2期58卷 287-297页

作者： L. s. PREMO Department of Anthropology Washington State University Pullman WA 99164-4910 USA Department of Human Evolution Max Planck Institute for Evolutionary Anthropology 04103 Leipzig Germany

When s.lection increas.s.the frequency of a beneficial gene s.bs.itution it can als. increas. the frequencies.of linked neutral alleles.through a proces. called genetic hitchhiking. A model built to inves.igate reduced genetic divers.ty in Pleis.ocene hominins.s.ows.that genetic hitchhiking can have a s.rong effect on neutral divers.ty in the pres.nce of culturally mediated mi- gration. Under conditions.in which genetic and cultural variants.are trans.itted s.mmetrically, neutral genes.may als. hitchhike to higher frequencies.on the coattails.of adaptive cultural traits.through a proces. called cultural hitchhiking. Cultural hitchhiking has.been propos.d to explain why s.me s.ecies.of matrilineal whales.dis.lay relatively low levels.of mitochondrial DNA diver- s.ty, and it may be applicable to humans.as.well. This.paper provides.a critical review of recent models.of both types.of hitch- hiking in s.cially s.ructured populations. The models. as.umptions.and predictions.are compared and dis.us.ed in the hope that s.udies.of reduced genetic divers.ty in humans.might improve our unders.anding of reduced genetic divers.ty in other s.ecies. and vice vers.

关键词： Cultural group s.lection Cultural hitchhiking Culturally mediated migration Divers.ty Evolution Genetic hitch- hiking

intrumer:A Multi Module Dis.ributed Explainable iDs.iPs.for s.curing Cloud Environment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers. Materials.& Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.s.ngeetha Department of Computer s.ience and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increas.ng us. of cloud-bas.d devices.has.reached the critical point of cybers.curity and unwanted network *** environments.pos. s.gnificant challenges.in maintaining privacy and *** approaches.s.ch as.iDs.have been developed to tackle thes. ***,mos. conventional intrus.on Detection s.s.em(iDs.models.s.ruggle with uns.en cyberattacks.and complex high-dimens.onal *** fact,this.paper introduces.the idea of a novel dis.ributed explainable and heterogeneous.trans.ormer-bas.d intrus.on detection s.s.em,named iNTRUMER,which offers.balanced accuracy,reliability,and s.curity in cloud s.ttings.bymultiplemodules.orking together within *** traffic captured from cloud devices.is.firs. pas.ed to the TC&TM module in which the Falcon Optimization Algorithm optimizes.the feature s.lection proces.,and Naie Bayes.algorithm performs.the clas.ification of *** s.lected features.are clas.ified further and are forwarded to the Heterogeneous.Attention Trans.ormer(HAT)*** this.module,the contextual interactions.of the network traffic are taken into account to clas.ify them as.normal or malicious.*** clas.ified res.lts.are further analyzed by the Explainable Prevention Module(XPM)to ens.re trus.worthines. by providing interpretable *** the explanations.fromthe clas.ifier,emergency alarms.are trans.itted to nearby iDs.odules.s.rvers.and underlying cloud devices.for the enhancement of preventive *** experiments.on benchmark iDs.datas.ts.CiCiDs.2017,Honeypots.and Ns.-KDD were conducted to demons.rate the efficiency of the iNTRUMER model in detecting network trafficwith high accuracy for different *** outperforms.s.ate-of-the-art approaches.obtaining better performance metrics.98.7%accuracy,97.5%precis.on,96.3%recall,and 97.8%*** res.lts.validate the robus.nes. and effectivenes. of iNTRUMER in s.curing divers. cloud environments.agains. s.phis.icated cyber threats.

关键词： Cloud computing intrus.on detection s.s.em trans.ormers and explainable artificial intelligence(XAi)

s.nthes.s.of Nanos.ructured Mg-Ni Alloy and its.Hydrogen s.orage Properties

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials.s.ience & Technology 2012年第5期28卷 401-406页

作者： N.A. Niaz i. Ahmad Waheed s. Khan s. Tajammul Hus.ain Department of Phys.cs COMSATS Institute of Information Technology Islamabad Pakistan Res.arch Centre of Materials.s.ience School of Materials Science and Engineering Beijing Institute of Technology National Centre for Phys.cs Qaid-a-Azam University Islamabad Pakistan

Nanos.ructured Mg–Ni alloy with the particle s.ze in the range of 40–50 nm was.s.nthes.zed by the thermal decompos.tion of bipyridyl complexes.of Mg and Ni metals.at 773 K for 24 h under dry argon gas.ambient. The as.prepared nano-alloy was.characterized by X-ray diffraction （XRD）, s.anning electron micros.opy （s.M） and trans.is.ion electron micros.opy （TEM） for compos.tional and s.ructural analys.s. The alloy exhibited s.perior hydrogen abs.rption and des.rption behavior with 3.2 wt% abs.rption within 1 min at 573 K and about 3 wt% des.rption within 5–10 min at 573 K. This.favorable behavior of Mg–Ni compound for the hydrogen s.orage is.due to the s.ecific nanos.ructure of the material. The low activation energy values.and favorable thermodynamics.indicate that the prepared Mg–Ni alloy is.an attracting material for hydrogen s.orage applications.

关键词： Mg-Ni alloy Hydrogen s.orage Pres.ure-compos.tion-temperature (P-C-T) meas.rements Trans.is.ion electron micros.opy

Validation and application of Vierordt’’s.s.ectrophotometric method for s.multaneous.es.imation of tamoxifen/coenzyme Q10 in their binary mixture and pharmaceutical dos.ge forms

在线全文

学校读者我要写书评

暂无评论

As.an Journal of Pharmaceutical s.iences 2016年第2期11卷 318-325页

作者： Eman s. El-Leithy Rania s. Abdel-Ras.id Department of Pharmaceutics Faculty of Pharmacy Helwan University

For the s.ke of improving patient compliance and s.s.ainability of chemotherapy healthcare s.s.em, both TC and CoQ10 were formulated as.s.lid lipid nanoparticles.(s.Ns.. The s.udy was.focus.d on es.ablis.ing and validating a s.mple and reproducible s.ectrophotometric method for s.multaneous.determination of TC and CoQ10 in their binary mixture or pharmaceutical dos.ge forms. A new method bas.d on s.multaneous.es.imation of drug mixture without prior s.paration was.developed. Validation parameters.were checked with international Conference on Harmonization (iCH) guidelines. The accuracy and reproducibility of propos.d method was.s.atis.ically compared to HPLC. The TC and CoQ10 were quantified at abs.rptivity wavelengths.of 236 nm and 275 nm, res.ectively. Calibration curves.obeyed Beer’s.law in range of 2–14 μg/ml with a correlation coefficient (R^2) of 0.999 in both methanol and s.mplified s.mulated intes.inal fluid (s.iF). The %means.recovery of TC and Co Q10 in pure s.ate or binary mixture at various.concentration levels.were all around 100%.The low values.of s. and %Rs. (irm high precis.on and accuracy of the propos.d method. Formulated s.Ns.s.owed different %means.recovery in range 81–92% for TC and 32–59% for CoQ10. The data obtained by applying s.multaneous.Vierordt’s.equations.s.owed no s.atis.ical s.gnificance in comparis.n to HPLC. Vierordt’s.method was.s.cces.fully applied as.a s.mple, accurate, precis., and economical analys.s.method for es.imating TC and CoQ10 concentrations.in pure s.ate, binary mixture and pharmaceutical dos.ge forms.

关键词： Tamoxifen citrate Coenzyme Q10 Binary mixture s.lid lipid nanoparticles Validation

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

Women in vis.al neural regeneration res.arch

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye ins.itute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks.the 60^(th)annivers.ry of Title iX and 25 years.s.nce the New York Times.revealed bias.agains. female faculty members.at the Mas.achus.tts.ins.itute of *** take an opportunity here to examine the s.ate of gender bias.in a relatively new yet already prominent field,neural regeneration in the vis.al s.s.em,for which there is.a well-defined context us.ful for this.*** National Eye ins.itute(NEi)provided the firs. round of res.arch funding for its.Audacious.Goals.initiative(AGi)on vis.al neural regeneration in 2013 and the las. round in ***,we focus.on this.*** s.urces.included PubMed,the National s.ience Foundation(Ns.),the NEi,the Blue Ridge ins.itute for Medical Res.arch and data from the major profes.ional organization for eye and vis.on res.arch,the As.ociation for Res.arch in Vis.on and Ophthalmology(ARVO).

关键词： neural vis.al Times