检索结果-南通市图书馆

MiR-142-3p Regulates iLC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

Current Medical Science 2024年第1期44卷 195-211页

作者： Xiang-li PANG Jie Li Jing WANG si-si YAN Jing YANG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China Reproductive Medical Center Renmin Hospital of Wuhan UniversityWuhan 430060China Clinic Research Center for Assisted Reproductive Technology and Embryonic Development in Hubei Province Wuhan 430060China

Objective innate lymphoid cells(iLCs)are a class of newly discovered *** 1 iLCs(iLC1s)are identified in the decidua of humans and *** mobility group box 1(HMGB1)is predicted to be one of the target genes of miR-142-3p,which is closely related to pregnancy-related ***,miR-142-3p and HMGB1 are involved in regulating the NF-κB signaling *** study aimed to examine the regulatory effect of miR-142-3p on iLC1s and the underlying mechanism involving HMGB1 and the NF-κB signaling *** Mouse models of normal pregnancy and abortion were constructed,and the alterations of iLC1s,miR-142-3p,iLC1 transcription factor(T-bet),and pro-inflammatory cytokines of iLC1s(TNF-α,iFN-γand iL-2)were detected in mice from different *** targeting regulation of HMGB1 by miR-142-3p in iLC1s,and the expression of HMGB1 in normal pregnant mice and abortive mice were *** addition,the regulatory effects of miR-142-3p and HMGB1 on iLC1s were detected in vitro by CCK-8,Annexin-V/Pi,ELiSA,and RT-PCR,***,changes of the NF-κB signaling pathway in iLC1s were examined in the different *** the in vivo studies,miR-142-3p-Agomir was injected in the uterus of abortive mice to evaluate the abortion rate and alterations of iLC1s at the maternal-fetal interface,and further detect the expression of HMGB1,pro-inflammatory cytokines,and the NF-κB signaling *** The number of iLC1s was significantly increased,the level of HMGB1 was significantly upregulated,and that of miR-142-3p was considerably downregulated in the abortive mice as compared with the normal pregnant mice(all Pin addition,miR-142-3p was found to drastically inhibit the activation of the NF-κB signaling pathway(PiLC1s and the levels of pro-inflammatory cytokines were significantly downregulated and the activation of the NF-κB signaling pathway was inhibited in the miR-142-3p Agomir group(all Psion

关键词： maternal-fetal interface group 1 innate lymphoid cells(iLCis) high mobility group box 1(HMGB1) miR-142-3p abortion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

引用

Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-Ping Xu si-Lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,Lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning mechanical behaviors of highly entangled hydrogels with the random distribution of mobile entanglements

引用

Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 277-294页

作者： Jinlong LiU di LU Bin CHEN Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Beijing System Design institute of Electro-Mechanic Engineering Beijing 100854China intelligent Robotic Research Center Zhejiang LaboratoryHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou 311100China

Highly entangled hydrogels exhibit excellent mechanical properties,including high toughness,high stretchability,and low *** considering the evolution of randomly distributed entanglements within the polymer network upon mechanical stretches,we develop a constitutive theory to describe the large stretch behaviors of these *** the theory,we utilize a representative volume element(RVE)in the shape of a cube,within which there exists an averaged chain segment along each edge and a mobile entanglement at each *** employing an explicit method,we decouple the elasticity of the hydrogels from the sliding motion of their entanglements,and derive the stress-stretch relations for these *** present theoretical analysis is in agreement with experiment,and highlights the significant influence of the entanglement distribution within the hydrogels on their *** also implement the present developed constitutive theory into a commercial finite element software,and the subsequent simulations demonstrate that the exact distribution of entanglements strongly affects the mechanical behaviors of the structures of these ***,the present theory provides valuable insights into the deformation mechanism of highly entangled hydrogels,and can aid in the design of these hydrogels with enhanced performance.

关键词： highly entangled hydrogel constitutive theory entanglement gamma distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fermi Blazars in the Zwicky Transient Facility Survey:Properties of Large Optical Variations

引用

Research in Astronomy and Astrophysics 2024年第10期24卷 104-115页

作者： si-si Sun Zhong-Xiang Wang Shun-Hao Ji Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We analyze the optical light curve data,obtained with the Zwicky Transient Facility(ZTF)survey,for 47 γ-ray blazars monitored by the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope(Fermi).These 47sources are selected because they are among the Fermi blazars with the largest optical variations in the ZTF *** color-magnitude variation patterns are seen in them,with one being redder-to-stable-when-brighter(RSWB;in 31 sources)and the other being stable when brighter(in 16 sources).The patterns fit with the results recently reported in several similar studies with different ***,we find that the colors in the stable state of the sources share similar values,for which(after being corrected for the Galactic extinction)most sources are in a range of 0.4–*** feature could be intrinsic and may be applied in,for example,study of the intragalactic *** also determine the turning points for the sources showing the RSWB pattern,after which the color changes saturate and become *** find a correlation between optical fluxes and γ-ray fluxes at the turning *** physical implications of the correlation remain to be investigated,probably better with a sample of high-qualityγ-ray flux measurements.

关键词： (galaxies:)BL Lacertae objects:general (galaxies:)quasars:general gamma-rays:galaxies

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Modulus Heterogeneity on the Equilibrium Shape and Stress Field ofαPrecipitate in Ti-6Al-4V

引用

Computer Modeling in Engineering & Sciences 2024年第7期140卷 1017-1028页

作者： di Qiu Rongpei Shi Materials Genome institute Shanghai UniversityShanghai200444China School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen518055China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai200444China Zhejiang Laboratory Hangzhou311100China

For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the *** stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving *** study develops a phase-field model concerningmodulus *** effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is ***αprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial *** calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is *** addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied *** stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβ*** study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.

关键词： Elastic heterogeneity habit plane stress field titanium phase-field simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effect of Key Nodes on theMalware Dynamics in the industrial Control Network

引用

Computers, Materials & Continua 2024年第4期79卷 329-349页

作者： Qiang Fu JunWang Changfu si Jiawei Liu College of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China College of Computer Science and Engineering Northeastern UniversityShenyang110169China

As industrialization and informatization becomemore deeply intertwined,industrial control networks have entered an era of *** connection between industrial control networks and the external internet is becoming increasingly close,which leads to frequent security *** paper proposes a model for the industrial control *** includes a malware containment strategy that integrates intrusion detection,quarantine,and ***,the role of keynodes in the spreadofmalware is studied,a comparisonexperiment is conducted to validate the impact of the containment *** addition,the dynamic behavior of the model is analyzed,the basic reproduction number is computed,and the disease-free and endemic equilibrium of the model is also obtained by the basic reproduction ***,through simulation experiments,the effectiveness of the containment strategy is validated,the influence of the relevant parameters is analyzed,and the containment strategy is *** otherwords,selective immunity to key nodes can effectively suppress the spread ofmalware andmaintain the stability of industrial control *** earlier the immunization of key nodes,the *** the time exceeds the threshold,immunizing key nodes is almost *** analysis provides a better way to contain the malware in the industrial control network.

关键词： Key nodes dynamic model industrial control network simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unraveling the biological link between diabetes mellitus and prostate cancer:insights and implications

引用

World Journal of diabetes 2024年第6期15卷 1367-1373页

作者： Jian Li Zhi-Peng Li si-si Xu Wei Wang Department of interventional Oncology Municipal Hospital Affiliated to Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

This article is a comprehensive study based on research on the connection between diabetes mellitus(DM)and prostate cancer(PCa).it investigates the potential role of DM as an independent risk factor for PCa,delving into the biological links,including insulin resistance and hormonal *** paper critically analyzes previous studies that have shown varying results and introduces mendelian randomization as a method for establishing *** emphasizes the importance of early DM screening and lifestyle modifications in preventing PCa,and proposes future research directions for further understanding the DM-PCa relationship.

关键词： Biological mechanisms diabetes mellitus Mendelian randomization Prevention prostatic cancer Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

引用

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng si Yue-Yue Wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure and 2p decay mechanism of^(18)Mg

引用

Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long Zhou De-Qing Fang si-Min Wang Hui Hua Key Laboratory of Nuclear Physics and ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The noise spectral characteristics and noise reduction schemes of screw air-source heat pump:A case study

引用

Building simulation 2024年第1期17卷 53-70页

作者： Dongsheng Liu Yaohan Feng Jikang Jia Pengfei si Ya Feng China Southwest Architecture Design and Research institute Co.Ltd. Chengdu 610041China CSCEC Green Construction Engineering Research Center Chengdu 610041China

The screw air-source heat pump can cause incessant high noise levels during operation,which might hinder adoption of this energy-efficient heat ***,acoustic measurements and comparison testing were performed in this *** measurements revealed that the compressor is the main noise source of the heat pump,and it shows a multipeak frequency distribution and a wide frequency spectrum under different work conditions,with multiple peaks at 63,250,and 1000 ***,a compressor sound insulation cover with broadband absorption was proposed,and it was experimentally proven that the insulation cover can reduce the maximum sound pressure level of one unit from 89.8 dBA to 79.1 ***,we proposed several noise reduction strategies and compared their noise reduction effects using computer *** results showed that the noise problem can be effectively improved through the rational design of the sound barrier and the layout and opening options of heat *** distance between the sound barrier and heat pump and the sound attenuation due to diffraction ALa exhibit a U-shaped *** buildings of different heights,the optimal heights of noise barrier are *** 5.5-meter is the optimal height of the sound barrier for single-story *** conclusions can be applied to other building projects for heat pump noise reduction.

关键词： acoustic simulation broadband noise noise reduction air-source heat pump sound barrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：