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differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo diana Simón Johnny di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class ii(MHCii) neuroprotection olfactory ensheathing glia retinal ganglion cells

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2011—2020年广州市肺结核死亡趋势及年龄-时期-队列模型分析

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中国防痨杂志 2025年第1期47卷 44-50页

作者：李雪秋刘群唐科吴迪广州市胸科医院结核病防治所一分所广州510095 广东省生物制品与药物研究所药理研究室广州510440 广州市疾病预防控制中心慢性非传染性疾病预防控制部广州510440 广东医科大学公共卫生学院东莞523808

目的:分析2011—2020年广州市肺结核患者的死亡情况和死亡率变化趋势,为制定防控策略和措施提供科学依据。方法:采用Joinpoint回归模型分析2011—2020年广州市全年龄段人群肺结核死亡率变化趋势,并计算年度变化百分比(annual percent ch... 详细信息

目的:分析2011—2020年广州市肺结核患者的死亡情况和死亡率变化趋势,为制定防控策略和措施提供科学依据。方法:采用Joinpoint回归模型分析2011—2020年广州市全年龄段人群肺结核死亡率变化趋势,并计算年度变化百分比(annual percent change,APC)和平均年度变化百分比(average annual percent change,AAPC);使用年龄-时期-队列模型分析广州市20~85岁人群肺结核死亡风险的年龄、时期和队列效应。结果:广州市2011—2020年报告肺结核死亡患者2144例,年均报告标化死亡率为2.57/10万;男性肺结核标化死亡率为4.19/10万,约为女性标化死亡率(0.96/10万)的4.4倍。10年间广州市肺结核年龄标化死亡率总体呈现下降趋势,AAPC为-4.15%(95%Ci:-6.41%~-1.85%,P=0.003);其中,女性肺结核死亡率下降速度高于男性,AAPC分别为-6.72%(95%Ci:-10.38%~-2.92%,P=0.004)和-3.55%(95%Ci:-6.19%~-0.85%,P=0.017)。在不同年龄段人群中,0~49岁和≥65岁年龄段人群肺结核死亡率均呈现明显下降趋势,AAPC分别为-7.05%(95%Ci:-11.52%~-2.34%,P=0.009)和-3.94%(95%Ci:-6.22%~-1.62%,P=0.005)。年龄-时期-队列模型的年龄效应显示,随着年龄的增长,肺结核死亡风险不断上升,≥65岁人群尤为显著,发病率由66~67岁年龄组的2.93/10万增长至84~85岁年龄组的6.10/10万。时期效应显示,肺结核死亡风险随着时期的变化总体呈现下降趋势,相对危险度(risk ratio,RR)从2011—2012年时期组的1.35下降至2019—2020年时期组的0.81。队列效应显示,越晚出生的人群肺结核死亡风险越低,RR值从1926—1927年出生队列的5.91降低至1998—1999年出生队列的0.16。结论:广州市肺结核死亡率总体呈不断下降的趋势,但男性和女性肺结核死亡率差距较大。需重点关注男性和≥65岁年龄段的老年人群,并实施针对性的防控和治疗措施。

关键词：结核,肺死亡率回归分析队列研究

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Space, Time, and Their Transformations

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Journal of Systems Engineering and Electronics 1995年第4期6卷 25-44页

作者： F.Selleri (Universita di Bari-dipart. di Fisica, iNFN-Sezione di Bari,Via Amendola 173, i-70126 Bari) Universita di Bari-dipart. di Fisica INFN-Sezione di Bari Via Amendola 173 1-70126 Bari

We construct a set T of space-the transformations between inertial systems that are completely equivalent for explaining the experimental evidence, by starting from two empirically based assumptions: (1) The two-way velocity of light is c in all inertial systems and in all directions; (2) Time dilation effects take place with the usual relativistic factor. The Lorentz transformation is an element of T and any two elements of T differ only as to a convention regarding clock synchronization. The simplest choice is to transform time independently of space coordinates (absolute synchronization) and can be called 'inerital transformation.' When accelerations are considered the equivalence is broken and the inertial transformation emerges as closest to physical reality.

关键词： Special relativity Space and time.

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GUE via Frobenius *** Matrix Gravity to Topological Gravity and Back

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Acta Mathematica Sinica,English Series 2024年第1期40卷 383-405页

作者： di YANG School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026P.R.China

Dubrovin establishes a certain relationship between the GUE partition function and the partition function of Gromov-Witten invariants of the complex projective *** this paper,we give a direct proof of Dubrovin’s *** ... 详细信息

关键词： Frobenius manifold Dubrovin-Zhang hierarchy GUE Toda lattice hierarchy jet space topological gravity matrix gravity

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法压式冲泡对海南罗布斯塔咖啡感官品质的影响

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食品科学 2025年第1期46卷 108-120页

作者：刘迪劳菲董文江于鑫欣中国农业大学食品科学与营养工程学院国家果蔬加工工程技术研究中心农业农村部果蔬加工重点实验室北京市食品非热加工重点实验室北京100083 中国热带农业科学院香料饮料研究所海南万宁571533 海南省特色热带作物适宜性加工与品质控制重点实验室国家重要热带作物工程技术研究中心海南万宁571533

以中度烘焙海南罗布斯塔咖啡为研究对象,制备可溶性固形物质量分数为2%的法压式咖啡,采用喜好度评价对4种冲泡参数进行单因素和响应面试验优化,通过感官定量描述分析结合气相色谱-质谱联用法、超高效液相色谱法挖掘咖啡喜好度与其感官... 详细信息

以中度烘焙海南罗布斯塔咖啡为研究对象,制备可溶性固形物质量分数为2%的法压式咖啡,采用喜好度评价对4种冲泡参数进行单因素和响应面试验优化,通过感官定量描述分析结合气相色谱-质谱联用法、超高效液相色谱法挖掘咖啡喜好度与其感官特性及风味物质之间的相关性信息。结果表明,咖啡萃取质量浓度会随着咖啡粒径减小、粉水比增加、冲泡水温升高或冲泡时间延长而显著增大(Pin时达到最高(3.3±1.6)。咖啡中共检测出78种挥发性成分,通过气味活性值分析得大马士酮、3-乙基-2,5-甲基吡嗪等关键香气化合物10种。Pearson相关性分析表明,喜好度与咖啡的圆润感、巧克力香属性呈正相关,与咖啡因、具有丁香味和酚味的4-乙基愈创木酚、4-乙烯基愈创木酚及具有粪臭味的3-甲基吲哚呈负相关。本研究能为挖掘海南罗布斯塔咖啡的风味喜好及其物质基础提供一定理论依据。

关键词：罗布斯塔咖啡冲泡参数感官定量描述分析气相色谱-质谱联用 Pearson相关性

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Numerical simulation of dynamic characteristics of a cable-stayed aqueduct bridge

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 569-579页

作者： LiYuchun di Qingshuang Department of Hydraulic Engineering Tongji University Shanghai 200092 China Research institute of Structural Engineering and disaster Reduction Tongji University Shanghai 200092 China

in this paper, a full-scale 3-D finite element model of the Jundushan cable-stayed aqueduct bridge is established with ANSYS Code. The shell, fluid, tension-only spar and beam elements are used for modeling the aqueduct deck, filled water, cables and support towers, respectively. A multi-element cable formulation is introduced to simulate the cable vibration. The dry （without water） and wet （with water） modes of the aqueduct bridge are both extracted and investigated in detail. The dry modes of the aqueduct bridge are basically similar to those of highway cable-stayed bridges. A dry mode may correspond to two types of wet modes, which are called the in-phase （with lower frequency） and out-of-phase （with higher frequency） modes. When the water-structure system vibrates in the in-phase/out-of-phase modes, the aqueduct deck moves and water sloshes in the same/opposite phase-angle, and the sloshing water may take different surface-wave modes. The wet modes of the system reflect the properties of interaction among the deck, towers, cables and water. The in-phase wet frequency generally decreases as the water depth increases, and the out-of-phase wet frequency may increase or decrease as the water depth increases.

关键词： cable-stayed aqueduct bridge dynamic characteristics fluid-structure interaction numerical simulation

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Liquid suspensions of single and binary component solid particles-An overview

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China Particuology 2007年第5期5卷 312-320页

作者： Renzo di Felice dipartimento di ingegneria Chimica e di Processo "G.B. Bonino" Università degli Studi di Genovavia Opera Pia1516145 GenovaItaly

in this paper theoretical approaches and experimental findings relative to the hydrodynamics of liquid suspensions of solid particles by liquids are reported and discussed. For the single particle specie systems, advantages and possible faults of well known empirical correlations are discussed. For binary-solid mixture suspensions, experimental evidence are reviewed and approaches capable of successfully describing observed behaviour are reported.

关键词： Sedimentation Fluidization Voidage function Binary-mixture

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Bayesian compressive principal component analysis

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Frontiers of Computer Science 2020年第4期14卷 29-38页

作者： di MA Songcan CHEN College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing211106China College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsMIIT Key Laboratory of Pattern Analysis and Machine IntelligenceNanjing211106China

Principal component analysis(PCA)is a widely used method for multivariate data analysis that projects the original high-dimensional data onto a low-dimensional subspace with maximum ***,in practice,we would be more likely to obtain a few compressed sensing(CS)measurements than the complete high-dimensional data due to the high cost of data acquisition and *** this paper,we propose a novel Bayesian algorithm for learning the solutions of PCA for the original data just from these CS *** this end,we utilize a generative latent variable model incorporated with a structure prior to model both sparsity of the original data and effective dimensionality of the latent *** proposed algorithm enjoys two important advantages:1)The effective dimensionality of the latent space can be determined automatically with no need to be pre-specified;2)The sparsity modeling makes us unnecessary to employ multiple measurement matrices to maintain the original data space but a single one,thus being storage *** results on synthetic and real-world datasets show that the proposed algorithm can accurately learn the solutions of PCA for the original data,which can in turn be applied in reconstruction task with favorable results.

关键词： compressed sensing principal component analysis Bayesian learning sparsity modeling

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Atomic design of carbon-based dual-metal site catalysts for energy applications

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Nano Research 2023年第5期16卷 6477-6506页

作者： Huishan Shang di Liu School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Department of Chemistry Tsinghua UniversityBeijing 100084China

Carbon-based dual-metal sites catalysts(DMSCs)have emerged as a new frontier in the field of sustainable energy due to their unique coordination environments,electronic structure,the maximized atom *** reasonable utilization of carbonbased DMSCs provides new possibilities to achieve the outstanding catalytic performance,remarkable selectivity,recyclability in energy-related *** on this,this review intends to summarize the recent breakthroughs in carbonbased DMSCs for the energy ***,the definition and classifications of DMSCs are proposed,mainly dividing into three types(isolated dual-metal site pairs,binuclear homologous dual-metal sites pairs,binuclear heterologous dual-metal sites pairs).Subsequently,we discuss the potential of DMSCs targeting on energy conversion reactions,such as electrocatalytic hydrogen evolution reaction(HER),oxygen evolution reaction(OER),oxygen reduction reaction(ORR),CO_(2)reduction reaction(CO_(2)RR),N_(2) reduction reaction(NRR).Finally,we predict the remaining challenges and possible opportunities on the unique carbon-based DMSCs for energy applications in the future.

关键词： dual-metal site catalysts carbon atomic design energy applications

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Finite-time composite guidance law with input constraint and dynamics compensation

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Chinese Journal of Aeronautics 2020年第2期33卷 664-671页

作者： Meijun DUAN di ZHOU School of Astronautics Harbin Institute of TechnologyHarbin 150001China

Guidance laws are proposed for a near space interceptor with on-off type thrust as *** target-interceptor engagement kinematics is integrated with the first-order dynamics of thruster to design guidance *** bang-bang type guidance law with linear sliding mode is proposed to deal with thruster dynamics,and the sufficient condition for finite time convergence is rigorously proved based on the finite-time convergence *** to the sufficient condition,a sliding mode guidance law with hysteresis-band switching is introduced to reduce the switching frequency of *** two guidance laws are combined into a composite guidance law to improve the guidance *** results show that the line-of-sight angular rate can converge to a neighborhood of the equilibrium point before the final time of the guidance process,and the composite guidance law has better performance than typical guidance laws.

关键词： Dynamics Finite-time convergence Guidance Hysteresis-band switching Near space interceptor Output constraint

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