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CNKSR2 i.teractome analysi. i.di.ates i.s associ.ti.n wi.h the centrosome/mi.rotubule system

Neural Regenerati.n Research 2025年第8期20卷 2420-2432页

作者： Li. Yi. Yalan Xu Ji. Mu Yu Leng Lei.Ma Yu Zheng Rui.hi.Li.Yi. Wang Pei.eng Li.Hai.Zhu Dong Wang Ji.g li i.sti.ute for Translati.nal Medi.i.e The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basi. Medi.i.e Qingdao UniversityQingdaoShandong ProvinceChina College of Li.e Sci.nces and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protei. connector enhancer of ki.ase suppressor of Ras 2(CNKSR2),present i. both the postsynapti. densi.y and cytoplasm of neurons,i. a scaffoldi.g protei. wi.h several protei.-bi.di.g *** of the CNKSR2 gene have been i.pli.ated i. neurodevelopmental di.orders,parti.ularly i.tellectual di.abi.i.y,although the preci.e mechani.m i.volved has not yet been fully *** has demonstrated that CNKSR2 plays a role i. faci.i.ati.g the locali.ati.n of postsynapti. densi.y protei. complexes to the membrane,thereby i.fluenci.g synapti. si.nali.g and the morphogenesi. of dendri.i. ***,the functi.n of CNKSR2 i. the cytoplasm remai.s to be *** thi. study,we used i.munopreci.i.ati.n and hi.h-resoluti.n li.ui. chromatography-mass spectrometry to i.enti.y the i.teractors of *** a combi.ati.n of bi.i.formati. analysi. and cytologi.al experi.ents,we found that the CNKSR2 i.teractors were si.ni.i.antly enri.hed i. the proteome of the *** also showed that CNKSR2 i.teracted wi.h the mi.rotubule protei. DYNC1H1 and wi.h the centrosome marker *** colocali.ati.n analysi. confi.med the centrosomal locali.ati.n of *** we downregulated CNKSR2 expressi.n i. mouse neuroblastoma cells(Neuro 2A),we observed si.ni.i.ant changes i. the expressi.n of numerous centrosomal *** mani.ulati.n also affected centrosome-related functi.ns,i.cludi.g cell si.e and shape,cell proli.erati.n,and ***,we found that CNKSR2 i.teractors were hi.hly enri.hed i. de novo vari.nts associ.ted wi.h i.tellectual di.abi.i.y and auti.m spectrum *** fi.di.gs establi.h a connecti.n between CNKSR2 and the centrosome,and offer new i.si.hts i.to the underlyi.g mechani.ms of neurodevelopmental di.orders.

关键词： auti.m spectrum di.order centrosome CNKSR2 i.tellectual di.abi.i.y i.teractome mass spectrometry mi.rotubule neurodevelopmental di.ease protei. complexes protei.-protei. i.teracti.ns

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Cali.rati.n of the Solar X-ray Detector on-board the Macao Sci.nce Satelli.e-1B for Soft X-ray Detecti.n

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Sci.nce Chi.a Earth Sci.nces 2025年第1期68卷 11-26页

作者： Man-Hei.NG Xi.opi.g ZHANG Ji.nwu CHEN Yongqi.ng SHi.Fuchang ZUO Wenxi.PENG Wei.hun FU Li.nsheng Li.Pengwei.LUO Chi.Long TANG Guozheng ZHANG Zhi.u MEi.Li.WANG Cunhui.Li.Ji.mi.g OU Yanyan XU State Key Laboratory of Lunar and Planetary Sci.nces Macau University of Science and Technology Chi.a Nati.nal Space Admi.i.trati.n (CNSA) Macau Center for Space Exploration and Science Space Optoelectroni. Measurement and Percepti.n Laboratory Beijing Institute of Control Engineering i.sti.ute of Hi.h Energy Physi.s Chinese Academy of Sciences Sci.nce and Technology on Vacuum Technology and Physi.s Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Sci.nce Satelli.e-1B(MSS-1B) was successfully launched vi. the Chi.ese Long March-2C rocket on 21 May 2023, and commenced operati.ns i. early June of the same year. The MSS-1B/Soft X-ray Detecti.n Uni.s(SXDUs) employ two si.i.on dri.t detectors(SDDs), provi.i.g a wi.e range of energy spectra spanni.g from 0.7 to 24 keV. Notably, the SXDUs deli.er a hi.h-resoluti.n capabi.i.y of 0.14 keV@5.9 keV and operate wi.h a ti.e cadence of 1 second. Here, we perform thorough cali.rati.ns of the MSS-1B/SXDUs, employi.g a combi.ati.n of ground experi.ents and si.ulati.ns. i. addi.i.n, quanti.ati.e analysi. compari.g the flux measurements obtai.ed by the MSS-1B/SXDUs to the data collected by the Geostati.nary Operati.nal Envi.onmental Satelli.e(GOES), provi.es compelli.g evi.ence of thei. consi.tency. Furthermore, the preli.i.ary spectral analysi. results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocki.g thei. potenti.l for faci.i.ati.g the study of dynami. evoluti.n of solar flares. Moreover, the i.novati.e MSS-1B/Solar X-ray Detector faci.i.ates concurrent observati.ns of solar soft and hard X-rays, thereby maki.g valuable contri.uti.ns to the advancements i. solar research.

关键词： Macao Sci.nce Satelli.e-1B (MSS-1B) Cali.rati.n Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

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Deci.i.n maki.g module based on stochasti. magneti. tunnel juncti.ns

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Sci.nce Chi.a(Physi.s,Mechani.s & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yi.an Mi.o Li.Zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studi.s and Department of Physi.s Beijing Normal University i.sti.ute for Nanoelectri. Devi.es and Quantum Computi.g Fudan University i.terdi.ci.li.ary Center for Theoreti.al Physi.s and i.formati.n Sci.nces Fudan University

i. bi.logi.al neural systems, noi.e i. ubi.ui.ous but does not affect the correct deci.i.ns made i. the complex cogni.i.e ***-maki.g i. bi.logi.al neural system i. typi.ally achi.ved by accumulati.g i.put i.formati.n over a peri.d of *** by recent developments i. neurosci.nces, we desi.n a deci.i.n-maki.g module based on spi.troni. devi.es, uti.i.i.g superparamagneti. tunnel juncti.ns as arti.i.i.l neurons. The feasi.i.i.y of thi. deci.i.n-maki.g module i. veri.i.d through ci.cui. si.ulati.ns. Taki.g a multi.layer perceptron as an example, the module si.ni.i.antly i.proves the accuracy of the perceptron i. the handwri.ten di.i. recogni.i.n task. Furthermore, the spi.troni. deci.i.n-maki.g module offers advantages over the conventi.nal pooli.g methods, such as adapti.e deci.i.n ti.e, hi.h performance and the absence of analog-to-di.i.al conversi.n. The deci.i.n-maki.g module i. flexi.le to be i.tegrated i.to arti.i.i.l neural networks and provi.es a general yet effecti.e soluti.n to enhance performance agai.st devi.e noi.e.

关键词： neuromorphi. computi.g spi.troni.s magneti. tunnel juncti.n neural networks

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Engi.eeri.g atomi. Rb-N confi.urati.ns to tune radi.al pathways for hi.hly selecti.e photocatalyti. H2O2 synthesi. coupled wi.h bi.mass valori.ati.n

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Journal of Energy Chemi.try 2025年第1期100卷 215-225页

作者： Ji.ye Li.Shuang Pan Yi.uang Chen Qi.ng Li. College of Chemi.try and Materi.ls Engi.eeri.g Wenzhou University Guangdong Provi.ci.l Key Laboratory of Chemi.al Measurement and Emergency Test Technology (Chi.a) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalyti. oxygen reducti.n for hydrogen peroxi.e （H2O2） synthesi. presents a green and costeffecti.e producti.n ***,achi.vi.g hi.hly selecti.e H2O2synthesi. remai.s challengi.g,necessi.ati.g preci.e control over free radi.al reacti.n pathways and mi.i.i.i.g undesi.able oxi.ati.e ***,we report for the vi.i.le li.ht-dri.en si.ultaneous co-photocatalyti. reducti.n of O2to H2O2and oxi.ati.n of bi.mass usi.g the atomi. rubi.i.m-ni.ri.e modi.i.d carbon ni.ri.e（CNRb）.The opti.i.ed CNRb catalyst demonstrates a record photoreducti.n rate of 8.01 mM h-1for H2O2generati.n and photooxi.ati.n rate of 3.75 mM h-1for furfuryl alcohol to furoi. aci.,achi.vi.g a remarkable solar-to-chemi.al conversi.n （SCC） effi.i.ncy of up to 2.27%.Experi.ental characteri.ati.ns and DFT calculati.n di.closed that the i.troduci.g atomi. Rb–N confi.urati.ns allows for the hi.h-selecti.e generati.n of superoxi.e radi.als whi.e suppressi.g hydroxyl free radi.al *** i. because the Rb–N serves as the new alternati.e si.e to percei.e a stronger connecti.n posi.i.n for O2adsorpti.n and rei.force the capabi.i.y to extract protons,thereby tri.geri.g a hi.h selecti.e redox product *** study holds great potenti.l i. preci.ely regulati.g reacti.e radi.al processes at the atomi. level,thereby pavi.g the way for effi.i.nt synthesi. of H2O2coupled wi.h bi.mass valori.ati.n.

关键词： Free radi.al reacti.ns

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Flow Reversal of Fully-Developed Mi.ed MHD Convecti.n i. Verti.al Channels

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Chi.ese Physi.s Letters 2010年第2期27卷 138-140页

作者： H. Saleh, i. Hashi. Centre for Modelli.g and Data Analysi. School of Mathematical Sciences Universiti Kebangsaan Malaysia 43600 UKM Bangi Selangor Malaysia

The present analysi. i. concerned wi.h flow reversal phenomena of the fully-developed lami.ar combi.ed free and forced MHD convecti.n i. a verti.al parallel-plate channel. The effect of vi.cous di.si.ati.n i. taken i.to account. Flow reversal adjacent to the cold （or hot） wall i. found to exi.t wi.hi. the channel as Gr/Re i. above （or below） a threshold value. Parameter zones for the occurrence of reversed flow are presented.

关键词： Chi.ese cli.ate network complex systems small world communi.y

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Si.C Foam Porous-Medi.m Combusti.n Power-Generati.n System for Low-Calori.i.-Value Bi.mass Syngas

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Journal of Thermal Sci.nce 2025年第1期34卷 206-222页

作者： YANG Ji.nwen CHEN Wei.CAO Bi.gwei.Li. Xi.hui.Li.Hang College of Mechani.al and Aerospace Engi.eeri.g Jilin University School of Mechani.al and Vehi.le Engi.eeri.g Changchun University

Syngas produced from the gasi.i.ati.n of organi. feedstocks from bi.mass i. one of the clean and sustai.able sources of *** advantages of si.ple access and renewabi.i.y of bi.mass energy can meet the energy needs of temporary power *** study presents a bi.mass power-generati.n system for vehi.ular *** bi.mass and a free-pi.ton Sti.li.g engi.e generator（FPSEG） as the pri.ary materi.l and pri.e mover,respecti.ely,bi.mass energy i. converted i.to electri.i.y by combusti.g the syngas to heat the *** and key parameter desi.n for bi.mass gasi.i.ati.n and thermoelectri. conversi.n systems wi.hi. a power generati.n system were performed.A porous medi.m area was constructed usi.g Si.C foam cerami.s to obtai. an energy-conversi.n experi.ental *** effects of bed hei.ht,porosi.y,porous-regi.n di.meter,and ai.-i.take condi.i.ns on the power-generati.n performance were i.vesti.ated,and opti.i.ati.ns were performed for the thermoelectri. conversi.n *** rate of i.crease duri.g FPSEG power generati.n fi.st i.creased and then decreased wi.h i.creasi.g bed hei.ht,peaki.g at a bed hei.ht of 40 *** i.creasi.g porous-regi.n di.meter accelerated FPSEG power generati.n,whereas porosi.y changes i. the porous medi. di. not si.ni.i.antly affect the rate of change duri.g FPSEG power *** i.creasi.g ai. i.take,the rate of i.crease duri.g power generati.n fi.st i.creased and then *** maxi.um change rate and the hi.hest thermoelectri. conversi.n effi.i.ncy of the power-generati.n system occurred at 9.5 m3/h and 6.5 m3/h（～45.1%）ai. i.takes,*** the thermal i.erti. and combusti.n structure of the thermoelectri. conversi.n system si.ni.i.antly i.creased the power-generati.n rate of the system,wi.h 1.8 W/s bei.g observed at a 9.7 m3/h ai. i.take.

关键词： bi.mass combi.ed heat and power (CHP) gasi.i.ati.n porous medi. combusti.n power generati.n

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Constructi.n of Di.ferent Ki.ds of Atomi. and Molecular Orbi.als Usi.g Complete Orthonormal Sets of ψ^α-ETO i. Si.gle Exponent Approxi.ati.n

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Chi.ese Physi.s Letters 2008年第7期25卷 2444-2447页

作者： Gusei.ov i. i.rafi. Ertfi.k Murat Department of Physi.s Faculty of Arts and Sciences Onsekiz Mart University ~anakkale Turkey

Usi.g complete orthonormal sets of ψ^α-exponenti.l type orbi.als i. si.gle exponent approxi.ati.n the new approach has been suggested for constructi.n of di.ferent ki.ds of functi.ns whi.h can be useful i. the theory of li.ear combi.ati.n of atomi. orbi.als. These functi.ns can be chosen properly accordi.g to the nature of the problems under consi.erati.n. Thi. i. rather i.portant because the choi.e of the basi. set may be play a cruci.l role i. appli.ati.ns to atomi. and molecular problems. As an example of appli.ati.n, di.ferent atomi. orbi.als for the ground states of the neutral and the fi.st ten cati.ni. members of the i.oelectroni. seri.s of He atom are constructed by the soluti.n of Hartree-Fock-Roothaan equati.ns usi.g ψ^1, ψ^0 and ψ^-1 basi. sets. The cMculated results are close to the numeri.al Hartree-Fock values. The total energy, expansi.n coeffi.i.nts, orbi.al exponents and vi.i.l rati. for each atom are presented.

关键词： the power-law exponents preci.i.ati.n durati.e abrupt preci.i.ati.n change

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Controlled cati.ni. ri.g-openi.g polymeri.ati.n of L-lacti.e by organi. i.n pai.: novel approach to i.otacti.-ri.h and crystalli.e polylacti.e

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Sci.nce Chi.a Chemi.try 2025年第1期68卷 394-402页

作者： Zhi.i.ng Di.g Mi.gqi.n Wang Zi.i.g Zhou Bi. Wang Yuesheng li Ti.nji. Key Laboratory of Composi.e & Functi.nal Materi.ls School of Materials Science and Engineering Tianjin University

Li.i.g/controlled cati.ni. ri.g-openi.g polymeri.ati.n （ROP） of L-lacti.e i. a promi.i.g approach to i.otacti.-ri.h and crystalli.e poly（L-lacti.e）.i. contrast wi.h the unsubsti.uted lactones,L-LA can not be polymeri.ed by organi. Lewi. aci.s or carbeni.m i.ns,and the state of the art i. thi. fi.ld i. the cati.ni. ROP of L-LA catalyzed by Br?nsted aci./alcohol system vi. acti.ated monomer ***,we reported the fi.st example of controlled cati.ni. ROP of L-LA by usi.g Meerwei.type i.n pai.[Me3O]+[B（C6F5）4]-as the catalyst.[Me3O]+[B（C6F5）4]-promoted rapi. L-LA cati.ni. polymeri.ati.n i. the absence of alcohol,produci.g i.otacti.-ri.h and crystalli.e PLLA wi.hout transesteri.i.ati.n and epi.eri.ati.n si.e *** acti.ated chai. end mechani.m,i.volvi.g twi.e SN2 substi.uti.n and confi.urati.n-i.versi.n （S→R→S） wi.h the assi.tance of released Me2O,was proposed and further veri.i.d by densi.y functi.nal theory and control *** work expands the catalyti. toolbox of i.otacti.-ri.h and crystalli.e polylacti.e *** represents a uni.ue example of cati.ni.-controlled polymeri.ati.n of L-LA catalyzed by an organi. i.n pai..

关键词： organi. i.n pai. controlled cati.ni. ri.g-openi.g polymeri.ati.n acti.ated chai. end mechani.m i.otacti.-ri.h polylacti.e

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Fi.e-Di.ensi.nal Cosmologi.al Model wi.h Vari.ble G and A

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Chi.ese Physi.s Letters 2007年第8期24卷 2185-2188页

作者： H. Baysal i. Yllmaz Department Secondary Sci.nce and Mathemati.s Educati.n Education Faculty Canakkale Onsekiz Mart University 17100 Canakkale Turkey Department of Physi.s Art and Science Faculty Canakkale Onsekiz Mart University 17020 Canakkale Turkey

Ei.stei.＇s fi.ld equati.ns wi.h C and A both varyi.g wi.h ti.e are consi.ered i. the presence of a perfect flui. for fi.e-di.ensi.nal cosmologi.al model i. a way whi.h conserves the energy momentum tensor of the matter content. Several sets of expli.i. soluti.ns i. the fi.e-di.ensi.nal Kaluza-Klei. type cosmologi.al models wi.h vari.ble G and A are obtai.ed. The di.i.i.hment of extra di.ensi.n wi.h the evoluti.n of the uni.erse for the fi.e-di.ensi.nal model i. exhi.i.ed. The physi.al properti.s of the models are exami.ed.

关键词： Fi.e-Di.ensi.nal Cosmologi.al Model Vari.ble

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Turbulent Agglomerati.n of Mi.roparti.les i. a Cyli.der Wake Flow Usi.g LES-DEM:Focusi.g on the Effect of the Reynolds Number

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Journal of Thermal Sci.nce 2025年第1期34卷 34-49页

作者： WANG Shuang MU Li. Li.Xue Xi. Jun DONG Mi.g School of Energy and Power Engi.eeri.g Dalian University of Technology School of Opti.al i.formati.n and Energy Engi.eeri.g Wuhan Institute of Technology School of Energy and Envi.onment Shenyang Aerospace University

Turbulent agglomerati.n i. vi.wed as a promi.i.g technology for enhanci.g fi.e parti.le removal *** better understand parti.le transport,agglomerati.n behavi.rs,and flui.-parti.le i.teracti.ns,we numeri.ally explored these phenomena under cyli.dri.al vortex wake i.fluence usi.g a coupled large eddy si.ulati.n and di.crete element method（LES-DEM） *** vali.i.y of the LES approach was veri.i.d by compari.on wi.h avai.able di.ect numeri.al si.ulati.n（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for parti.le-parti.le *** parti.le di.persi.n and agglomerati.n characteri.ti.s of parti.les wi.h di.ferent di.meters（dp=2-20 μm） i. the lami.ar and transi.i.n of shear layer（TrSL） flow regi.es were *** parti.les were concentrated at the vortex centers,whi.e larger parti.les accumulated around the *** agglomerati.n effi.i.ncy exhi.i.ed an M-shaped profi.e spanwi.e（y-di.ecti.n）.Wi.h i.creasi.g Reynolds number,the agglomerati.n effi.i.ncy and turbulence i.tensi.y *** parti.le agglomerati.n effi.i.ncy peaks at a certai. Reynolds ***,at hi.her Reynolds numbers,reduci.g the resi.ence ti.e of parti.les i. the flow fi.ld decreases the agglomerati.n effi.i.ncy.

关键词： di.crete element method large eddy si.ulati.n mi.roparti.le parti.le agglomerati.n

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