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The Role of Homocysteine and Other Clinical Laboratory Markers in Assessing Cardiovascular Risk in Patients on Hemodialysis

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Journal of Life Sciences 2016年第1期10卷 48-53页

作者： irena ivanova Gencheva-Angelova Adelaida Lazarova Ruseva Pavlina Dimitrova Yordanova-Laleva UMHA T Medical University Pleven 5800 Bulgaria

Cardiovascular diseases constitute approximately 50% of deaths among dialysis patients in the USA and Europe. The increase in traditional and nontraditional cardiovascular risk factors in determining the high mortality of patients with end-stage renal disease （ESRD） is complicated due to the high frequency of risk factors in these patients. Some laboratory markers like homocysteine, albumin, cholesterol, triglycerides, LDL-cholesterol, and creatinine could be efficient in marking the risk of cardiovascular disease in these patients. We use Roche assay tests, based on routinely principles to determine this laboratory parameters used in the clinical laboratory. All laboratory parameters we measured on a biochemistry auto analyser Cobas integra 400 at the clinical laboratory of University Hospital--Pleven. Using a statistical program a research was done on the quantitative characteristics and prognostic capabilities of homocysteine and other biochemical parameters. We determined the diagnostic specificity and sensitivity of our lab performance against vascular disease （heart attack or stroke） by ROC curves. For each of the observed values of biochemical parameters we calculated the diagnostic sensitivity and specificity. The threshold values for which the parameters have the highest sensitivity and specificity have been concluded. Summary of diagnostic value of parameters to judge the coefficient AUC--area under the curve, for cholesterol, LDL, triglycerides, albumin, it was a significant （P 〈 0.05）. Homocysteine and the rest of the studied by us laboratory parameters can be regarded as laboratory markers of choice for assessing the risk of heart attack or stroke in patients on dialysis.

关键词： Homocysteine albumin end-stage renal disease cardiovascular risk factors.

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Kala-Azar： Nature, Biophysical Aspects, Clinical Manifestation and Treatment

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Journal of Pharmacy and Pharmacology 2017年第1期5卷 33-36页

作者： Ersin ismail Velina Bogdanova Georgi Shopov Svetoslav Dobrev Natasha ivanova Faculty of Medicine Medical University of Varna Varna 9010 Bulgaria Department of Medical Physics and Biophysics Faculty of Pharmacy Medical University of Varna Varna 9010 Bulgaria

The aim of this study is to focus on a disease with a potential global health risk--VL （visceral leishmaniasis） or kala-azar. By understanding the mechanism of occurrence, development and countering infection, we can expect significant improvement in the indicators of morbidity and mortality. The specific method of transmission, as well as the necessary conditions for it, opens wide opportunities for prevention. The biophysical aspects that we present make it possible to assess the seriousness of the advancing physiological changes. This ensures adequate evaluation of the associated risks and search for an optimal therapy. We have found that from the first manifestations ofkala-azar up until today, a series of countermeasures have been taken up. Acknowledging and expecting the massiveness of the infectious process, it is possible for it to cover areas whose population is unprepared to handle the contamination optimally. This requires the continuation of studies aimed at finding the most affordable and biologically tolerable medicine. The available treatment option for visceral leishmaniasis is problematic when it comes to efficacy, adverse effects and cost, making the treatment a complex issue. Not to mention toxicity of the drugs, ability to monitor side effects, length of treatment and capacity of the healthcare service to administer an accurate therapy. The main drugs available for treatment of VL （visceral leishmaniasis） are systemic agents like Antimony, Amphotericin and nowadays the oral drug Miltefosine.

关键词： Kala-azar transmission biophysical aspects biologically tolerable medicine therapy

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未来主义的交通工具设计,让人眼前一亮

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工业设计 2024年第5期 22-22页

作者： Maks Chaschin Alexey Blinkov Blinkova Design Alex Braverman Vladimir Plekhanov Roman Mishchenko Vladislav Chikin Alexey Zalata Эдуард Тян irina ivanova Nikita Pavlov 2050 Lab

来源:https://***/galleries/4b3aca9bfeeca513e932e2a1c0eb92a5?favorite=true这款未来主义交通工具从乘客体验出发,遵循人机工程学设计理念,让乘客即使在城市运营的高峰时段也能感到愉快。与上一代的设计相比,该交通工具重新布置了入... 详细信息

来源:https://***/galleries/4b3aca9bfeeca513e932e2a1c0eb92a5?favorite=true这款未来主义交通工具从乘客体验出发,遵循人机工程学设计理念,让乘客即使在城市运营的高峰时段也能感到愉快。与上一代的设计相比,该交通工具重新布置了入口处的柱子,将过道增加了100毫米,座椅加宽了30毫米,使乘坐舱变得更加宽敞。对乘客来说,即便穿着厚厚的冬装,也能获得舒适的乘坐体验。设计团队考虑了不同乘客的旅行场景,例如有孩子的乘客、行李很多的旅客或者残疾人等,在设计中兼顾每一类人群的便利性。导航系统基于人性化理念设计,让视障人士可以感知入口照明的线条。乘坐舱内的材料亲近自然,改进后的座椅面料也变得更加耐用和舒适。

关键词：人性化理念视障人士人机工程学城市运营未来主义交通工具设计导航系统亲近自然

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走进艺术世界印象派花园

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室内设计与装修 2019年第6期 110-115页

作者：〔保加利亚〕Branimira ivanova Desislava ivanova 叮当(编译) 不详

'印象派花园'所想要呈现空间就如同它的名字一样,设计师希望能够将使用者带入当下的艺术世界。这个住宅项目的设计灵感来源于19世纪一些伟大的印象派画家,而它的名字则直接源自画家克劳德·莫奈的花园。花园本身就是一个拥有各种形状和... 详细信息

'印象派花园'所想要呈现空间就如同它的名字一样,设计师希望能够将使用者带入当下的艺术世界。这个住宅项目的设计灵感来源于19世纪一些伟大的印象派画家,而它的名字则直接源自画家克劳德·莫奈的花园。花园本身就是一个拥有各种形状和颜色的私密场所,住宅同样也是一个非常私人的空间,人们可以在这里放松、冥想,是一个可以卸下防备、不被束缚、释放自我的安全港湾。

关键词：印象派设计灵感

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Tunable interlayer excitons and switchable interlayer trions via dynamic near-field cavity

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Light(Science & Applications) 2023年第3期12卷 425-434页

作者： Yeonjeong Koo Hyeongwoo Lee Tatiana ivanova Ali Kefayati Vasili Perebeinos Ekaterina Khestanova Vasily Kravtsov Kyoung-Duck Park Department of Physics Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea School of Physics and Engineering ITMO UniversitySaint Petersburg197101Russia Department of Electrical Engineering University at BuffaloNew YorkNY14260USA

Emerging photo-induced excitonic processes in transition metal dichalcogenide(TMD)heterobilayers,e.g.,interplay of intra-and inter-layer excitons and conversion of excitons to trions,allow new opportunities for ultrathin hybrid photonic ***,with the associated large degree of spatial heterogeneity,understanding and controlling their complex competing interactions in TMD heterobilayers at the nanoscale remains a ***,we present an all-round dynamic control of interlayer-excitons and-trions in a WSe_(2)/Mo_(0.5 )W_(0.5) Se_(2) heterobilayer using multifunctional tip-enhanced photoluminescence(TEPL)spectroscopy withial ***,we demonstrate the bandgap tunable interlayer excitons and the dynamic interconversion between interlayer-trions and-excitons,through the combinational tip-induced engineering of GPa-scale pressure and plasmonic hot electron injection,with simultaneous spectroscopic TEPL *** unique nano-opto-electro-mechanical control approach provides new strategies for developing versatile nano-excitonic/trionic devices using TMD heterobilayers.

关键词： interlayer dynamic tunable

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Demographic ageing,health status and life quality of the elderly in Russia

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China Population and Development Studies 2023年第2期7卷 130-159页

作者： Alla ivanova Elena Zemlyanova Tamara Sabgayda Victoria Semyonova Aleksandr Zubko irina Kryukova institute for Demographic Research of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences(Health and Self-Preservation Behavior Department) st.Fotievad.6k.1119333 MoscowRussia Research institute of Healthcare Organization and Medical Management of the Moscow Healthcare Department st.Sharikopodshipnikovskaya9115088 MoscowRussia

Within the context of the national policy on the elderly,the paper presents trends in demographic ageing,health and life quality of the elderly in *** and political consequences of the XX century have resulted in significant fluctuations in the number of individual generations,forming a long-term fluctuating trend in demographic ageing in *** historical disproportions have overlapped with regional variations in ageing rates due to significant inter-regional population movements,rural-urban migration,substantial gender differences in trends and scales of mortality and fertility *** a result,levels of demographic ageing in Russia vary more than three-fold,worsening in females and rural *** problems are aggravated by unsatisfactory health status of the elderly,manifested in high burden of chronic diseases(especially cardiovascular diseases),leading to life restrictions up to loss of the ability to ***-tech cardiac surgery contributes to life prolongation and improved physical and psychological ***,during rehabilitation,most patients are reluctant to change their unhealthy lifestyle associated with cardio *** and psychoactive substance abuse(in males)are the risk factors of suicidal behaviour,while accessibility of medications,including sleeping pills,firearms,*** to realization of this *** conditions of the elderly and their access to quality social services are important components of wellbeing in terms of *** satisfactory living conditions,the situation significantly differs by type(urban/rural)and size of the *** microsocial contacts with children,family and friends is a powerful source of psychological comfort and social wellbeing.

关键词： Population ageing National policy on the elderly Age structure Share of the elderly Physical wellbeing Psychological wellbeing Social wellbeing Polymorbidity Comorbidities

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Nonlinear polaritons in a monolayer semiconductor coupled to optical bound states in the continuum

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Light(Science & Applications) 2020年第1期9卷 1480-1487页

作者： Vasily Kravtsov Ekaterina Khestanova Fedor A.Benimetskiy Tatiana ivanova Anton K.Samusev ivan S.Sinev Dmitry Pidgayko Alexey M.Mozharov ivan S.Mukhin Maksim S.Lozhkin Yuri V.Kapitonov Andrey S.Brichkin Vladimir D.Kulakovskii ivan A.Shelykh Alexander i.Tartakovskii Paul M.Walker Maurice S.Skolnick Dmitry N.Krizhanovskii ivan V.iorsh iTMO University Saint Petersburg 197101Russia St.Petersburg Academic University Saint Petersburg 194021Russia Saint Petersburg State University ul.Ulyanovskaya 1Saint Petersburg 198504Russia institute of Solid State Physics RASChernogolovka 142432Russia Science institute University of IcelandDunhagi 3IS-107ReykjavikIceland Department of Physics and Astronomy University of SheffieldSheffield S37RHUK

Optical bound states in the continuum(BiCs)provide a way to engineer very narrow resonances in photonic *** extended interaction time in these systems is particularly promising for the enhancement of nonlinear optical processes and the development of the next generation of active optical ***,the achievable interaction strength is limited by the purely photonic character of optical ***,we mix the optical BiC in a photonic crystal slab with excitons in the atomically thin semiconductor MoSe_(2) to form nonlinear exciton-polaritons with a Rabi splitting of 27 meV,exhibiting large interaction-induced spectral *** asymptotic BiC-like suppression of polariton radiation into the far field toward the BiC wavevector,in combination with effective reduction of the excitonic disorder through motional narrowing,results in small polariton linewidths below 3 *** with a strongly wavevector-dependent Q-factor,this provides for the enhancement and control of polariton–polariton interactions and the resulting nonlinear optical effects,paving the way toward tuneable BiC-based polaritonic devices for sensing,lasing,and nonlinear optics.

关键词： polar nonlinear continuum

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形式和颜色之间的舞蹈与蒙德里安共进早餐

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室内设计与装修 2019年第6期 105-109页

作者：〔保加利亚〕Branimira ivanova Desislava ivanova 悠悠(编译) 不详

'与蒙德里安共进早餐'是一个实验性项目,空间的形式、使用的线条和颜色都旨在能够对使用者产生愉悦身心的积极影响。整个项目的设计灵感来源于荷兰画家蒙德里安的作品,他采用水平和垂直两种线条,以此构成各种不同的正方形和长方形,简单... 详细信息

'与蒙德里安共进早餐'是一个实验性项目,空间的形式、使用的线条和颜色都旨在能够对使用者产生愉悦身心的积极影响。整个项目的设计灵感来源于荷兰画家蒙德里安的作品,他采用水平和垂直两种线条,以此构成各种不同的正方形和长方形,简单而又复杂的图形以红、黄、蓝三原色或黑、白、灰来表示色彩的纯净。在他的笔下色彩充满了活力,运用黄金分割和等比数列将画面或图形按照一定的比例进行分割、排列,创造富有节奏与韵律的秩序与美感,蒙德里安用画作展示了他如何将世界、自然和人类视为一体,他的画作呈现出一种不同元素在统一整体内的完美和谐。

关键词：蒙德里安设计灵感

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Analysis of known point mutations and SNPs in genes responsible for monogenic Parkinson’s disease in Russian patients

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Advances in Parkinson's Disease 2013年第1期2卷 28-30页

作者： Elena V. Filatova Maria i. Shadrina Ekaterina Y. Fedotova irina A. ivanova-Smolenskaya Sergei N. illarioshkin Svetlana A. Limborska Petr A. Slominsky institute of Molecular Genetics Russian Academy of Sciences Moscow Russia Research Centre of Neurology Russian Academy of Medical Sciences Moscow Russia

Background: Parkinson’s disease (PD) is caused by complex interactions between genetic and environmental factors. Mendelian forms of PD rarely occur in practice, but respective genes may play some role in pathogenesis of a common sporadic form of the disease. Methods: We analyzed most frequent known point mutations (PMs) and single-nucleotide polymorphisms (SNPs) in genes responsible for monogenic PD in 408 Russian patients, using arrayed primer extension (APEX), real-time PCR, and restriction fragment length polymorphism analysis. Results: We detected only three heterozygous PMs in the PARK2 gene in three non-related patients with early-onset sporadic PD. No association between PD and the studied SNPs was identified. Conclusion: The examined PMs and SNPs in genes responsible for monogenic PD do not contribute significantly to the development of sporadic PD in Russia.

关键词： Parkinson’s Disease Point Mutations Single-Nucleotide Polymorphisms

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Porous Structure, Salt Component Distribution and Catalytic Preference of Zinc Acetate Catalysts for Vinylacetate Synthesis on Modified Carbon Supports

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Journal of Chemistry and Chemical Engineering 2011年第5期5卷 473-477页

作者： Hoang Kim Bong Oleg Naumovich Temkin Hoang Huu Binh Dorina ivanova Yamandiy Moscow State Academy of Fine Chemical Technology named after M. i~： Lomonosov 1195 71 Moscow avenue Vernadskogo 86.Russian Federation. Sibur limited liability company - the management company of Joint-Stock Company Sibur Holding.

The main problem in an efficient Zn（CH3COO）2/AC （AC-activated carbon） catalyst preparation is the achievement of uniform distribution of highly dispersed salt component on the activated carbon （AC） surface. The solution of this problem is modification of the AC by hydrogen peroxide （H202） oxidation of the surface and treatment of AC with acetic acid as well as special methods of salt deposition and catalyst drying. The investigations of these ways of AC surface modification （treatment of AC with acetic acid and H2O2） have demonstrated the obtained AC to have both an increased adsorption capacity as to Zn（OAc）2 and optimum volumes of meso- and micro-pores as well as high catalyst activity in vinyl acetate （VA） synthesis. The characteristics of supports and catalysts were found out by benzene, water and acetic acid vapors adsorption. The distribution of the salt on the AC surface was studied by small-angle X-ray scattering （SAXS）, by scanning electron microscopy （SEM） and X-ray micro-analysis （XMA）. The catalysts were tested in vinyl acetate synthesis in flow-bed isothermal reactor by cyclic method at 175, 205 and 230℃.

关键词： Activated carbon kinetic adsorption porosity nanostructures vinyl acetate synthesis catalysts activity.

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