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Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism

World Journal of Gastroenterology 2010年第23期16卷 2959-2962页

作者： Jeroen i Lenz Jimmy M Jacobs Bart Op de Beeck i.an a huyghe Paul A Pelckmans Tom G Moreels Division of Gastroenterology and Hepatology Antwerp University Hospital Division of Radiology Antwerp University Hospital Division of Nuclear Medicine Antwerp University Hospital

We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid *** the acute pancreatitis was treated *** patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic *** the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very *** pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been *** is important to treat the provoking ***,the cause of hypercalcemia should be identif ied *** resection of the parathyroid adenoma is the ultimate therapy.

关键词： Acute necrotizing pancreatitis Hypercalcemia Primary hyperparathyroidism Parathyroid adenoma

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immunotherapy with immune checkpoint inhibitors in colorectal cancer:what is the future beyond deficient mismatch-repair tumours?

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Gastroenterology Report 2020年第1期8卷 11-24,I0001页

作者： Nicolas huyghe Pamela Baldin Marc Van den Eynde institut de Recherche Clinique et Expe´rimentale(Pole MiRO) UCLouvainBrusselsBelgium Department of Pathology Cliniques Universitaires St-LucInstitut Roi Albert IIBrusselsBelgium Department of Medical Oncology Cliniques Universitaires St-LucInstitut Roi Albert IIBrusselsBelgium

Following initial success in melanoma and lung tumours,immune checkpoint inhibitors(iCis)are now well recognized as a major immunotherapy treatment modality for multiple types of solid *** colorectal cancer(CRC),the small subset that is mismatch-repair-deficient and microsatellite-instability-high(dMMR/MSi-H)derive benefit from immunotherapy;however,the vast majority of patients with proficient MMR(pMMR)or with microsatellite stable(MSS)CRC do *** and the consensus molecular subtype classifications are promising biomarkers in predicting therapeutic efficacy in selected *** pMRR/MSS CRC,biomarkers are also needed to understand the molecular mechanisms governing immune reactivity and to predict their relationship to *** continuous development of such biomarkers would offer new perspectives and more personalized treatments by targeting oncological options,including iCis,which modify the tumour-immune *** this review,we focus on CRC and discuss the current status of iCis,the role of biomarkers to predict response to immunotherapy,and the approaches being explored to render pMMR/MSS CRC more immunogenic through the use of combined therapies.

关键词： colorectal cancer immunotherapy immune checkpoint inhibitors immune response immunoscore

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地震与太阳有联系吗?

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世界科学 1985年第5期 30-31+28页

作者： Patrick huyghe 徐崇敬

一位持异见的科学家指出,耀斑触发了地震,这一见解使地震预言者大吃一惊。加利福尼亚一位科学家认为,象地震、人类疾病和纵火之类形形式式的灾难,可能都是由大阳触发的,这一观点使她的同事们极为惊异。正当科学界对她大加嘲笑的时候,负... 详细信息

一位持异见的科学家指出,耀斑触发了地震,这一见解使地震预言者大吃一惊。加利福尼亚一位科学家认为,象地震、人类疾病和纵火之类形形式式的灾难,可能都是由大阳触发的,这一观点使她的同事们极为惊异。正当科学界对她大加嘲笑的时候,负责地震预测的官员们却鼓励她继续研究下去。这位研究人员究竟是一位伽利略传统的倡导者,还只是另一个为了适应她所偏爱的理论而曲解手中数据的、过于热切的灵魂呢?下面就是有关她的报道。读了这篇文章,你自己斟酌吧,究竟是全信、部分相信、还是完全不信。

关键词：极低频电磁辐射太阳活动地震

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