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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： María Rodriguez-Ayllon Patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-García Cristina Molina-Hidalgo Manuel Gómez-Río Belinda Brown Kirk i.Erickson irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CiBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,Web of Science,PsyciNFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:in total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%Ci):-1.41 to 0.03;i^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%Ci:0.05-0.18;i^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise PET

An investigation into Forced Convection of a Nanofluid Flowing in a Rectangular Microchannel under the influence of a Magnetic Field

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Fluid Dynamics & Materials Processing 2024年第2期20卷 311-323页

作者： Muataz S.Alhassan Ameer A.Alameri Andrés Alexis Ramírez-Coronel i.B.Sapaev Azher M.Abed David-Juan Ramos-Huallpartupa Rahman S.Zabibah Division of Advanced Nanomaterial Technologies Scientific Research CenterAl-Ayen UniversityThi-QarIraq Department of Chemistry College of ScienceUniversity of BabylonBabylonIraq Research Group in Educational Statistics National University of EducatiosnAzoguesEcuador Department Physics and Chemistry Tashkent Institute of Irrigation and Agricultural Mechanization EngineersNational Research UniversityTashkentUzbekistan Akfa University TashkentUzbekistan New Uzbekistan University TashkentUzbekistan Department of Airconditioning and Refrigeration Engineering Al-Mustaqbal University CollegeHilla51001Iraq Academic Department of Agro-industrial Engineering and Technology Universidad Nacional JoséMaría ArguedasApurimacPerú The islamic University NajafIraq

in line with recent studies,where it has been shown that nanoﬂuids containing graphene have a stronger capacity to boost the heat transfer coefﬁcient with respect to ordinary nanoﬂuids,experiments have been conducted using water with cobalt ferrite/graphene *** particular,a circular channel made of copper subjected to a constant heatﬂux has been *** nanoparticles are sensitive to the presence of a magneticﬁeld,different conditions have been examined,allowing both the strength and the frequency of such aﬁeld to span relatively wide ranges and assuming different concentrations of *** to theﬁndings,the addition of nanoparticles to theﬂuid causes its rotation speed to increase by a factor of two,whereas ultraviolet radiation plays a negligible *** amount of time required to attain the maximum rotation speed of the nanoﬂuid and the Nusselt number have been measured under both constant and alternating magneticﬁelds for a ferroﬂuid with a concentration of 0.5%and atﬂow Reynolds number of 550 and 1750.

关键词： Nano fluid rectengular tube magnetic field

A Novel Approach for Developing a Linear Regression Model within Logistic Cluster Using Scikit-Learn

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Journal of Data Analysis and information Processing 2024年第3期12卷 348-369页

作者： Nwosu Ambrose Gilbert i. O. Aimufua Choji Davou Nyap Departments of Computer Sciences Nasarawa State University Keffi Nigeria Departments of Computer Sciences University of Jos Jos Nigeria

Due to the rapid development of logistic industry, transportation cost is also increasing, and finding trends in transportation activities will impact positively in investment in transportation infrastructure. There is limited literature and data-driven analysis about trends in transportation mode. This thesis delves into the operational challenges of vehicle performance management within logistics clusters, a critical aspect of efficient supply chain operations. it aims to address the issues faced by logistics organizations in optimizing their vehicle fleets’ performance, essential for seamless logistics operations. The study’s core design involves the development of a predictive logistics model based on regression, focused on forecasting, and evaluating vehicle performance in logistics clusters. it encompasses a comprehensive literature review, research methodology, data sources, variables, feature engineering, and model training and evaluation and F-test analysis was done to identify and verify the relationships between attributes and the target variable. The findings highlight the model’s efficacy, with a low mean squared error (MSE) value of 3.42, indicating its accuracy in predicting performance metrics. The high R-squared (R2) score of 0.921 emphasizes its ability to capture relationships between input characteristics and performance metrics. The model’s training and testing accuracy further attest to its reliability and generalization capabilities. in interpretation, this research underscores the practical significance of the findings. The regression-based model provides a practical solution for the logistics industry, enabling informed decisions regarding resource allocation, maintenance planning, and delivery route optimization. This contributes to enhanced overall logistics performance and customer service. By addressing performance gaps and embracing modern logistics technologies, the study supports the ongoing evolution of vehicle performance management

关键词： Mean Squared Error R2 Score F-Test MSE

A Radial Basis Function Method with improved Accuracy for Fourth Order Boundary Value Problems

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Journal of Applied Mathematics and Physics 2024年第7期12卷 2559-2573页

作者： Scott A. Sarra Derek Musgrave Marcus Stone Joseph i. Powell Department of Mathematics Marshall University Huntington WV USA

Accurately approximating higher order derivatives is an inherently difficult problem. it is shown that a random variable shape parameter strategy can improve the accuracy of approximating higher order derivatives with Radial Basis Function methods. The method is used to solve fourth order boundary value problems. The use and location of ghost points are examined in order to enforce the extra boundary conditions that are necessary to make a fourth-order problem well posed. The use of ghost points versus solving an overdetermined linear system via least squares is studied. For a general fourth-order boundary value problem, the recommended approach is to either use one of two novel sets of ghost centers introduced here or else to use a least squares approach. When using either ghost centers or least squares, the random variable shape parameter strategy results in significantly better accuracy than when a constant shape parameter is used.

关键词： Numerical Partial Differential Equations Boundary Value Problems Radial Basis Function Methods Ghost Points Variable Shape Parameter Least Squares

Production and achievements of Sesamum indicum industry in the world: Past and current state

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Oil Crop Science 2024年第3期9卷 187-197页

作者： Sanni G.B.T.A. Ezin V. Chabi i.B. Missihoun A.A. Florent Q. Hamissou Z. Niang M. Ahanchede A. Department of Crop Production Faculty of Agricultural Sciences University of Abomey-Calavi 01 Cotonou BP 526 Benin Laboratory of Valorization and Quality Management of Food Bio-ingredients Faculty of Agricultural Sciences University of Abomey-Calavi Cotonou 01BP 526 Benin Laboratory of Genetic and Biotechnology Faculty of Sciences and Technology University of Abomey-Calavi BP 526 Cotonou Benin Department of Vegetal Production Abdou Moumouni University Faculty of Agronomy BP: 10960 Niger iSRA-CERAAS Thiès-Escale Thiès BP 3320 Senegal

Sesame production is important in agriculture, food industry, and the crop diversity due to its rich nutritional profile and health benefits. Despite its significant value, sesame is still an orphan crop that has received little scientific attention, resulting in low yield compared to other major oilseed crops. This review offers a comprehensive overview of the present state of production, knowledge, and research advancements concerning Sesamum indicum on a global scale. The FAOSTAT database was extensively used to examine the global trends from 1961 to 2021. in the past 60 years, global sesame production has substantially increased, with Asia and Africa being the primary producers. The integration of omics technologies and biotechnological interventions has revolutionized our understanding of the genetic basis of sesame, enhanced productivity, invigorated stress resilience, and improved seed quality. High-throughput sequencing methods such as RNA-seq, RAD-seq, SLAF-seq, and GBS technology are used in various studies, linkage mapping, and identification of trait-associated markers. Fine linkage maps, and multi-omics studies such as genomics, proteomics, transcriptomics, and metabolomics have been employed in sesame research for gene and QTL mapping. Proteins and metabolic pathways related to oil content, yield, and stress tolerance were reported. Genes and QTLs related to yield and its components, drought, salt, and osmotic stress tolerance were discovered. Candidate genes associated with capsule shattering and seed shattering were recently revealed. For more achievement in sesame, it is important to enhance sesame production efficiency through mechanization, advanced agricultural practices, and knowledge dissemination to farmers. MAS and multi-omics integration should be particularly reinforced. The advancements in sesame production present a significant and promising opportunity for farmers, governments, and stakeholders in the agricultural sector. © 2024 the Oil

关键词： Genetic markers Oil yield Omics improvement Sesame industry Sesamum indicum

intermittent fasting and the liver: Focus on the Ramadan model

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World Journal of Hepatology 2024年第8期16卷 1070-1083页

作者： Mohamed H Emara Hanan Soliman Ebada M Said Hassan Elbatae Mostafa Elazab Shady Elhefnawy Tarik i Zaher Ahmed Abdel-Razik Mohamed Elnadry Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Department of Tropical Medicine and infectious Diseases Tanta UniversityTanta 31512Egypt Department of Hepatology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Mansoura UniversityMansoura 35516Egypt Department of Hepato-Gastroenterology and infectious Diseases Al-Azhar UniversityCairo 11651Egypt

intermittent fasting(iF)is an intervention that involves not only dietary modific-ations but also behavioral changes with the main core being a period of fasting alternating with a period of controlled *** duration of fasting differs from one regimen to *** fasting(RF)is a religious fasting for Muslims,it lasts for only one month every one lunar *** this model of fasting,observers abstain from food and water for a period that extends from dawn to *** period of daily fasting is variable(12-18 hours)as Ramadan rotates in all seasons of the ***,longer duration of daily fasting is observed during the *** fact,RF is a peculiar type of *** is a dry iF as no water is allowed during the fasting hours,also there are no calorie restrictions during feeding hours,and the mealtime is exclusively *** three variables of the RF model are believed to have a variable impact on different liver *** was evaluated by different observational and interventional studies among patients with non-alcoholic fatty liver disease and it was associated with improve-ments in anthropometric measures,metabolic profile,and liver biochemistry regardless of the calorie restriction among lean and obese *** situation is rather different for patients with liver *** was associated with adverse events among patients with liver cirrhosis irrespective of the underlying etiology of *** patients developed new ascites,ascites were increased,had higher serum bilirubin levels after Ramadan,and frequently developed hepatic encephalopathy and acute upper gastrointestinal *** complications were higher among patients with Child class B and C cirrhosis,and some fatalities occurred due to *** transplant recipients as a special group of patients,are vulnerable to dehydration,fluctuation in blood immunosuppressive levels,likelihood of deterioration and hence observing RF without special precautions

关键词： intermittent fasting Ramadan fasting Non-alcoholic fatty liver disease Liver cirrhosis Peptic ulcer Liver transplantation Gilbert syndrome

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： i.A.O.Beeren G.Dos Santos P.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal iCVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain iKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor ii(BMPRii)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

Plasma electrolytic formation and characterization of MnWO_(4)/WO_(3) film heterostructures

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ChemPhysMater 2024年第3期3卷 293-302页

作者： M.S.Vasilyeva i.V.Lukiyanchuk Yu.B.Budnikova V.G.Kuryavyi D.H.Shlyk G.A.Zverev Department of Chemistry and Materials of institute of High Technology and Advanced Materials Far Eastern Federal UniversityFEFU CampusVladivostok 690922Russia institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok 690022Russia

MnWO_(4)/WO_(3) p-n heterojunction films were fabricated using a one-step method consisting of the plasma electrolytic oxidation(PEO)of titanium in homogeneous electrolytes containing paratungstate ions and stable watersoluble EDTA-chelated *** influences of the formation current density and W:Mn molar ratio of the electrolyte,which was varied from 1:2 to 2:1,on the composition,morphology,and optical and photocatalytic properties of the resulting coatings were studied.X-ray diffraction analysis,scanning electron microscopy,energy dispersive X-ray analysis,Raman spectroscopy,and ultraviolet diffuse reflectance spectroscopy were used to characterize the formed *** of the W:Mn ratio of the electrolyte,the coatings contained crystalline t-WO_(3) and m-MnWO_(4).Depending on the formation conditions,the optical band gap energies of the composites varied from 2.63 to 3.01 *** largest absorption red shift and lowest band gap energy were observed in the film composite formed in an electrolyte with W:Mn=2:1,at a current density of 0.2 A cm^(−2).Composites obtained in electrolytes with W:Mn ratios of 2:1 and 1:1 exhibited photocatalytic activity in the degradation of rhodamine C and methyl orange dyes in the presence of 10 mmol L^(–1) H2O_(2) under ultraviolet and visible light *** role of hydrogen peroxide in this dye degradation on PEO-coated composites under light irradiation is discussed.

关键词： Plasma electrolytic oxidation Manganese tungstate Tungsten oxide Titanium Optical properties p-n heterojunction

On Some Properties of Graph of Prefix Code

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1571-1581页

作者： Nikolai i. Krainiukov Mikhail E. Abramyan Boris F. Melnikov Faculty of Computational Mathematics and Cybernetics Shenzhen MSU-BIT University Shenzhen China Department of Algebra and Discrete Mathematics Southern Federal University Rostov-on-Don Russian Federation

We investigate decomposition of codes and finite languages. A prime decomposition is a decomposition of a code or languages into a concatenation of nontrivial prime codes or languages. A code is prime if it cannot be decomposed into at least two nontrivial codes as the same for the languages. in the paper, a linear time algorithm is designed, which finds the prime decomposition. if codes or finite languages are presented as given by its minimal deterministic automaton, then from the point of view of abstract algebra and graph theory, this automaton has special properties. The study was conducted using system for computational Discrete Algebra GAP. .

关键词： Finite Languages Minimal Deterministic Automata Concatenation Codes Graph of Automaton Free Algebra