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Update on Diagnosis and Management of Conjunctival Papilloma

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Eye and Vision 2019年第1期6卷 131-147页

作者： Despoina Theotoka Melina i.Morkin Anat Galor Carol l.Karp Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th StreetMiamiFL 33136USA Miami Veterans Administration Medical Center 1201 NW 16th StreetMiami 33125FLUSA

Conjunctival papilloma is an acquired benign squamous cell tumor that can present at any age,but most frequently in the third and fourth decades of *** have been associated with human papilloma virus(HPV)infection,usually types 6 and *** histopathological diagnosis remains the gold standard,the advent of newer non-invasive imaging modalities such as optical coherence tomography(OCT)is transforming the way we diagnose and treat ocular surface tumors,including conjunctival *** of these lesions can prove a challenge to the treating physician since not all lesions respond to medical and/or surgical therapy and in fact may worsen after surgical *** this review,the epidemiology,pathophysiology,clinical characteristics,and diagnosis of conjunctival papilloma including the use of OCT are ***,efficacy,and side effects of currently available management options are also reviewed to guide the selection of the best treatment approach.

关键词： Conjunctival papilloma Squamous cell papilloma Optical coherence tomography Treatment interferon Mitomycin Surgery Cryotherapy Human papilloma virus

Rice spouted bed for manufacturing inclusion complexes of Endopleura uchi l extracts in β-cyclodextrin

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Particuology 2019年第1期17卷 208-215页

作者： l.V.D. Freitas A.C.R. Montes E.i.A. Campos E.C. Conceicao l.A. Tacon A.D. lanchote l.A.P.Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n14040-903Ribeirao PretoSPBrazil

Uxi (Endopleura uchi) is a plant from the Brazilian Amazon. it has many biological activities that are attributed to its main active component, bergenin (BG), which has low water solubility. The aim of this work was to obtain β-cyclodextrin (β-CD) inclusion complexes of uxi using lyophilized cooked rice as the solid substrate. The process was studied using a Box–Behnken design with the solution feed rate, molar ratio of β-CD to BG, and rice bed load as factors. These factors greatly affected the product bulk density, angle of repose, water content, and BG content, loss, and water solubility. The optimum process conditions determined using a desirability functions methodology were an extract feed rate of 1 ml/min, a ratio of β-CD to BG of 3:1, and a substrate load of 100 g. The predicted values under the optimum conditions were close to the experimental results of a water content of 5.8%± 0.2%, BG content of 985.7 ± 15.4 μg/g, BG water solubility of 2230.2 ± 21.1 μg/ml, and BG loss of 1.2%± 0.1%. These results confirm that spouted beds are an important tool for rapid, one-step preparation of pharmaceutical β-CD inclusion complexes in a solid form.

关键词： Bergenin Chromatography Yield Active loss Solubility

Synthesis and Structure of bc-Dichloro-af-dihydroxo-de-bis(N-3-pyridinylmethanesulfonamide)platinum(Ⅳ) Diydrate

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Chinese Journal of Structural Chemistry 2012年第10期31卷 1476-1482页

作者： Nicolay i. DODOFF Boris l. SHiVACHEV Rositsa P. NiKOlOVA Maria lAliA-KANTOURi Vesna MilETi Tamara i. PAJPANOVA Acad. R. Tsanev institute of Molecular Biology Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 21 1113 Sofia Bulgaria institute of Mineralogy and Crystallography Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 107 1113 Sofia Bulgaria Department of Chemistry Faculty of Sciences Aristotle University of Thessaloniki P.O. Box 135 54124 Thessaloniki Greece institute of Chemistry Faculty of Science University of Kragujevac 34000 Kragujevac Serbia

The Pt（iV） complex cis,cis,trans-[Pt（PMSA）2Cl2（OH）2]·2H2O（1）, where PMSA = N-3-pyridinylmethanesulfonamide, has been synthesized and characterized by elemental analysis, molar electric conductivity and iR spectrum. X-ray crystallography revealed that the title compound crystallizes in the monoclinic C2/c space group with unit cell dimensions a = 16.5424（7）, b = 8.6973（3）, c = 16.6079（6） A, β = 117.185（5）° and Z = 4. Pt（iV） has an octahedral coordination geometry and the PMSA ligands are coordinated via the pyridine N atom. They are in a transoid orientation between each other and are inclined in the same direction with respect to the Pt-C1-Cli-N-Ni plane at an angle of 64.6（1）° （symmetry operation：（i） 1- x, y, 3/2-z）. The structure is stabilized by a system of hydrogen bonds involving the complex and water molecules.

关键词： Pt(iV) complex sulfonamide pyridine crystal structure cytostatic

R-Technology of Programming: Basic Notions and implementation

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Journal of Computer Science & Technology 1992年第4期7卷 345-355页

作者： i. V. Vel'bitsky A. l. Kovalev i.V. Kasatkina 王镭 Technosoft Kiev USSR Kiev Polytechnical institute Kiev USSR Tianjin University Tianjin 300072 China

This paper presents a kind of visual programming, which is called R-technology of programming. The R-technology is independent of any programming language or operating system and the R-chart is in accord with international standard (iSO 8631H). The package of R-technology has been applied to the high level languages such as PASCAl, C, ASSEMBlER, FORTRAN, Pl/1, MODUlA-2 and RTRAN. This package is applied to computers ranging from mainframes (iBM 370) and minis (VAX) to micros (iBM/PC).

关键词： Basic Notions and implementation data R-Technology of Programming

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Valorization of AZ91 by the hydrolysis reaction for hydrogen production(Electrochemical approach)

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Journal of Magnesium and Alloys 2021年第6期9卷 1942-1953页

作者： S.Al Bacha i.Aubert M.Zakhour M.Nakhl J.l.Bobet lCPM/PR2N(EDST) Lebanese UniversityFaculty of Science II90656 Jdeidet El MetnLebanon Universitéde Bordeaux ICMCBCNRSUMR 5026F-33600 PessacFrance University of Bordeaux CNRSArts et MétiersInstitute of technologyBordeaux INPINRAEI2M BordeauxF-33400 TalenceFrance

The hydrolysis of Mg-based materials appears to be an ideal solution for clean energy *** hydrogen was produced by the hydrolysis reaction of a"standard"AZ91 alloy(called AZ91 in the following)in"model"seawater *** milling speeds(i.e.250 rpm and 350 rpm)were tested to enhance the reactivity of *** and AlCl_(3)were used as ball milling *** at higher rotational speed is more energetic,hence it ameliorates the most the hydrolysis performance of *** both milling additives,AlCl_(3)enhances the most the hydrolysis of AZ91 with a generation of 65%of its theoretical H_(2)generation *** best material was obtained by milling AZ91 at 350 rpm with graphite for 2 h followed by a further milling with AlCl_(3)for 2h-a yield of 75%of its theoretical H_(2)generation capacity was reached within a few *** corrosion behavior of milled AZ91 was investigated by anodic polarization and electrochemical impedance spectroscopy(EiS).The calculated electrochemical parameters from EiS fitting of two materials milled under different conditions but with the same milling additive are approximately the *** suggests that,in order to fully evaluate the reactivity of AZ91,hydrolysis,anodic polarization and EiS must be considered.

关键词： Ball milling AZ91 Mg_(17)Al_(12) Corrosion Hydrogen Electrochemical impedance spectroscopy

Self-assembled patches in PtSi/n-Si(111)diodes

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Journal of Semiconductors 2018年第5期39卷 41-47页

作者： i.M.Afandiyeva S.Altιndal l.K.Abdullayeva A.i.Bayramova Baku State University Institute for Physics ProblemBakuAzerbaijan Physics Department Faculty of SciencesGazi UniversityAnkaraTurkey Physics Department Azerbaijan University of Architecture and ConstructionBakuAzerbaijan

Using the effect of the temperature on the capacitance–voltage（C–V）and conductance–voltage（G/ω–V）characteristics of PtSi/n-Si（111）Schottky diodes the profile of apparent doping concentrationthe potential difference between the Fermi energy level and the bottom of the conduction bandapparent barrier heightseries resistanceand the interface state density Nss have been *** the temperature dependence of（C–V）it was found that these parameters are non-uniformly changed with increasing temperature in a wide temperature range of 79–360 *** voltage and temperature dependences of apparent carrier distribution we attributed to the existence of self-assembled patches similar the quantum wells,which formed due to the process of Pt Si formation on semiconductor and the presence of hexagonal voids of Si（111）.

关键词： Schottky barrier diode(SBD) temperature dependence self-assembled patches temperature dependence PtSi/n-Si(111) C–V characteristics quantum wells

influence of Multi-pass Friction Stir Processing on Microstructure and Mechanical Properties of Die Cast Al–7Si–3Cu Aluminum Alloy

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Acta Metallurgica Sinica(English letters) 2016年第5期29卷 431-440页

作者： l.John Baruch R.Raju V.Balasubramanian A.G.Rao i.Dinaharan Department of Mechanical Engineering Madanapalle Institute of Technology and ScienceMadanapalleAndhra Pradesh 517325India Department of industrial Engineering College of EngineeringAnna UniversityChennaiTamil Nadu 600025India Department of Manufacturing Engineering Centre for Materials Joining and Research(CEMAJOR)Annamalai UniversityAnnamalai NagarChidambaramTamil Nadu608002India Marine Materials Division Naval Materials Research LaboratoryThaneMaharashtra 421506India Department of Mechanical Engineering Science University of JohannesburgAuckland Park Kingsway CampusJohannesburg 2006South Africa

The influence of overlap multi-pass friction stir processing on the microstructure and the mechanical properties, in particular, strength, ductility and hardness of die cast A1-7Si-3Cu aluminum alloy was investigated. it was observed that increase in the number of overlap passes friction stir processing resulted in significant refinement and redistribution of aluminum silicon eutectic phase and elimination of casting porosities. The microstructural refinement by the friction stir processing not only increases the ultimate tensile strength from 121 to 273 MPa, but also increases the ductility as observed by the increase in fracture strain from 1.8% to 10%. Analysis of the fractured surface reveals that the microstructural refinement obtained by friction stir processing plays a vital role in transforming the fracture mode from completely mixed mode to the ductile mode of the fracture with increasing number of passes. The change in the size, shape, morphology and distribution of eutectic silicon particles and elimination of the porosities are the main reasons for the increases in tensile strength and ductility due to friction stir processing.

关键词： Friction stir processing Overlap multi-pass Microstructure Mechanical properties

A look into the past, present and future potential distributions of Talinopsis frutescens, a North American endemic lineage closely related to Cactaceae

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Journal of Arid land 2020年第1期12卷 104-114页

作者： Mónica i MiGUEl-VÁZQUEZ Yasser S lÓPEZ DE OlMOS R Gilberto OCAMPO Department of Biology Basic Sciences CenterAutonomous University of Aguascalientes940 University AvenueAguascalientes 20130Mexico Biological and Health Sciences PhD Program Department of BiologyBiological and Health Sciences DivisionAutonomous Metropolitan UniversityIztapalapa 09340Mexico

Talinopsis frutescens(Anacampserotaceae,a family that is close related to Cactaceae)is a succulent species endemic to North *** aim of this study was to explore,using Ecological Niche Modeling(ENM),changes in potential distribution ranges considering different climate scenarios:past conditions during the last inter Glacial(liG)and the last Glacial Maximum(lGM),the present and projections for 2070(RCP 2.6 to 8.5).A pattern of contraction is observed during the liG,which agrees with other studies focused in species from arid *** pattern was followed by a migration towards the south during the lGM and a possible recent expansion to the north as is observed in the present *** future projections show the same contraction and fragmentation patterns,resulting in three discontinuous areas:the northern part of the Chihuahuan Desert,the southern-central part of the Mexican Plateau,and the smallest one in the Tehuacán-Cuicatlán *** projections for future scenarios agree with other studies and support that global climate change tends to alter the current distribution of arid environment species.

关键词： Anacampserotaceae Caryophyllales ecological niche modeling succulent plants potential distribution