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Emergi.g s.ructures.and dynami. mechani.ms.ofγ-s.cretas. for Alzhei.er’s.di.eas.

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Neural Regenerati.n Res.arch 2025年第1期20卷 174-180页

作者： Yi.glong Mi.o Mi.hael s.Wolfe Computati.nal Medi.i.e Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medi.i.al Chemi.try University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”i. a membrane-embedded proteas. complex that cleaves.150+pepti.e s.bs.rates.wi.h central roles.i. bi.logy and medi.i.e,i.cludi.g amyloi. precurs.r protei. and the Notch fami.y of cell-s.rface *** i.γ-s.cretas. and amyloi. precurs.r protei. lead to early-ons.t fami.i.l Alzhei.er’s.di.eas..γ-s.cretas. has.thus.s.rved as.a cri.i.al drug target for treati.g fami.i.l Alzhei.er’s.di.eas. and the more common late-ons.t Alzhei.er’s.di.eas. as.***,cri.i.al gaps.remai. i. unders.andi.g the mechani.ms.of proces.i.e proteolys.0} of s.bs.rates.the effects.of fami.i.l Alzhei.er’s.di.eas. mutati.ns.and allos.eri. modulati.n of s.bs.rate cleavage byγ-*** thi. revi.w,we focus.on recent s.udi.s.of s.ructural dynami. mechani.ms.ofγ-*** mechani.ms.i.cludi.g the“Fi.-s.ay-Tri.,”“s.i.i.g-Unwi.di.g,”and“Ti.ti.g-Unwi.di.g,”have been propos.d for s.bs.rate proteolys.0} of amyloi. precurs.r protei. byγ-s.cretas. bas.d on all-atom molecular dynami.s.*** an i.correct regi.try of the Notch1 s.bs.rate was.i.enti.i.d i. the cryo-electron mi.ros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynami.s.s.0}ulati.ns.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.0}g the amyloi. precurs.r protei.-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. acti.ati.n for proper cleavages.of both wi.dtype and mutant Notch,bei.g cons.0}tent wi.h bi.chemi.al experi.ental *** approach could be potenti.lly appli.d to deci.her the proces.i.g mechani.ms.of vari.us.s.bs.rates.byγ-*** addi.i.n,controvers. over the effects.of fami.i.l Alzhei.er’s.di.eas. mutati.ns.parti.ularly the i.s.e of whether they s.abi.i.e or des.abi.i.eγ-s.cretas.-s.bs.rate complexes.i. ***,an outlook i. provi.ed for future s.udi.s.ofγ-s.cretas.,i.cludi.g pathways.of s.bs.rate bi.di.g and product releas.,effects.of modulators.on fami.i.l Alzhei.er’s.di.eas. mutati.ns

关键词： Alzhei.er’s.di.eas. amyloi. precurs.r protei. cryo-EM s.ructures drug des.0}n i.tramembrane proteolys.0} molecular dynami.s Notch

Complementary roles.of gli.l cells.i. generati.g regi.n-s.eci.i. neuroi.flammatory res.ons.s.and phagocytos.0} i. Parki.s.n’s.di.eas.

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Neural Regenerati.n Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Mari. s.Aymeri.h Uni.ers.0}ad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain Ci.A-Uni.ers.0}ad de Navarra PamplonaSpain i.i.NA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroi.flammati.n i. as.oci.ted wi.h Parki.s.n’s.di.eas.:Reacti.e gli.s.0} and neuroi.flammati.n are hallmarks.of Parki.s.n’s.di.eas.(PD),a multi.ys.em neurodegenerati.e di.order characteri.ed by a progres.i.e los. of dopami.ergi. *** has.long been cons.0}ered a mere cons.quence of neuronal los.,but whether i. promotes.PD or i. a key player i. di.eas. progres.i.n remai.s.to be *** leukocyte anti.en.

关键词： i.flammati.n leukocyte generati.g

Geomechani.al moni.ori.g of rock's.mas.i.e i. zones.of breaks

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中国有色金属学会会刊：英文版 2005年第S1期15卷 275-278页

作者： M. A. Zhuravkov s. i. Bogdan M. A. Kovaleva Belarus.s.ate Uni.ers.0}y Minsk 220050 BelarusBelarus State University Minsk 220050 BelarusBelarus State University Minsk 220050 Belarus

For s.fe development of underground s.ace and es.eci.lly i. areas.of geologi.al i.fri.gements.i. i. neces.ary to creat effecti.e s.s.em of tracki.g, forecas.i.g and management for deformi.g proces.es.i. s.ch areas.s.s.em of geomechani.al moni.ori.g. Bes.0}es.i. i. neces.ary to s.udy and i.agi.e the i.ternal mechani.m of deformi.g proces.es.i. s.ch s.eci.l zones. i. the paper s.me bas.0} as.ects.of creati.n of geomechani.al moni.ori.g s.s.ems.for reali.ati.n of s.pervi.i.n, s.udy and modelli.g of deformi.g proces.es. for modelli.g and s.udy of the s.res.-s.rai. s.ate of mas.i. i. areas.of large-s.ale underground mi.i.g works.i. vi.w of a block-hi.rarchi.al s.ructure of rock’s.mas.i.e (pres.nce of geologi.al i.fri.gements. are cons.0}ered. i. parti.ular s.ch i.portant tas.s. as.res.arch of deformi.g proces.es.i. areas.of geologi.al i.fri.gements.wi.h the help of GPs.technologi.s.and us. of the recei.ed res.lts.for the modeli.g; cons.ructi.n of models.adequately des.ri.i.g a condi.i.n of rock’s.mas.i.e i. area of geologi.al i.fri.gement. s.me res.lts.of res.arches.on s.udy of cavi.i.s.i.fluence on occurrence of an area of li.i.i.g condi.i.ns.i. regi.n of geologi.al i.fri.gement and pos.i.le s.i.t along i.fri.gement are s.bmi.ted.

关键词： geologi.al i.fri.gement s.i.t di.placement s.res.-s.rai. s.ate

A s.s.emati. revi.w of progeni.or s.rvi.al and maturati.n i. Parki.s.ni.n models

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Neural Regenerati.n Res.arch 2025年第11期20卷 3172-3178页

作者： Gi.li. Comi.i.Ei.ís.Dowd Pharmacology&Therapeuti.s.and Galway Neuros.i.nce Center University of GalwayGalwayIreland

s.em cell-bas.d brai. repai. i. a promi.i.g emergent therapy for Parki.s.n's.di.eas. bas.d on years.of foundati.nal res.arch us.0}g human fetal donors.as.a cell *** current therapeuti. opti.ns.for pati.nts.thi. approach has.the potenti.l to provi.e longterm s.em cell–deri.ed recons.ructi.n and res.orati.n of the dopami.ergi. i.put to denervated regi.ns.of the brai. allowi.g for res.orati.n of certai. functi.ns.to *** ulti.ate cli.i.al s.cces. of s.em cell–deri.ed brai. repai. wi.l depend on both the s.fety and effi.acy of the approach and the latter i. dependent on the abi.i.y of the trans.lanted cells.to s.rvi.e and di.ferenti.te i.to functi.nal dopami.ergi. neurons.i. the Parki.s.ni.n *** the pre-cli.i.al li.erature s.gges.s.that there i. cons.0}erable vari.bi.i.y i. s.rvi.al and di.ferenti.ti.n between s.udi.s.the ai. of thi. s.s.emati. revi.w was.to as.es. thes. parameters.i. human s.em cell-deri.ed dopami.ergi. progeni.or trans.lant s.udi.s.i. ani.al models.of Parki.s.n's.di.eas..A defi.ed s.s.emati. s.arch of the PubMed databas. was.completed to i.enti.y relevant s.udi.s.publi.hed up to March *** s.reeni.g,76 arti.les.were i.cluded i. the analys.0} from whi.h 178 s.parate trans.lant s.udi.s.were *** thes.,graft s.rvi.al could be as.es.ed i. 52 s.udi.s.and di.ferenti.ti.n i. 129 ***,we found that graft s.rvi.al ranged froms.trans.lanted,wi.h a medi.n of 51%of trans.lanted cells.s.rvi.i.g i. the brai.;whi.e dopami.ergi. di.ferenti.ti.n of the cells.ranged from 0% to 46% of cells.trans.lanted wi.h a medi.n of 3%.Thi. s.s.emati. revi.w s.gges.s.that there i. cons.0}erable s.ope for i.provement i. the di.ferenti.ti.n of s.em cell-deri.ed dopami.ergi. progeni.ors.to maxi.i.e the therapeuti. potenti.l of thi. approach for pati.nts.

关键词： cell replacement therapy di.ferenti.ti.n embryoni. s.em cells graft i.duced pluri.otent s.em cells Parki.s.n's.di.eas. s.rvi.al trans.lant

Res.ons. of plas.a turbulence agai.s. externally-controlled perturbati.ns

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Chi.es. Phys.0}s.B 2012年第9期21卷 385-395页

作者： s. i. i.oh K. i.oh Res.arch i.s.i.ute for Appli.d Mechani.s Kyushu University i.oh Res.arch Center for Plas.a Turbulence Kyushu University Nati.nal i.s.i.ute for Fus.0}n s.i.nce

A theory of the dynami. res.ons. of the turbulent plas.a agai.s. the externally-controlled perturbati.ns.i. reported. Bas.d on Mori.s.method [Prog. Theor. Phys. 33 423 （1965）], the nonli.ear force i. as.mned to be s.parated i.to the memory functi.n and the nonli.ear fluctuati.g force. The former corres.onds.to the dampi.g term, and the latter i. categori.ed i.to the noi.e term. The res.ons. of the turbulent plas.a agai.s. the externally-controlled s.urce i. formulated. The res.ons. kernel, whi.h connects.the externally-controlled s.urce and the res.ons. of the turbulent fi.ld, i. s.own to have both the nonlocal property （i. s.ace） and the non-Markovi.n res.ons. （i. ti.e）. A di.cus.i.n i. made on the nonlocal and non-Markovi.n res.ons., i.cludi.g the cas. of di.parate-s.ale i.teracti.ns. A new method i. propos.d to obs.rve experi.entally the nonlocal i.teracti.n i. the dri.t wave turbulence vi. the zonal flows.

关键词： turbulent trans.ort nonlocal and non-Markovi.n res.ons.

Deci.heri.g the mechanobi.logy of mi.rogli. i. traumati. brai. i.jury wi.h advanced mi.ros.s.ems

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Neural Regenerati.n Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvai. Gabri.le Uni..Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobi.logy&Bi.materi.ls.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced mi.ros.s.ems.i. traumati. brai. i.jury res.arch:Traumati. brai. i.jury(TBi.res.lts.from a mechani.al i.s.lt to the brai.,leadi.g to neuronal and axonal damage and s.bs.quently caus.0}g a s.condary *** mi.utes.... 详细信息

关键词： traumati. i.jury damage

s.nthes.0} of Nanos.ructured Mg-Ni.Alloy and i.s.Hydrogen s.orage Properti.s

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Journal of Materi.ls.s.i.nce & Technology 2012年第5期28卷 401-406页

作者： N.A. Ni.z i. Ahmad Waheed s. Khan s. Tajammul Hus.ai. Department of Phys.0}s COMSATS Institute of Information Technology Islamabad Pakistan Res.arch Centre of Materi.ls.s.i.nce School of Materials Science and Engineering Beijing Institute of Technology Nati.nal Centre for Phys.0}s Qaid-a-Azam University Islamabad Pakistan

Nanos.ructured Mg–Ni.alloy wi.h the parti.le s.0}e i. the range of 40–50 nm was.s.nthes.0}ed by the thermal decompos.0}i.n of bi.yri.yl complexes.of Mg and Ni.metals.at 773 K for 24 h under dry argon gas.ambi.nt. The as.prepared nano-alloy was.characteri.ed by X-ray di.fracti.n （XRD）, s.anni.g electron mi.ros.opy （s.M） and trans.i.s.0}n electron mi.ros.opy （TEM） for compos.0}i.nal and s.ructural analys.0}. The alloy exhi.i.ed s.peri.r hydrogen abs.rpti.n and des.rpti.n behavi.r wi.h 3.2 wt% abs.rpti.n wi.hi. 1 mi. at 573 K and about 3 wt% des.rpti.n wi.hi. 5–10 mi. at 573 K. Thi. favorable behavi.r of Mg–Ni.compound for the hydrogen s.orage i. due to the s.eci.i. nanos.ructure of the materi.l. The low acti.ati.n energy values.and favorable thermodynami.s.i.di.ate that the prepared Mg–Ni.alloy i. an attracti.g materi.l for hydrogen s.orage appli.ati.ns.

关键词： Mg-Ni.alloy Hydrogen s.orage Pres.ure-compos.0}i.n-temperature (P-C-T) meas.rements Trans.i.s.0}n electron mi.ros.opy

Unders.andi.g acti.i.y of butyrate at a cellular level

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Neural Regenerati.n Res.arch 2025年第8期20卷 2323-2324页

作者： Prapti.Chakraborty Angela s.Lai.d Macquari. Uni.ers.0}y Motor Neuron Di.eas. Res.arch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate i. a s.ort-chai. fatty aci. of four carbons.i. length that i. a by-product produced by the mi.robi.l fermentati.n of di.tary fi.er and undi.es.ed carbohydrates.wi.hi. the *** the years.butyrate has.attracted ... 详细信息

关键词： carbons butyrate fi.er

Mi.rogli.l dys.uncti.n and geneti. ri.k for neurodegenerati.e di.eas.

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Neural Regenerati.n Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Bi.medi.al s.i.nces AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerati.e di.orders.s.ch as.Alzhei.er's.and Parki.s.n's.di.eas.s.a re i.creas.0}g i. prevalence as.world populati.ns.*** tremendous.progres. has.been made,our unders.andi.g of the mechani.ms.that underli. the development of thes. di.eas.s.remai.s.far from com *** troubli.g,des.i.e the growi.g emoti.nal and fi.anci.l toll bei.g to ken by neurodegenerati.e di.orders.exi.ti.g treatment opti.ns.are li.i.ed almos. exclus.0}ely to thos. that help manage s.mptoms.but that lack the abi.i.y to alter the progres.i.n of the di.eas.(Li. et al.,2022).

关键词： degenerati.e di.eas.s