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i.terplay between mesenchymal stromal cells and the i.mune system after transplantati.n: i.pli.ati.ns for advanced cell therapy i. the reti.a

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Neural Regenerati.n Research 2024年第3期19卷 542-547页

作者： María Norte-Muñoz Davi. garcía-Bernal Di.go garcía-Ayuso Manuel Vi.al-Sanz Marta Agudo-Barri.so Grupo de i.vesti.aci.n Oftalmología Experi.ental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de i.vesti.aci.n Trasplante Hematopoyéti.o y Terapi. celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal stromal cell-based therapi.s for neurodegenerati.e di.eases are wi.ely i.vesti.ated i. precli.i.al *** stromal cells are well posi.i.ned as therapeuti.s because they address the underlyi.g mechani.ms of neurodegenerati.n,namely trophi. factor depri.ati.n and *** studi.s have focused on the benefi.i.l effects of mesenchymal stromal cell transplantati.n on neuronal survi.al or functi.nal ***,li.tle attenti.n has been pai. to the i.teracti.n between mesenchymal stromal cells and the host i.mune system due to the i.munomodulatory properti.s of mesenchymal stromal cells and the long-held beli.f of the i.munopri.i.eged status of the central nervous ***,we revi.w the crosstalk between mesenchymal stromal cells and the i.mune system i. general and i. the context of the central nervous system,focusi.g on recent work i. the reti.a and the i.portance of the type of transplantati.n.

关键词： adapti.e i.muni.y cell therapy central nervous system i.mune system i.nate i.muni.y mesenchymal stromal cells neuroregenerati.n precli.i.al studi.s reti.a transplantati.n

Ki.emati.s ofmandi.ular advancement devi.es(MADs):Why do some MADs move the lower jaw backward duri.gmouth openi.g?

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Bi.-Desi.n and Manufacturi.g 2024年第5期7卷 637-650页

作者： Juan A.Cabrera Alex Bataller Sergi. Posti.o Marcos garcía Mechani.al Engi.eeri.g Department University of Malaga29071 MalagaSpain

Mandi.ular advancement devi.es(MADs)are wi.ely used treatments for obstructi.e sleep *** functi.n by advanci.g the lower jaw to open the upper *** i.crease pati.nt comfort,most pati.nts allow the mouth to be ***,not all systems mai.tai. the lower jaw i. a forward posi.i.n duri.g mouth openi.g,whi.h results i. the producti.n of a retrusi.n that favors the collapse of the upper ***,the ki.emati. behavi.r of the mechani.m formed by the mandi.le-devi.e assembly depends on jaw *** means that,duri.g mouth openi.g,some devi.es cause lower jaw protrusi.n i. some pati.nts,but cause i.s retracti.n i. *** thi. study,we report the behavi.r of well-known devi.es currently on *** do so,we developed a ki.emati. model of the lower jawdevi.e *** vali.ated for all devi.es analyzed usi.g a hi.h-resoluti.n camera *** results show that some of the devi.es analyzed here di. not produce the correct behavi.r duri.g pati.nt mouth openi.g.

关键词： Mandi.ular advancement devi.es Lower jaw ki.emati.s Sleep apnea

An Effi.i.nt Real Space Method for Orbi.al-Free Densi.y-Functi.nal Theory

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Communi.ati.ns i. Computati.nal Physi.s 2007年第2期2卷 334-357页

作者： Carlos J.garcıa-Cervera Department of Mathemati.s University of CaliforniaSanta BarbaraCA 93106USA.

We consi.er the Thomas-Fermi.von Wei.sacker energy functi.nal,wi.h the Wang-Teter correcti.n,and present an effi.i.nt real space method for Orbi.al-Free Densi.y Functi.nal *** i. proved that the energy mi.i.i.er sati.fi.s a second order quasi.i.ear elli.ti. equati.n,even at the poi.ts where the electron densi.y *** i.formati.n i. used to construct an effi.i.nt energy mi.i.i.ati.n method for the resulti.g constrai.ed problem,based on the truncated Newton method for unconstrai.ed *** Wang-Teter kernel i. analyzed,and i.s behavi.r i. real space at short and far di.tances i. determi.ed.A second order accurate di.creti.ati.n of the energy i. obtai.ed usi.g fi.i.e *** effi.i.ncy and accuracy of the method i. i.lustrated wi.h numeri.al si.ulati.ns i. an Alumi.i.m FCC latti.e.

关键词： Densi.y functi.nal theory truncated Newton method constrai.ed opti.i.ati.n.

Green i.ni. metal-organi. frameworks as nanocatalysts for CO_(2)fi.ati.n

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Nano Research 2025年第1期18卷 260-269页

作者： Nuri. Martín Mi.uel Mai.eles-Porcar Juli.n Sánchez Velandi. Belén Altava Franci.co G.Ci.ujano Eduardo garcía-Verdugo Departamento de Quími.a i.orgáni.a y Orgáni.a Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni.and Zn i.o-reti.ular coordi.ati.n polymers of 2,5-di.ydroxyterphthali. aci.(H_(2)dot)can be rapi.ly obtai.ed under room temperature and aqueous condi.i.ns usi.g ei.her sodi.m or ammoni.m hydroxi.e as the bases to deprotonate the *** use of metal bromi.es and tetrabutylammoni.m hydroxi.e(TBAOH)as the base allows the green synthesi. of i.ni. metal-organi. frameworks(MOFs),characteri.ed by X-ray di.fracti.n(XRD),Fouri.r transform i.frared(FTi.),scanni.g electron mi.roscopy(SEM),thermo gravi.etri. analysi.(TGA),H-nuclear magneti. resonance(NMR),elemental analysi.,and X-ray photoelectron spectroscopy(XPS),and employed i. the pressure,solvent,and addi.i.e-free CO_(2)fi.ati.n to epoxi.es by i.s cycloaddi.i.n to epi.hlorohydri.,exhi.i.i.g a cooperati.e behavi.r between the MOF and the i.ni. li.ui. formed wi.hi. the framework,achi.vi.g TONs of the confi.ed tetrabutylammoni.m bromi.e(TBABr)up to 700.

关键词： metal-organi. frameworks(MOFs) i.ni. li.ui.s heterogeneous catalysi. CO_(2)conversi.n

Further the li.ui. bi.psy:Gatheri.g pi.ces of the puzzle of genometastasi. theory

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World Journal of Cli.i.al Oncology 2017年第5期8卷 378-388页

作者： Ana garcía-Casas Dolores C garcía-Olmo Dami.n garcía-Olmo Uni.ersi.ad Complutense de Madri. Centre de Recerca Experi.ental Bi.mèdi.a Apli.ada(CREBA) IRBLLEIDA Department of Surgery Universidad Autónoma de MadridInstituto de Investigación SanitariaFundación Jiménez Díaz

Metastasi. i. the major cause of mortali.y i. cancer di.ease and sti.l consti.utes one of the most controversi.l mechani.m,not yet fully *** i. almost beyond doubt i. that ci.culatory system i. cruci.l for cancer *** thi. system,much attenti.n has been recently pai. to li.ui. *** techni.ue i. ai.ed to detect ci.culati.g tumor cells (CTCs) and ci.culati.g nuclei. aci.s so i. can be used as a tool for di.gnosti.,prognosti. and follow-up of *** CTCs tend to be scarce i. serum and plasma from cancer pati.nt,abundant ci.culati.g nuclei. aci.s can be detected i. the same *** fact,together wi.h the geneti. ori.i. of cancer,stands out the relevance of ci.culati.g nuclei. aci.s and shed li.ht i.to the role of nuclei. aci.s as dri.ers of metastasi.,a recently di.covered phenomenon called *** i.novati.e theory supports the transfer of oncogenes from cancer cells to normal and suscepti.le cells located i. di.tant target organs through ci.culatory *** i. more,many bi.logi.al processes haven been descri.ed to deli.er and secrete ci.culati.g nuclei. aci.s i.to the ci.culati.n whi.h can allow such hori.ontal transfer of *** thi. revi.w,we focus not only on these mechani.ms but also we demonstrate i.s putati.e role i. cancer propagati.n and gi.e i.si.hts about possi.le therapeuti. strategi.s based on thi. *** objecti.e i. to demonstrate how fi.di.gs about cell-to-cell communi.ati.ns and previ.us results can agree wi.h thi. unprecedented theory.

关键词： Genometastasi. Cancer metastasi. Ci.culati.g Nuclei. aci.s:Ci.culati.g tumor cells Li.ui. bi.psy Exosomes Vi.tosomes

i.vasi.e strategy i. elderly pati.nts wi.h acute coronary syndrome i. 2018: close to the truth?

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Journal of Geri.tri. Cardi.logy 2019年第2期16卷 114-120页

作者： Sergi. garcía-Blas Clara Bonanad Juan Sanchi. Servei.de Cardi.logi. Hospital Clínic Universitari de València INCLIVA Universitat de ValènciaCIBERCV

Elderly populati.n consti.utes an i.creasi.gly larger proporti.n of pati.nts admi.ted for acute coronary syndromes(ACS).The opti.al management of ACS i. these pati.nts i. sti.l a challenge due to thei. cli.i.al peculi.ri.i.s and the pauci.y of speci.i. data,and they have been tradi.i.nally managed more conservati.ely mai.ly based on subjecti.e *** ST^segment elevati.n acute myocardi.l i.farcti.n urgent reperfusi.n i. the standard of care and there i. no upper age *** non-ST segment elevati.n acute myocardi.l i.farcti.n evi.ence i. controversi.l,i.complete and mai.ly focused on chronologi.al *** a stri.t conservati.e strategy should be avoi.ed,routi.e i.vasi.e strategy may reduce the occurrence of myocardi.l i.farcti.n and need for revasculari.ati.n at follow-up wi.h no establi.hed benefi. i. terms of *** characteri.ti.s associ.ted wi.h agi.g,such as comorbi.i.i.s and frai.ty,further di.cri.i.ate pati.nt's ri.k beyond *** i. scarce,but i. suggests that these features may modulate the benefi. of i.vasi.e strategy i. thi. *** tri.ls should clari.y the opti.al management of ACS based on these parameters.

关键词： Acute coronary syndromes Comorbi.i.y Frai.ty Percutaneous coronary i.terventi.n The elderly

A Complete Di.phanti.e Characteri.ati.n of the Rati.nal Torsi.n of an Elli.ti. Curve

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Acta Mathemati.a Si.i.a,Engli.h Seri.s 2012年第1期28卷 83-96页

作者： i.ene garcíA-SELFA Jos M.TORNERO Departamento de Matemáti.as Universidad de HuelvaFacultad de Ciencias ExperimentalesCampus de El CarmenAvenida de las Fuerzas Armadass/n21071 HuelvaSpain Departamento de ' Algebra Universidad de SevillaP.O.116041080 SevillaSpain

We gi.e a complete characteri.ati.n for the rati.nal torsi.n of an elli.ti. curve i. terms of the （non-）exi.tence of i.tegral soluti.ns of a system of di.phanti.e equati.ns.

关键词： Elli.ti. curves di.phanti.e equati.ns

Stem cell therapy for faecal i.conti.ence: Current state and future perspecti.es

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World Journal of Stem Cells 2018年第7期10卷 82-105页

作者： Jacobo Trébol Ana Carabi.s-Orgaz Mari.no garcía-Arranz Dami.n garcía-Olmo General and Di.esti.e Tract Surgery Department Salamanca University Healthcare Centre Anaesthesi.logy Department Complejo Asistencial de ávila New Therapi.s Laboratory Instituto de Investigación Sanitaria-Fundación Jiménez Díaz General and Di.esti.e Tract Surgery Department Quiron-Salud Hospitals Surgery Department Universidad AutónomaMadrid

Faecal conti.ence i. a complex functi.n i.volvi.g di.ferent organs and systems. Faecal i.conti.ence i. a common di.order wi.h di.ferent pathogeneses, di.abli.g consequences and hi.h repercussi.ns for quali.y of li.e. Current management modali.i.s are not i.eal, and the development of new treatments i. needed. Si.ce 2008, stem cell therapi.s have been vali.ated, 36 publi.ati.ns have appeared(29 i. precli.i.al models and seven i. cli.i.al setti.gs), and si. regi.tered cli.i.al tri.ls are currently ongoi.g. Some publi.ati.ns have combi.ed stem cells wi.h bi.engi.eeri.g technologi.s. The ai. of thi. revi.w i. to i.enti.y and summari.e the exi.ti.g publi.hed knowledge of stem cell uti.i.ati.n as a treatment for faecal i.conti.ence. A narrati.e or descri.ti.e revi.w i. presented. Precli.i.al studi.s have demonstrated that cellular therapy, mai.ly i. the form of local i.jecti.ns of muscle-deri.ed(muscle deri.ed stem cells or myoblasts deri.ed from them) or mesenchymal(bone-marrow-or adi.ose-deri.ed) stem cells, i. safe. Cellular therapy has also been shown to sti.ulate the repai. of both acute and subacute anal sphi.cter i.juri.s, and some encouragi.g functi.nal results have been obtai.ed. Stem cells combi.ed wi.h normal cells on bi.engi.eered scaffolds have achi.ved the successful creati.n and i.plantati.n of i.tri.si.ally-i.nervated anal sphi.cter constructs. The cli.i.al evi.ence, based on adi.ose-deri.ed stem cells and myoblasts, i. extremely li.i.ed yet has yi.lded some promi.i.g results, and appears to be safe. Further i.vesti.ati.n i. both ani.al models and cli.i.al setti.gs i. necessary to drawi.g conclusi.ns. Nevertheless, i. the preli.i.ary results are confi.med, stem cell therapy for faecal i.conti.ence may well become a cli.i.al reali.y i. the near future.

关键词： Faecal i.conti.ence Anal sphi.cter Cell i.plantati.n Ti.sue engi.eeri.g Cell therapy Stem cells

Hydrothermal Synthesi. and Characteri.ati.n of Europi.m-doped Bari.m Ti.anate Nanocrystalli.es

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Nano-Mi.ro Letters 2013年第1期5卷 57-65页

作者： Margari.a garcía-Hernndez Genevi.ve Chadeyron Dami.n Boyer Antoni.ta garcía-Muri.lo Feli.e Carri.lo-Romo Rachi. Mahi.u Uni.ersi.ad Autónoma Metropoli.ana Departamento de Ciencias NaturalesDCNIUnidad CuajimalpaPedro Antonio de los Santos 8411850 Mxico D.F. Mxico Clermont Uni.ersi. i.sti.ut de Chi.i. de Clermont-Ferrand UMR 6296CNRS/UBP/ENSCCFBP 10448F-63000 Clermont-Ferrand i.sti.uto Poli.cni.o Naci.nal CIITEC IPNCerrada de Cecati S/N. Col. Santa CatarinaAzcapotzalco Mxico D.F. C.P. 02250Mxico

Bari.m ti.anate nanocrystalli.es were synthesi.ed by a hydrothermal techni.ue from bari.m chlori.e and tetrabutyl ti.anate. Si.gle-crystalli.e cubi. perovski.e Ba Ti._3 consi.ti.g of spheri.al parti.les wi.h di.meters rangi.g from 10 to 30 nm was easi.y achi.ved by thi. route. i. order to study the i.fluence of the synthesi. process on the morphology and the opti.al properti.s, bari.m ti.anate was also prepared by a soli.-state reacti.n. i. thi. case, only the tetragonal phase whi.h crystalli.es above 900 was observed. Hi.h-temperature X-ray di.fracti.n measurements were performed to i.vesti.ate the crystalli.ati.n temperatures as well as the parti.le si.es vi. the Scherrer formula. The latti.e vi.rati.ns were evi.enced by i.frared spectroscopy. Eu^(3+)was used as a structural probe, and the lumi.escence properti.s recorded from Ba Ti._3 :Eu^(3+)and elaborated by a soli.-state reacti.n and hydrothermal process were compared. The reddi.h emi.si.n of the europi.m i. i.creased by the nanometri. parti.les.

关键词： BaTi.3 Europi.m Nanocrystalli.es Hydrothermal techni.ue