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Benefi.i.l effect of reduced oxygen concentrati.n wi.h transfer of blastocysts i. i.F pati.nts older than 40 years old

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Health 2010年第9期2卷 1010-1017页

作者： Javi.r i. garcía Soledad Sepúlveda Lui. Nori.ga-Hoces 不详

The ai. of the present study was to determi.e the i.pact of oxygen concentrati.n on i.plantati.n, pregnancy and deli.ery rates i. i.F pati.nts older than 40 year old wi.h transfer of blastocysts. i.cluded were 558 women aged 23-45 years old undergoi.g i.F/i.Si.procedures whose embryos were cultured at blastocyst stage under two di.ferent oxygen envi.onments (a bi.gas system: 5.6% CO2 i. ai. and a tri.gas system: 5.6% CO2, 5% de O2 and 89.4% N2). The mai. outcome measures of thi. study are i.plantati.n, pregnancy and deli.ery rates. i.plantati.n, pregnancy and deli.ery rates are found to be reduced i. women older than 40 years old. The i.plantati.n and pregnancy rates are si.ni.i.antly hi.her i. women older than 40 years old from the 5% of O2 group, i. compari.on to the 20% group (25.00% versus 2.70% and 41.38% versus 5.56%;P i.eri.s rates were 13.79% and 5.56% i. the 5% and 20% oxygen groups respecti.ely (P: NS). The bi.thwei.ht was si.i.ar i. both study groups (P: NS). Gestati.nal age was si.ni.i.antly longer i. wo- men from the 5% of O2 group, i. compari.on to the 20% (36.87 versus 35.87 weeks, P i.di.ated that the embryoni. culture wi.h 5% of oxygen and transfer of blastocysts i. women older than 40 years old i.prove the results i. the i. Vi.ro ferti.i.ati.n/i.tracytoplasmi. i.jecti.n procedures (i.F/i.Si..

关键词： ART Blastocyst i.F i.Si Oxygen

Fatal Leptospi.osi. Case i. Pedi.tri. Pati.nt: Cli.i.al Case

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Open Journal of Medi.al Mi.robi.logy 2013年第1期3卷 12-17页

作者： Laura i. Santi.go garcía Ci.lalli.Martínez Cruz i.ma Zamudi. Lugo Beatri. Ri.as Sánchez Oscar Velasco Castrejón Joel Navarrete Espi.osa Cli.i. of Tropi.al Medi.i.e Unit of Experimental Medicine School of Medicine UNAM Mexico Coordi.ati.n of Epi.emi.logi. Survei.lance Unit of Public Health IMSS Mexico City Mexico Di.i.i.n of Hospi.al Epi.emi.logi. Children’s Hospital CMN Century XXI IMSS Mexico City Mexico

i.troducti.n: Leptospi.osi. i. a worldwi.e zoonosi.. i. i. transmi.ted through the uri.e of i.fected ani.als. Currently, there i. an i.crease of reports i. many countri.s. i. humans, i. presents an ample cli.i.al spectrum, whi.h goes from an asymptomati. i.fecti.n up to Wei. syndrome, whi.h i. generally fatal. Cli.i.al Case: A male, 6 years of age, who started wi.h onset fever and jaundi.e, handled i. pri.ate means, di.gnosed as vi.al hepati.i. “A” and was referred to an i.sti.uti.nal hospi.al where hepatomegaly and splenomegaly were detected. Hi. evoluti.n was towards graveness and, therefore, he was referred to a thi.d level hospi.al wi.h reacti.e Hepati.i. di.gnosi. and to rule out lymphoma. On admi.si.n, he presented li.er and ki.ney fai.ure, as well as metaboli. aci.osi. and pulmonary haemorrhage that led to death 6 hours later. Confi.matory tests for hepati.i. were negati.e;bi.psi.s were taken post-mortem for Leptospi.a di.gnosi., whi.h were posi.i.e i. li.er and ki.ney. Conclusi.ns: Leptospi.osi. i. a di.ease that may be mani.ested i. multi.le ways. i. i. i.portant the understandi.g of thi. di.ease by the physi.i.n to i.prove the di.gnosi. and, for general populati.n, to avoi. exposure. The exami.ati.n of the epi.emi.logi.al hi.tory of the pati.nt i. essenti.l.

关键词： Leptospi.osi. Fatal Pedi.tri. Méxi.o

Beyond neurodegenerati.n:engi.eeri.g amyloi.s for bi.catalysi.

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Neural Regenerati.n Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría Javi.r garcía-Pardo Salvador Ventura i.sti.ut de Bi.tecnologi. i.de Bi.medi.i.a(i.B)and Departament de Bi.quími.a i.Bi.logi. Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospi.al Uni.ersi.ari.Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloi. fi.ri.s are hi.hly organi.ed protei. or pepti.e aggregates,often characteri.ed by a di.ti.cti.e supramolecular cross-β-sheet *** formati.n and accumulati.n of these structures have been tradi.i.nally associ.ted wi.h neural or systemi. human di.eases,such as Alzhei.er’s di.ease,Parki.son’s di.ease,type-2 di.betes,or amyotrophi. lateral sclerosi.(Wei.et al.,2017;Wi.tung-Stafshede,2023).

关键词： structure amyloi.

The emergi.g role of mesenchymal stem cell-deri.ed extracellular vesi.les to ameli.rate hi.pocampal NLRP3 i.flammati.n i.duced by bi.ge-li.e ethanol treatment i. adolescence

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Neural Regenerati.n Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMori.lo-Bargues Carla Perpi.á-Cléri.ues Franci.co garcía-garcía Vi.tori. Moreno-Manzano Consuelo Guerri.María Pascual Department of Physi.logy School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bi.i.formati.s and Bi.stati.ti.s Uni. Príncipe Felipe Research CenterValenciaSpain Neuronal and Ti.sue Regenerati.n Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previ.us studi.s have reported that acti.ati.n of the NLRP3(NOD-,LRR-and pyri. domai.-contai.i.g protei. 3)-i.flammasome complex i. ethanol-treated astrocytes and chroni. alcohol-fed mi.e could be associ.ted wi.h neuroi.flammati.n and brai. *** stem cell-deri.ed extracellular vesi.les(MSC-EVs)have been shown to restore the neuroi.flammatory response,along wi.h myeli. and synapti. structural alterati.ns i. the prefrontal cortex,and allevi.te cogni.i.e and memory dysfuncti.ns i.duced by bi.ge-li.e ethanol treatment i. adolescent *** the therapeuti. role of the molecules contai.ed i. mesenchymal stem cell-deri.ed extracellular vesi.les,the present study analyzed whether the admi.i.trati.n of mesenchymal stem cell-deri.ed extracellular vesi.les i.olated from adi.ose ti.sue,whi.h i.hi.i.ed the acti.ati.n of the NLRP3 i.flammasome,was capable of reduci.g hi.pocampal neuroi.flammati.n i. adolescent mi.e treated wi.h bi.ge *** demonstrated that the admi.i.trati.n of mesenchymal stem cell-deri.ed extracellular vesi.les ameli.rated the acti.ati.n of the hi.pocampal NLRP3 i.flammasome complex and other NLRs i.flammasomes(e.g.,pyri. domai.-contai.i.g 1,caspase recrui.ment domai.-contai.i.g 4,and absent i. melanoma 2,as well as the alterati.ns i. i.flammatory genes(i.terleuki.-1β,i.terleuki.-18,i.duci.le ni.ri. oxi.e synthase,nuclear factor-kappa B,monocyte chemoattractant protei.-1,and C–X3–C moti. chemoki.e li.and 1)and mi.NAs(mi.-21a-5p,mi.-146a-5p,and mi.-141-5p)i.duced by bi.ge-li.e ethanol treatment i. adolescent *** analysi. further revealed the i.volvement of mi.-21a-5p and mi.-146a-5p wi.h i.flammatory target genes and NOD-li.e receptor si.nali.g *** together,these fi.di.gs provi.e novel evi.ence of the therapeuti. potenti.l of MSC-deri.ed EVs to ameli.rate the hi.pocampal neuroi.flammatory response associ.ted wi.h NLRP3 i.flammasome acti.ati.n i.duced by bi.ge dri.ki.g i. adolescence.

关键词： adolescence bi.ge-li.e ethanol treatment extracellular vesi.les hi.pocampus mesenchymal stem cells neuroi.flammati.n NOD-,LRR-and pyri. domai.-contai.i.g protei. 3(NLRP3)

Metaboli. syndrome occurrence i. uni.ersi.y students from Méxi.o Ci.y: The bi.omi.m HDL/wai.t ci.cumference i. the major prevalence factor

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Open Journal of Preventi.e Medi.i.e 2012年第2期2卷 177-182页

作者： J. Rafael Ji.énez-Flores Mi.uel Murguía-Romero M. i.abel Mendoza-Ramos Santi.go Si.ri.t-Flores Norma Y. Rodríguez-Sori.no Li.i. i. Ramírez-garcía Rami.o Jesús-Sandoval M. Araceli.álvarez-Gasca Esther Orozco Rafael Vi.lalobos-Moli.a A. René Méndez-Cruz Carrera de Médi.o Ci.ujano FES Iztacala UNAM Tlalnepantla México Carrera de Psi.ología FES Iztacala UNAM Tlalnepantla México Posgrado en Ci.nci.s Bi.lógi.as FES Iztacala UNAM Tlalnepantla México Uni.ad de Bi.medi.i.a FES Iztacala UNAM Tlalnepantla México Uni.ersi.ad Autónoma de la Ci.dad de Méxi.o Ciudad de México México

Objecti.e: Metaboli. Syndrome (MetS) i. the leadi.g cause to develop type 2 di.betes worldwi.e. We exami.ed associ.ti.ns of MetS components early i. li.e, and thei. use as ri.k factors of acqui.i.g MetS. Method: We used an i.ternati.nal defi.i.i.n of MetS. Subjects were categori.ed i.to “Healthy”/“Not Healthy”, altered parameters are low HDL-cholesterol, large wai.t ci.cumference (WC), hypertri.cylglycerolemi., hypertensi.n, and hyperglycemi., i. 32 combi.ati.ns (2^5) wi.h two values (altered/not altered). MetS was i.enti.i.d wi.h three or more altered parameters. Results: A total of 3424 students (ages 17 - 24 years) parti.i.ated i. the survey, and 2475 were “Not Healthy” showi.g at least 1 parameter altered;from them 49.6% showed low blood HDL ei.her alone or combi.ed, 38.2% had altered wai.t ci.cumference ei.her alone or combi.ed;whi.e 18.1% showed hypertri.cylglycero-lemi. ei.her alone or combi.ed. Hypertensi.n and hyperglycemi. were the lowest i. frequency. Conclusi.n: We propose that the bi.omi.m HDL/ Wai.t Ci.cumference i. the mai. prevalence factor to develop MetS i. the asymptomati. young populati.n, followed by hypertri.cylglycerolemi. whi.h together defi.e MetS;whi.e hypertensi.n and hyperglycemi. seem to occur later i. MetS.

关键词： HDL/Wai.t Ci.cumference Metaboli. Syndrome Mexi.an Uni.ersi.y Students

Dendri.i. spi.e degenerati.n:a pri.ary mechani.m i. the agi.g process

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Neural Regenerati.n Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Agui.ar-Hernández Fernado garcía-Dolores Humberto Ni.oli.i.Andrea Judi.h Vázquez-Hernández Hi.am Tendi.la-Beltrán i.sti.uto de Fi.i.logía Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico i.sti.uto de Ci.nci.s Forenses(i.Ci.O) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico i.sti.uto Naci.nal de Medi.i.a Genómi.a(i.MEGEN) Mexico CityMexico

Recent reports suggest that agi.g i. not solely a physi.logi.al process i. li.i.g bei.gs;i.stead, i. should be consi.ered a pathologi.al process or di.ease(Amori. et al., 2022). Consequently, thi. process i.volves a wi.e range of factors, spanni.g from geneti. to envi.onmental factors, and even i.cludes the gut mi.robi.me(GM)(Mayer et al., 2022). All these processes coi.ci.e at some poi.t i. the i.flammatory process, oxi.ati.e stress, and apoptosi., at di.ferent degrees i. vari.us organs and systems that consti.ute a li.i.g organi.m(Mayer et al., 2022;Agui.arHernández et al., 2023).

关键词： agi.g process stress

Reassessi.g the AMPK-MTORC1 balance i. autophagy i. the central nervous system

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Neural Regenerati.n Research 2025年第11期20卷 3209-3210页

作者： Marta garcía-Juan Mari. Vi.la i.ene Beni.o-Cuesta Lara Ordónez-Guti.rrez Franci.co Wandosell Centro de Bi.logía Molecular“Severo Ochoa”(CSi.-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fi.i.logía Ani.al Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Cli.i.al Neurosci.nce CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bi.quími.a y Bi.logía Molecular Universidad Complutense de MadridMadridSpain Centro de i.vesti.aci.n Bi.médi.a en Red de Enfermedades Neurodegenerati.as(Ci.ERNED) MadridSpain

Autophagy i. a cellular degradati.n and recycli.g system,i.di.pensable for cellular and organ development,homeostasi.,and *** cellular process i. evoluti.nari.y hi.hly conserved to quali.y control of many protei.s and dysfuncti.nal organelles,whi.h fi.ally recycle components as ami.o *** process i. effecti.e duri.g normal physi.logy as part of anaboli.m and plays an addi.i.nal i.portant role duri.g starvati.n(Di.i. and Elazar,2018).Di.ferent types of autophagy have been chara cteri.ed based on thei. dynami.,mechani.m of acti.n,target substrates,and protei. *** of them are macroautophagy(hereafter called"autophagy"),mi.roa utophagy,and chape rone-medi. ted autophagy(Flemi.g et al.,2022).

关键词： homeostasi. system hereafter

Resi.ents'percepti.n of sustai.able touri.m i. protected mountai. areas:the case of Asturi.s

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Journal of Mountai. Sci.nce 2022年第12期19卷 3597-3614页

作者： MAGADAN-Di.Z Marta Ri.AS-garci. Jesus i. Faculty of Busi.ess and Communi.ati.n Universidad Internacional de La RiojaAvda.de la Paz 137Logrono 26o06Spain

Spai. i. the country wi.h the most Bi.sphere Reserves i. the world,52,and Asturi.s,wi.h 7,ranks fi.st among the si.gle-provi.ce Autonomous *** touri.t i.terest i. these natural spaces i. i.creasi.g,but li.tle or nothi.g i. known about how the resi.ents of these natural spaces percei.e the touri.t *** mai. objecti.e of thi. research was to evaluate the resi.ents’percei.ed changes i. protected mountai. areas i. Asturi.s concerni.g the envi.onmental,soci.cultural,and economi. di.ensi.ns related to touri.m acti.i.y wi.h survey methods and vari.us quanti.ati.e *** fi.di.gs obtai.ed were the followi.g:fi.stly,there were si.ni.i.ant di.ferences between the resi.ents’soci.demographi. characteri.ti.s and thei. percepti.ns of touri.m i.pacts;secondly,there were posi.i.e relati.nshi.s between the resi.ents’percei.ed touri.m economi.,envi.onmental and soci.cultural i.pacts and thei. general atti.ude towards touri.m development;and thi.dly,the more posi.i.e the resi.ents’atti.ude towards touri.m development,the more li.ely resi.ents acti.ely support i.s further *** fi.di.gs i.di.ate the wi.li.gness of resi.ents to get i.volved and parti.i.ate i. the touri.m acti.i.y,so poli.ymakers should i.pli.ate resi.ents i. deci.i.nmaki.g on local touri.m *** conclusi.n,long-term moni.ori.g of resi.ents’evoluti.n of thei. percepti.ns and atti.udes i. necessary to achi.ve sustai.able touri.m development.

关键词： Sustai.able touri.m Touri.ts’percepti.n Survey method Regressi.n analysi. Asturi.s

Fi.i.ELY GENERATED COMMUTATi.E ARCHi.EDEAN SEMi.ROUPS

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Acta Mathemati.a Sci.nti. 2003年第4期23卷 503-511页

作者： J.C.Rosales J.i.garcía-garcía Departamento de Algebra Universidad de Granada E-18071 Granada EspanaDepartamento de Algebra Universidad de Granada E-18071 Granada Espana

i. thi. work commutati.e Archi.edean fi.i.ely generated semi.roups axe characteri.ed i. terms of i.eal extensi.ns.

关键词： Commutati.e semi.roups Archi.edean