检索结果-南通市图书馆

Flexi.le ultra-thi. super-resoluti.n endoscopy

在线全文

学校读者我要写书评

暂无评论

Sci.nce Chi.a(Physi.s,Mechani.s & Astronomy) 2024年第3期67卷 171-172页

作者： George S.D.gordon Department of Electri.al and Electroni. Engi.eeri.g University of NottinghamNottingham NG7 2RDUK

i. recent years, multi.ode fi.er(MMF) has become an i.portant tool for hi.h-resoluti.n endoscopi. i.agi.g i. narrow channels(e.g., i. the brai. vi. needles or i.si.e blood vessels) due to i.s hi.h mode densi.y and fi.e di.meter, typi.ally i.espread deployment i. appli.ati.ns i. that reali.ti. perturbati.ns, i.cludi.g bendi.g, twi.ti.g and changes i. temperature, cause unacceptable i.age degradati.n.

关键词： fi.er resoluti.n typi.ally

Apoer2/Lrp8:the undercover cop of synapti. homeostasi.

在线全文

学校读者我要写书评

暂无评论

Neural Regenerati.n Research 2024年第12期19卷 2563-2564页

作者： gordon C.Werthmann Joachi. Herz Department of Molecular Geneti.s and Center for Translati.nal Neurodegenerati.n Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neurosci.nce Department of Neurology Uni.ersi.y of Texas Southwestern Medi.al Center at Dallas DallasTXUSA

Apoli.oprotei. E receptor 2(ApoER2)i. a receptor for the protei. ApoE,the most common geneti. ri.k factor for late-onset Alzhei.er's di.ease(AD).i. i. also a key modulator of syna pti. homeostasi.,i. part through i.s effect on the expressi.n of neuronal genes i.cludi.g those i.pli.ated i. AD and other neuropsychi.tri. *** thi. perspecti.e,we hi.hli.ht several genes affected by ApoER2 and i.s alternati.ely spli.ed forms and how aberrant expressi.n can be rescued by the rei.troducti.n of the ApoER2 i.tracellular domai. i. the mouse hi.pocampus.

关键词： homeostasi. ApoE Alzhei.er

Mi.ed plasti.s waste valori.ati.n to hi.h-added value products vi. thermally i.duced phase separati.n and spi.-casti.g

在线全文

学校读者我要写书评

暂无评论

Green Energy & Envi.onment 2024年第10期9卷 1627-1640页

作者： Junai. Saleem Moghal Zubai. Khali. Bai. Usman Bi. Shahi. Rafael Luque gordon McKay Di.i.i.n of Sustai.able Development College of Science and EngineeringHamad Bin Khalifa University Center for Advanced Materi.ls Qatar University Department of Chemi.al and Bi.logi.al Engi.eeri.g The Hong Kong University of Science and Technology Uni.ersi.ad ECOTEC

Plasti. waste i. an underuti.i.ed resource that has the potenti.l to be transformed i.to value-added ***,i.s chemi.al di.ersi.y leads to cost-i.tensi.e sorti.g techni.ues,li.i.i.g recycli.g and upcycli.g ***,we report an open-loop recycli.g method to produce graded feedstock from mi.ed polyolefi.s waste,whi.h makes up 60%of total plasti. *** method uses heat flow scanni.g to quanti.y the composi.i.n of plasti. waste and resolves i.s compati.i.i.y through controlled *** resulti.g feedstock i. then used to synthesi.e blended pellets,porous sorbents,and superhydrophobi. coati.gs vi. thermally i.duced phase separati.n and *** hybri. approach broadens the opportuni.i.s for reusi.g plasti. waste,whi.h i. a step towards creati.g a more ci.cular economy and better waste management practi.es.

关键词： Plasti. waste Valori.ati.n Superhydrophobi. coati.gs Blended pellets Porous materi.ls Sorbents

Customi.ed scaffolds for large bone defects usi.g 3D‑pri.ted modular blocks from 2D‑medi.al i.ages

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bi.-Desi.n and Manufacturi.g 2024年第1期7卷 74-87页

作者： Ani. AAcar Evangelos Daskalaki. Paulo Bartolo Andrew Wei.htman Glen Cooper gordon Blunn Bahatti. Koc Faculty of Engi.eeri.g and Natural Sci.nces Sabanci UniversityIstanbul 34956Türkiye D Bi.pri.ti.g Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechani.al Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Si.gapore Centre for 3D Pri.ti.g School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Bi.medi.al Sci.nces University of PortsmouthPortsmouth PO12UPUK

Addi.i.e manufacturi.g(AM)has revoluti.ni.ed the desi.n and manufacturi.g of pati.nt-speci.i.,three-di.ensi.nal(3D),complex porous structures known as scaffolds for ti.sue engi.eeri.g *** use of advanced i.age acqui.i.i.n techni.ues,i.age processi.g,and computer-ai.ed desi.n methods has enabled the preci.e desi.n and addi.i.e manufacturi.g of anatomi.ally correct and pati.nt-speci.i. i.plants and ***,these sophi.ti.ated techni.ues can be ti.econsumi.g,labor-i.tensi.e,and ***,the necessary i.agi.g and manufacturi.g equi.ment may not be readi.y avai.able when urgent treatment i. needed for trauma *** thi. study,a novel desi.n and AM methods are proposed for the development of modular and customi.able scaffold blocks that can be adapted to fi. the bone defect area of a *** modular scaffold blocks can be combi.ed to qui.kly form any pati.nt-speci.i. scaffold di.ectly from two-di.ensi.nal(2D)medi.al i.ages when the surgeon lacks access to a 3D pri.ter or cannot wai. for lengthy 3D i.agi.g,modeli.g,and 3D pri.ti.g duri.g *** proposed method begi.s wi.h developi.g a bone surface-modeli.g algori.hm that reconstructs a model of the pati.nt’s bone from 2D medi.al i.age measurements wi.hout the need for expensi.e 3D medi.al i.agi.g or *** algori.hm can generate both pati.nt-speci.i. and average bone ***,a bi.mi.eti. conti.uous path planni.g method i. developed for the addi.i.e manufacturi.g of scaffolds,allowi.g porous scaffold blocks wi.h the desi.ed bi.mechani.al properti.s to be manufactured di.ectly from 2D data or *** algori.hms are i.plemented,and the desi.ned scaffold blocks are 3D pri.ted usi.g an extrusi.n-based AM *** and i.structi.ns are also provi.ed to assi.t surgeons i. assembli.g scaffold blocks for the self-repai. of pati.nt-speci.i. large bone defects.

关键词： Addi.i.e manufacturi.g Modular scaffolds Large bone defect Customi.ed scaffold desi.n Pati.nt-speci.i. scaffolds

Allogenei. and autologous stem cell transplantati.n wi.h busulfan, cyclophosphami.e, and etoposi.e condi.i.ni.g therapy for relapsed/refractory non-Hodgki. lymphoma

在线全文

学校读者我要写书评

暂无评论

Modern Chemotherapy 2013年第4期2卷 57-65页

作者： Neeli.a Vi.ula Andrew M. Evens i.ene B. Helenowski.Borko Jovanovi. Jane N. Wi.ter Jayesh Mehta Seema Si.ghal Stephani. F. Wi.li.ms Olga Frankfurt Jessi.a K. Altman Joanne Monreal Leo i. gordon Department of Preventi.e Medi.i.e Northwestern University Chicago USA Di.i.i.n of Hematology-Oncology Northwestern University Chicago USA Di.i.i.n of Hematology-Oncology Northwestern University Chicago USA Di.i.i.n of Hematology-Oncology The University of Massachusetts Medical School Worcester USA Di.i.i.n of Hematology-Oncology University of California San Francisco USA

The opti.al stem cell transplantati.n (SCT) condi.i.ni.g therapy for relapsed/refractory non-Hodgki. lymphoma (NHL) i. not clearly defi.ed. i. a retrospecti.e analysi., we exami.ed 25 pati.nts wi.h “hi.h ri.k” relapsed/refractory NHL who recei.ed busulfan, cyclophosphami.e, and etoposi.e (Bu/Cy/VP16) condi.i.ni.g wi.h autologous or allogenei. SCT. The majori.y of pati.nts had aggressi.e hi.tology and 52% had pri.ary refractory NHL. Furthermore, 48% of pati.nts had chemotherapy-resi.tant di.ease at the ti.e of SCT. Fi.ty-si. percent of pati.nts underwent allogenei. SCT, whi.e 44% had autologous SCT. The medi.n engraftment ti.e for neutrophi.s and platelets was 13.5 and 14 days, respecti.ely. The 100-day treatment-related mortali.y (TRM) was 16%, whi.e the 2-year non-relapse mortali.y (NRM) rate was also 16%. At a medi.n follow-up of 15 months, the esti.ated 2-year di.ease-free survi.al (DFS) rate was 64% (95% confi.ence i.terval (Ci.: 36%-82%) and the esti.ated 2-year overall survi.al (OS) was 69% (95% Ci. 40%-86%). Furthermore, the 2-year di.ease-speci.i. survi.al (DSS) rate was 73% (95% Ci. 40%-90%). Usi.g Cox proporti.nal hazard modeli.g, the i.ternati.nal Prognosti. i.dex at ti.e of relapse predi.ted DFS and OS. Altogether, Bu/Cy/VP16 was associ.ted wi.h early TRM;however, late toxi.i.i.s (i.cludi.g NRM) were uncommon resulti.g i. relati.ely good survi.al rates i. a hi.h-ri.k relapsed/refractory NHL populati.n.

关键词： Stem Cell Transplantati.n Busulfan Cyclophosphami.e Etoposi.e Non-Hodgki. Lymphoma

Fi.ed-effect and random-effects models i. meta-analysi.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chi.ese Medi.al Journal 2024年第1期137卷 1-4页

作者： Chunjuan Zhai.gordon Guyatt Department of Cardi.logy Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong 250021China Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8S 4L8OntarioCanada

A systemati. revi.w synthesi.es evi.ence addressi.g a structured cli.i.al questi.n usi.g systemati. and expli.i. methods to search,i.enti.y,screen,cri.i.ally apprai.e,and extract and analyze data from relevant studi.s.[1]A meta-analysi.,on the other hand,i. a stati.ti.al method that combi.es the quanti.ati.e results of avai.able pri.ary studi.s addressi.g the same questi.n to generate a pooled summary esti.ate and confi.ence i.terval(Ci..[2]Meta-analyses can i.crease stati.ti.al power,enhance preci.i.n,and answer questi.ns that si.gle tri.ls are underpowered to *** there are systemati. revi.ws where meta-analyses are not appropri.te,when they are well-conducted and reported,systemati. revi.ws combi.ed wi.h meta-analyses provi.e valuable i.formati.n for cli.i.i.ns,researchers,and poli.ymakers.

关键词： Fi.ed analysi. effect

Hi.hly stretchable double-network gel electrolytes i.tegrated wi.h texti.e electrodes for wearable thermo-electrochemi.al cells

在线全文

学校读者我要写书评

暂无评论

SusMat 2024年第4期4卷 77-89页

作者： Yuetong Zhou Di.g Zhang Shuai.Zhang Yuqi.g Li. Rujun Ma gordon Wallace Jun Chen School of Materi.ls Sci.nce and Engi.eeri.g National Institute for Advanced MaterialsNankai UniversityTianjinChina i.telli.ent Polymer Research i.sti.ute ARC Centre of Excellence for Electromaterials ScienceAustralian Institute for Innovative MaterialsUniversity of WollongongNorth WollongongNew South WalesAustralia State Key Laboratory of Electroni. Thi. Fi.m and i.tegrated Devi.es University of Electronic Science and Technology of ChinaChengduChina

Thermo-electrochemi.al cells(TECs)provi.e a new potenti.l for self-powered devi.es by converti.g heat energy i.to ***,challenges sti.l remai. i. the fabri.ati.n of flexi.le and tough gel electrolytes and thei. compat-i.i.i.y wi.h redox acti.es;otherwi.e,contact problems exi.t between electrolytes and electrodes duri.g stretchi.g or ***,a novel robust and neutral hydrogel wi.h outstandi.g stretchabi.i.y was developed vi. double-network of crossli.ked carboxymethyl chi.osan and polyacrylami.e,whi.h accommodated both n-type(Fe^(2+)/Fe^(3+))and p-type([Fe(CN)_(6)]^(3-)/[Fe(CN)_(6)]^(4-))redox couples and mai.tai.ed stretchabi.i.y(>300%)and recoverabi.i.y(95%compressi.n).Moreover,poly(3,4-ethylenedi.xythi.phene):poly(styrene sulfonate)texti.e elec-trodes wi.h porous structure are i.tegrated i.to gel electrolytes that avoi. contact i.sues and effecti.ely boost the P_(max) of n-and p-type thermocell by 76%and 26%,*** opti.i.ed thermocell exhi.i.s a qui.k current densi.y response and i. conti.ually fully operati.nal under deformati.ns,whi.h sati.fi.s the worki.g condi.i.ns of wearable *** thermocells(four pai.s)are effecti.ely connected i. alternati.g si.gle n-and p-type cells i. seri.s and out-putted nearly 74.3 mV atΔT=10℃.The wearable devi.e i. manufactured i.to a soft-pack thermocells to successfully harvest human body heat and i.lumi.ate an LED,demonstrati.g the potenti.l of the actual appli.ati.n of the thermocell devi.es.

关键词： human body heat porous texti.e electrodes stretchable double-network hydrogel electrolytes thermo-electrochemi.al cells wearable devi.es

Targeti.g proprotei. convertase subti.i.i./kexi. type 9(PCSK9):from bench to bedsi.e

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Si.nal Transducti.n and Targeted Therapy 2024年第2期9卷 509-557页

作者： Xuhui.Bao Yongjun Li.ng Hanman Chang Ti.nji.Cai.Bai.i. Feng Konstanti. gordon Yuekun Zhu Hai.i.n Shi.Yundong He Li.i.Xi. i.sti.ute of Therapeuti. Cancer Vacci.es Fudan University Pudong Medical CenterShanghaiChina Shanghai.Key Laboratory of Regulatory Bi.logy School of Life SciencesEast China Normal UniversityShanghaiChina Department of Oncology Fudan University Pudong Medical CenterShanghaiChina Center for Cli.i.al Research Fudan University Pudong Medical CenterShanghaiChina Cli.i.al Research Center for Cell-based i.munotherapy Fudan UniversityShanghaiChina Department of Pathology Duke University Medical CenterDurhamNCUSA Center for Medi.al Research and i.novati.n Fudan University Pudong Medical CenterShanghaiChina i.sti.ute for Food Safety and Health Illinois Institute of TechnologyChicagoILUSA Department of Soci.logy University of MacaoTaipaMacaoChina Medi.al i.sti.ute Peoples’Friendship University of RussiaMoscowRussia A.Tsyb Medi.al Radi.logi.al Research Center ObninskRussia Department of Colorectal Surgery The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Shanghai.Key Laboratory of Compound Chi.ese Medi.i.es Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineZhangjiang Hi-tech ParkShanghaiChina Department of Radi.ti.n Oncology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina

Proprotei. convertase subti.i.i./kexi. type 9(PCSK9)has evolved as a pi.otal enzyme i. li.i. metaboli.m and a revoluti.nary therapeuti. target for hypercholesterolemi. and i.s related cardi.vascular di.eases(CVD).Thi. comprehensi.e revi.w deli.eates the i.tri.ate roles and wi.e-rangi.g i.pli.ati.ns of PCSK9,extendi.g beyond CVD to emphasi.e i.s si.ni.i.ance i. di.erse physi.logi.al and pathologi.al states,i.cludi.g li.er di.eases,i.fecti.us di.eases,autoi.mune di.orders,and notably,*** explorati.n offers i.si.hts i.to the i.teracti.n between PCSK9 and low-densi.y li.oprotei. receptors(LDLRs),eluci.ati.g i.s substanti.l i.pact on cholesterol homeostasi. and cardi.vascular *** also detai.s the evoluti.n of PCSK9-targeted therapi.s,translati.g foundati.nal bench di.coveri.s i.to bedsi.e appli.ati.ns for opti.i.ed pati.nt *** advent and cli.i.al approval of i.novati.e PCSK9 i.hi.i.ory therapi.s(PCSK9-i.s),i.cludi.g three monoclonal anti.odi.s(Evolocumab,Ali.ocumab,and Tafoleci.ab)and one small i.terferi.g RNA(si.NA,i.cli.i.an),have marked a si.ni.i.ant breakthrough i. cardi.vascular *** therapi.s have demonstrated unparalleled effi.acy i. mi.i.ati.g hypercholesterolemi.,reduci.g cardi.vascular ri.ks,and have showcased profound value i. cli.i.al appli.ati.ns,offeri.g novel therapeuti. avenues and a promi.i.g future i. personali.ed medi.i.e for cardi.vascular ***,emergi.g research,i.clusi.e of our fi.di.gs,unvei.s PCSK9’s potenti.l role as a pi.otal i.di.ator for cancer prognosi. and i.s prospecti.e appli.ati.n as a transformati.e target for cancer *** revi.w also hi.hli.hts PCSK9’s aberrant expressi.n i. vari.us cancer forms,i.s associ.ti.n wi.h cancer prognosi.,and i.s cruci.l roles i. carci.ogenesi. and cancer *** conclusi.n,thi. synthesi.ed revi.w i.tegrates exi.ti.g knowledge and novel i.si.hts on PCSK9,provi.i.g a holi.ti. perspecti.e on i.s transformati.e i.pact i. reshapi.g therapeuti. paradi.ms acr

关键词： PCSK9 metaboli.m convert

Geochemi.al fi.gerpri.ts and hydrocarbon potenti.l of Paleocene mudrocks i. the Tano Basi., Ghana: i.si.hts from bi.markers and stable carbon i.otopes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geochi.i.a 2024年第2期43卷 255-279页

作者： Kojo Amoako Nancy Pearl Osei.Boakye Ni.gni.g Zhong N’Guessan Francoi. De Sales Konan gordon Foli.Pri.ce Opoku Appau Cli.ford Fenyi.Ebenezer Apesegah Research Group for Mari.e Geochemi.try(i.BM-MPi.Bri.gi.g Group) Institute for Chemistry and Biology of the Marine Environment(ICBM)Carl von Ossietzky University OldenburgAmmerlander Heerstr.26129 OldenburgGermany State Key Laboratory of Petroleum Resources and Prospecti.g College of GeosciencesChina University of PetroleumBeijing 102249China Department of Geologi.al Engi.eeri.g Faculty of Civil and Geo-EngineeringKwame Nkrumah University of Science and TechnologyKumasiGhana Ghana Nati.nal Gas Company 225 Osibisa CloseAirport WestAccraGhana Petroleum Corporati.n GNPCPMBPetroleum HouseTemaGhana

The Paleocene mudrocks i. Ghana’s Tano Basi. have recei.ed li.i.ed attenti.n despi.e ongoi.g efforts to explore hydrocarbon resources.A thorough geochemi.al analysi. i. i.perati.e to assess these mudrocks’petroleum generati.n potenti.l and formulate effecti.e explorati.n *** thi. study,a comprehensi.e geochemi.al analysi. was carri.d out on ten Paleocene rock cutti.gs extracted from TP-1,a di.covery well wi.hi. the Tano *** analyti.al techni.ues,i.cludi.g total organi. carbon(TOC)analysi.,Rock–Eval pyrolysi.,gas chromatography-mass spectrometry,and i.otope rati.-mass spectrometry,were employed to eluci.ate thei. hydrocar-bon potenti.l and organi. ***ﬁndi.gs i. thi. study were subsequently compared to exi.ti.g geochemi.al data on Paleocene source rocks i. the South Atlanti. margi.al *** results i.di.ated that the Paleocene samples have TOC content rangi.g from 0.68 to 2.93 wt%.The prevalent kerogen types i.enti.ed i. these samples were Type Ⅱ and Type Ⅲ.Molecular and i.otope data suggest that the organi. matter found i. the Paleocene mudrocks can be traced back to land plants and lower aquati. *** mudrocks were deposi.ed i. a transi.ti.nal envi.onment wi.hﬂuctuati.g water sali.i.y,charac-teri.ed by sub-oxi. redox *** i.di.es,both bulk and molecular,i.di.ated a spectrum of maturi.y levels wi.hi. the Paleocene mudrocks,spanni.g from i.mature to margi.ally mature,wi.h i.creasi.g maturi.y observed wi.h greater *** compari.on,the organi. composi.i.n and deposi.i.nal envi.onments of Paleocene source rocks i. the Tano Basi. closely resemble those found i. the Ni.er Delta Basi.,Douala,and Kri.i.Campo Basi.s,the Kwanza Formati.n i. Angola,and certai. Brazi.i.n margi.al ***,i. i. worth noti.g that Paleocene source rocks i. some of the basi.s,such as the Ni.er Delta and Brazi.i.n margi.al basi.s,exhi.i. rela-ti.ely hi.her thermal maturi.y levels compared to those observed i. the current Paleocene samp

关键词： Paleocene source rocks Source i.put Deposi.i.nal envi.onment Thermal maturi.y Hydrocarbon potenti.l Tano Basi. West Afri.a