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Quality of survival in patients treated for malignant biliary obstruction caused by unresectable pancreatic head cancer: surgical versus non-surgical palliation

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Hepatobiliary & Pancreatic Diseases International 2008年第6期7卷 643-648页

作者： hyung ook kim Sang Il Hwang Hungdai kim Jun Ho Shin Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

BACKGROUND:Appropriate palliation for unresectable pancreatic head cancer is most *** study was undertaken to compare the survival of patients with biliary obstruction caused by unresectable pancreatic head cancer after surgical and non-surgical palliation. METHODS:We retrospectively reviewed 69 patients who underwent palliative treatment for unresectable pancreatic head ***-two patients with locally advanced disease (local vascular invasion)and 17 with distant metastatic disease were *** patients were divided into two groups,surgical and non-surgical palliation. RESULTS:Thirty-eight patients underwent biliary bypass surgery and 31 had percutaneous transhepatic biliary drainage(PTBD).There was no significant difference in the early complications,successful biliary drainage, recurrent jaundice,and 30-day mortality between surgical palliation and ***,in 52 patients whose tumor was unresectable secondary to local vascular invasion,the rate of recurrent jaundice after successful surgical biliary palliation was lower than that in patients who had non- surgical palliation(P<0.05).The patients who underwent surgical palliation had a longer hospital-free survival rate(P<0.001),although they had a longer postoperative hospital stay(P=0.004)during the first admission ***:In patients with preoperative evaluations showing potentially resectable tumors and/or no metastatic lesions,surgical exploration should be ***,in patients who have unresectable cancer or limited metastatic disease on exploration,surgical palliation should be performed for longer survival and better quality of survival.

关键词： pancreatic cancer obstructive jaundice palliation

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Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 591-596页

作者： hyung ook kim Seung Kwon kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong Kyun Cho Byung Ik kim Departments of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Radiology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Division of Interventional Radiology Mallinckrodt Institute of RadiologyWashington University School of Medicine Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient *** ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating *** objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous ***:Eight patients(male,seven;age,49-67 years) with 8 HCCs in difficult locations were treated by intraoperative *** of the patients had local tumor progression after initial transarterial chemoembolization or ultrasound(US)guided percutaneous *** locations of the tumors were hepatic dome in six patients,posterior subcapsule in one,and caudate lobe in *** tumor size was 2.0 to 6.4 cm(mean,3.9 cm).Intraoperative RFA was performed at the tumor itself and an anticipated resection line under US guidance with 3 cm monopolar single or clustered internally cooled *** resection was performed in six *** month later,treatment response was assessed by contrast material-enhanced computed tomography(CT).CT studies were performed every 2 or 3 months after ***:RFA was technically successful in all tumors,and the contrast-enhanced CT images acquired one month later showed complete disappearance of tumor *** pneumothorax *** a median follow-up of 18 months(range,6-30 months),no tumors showed local *** the follow-up period,four new recurrent tumors were observed in three *** patients were alive at the time of this report and the other four died of hepatorenal syndrome,liver failure,and progression of new recurrent ***:Intraoperative RFA with tumor resection can be an alterative treatment option for HCC in locations difficult for a percutaneous approach.

关键词： hepatocellular carcinoma radiofrequency ablation intraoperative

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Surgical palliation of unresectable pancreatic head cancer in elderly patients

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World Journal of Gastroenterology 2009年第8期15卷 978-982页

作者： Sang Il Hwang hyung ook kim Byung Ho Son Chang Hak Yoo Hungdai kim Jun Ho Shin Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul 110-746 South Korea

AIM: To determine if surgical biliary bypass would provide improved quality of residual life and safe palliation in elderly patients with unresectable pancreatic head cancer. METHODS: Nineteen patients, 65 years of age or older, were managed with surgical biliary bypass (Group A). These patients were compared with 19 patients under 65 years of age who were managed with surgical biliary bypass (Group B). In addition, the results for group A were compared with those obtained from 17 patients, 65 years of age or older (Group C), who received percutaneous transhepatic biliary drainage to evaluate the quality of residual life. RESULTS: Five patients (26.0%) in Group A had complications, including one intraabdominal abscess, one pulmonary atelectasis, and three wound infections. One death (5.3%) occurred on postoperative day 3. With respect to morbidity, mortality, and postoperative hospitalization, no statistically significant difference was noted between Groups A and B. The number of readmissions and the rate of recurrent jaundice were lower in Group A than in Group C, to a statistically significant degree (P = 0.019, P = 0.029, respectively). The median hospital-free survival period and themedian overall survival were also signifi cantly longer in Group A (P = 0.001 and P < 0.001, respectively). CONCLUSION: Surgical palliation does not increase the morbidity or mortality rates, but it does increase the survival rate and improve the quality of life in elderly patients with unresectable pancreatic head cancer.

关键词： Adenocarcinoma Elderly Palliative surgery Pancreas neoplasms

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Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly

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World Journal of Gastroenterology 2009年第6期15卷 722-726页

作者： hyung ook kim Jung Won Yun Jun Ho Shin Sang Il Hwang Yong Kyun Cho Byung Ho Son Chang Hak Yoo Yong Lai Park Hungdai kim Departments of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of MedicineSeoul 110-746 South Korea Departments of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM:To evaluate the outcome of laparoscopic cholecystectomy(LC)in patients aged 80 years and older. METHODS:A total of 353 patients aged 65 to 79 years(group 1)and 35 patients aged 80 years and older(group 2)underwent *** were further classified into two other groups:those with uncomplicated gallbladder disease(group A)or those with complicated gallbladder disease(group B). RESULTS:There were no significant differences between the age groups(groups 1 and 2)with respect to clinical characteristics such as age,gender,comorbid disease,or disease *** operative time,conversion rate,and the incidence of major postoperative complications were similar in groups 1 and ***,the percentage of high-risk patients was significantly higher in group 2 than in group 1 (20.0%vs 5.7%,P<0.01).Group A comprised 322 patients with a mean age of 71.0±5.3 years,and group B comprised 51 patients with a mean age of 69.9±4.8 *** group B,mean operative time (78.4±49.3 min vs 58.3±35.8 min,P<0.01),mean postoperative hospital stay(7.9±6.5 d vs 5.0±3.7 d, P<0.01),and the incidence of major postoperative complications(9.8%vs 3.1%,P<0.05)were significantly greater than in group *** conversion rate tended to be higher in group B,but this difference was not significant. CONCLUSION:Perioperative outcomes in elderly patients who underwent LC seem to be influenced by the severity of gallbladder disease,and not by chronologic *** octogenarians,LC should be performed at an earlier,uncomplicated stage of the disease whenever possible to improve perioperative outcomes.

关键词： Elderly Laparoscopic cholecystectomy Octogenarians Gallbladder Cholecystitis

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Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam kim Jun Su Park En hyung kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

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Modeling the effects of constructed wetland on nonpoint source pollution control and reservoir water quality improvement

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Journal of Environmental Sciences 2010年第6期22卷 834-839页

作者： Jonghwa Ham Chun G.Yoon hyung-Joong kim hyung-Chul kim Rural Research Institute of KRC Environmental Science Department Konkuk University

This article describes the integrated modeling approach for planning the size and the operation of constructed wetlands for maximizing retention of nonpoint source pollutant loads and reservoir water-quality improvement at a catchment scale. The experimental field-scale wetland systems （four sets, 0.88 ha each） have been in operation since 2002, where water depth was maintained at 30-50 cm and hydraulic loading rate was at 6.3-18.8 cm/day. The wetland system was found to be adequate for treating polluted stream water with stable removal efficiency even during the winter. The integrated modeling system （modified-BASINS） was applied to the Seokmoon estuarine reservoir watershed and calibrated with monitoring data from constructed wetland, stream, and reservoir. The calibrated integrated modeling system estimated that constructing wetlands on 0.5% （about 114 ha） of the watershed area at the mouth of reservoir could reduce 11.61% and 13.49% of total external nitrogen and phosphorus loads, respectively. It also might improve the nitrogen and phosphorus concentration of the reservoir by 9.69% and 16.48%, respectively. The study suggested that about 0.1%-1.0% of the watershed area should be allocated for constructed wetland to meet specified water-quality standards for the estuarine reservoir at the polder area where land use planning is relatively less complicated.

关键词： constructed wetland estuarine reservoir integrated modeling system nonpoint source pollution control polder area water quality improvement

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The Effect of Diffuser Angle on the Discharge Coefficient of a Miniature Critical Nozzle

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Journal of Thermal Science 2010年第3期19卷 222-227页

作者： Jae hyung kim Heuy Dong kim Toshiaki Setoguchi School of Mechanical Engineering Andong National UniversityAndong760-749Korea Department of Mechanical Engineering Saga University1HonjoSagaJapan

Many researches on critical nozzles have been performed to accurately measure the mass flow rate of gas flow,and to standardize the performance as a flow ***,much interest is being paid on the measurement of very small mass flow rate in industry fields such as MEMS ***,the design and performance data of the critical nozzles obtained so far have been applied mainly to the critical nozzles with comparatively large diameters,and the works available on miniature critical nozzles are *** the present study,a computational fluid dynamics method has been applied to investigate the influence of the diffuser angle on discharge coefficient of the miniature critical *** computations,the throat diameter of critical nozzle is varied from 0.2 mm to 5.0 mm and the diffuser angle is changed from 2 deg to 8 *** computational results are validated with some experimental data *** results show that the present computational results predict appropriately the discharge coefficient of the gas flows through miniature critical *** is known that the discharge coefficient is considerably influenced by the diffuser angle,as the throat diameter of nozzle becomes small below a certain *** implies that the miniature critical nozzles should be carefully designed.

关键词： Compressible Flow Critical Nozzle Compressible Flow Discharge Coefficient Diffuser Configuration Reynolds Number

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Fractionation of heavy metals in runoff and discharge of a stormwater management system and its implications for treatment

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Journal of Environmental Sciences 2014年第6期26卷 1214-1222页

作者： Marla Maniquiz-Redillas Lee-hyung kim Department of Civil and Environmental Engineering Kongju National University

A stormwater management system utilizing the mechanisms of sedimentation and filtration/infiltration was developed and constructed for the immobilization of suspended solids and heavy metal constituents （Fe, Zn, Pb, Cr, Cu, Cd, Ni） in runoff. Monitoring took place between May 2010 and November 2012 on a total of 24 storm events. This research on the fractionation of heavy metals in runoff and discharge of a stormwater system provided insight on the actual efficiency of the system and determined the implications for treatment of the particulate-bound and dissolved heavy metals in runoff. Results revealed that the partitioning of heavy metal load in runoff in either dissolved or particulate-bound were influenced by flow rate and total suspended solids load, and evident in high-intensity storm （rainfall-runoff event）. On the other hand, the partitioning of heavy metal load discharge from the stormwater system was more apparent during the early period of discharge having higher variability in dissolved than particulate-bound heavy metal. Findings revealed that fractionation of heavy metals played an important role in the performance of the stormwater system; thus, must be considered in designing stormwater systems. For the stormwater system to be effective, it is recommended to design the system treating not only the early period of a storm （first flush criteria） rather until the peak part of the hydrograph （high flow rate where partitioning was greatest） from a load basis.

关键词： dissolvedheavy metalsparticulate-boundroad runoffstormwater management

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Extracts from Paeonia lactiflora Pallas, Rehmannia Glutinosa var. Purpurea Makino, Perilla Frutescens var. Acuta Kudo may increase the endometrial receptivity through expression of leukemia inhibitory factor and adhesion molecules

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Journal of Traditional Chinese Medicine 2019年第1期39卷 15-25页

作者： Eun-Yeong kim Tae-Wook Chung Hee-Jung Choi Yeon-Seop Jung Syng-ook Lee Jun-Yong Choi hyung Sik kim Sooseong You Myeong Soo Lee Ki-Tae Ha School of Korean Medicine and Korean Medical Research Center for Healthy Aging Pusan National UniversityYangsan 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-aging Pusan National UniversityYangsan 50612Republic of Korea Department of Food Science and Technology Keimyung UniversityDaegu 42601Republic of Korea National Clinical Research Center for Korean Medicine Korean Medicine Hospital of Pusan National UniversityYangsan 50612Republic of Korea Laboratory of Molecular Toxicology School of PharmacySungKyunKwan UniversitySuwon 16419Republic of Korea Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea

OBJECTIVE: To find out the combination of the extracts from Paeonia lactiflora Pallas(PL), Rehmannia Glutinosa var. Purpurea Makino(RG), Perilla Frutescens var. Acuta Kudo(PF) to increase endometrial ***: Herbal medicines were extracted with boiling water and polysaccharides were *** examined the effect of PL, RG, and PF(PRP), a most effective herbal formula deduced from constitutive ingredient herbs of Antai Yin which is composed of PRP, on the leukemia inhibitory factor(LIF) expression and endometrial ***: The combination of the extracts from PRP induced the LIF expression in Ishikawa cells and increased the adhesion between Ishikawa and JAr cells. In addition, PRP-induced attachment of JAr cells onto Ishikawa cells and expression of adhesion molecules, ITGAV, ITGB5, CD44 s, and Lselectin, are significantly reduced by knock-down of LIF ***: Induced by the combination of the PRP extracts, the adhesion between trophoblast and endometrial cells are mediated by expression of LIF and adhesion molecules. Thus, we suggest the combination of the PRP extracts may be a novel therapy for enhancing embryo implantation rate.

关键词： Paeonia Rehmannia Perilla Embryo implantation Endometrium Leukemia inhibitory factor Cell adhesion molecules

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Fabrication of Piezoelectric Cellulose Paper and Audio Application

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Journal of Bionic Engineering 2009年第1期6卷 18-21页

作者： Jung-Hwan kim Sungryul Yun Joo-hyung kim Jaehwan kim Creative Research Center for EAPap Actuator Department of Mechanical EngineeringINHA University253 Young-Hyun DongNam GuIncheon402-751Republic of Korea

We report the fabrication process of piezoelectric cellulose paper and the enhancement method of its piezoelectric property. Stretching method with different wet-drawing ratios was introduced to increase the piezoelectric property of cellulose paper during regeneration *** is observed that the Young's modulus and the piezoelectric charge constants are very dependent on the drawing ratio and the direction of nanofibrils of piezoelectric *** the enhanced piezoelectric property,we prove that the flexible regenerated piezoelectric cellulose can be applied to the potential acoustic applications such as thin piezoelectric paper speaker.

关键词： piezoelectric speaker piezoelectricity cellulose wet-drawing process

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