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世界临床病例杂志 2023年第27期11卷 6664-6669页

作者： Sang Jae Lee Si-Youn Song Min Kyoung Kim hyung gyun na Chang Hoon Bae Yong-Dae Kim Yoon Seok Choi Department of Otorhinolaryngology-Head and Neck Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Division of Hematology-Oncology Department of Internal MedicineCollege of MedicineYeungnam UniversityDaegu 42415South Korea Regional Center for Respiratory Diseases Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND Anaplastic thyroid cancer(ATC)is a rare but aggressive type of thyroid *** V600E-mutation,which is found in 10%-50%of ATCs,is associated with poor prognosis.A recent clinical trial reported a substantial clinical benefit of concomitant treatment of dabrafenib(BRAF inhibitor)and trametinib(MEK inhibitor)for treating BRAF V600E-mutant ***,reports on patients with ATC treated with this regimen following surgery are *** SUMMARY We report the case of a 63-year-old female patient diagnosed with BRAF V600Emutant *** three surgeries—total thyroidectomy,total laryngectomy,and neck dissection—she was diagnosed with lung metastasis during *** metastatic ATC was successfully treated with dabrafenib and *** patient achieved a complete response at the 32-mo *** Adjuvant chemotherapy with dabrafenib plus trametinib is efficacious for treatment and prevention of recurrent ATC with BRAF mutation following surgery.

关键词： Thyroid carcinoma Anaplastic BRAF Dabrafenib Trametinib Chemotherapy Adjuvant Case report

LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 177-189页

作者： Oh Kwang Kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae na Yan Gao Sam Seok Cho Sung Hwan Ki Youngshik Choe Jun Nyung Lee Yun-Sok Ha Eun Ju Bae Tae gyun Kwon Byung-Hyun Park Sangkyu Lee BK21 Plus KNU Multi-Omics Based Creative Drug Research Team College of PharmacyResearch Institute of Pharmaceutical SciencesKyungpook National UniversityDaegu 41566Republic of Korea Department of Biochemistry and Molecular Biology Chonbuk National University Medical SchoolJeonjuJeonbuk 54896Republic of Korea College of Pharmacy Chosun UniversityGwangju 61452Republic of Korea Korea Brain Research Institute Daegu 41068Republic of Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Urology Kyungpook National University HospitalDaegu 41566Republic of Korea College of Pharmacy Chonbuk UniversityJeonjuJeonbuk 54896Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men *** 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival *** great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain *** 5(SIRT5),an naD+-dependent desuccinylase,is hypothesized to be a key regulator of various ***,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively ***,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa *** correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also *** quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(K118su)of lactate dehydrogenase A(LDHA),which plays a role in increasing LDH *** a substrate of SIRT5,LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa *** study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment.

关键词： Sirtuin 5 Lactate dehydrogenase A Lysine succinylation PCa progression

Synergistic Effect of Watermelon Powder and Lactococcus lactis subsp lactis Supplemented Diet Partially Ameliorates Aβ42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila

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American Journal of Plant Sciences 2016年第6期7卷 991-1000页

作者： Dong gyun Ko Young Bum Eun Jong Uk na Sang-Tae Kim Korean Minjok Leadership Academy Hoengseong-gun Republic of Korea Biomedical Research Institute Department of Neuropsychiatry Bundang Hospital of Seoul National University College of Medicine Seongnam Republic of Korea

Oxidative stress has been strongly related with Alzheimer disease pathogenesis. We determined the effects of watermelon powder (WMP) and Lactococcus lactis subsp lactis (LAL) supplementation on the generated Aβ42-induced phenotypes in a Drosophila melanogaster model of AD. Enhanced Aβ42 expression in D. melanogaster neurons can diminish lifespan and flight ability. We have observed longevity methods to assay the effects of WMP and LAL on D. melanogaster survival. Furthermore, flies expressing Aβ42 in their body fed WMP and LAL had up to 90 days, or 35% longer median lifespan than those fed a control diet. In addition, synergistic effect of WMP and LAL improved Aβ42-induced flight impairments in the Drosophila wing tissues. Our microscope experiments revealed that individuals fed synergistic effect of WMP and LAL had ameliorated Aβ42 expression as well as increment of flight ability than Aβ42-induced flies. We propose that WMP is typically rich in L-citrulline and LAL, rich in naturally occurring probiotics and antioxidants, and that it promotes the survival of neurons in brain and wing muscle tissues with increased levels of Aβ42 via a protective cell survival mechanism.

关键词： Drosophila melanogaster Lactococcus lactis Watermelon Lifespan Ommatidia Aβ42

Dual PINK Mutant and A<i>β</i>42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila Partially Alleviates by a <i>Lactococcus lactis</i>Supplemented Diet

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Journal of Behavioral and Brain Science 2015年第7期5卷 266-273页

作者： Dong gyun Ko Young Bum Eun Jong Uk na Sang-Tae Kim Korean Minjok Leadership Academy Hoengseong-Gun Republic of Korea Department of Neuropsychiatry Bundang Hospital of Seoul National University College of Medicine Biomedical Research Institute Seongnam City Republic of Korea

Oxidative stress has been strongly related with Parkinson disease (PD) and Alzheimer disease pathogenesis. We determined the effects of Lactococcus lactis (LAL) supplementation on the generated loss-of-function mutants of PINK1 B9, an AR-JP-linked gene and Aβ42 induced phenotypes in a Drosophila melanogaster model of PD/AD. Enhanced mutant PINK1 B9 and Aβ42 expression in D. melanogaster dopaminergic (DA) neurons can curtail lifespan, flight muscle accompanied by locomotive defects and we have observed longevity methods to assay the effects of LAL on D. melanogaster survival. Furthermore, flies expressing mutant PINK1 B9 and Aβ42 in their brain fed LAL had up to the two weeks, or 25%, greater median lifespan than those fed a standard sucrose diet. In addition, LAL improved mutant PINK1 B9 and Aβ42-induced flight impairments in the Drosophila wing. Our microscopy analyses revealed that individuals fed LAL had improved atypical ommatidia as well as an increased thirteen percentage of flight ability than those fed a control diet. We propose that LAL, rich in naturally occurring probiotics and antioxidants, promotes the survival of neurons in brain and wing muscle tissues with increased levels of mutant PINK1 B9 and Aβ42 via a protective cell survival mechanism.

关键词： Drosophila melanogaster Lactococcus lactis PINK1 Lifespan Ommatidia Aβ42

Assessment of Sesquiterpene Lactones in Lettuce(Lactuca sativa L.)Germplasm

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Assessment of Sesquiterpene Lactones in Lettuce(Lactuca sati...

2014年中国作物学会学术年会

作者： Jeong-Ro Lee Susanna-Choi na-Young Ro Ho-Cheol Ko Jeong-Suk Sung Taek-Ryun Kown Young-Yi Lee Jae-gyun Gwag national Agrobiodiversity Center National Academy of Agricultural ScienceRural Development Administration

Sesquiterpene lactones(SLs) are a group of over 500 compounds,characteristic of the Asteraceae and sporadically occurring in other plant *** are interesting from the chemical and chemotaxonomic point of view,and show anti-tumour,anti-leukaemic,anti-cardiovascular disease,reduction of inflammation,anti-microbial *** have been indicated as a property connected to appetite and digestion promotion in *** of folk medicines also implicate SLs as the active ingredient in many treatments for other ailments such as diarrhea,burns,influenza,and *** of 266 accessions of lettuce(Lactuca sativa) germplasm introduced from 43 countries conserved in RDA genebank was used this *** was extracted by methanol from freeze-dried lettuce leaves,sampled at bolting *** SLs compounds,lactucin,lactucopicrin and 8-deoxylactucin,was quantified by *** range of lactucin content showed trace 120.0 μg/g of dried leaves and average was 19.0±1.3,and distribution range trace 488.1 μg and average 16.8±2.9 in 8-deoxylactucin content,and distribution range trace1,189.0 μg and average 195.2±9.9 in lactucopicrin content,and distribution range17.4,299.9 μg and average 231.0±11.4 in total SLs *** lettuce have lowest average total SLs content,on the contrary romaine have highest SLs content and ***,wild relatives,have higher than *** accessions have lowest average total SLs content and Great Britain accessions showed highest SLs *** showed higher than bred *** two accessions have more than500μg of total SLs and seventeen accessions have less than 50μg of total *** germplasm can be used as low SLs content cultivar breeding or high SLs content cultivar breeding sources as well as research materials for medical treatment such as,anti-tumour,anti-leukaemic,and antimicrobial activities,etc.

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批判与反思:新媒体对大学生休闲生活的影响

湖北理工学院学报（人文社会科学版） 2014年第6期31卷 38-40,44页

作者：谢晨罗乐均湖北理工学院师范学院湖北黄石435003 韩国釜山国立大学新闻传播学院韩国釜山609735 韩国仁济大学新闻传播学院韩国金海621749

被称为"第五媒体"的新媒体不仅在形式上、技术上是一种革新,更是在观念上的革新。这种革新不仅影响着人们的生活方式,也潜移默化地影响着人们的休闲方式。作为新兴事物的拥趸者,大学生的休闲方式在发生形式与内涵的双重变化。我们在肯... 详细信息

被称为"第五媒体"的新媒体不仅在形式上、技术上是一种革新,更是在观念上的革新。这种革新不仅影响着人们的生活方式,也潜移默化地影响着人们的休闲方式。作为新兴事物的拥趸者,大学生的休闲方式在发生形式与内涵的双重变化。我们在肯定新媒体带来休闲形式多样化、内容扩大化等正面影响的同时,更应该反思新媒体对大学生休闲生活的负面影响。文章用批判的眼光观察新媒体对大学生的休闲生活的影响,试图从反思中找到相应问题的解决之道。

关键词：新媒体休闲方式批判反思

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肝炎患者肝组织内纤连蛋白表达变化的研究

中华医院感染学杂志 2006年第9期16卷 990-992页

作者：王海滨石新惠张云杰张冬青孙娜解放军总医院第一附属医院北京100037

目的研究纤连蛋白(FN)在不同类型的肝炎和肝硬化患者肝组织中的表达和分布及其与血清透明质酸(HA)水平的关系。方法用免疫组化方法和常规病理技术确定纤连蛋白在正常和病变肝组织内的定位和表达量的变化规律,并以放射免疫学方法检测肝... 详细信息

目的研究纤连蛋白(FN)在不同类型的肝炎和肝硬化患者肝组织中的表达和分布及其与血清透明质酸(HA)水平的关系。方法用免疫组化方法和常规病理技术确定纤连蛋白在正常和病变肝组织内的定位和表达量的变化规律,并以放射免疫学方法检测肝病患者血清内透明质酸的含量。结果慢性活动性肝组织中肝细胞和内皮细胞内FN的阳性细胞率明显高于急性肝炎(AH)组和慢性迁延性肝炎(CPH)组(P<0.05);FN在肝硬化患者肝细胞内不表达,在内皮细胞内呈弱阳性表达,但在各型肝炎的炎症细胞浸润区内FN呈阳性表达;肝组织中FN阳性表达的患者血清内HA含量为(203.7±121.6)ng/ml,明显高于阴性和弱阳性表达患者(139.2±158.0)ng/ml和(130.4±65.1)ng/ml(P<0.01)。结论FN是肝纤维化的前驱物质,参与新生纤维组织的形成,与肝组织的损伤及其修复和血清内HA含量增大有关。

关键词：纤连蛋白透明质酸免疫组织化学肝炎肝硬化