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Chinese Medical Journal 2014年第21期127卷 3758-3763页

作者： Hyun-Jin Tae Joon Ha Park Jeong-Hwi Cho In Hye Kim Ji Hyeon Ahn Jae chul lee Jong-Dai Kim Jinseu Park Soo Young Choi Moo-Ho Won Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Chuncheon 200- 702 South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National University Chuncheon 200-701 South Korea

Background Oenanthe javanica is an aquatic perennial herb originated from East ***,the effects of Oenanthe javanica have been proven in various disease *** regarding the antioxidant effect of Oenanthe javanica in the kidney are still *** This study was therefore performed to investigate the effect of the Oenanthe javanica extract （OJE） in the rat kidney using immunohistochemistry for antioxidant enzymes,copper,zinc-superoxide dismutase （SOD1）,manganese superoxide dismutase （SOD2）,catalase （CAT） and glutathione peroxidase （GPx）.Sprague-Dawley rats were randomly assigned to three groups：（1） normal diet fed-group （normal-group）,（2） diet containing ascorbic acid （AA）-fed group （AA-group） as a positive control,（3） diet containing OJE-fed group （OJE-group）.AA and OJE were supplied during 28 *** The side-effects were not observed in all the *** of SOD1,SOD2,CAT and GPx were easily detected in the distal tubules of the kidney,and their immunoreactivities in the AA-and OJE-groups were increased to about 1.4-1.5 times and 2 times,respectively,compared with those in the *** OJE significantly increased expressions of SOD1 ＆ 2,CAT and GPx immunoreactivities in the distal tubules of the rat kidney,and this finding suggests that significant enhancements of endogenous enzymatic antioxidants by OJE treatment may be a legitimate strategy for decreasing oxidative stresses in the kidney.

关键词： Oenanthe javanica extract kidney superoxide dismutases 1 & 2 catalase glutathione peroxidase

Hippophae rhamnoides *** extract enhances cell proliferation and neuroblast differentiation through upregulation of intrinsic factors in the dentate gyrus of the aged gerbil

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Chinese Medical Journal 2014年第23期127卷 4006-4011页

作者： Ji Hyeon Ahn Bai Hui Chen Joon Ha Park In Hye Kim Jeong-Hwi Cho Jae-chul lee Bing Chun Yan Jung Hoon Choi In Koo Hwang Ju-Hee Park Sang-No Han Yun Lyul lee Myong Jo Kim Moo-Ho Won Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Institute of Integrative Traditional & Western Medicine Medical College Yangzhou University Yangzhou Jiangsu 225001 China Department of Anatomy College of Veterinary Medicine Kangwon NationaL University Chuncheon 200-701 South Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul 151-742 South Korea Samsung Herb Medicine Company Limitedl 304 BIO-ldong ChunCheon Biotechnology Innovation Center Chuncheon 200-957 South Korea Oriental Bio-herb Research Institute Kangwon National University Chuncheon 200-701 South Korea

Background Hippophae rhamnoides L.（HL） exerts antioxidant activities against various oxidative stress *** this study,we investigated effects of extract from HL leaves （HLE） on cell proliferation and neuroblast differentiation in the subgranular zone （SGZ） of the dentate gyrus （DG） of aged *** Aged gerbils （24 months） were divided into vehicle （saline）-treated-and *** vehicle and HLE were orally administered with 200 mg/kg once a day for 20 days before *** proliferation and neurobiast differentiation were examined in the DG using Ki67 and doublecortin （DCX）,*** also observed changes in immunoreactivities of superoxide dismutase 1 （SOD1） and superoxide dismutase 2 （SOD2）,brain-derived neurotrophic factor （BDNF）,and phospho-glycogen synthase kinase-3-beta （p-GSK-3β） to examine their relation with neurogenesis using *** The administration of HLE significantly increased the number of Ki67-positive cells and DCX-positive neuroblasts with well-developed processes in the SGZ of the DG of the *** addition,immunoreactivities of SOD1,SOD2,BDNF,and p-GSK-3β were significantly increased in granule and polymorphic cells of the DG in the HLE-treated-group compared with those in the *** HLE treatment significantly increased cell proliferation and neuroblast differentiation,showing that immunoreactivities of SOD1,SOD2,BDNF,and p-GSK-3β were significantly increased in the *** indicate that increased neuroblast differentiation neurogenesis may be closely related to upregulation of SOD1,SOD2,BDNF,and p-GSK-3β in aged gerbils.

关键词： aging antioxidants dentate gyrus hippophae rhamnoides extract neurogenesis neurotrophic factors

Effect of Oenanthe Javanica Extract on Antioxidant Enzyme in the Rat Liver

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Chinese Medical Journal 2015年第12期128卷 1649-1654页

作者： Choong-Hyun lee Joon-Ha Park Jeong-Hwi Cho In-Hye Kim Ji-Hyeon Ahn Jae-chul lee Bai Hui Chen Bich-Na Shin Hyun-Jin Tae Eun Joo Bae II-Jun Kang Moo-Ho Won Jong-Dai Kim Department of Pharmacy College of Pharmacy Dankook University Cheonan 330-714 South Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Department of Biomedical Science Research Institute for Bioscience and Biotechnology Hallym University Chunchon 200-702 South Korea Department of Pediatrics Chuncheon Sacred Heart Hospital College of Medicine Hallym University Chuncheon 200-701 South Korea Department of Food Science and Nutrition Hallym University Chuncheon 200-702 South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 200-701 South Korea

Background：Oenanthe javanica （***） has been known to have high antioxidant properties via scavenging reactive oxygen *** examined the effect of *** extract （OJE） on antioxidant enzymes in the rat ***：We examined the effect of the OJE on copper,zinc-superoxide dismutase （SOD1）,manganese superoxide dismutase （SOD2）,catalase （CAT）,and glutathione peroxidase （GPx） in the rat liver using immunohistochemistry and western blot ***-Dawley rats were randomly assigned to three groups;（1） normal diet fed group （normal-group）,（2） diet containing ascorbic acid （AA）-fed group （AA-group） as a positive control,（3） diet containing OJE-fed group （OJE-group）.Results：In this study,no histopathological finding in the rat liver was found in all the experimental *** of SOD1,SOD2,CAT,and GPx immunoreactive cells and their protein levels were significantly increased in the AA-fed group compared with those in the *** the other hand,in the OJE-group,numbers of SOD1,SOD2,CAT,and GPx immunoreactive cells in the liver were significantly increased by about 190%,478%,685%,and 346%,respectively,compared with those in the *** addition,protein levels of SOD 1,SOD2,CAT,and GPx in the OJE-group were also significantly much higher than those in the ***：OJE significantly increased expressions of SOD 1 and SOD2,CAT,and GPx in the liver cells of the rat,and these suggests that significant enhancements of endogenous enzymatic antioxidants by OJE might be a legitimate strategy for decreasing oxidative stresses in the liver.

关键词： Antioxidant Enzymes Immunohistochemistry Liver Oenanthe Javanica Extract Western Blotting

Digital staining in optical microscopy using deep learning-a review

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PhotoniX 2023年第1期4卷 64-95页

作者： Lucas Kreiss Shaowei Jiang Xiang Li Shiqi Xu Kevin C.Zhou Kyung chul lee Alexander Mühlberg Kanghyun Kim Amey Chaware Michael Ando Laura Barisoni Seung Ah lee Guoan Zheng Kyle J.Lafata Oliver Friedrich Roarke Horstmeyer Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Institute of Medical Biotechnology Friedrich-Alexander University(FAU)ErlangenGermany Department of Biomedical Engineering University of ConnecticutMansfieldConnecticutUSA Department of Radiation Physics Duke UniversityDurhamNC 27708USA Department of Electrical Engineering&Computer Sciences University of CaliforniaBerkeleyCAUSA School of Electrical&Electronic Engineering Yonsei UniversitySeoul 03722Republic of Korea Google Inc.Mountain ViewCA 94043USA Department of Pathology Duke UniversityDurhamNC 27708USA

Until recently,conventional biochemical staining had the undisputed status as well-established benchmark for most biomedical problems related to clinical diagnostics,fundamental research and *** this role as gold-standard,staining protocols face several challenges,such as a need for extensive,manual processing of samples,substantial time delays,altered tissue homeostasis,limited choice of contrast agents,2D imaging instead of 3D tomography and many ***-free optical technologies,on the other hand,do not rely on exogenous and artificial markers,by exploiting intrinsic optical contrast mechanisms,where the specificity is typically less obvious to the human *** the past few years,digital staining has emerged as a promising concept to use modern deep learning for the translation from optical contrast to established biochemical contrast of actual *** this review article,we provide an in-depth analysis of the current state-of-the-art in this field,suggest methods of good practice,identify pitfalls and challenges and postulate promising advances towards potential future implementations and applications.

关键词： Deep learning Digital staining Optical microscopy Virtual staining In-silica Pseudo-H&E Virtual fluorescence Generative models Image translation

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钢结构建筑柱失效的敏感度分析

钢结构(中英文) 2011年第4期 82-83页

作者： Jinkoo Kim Jun-Hee Park Tae-hyung lee

研究钢结构建筑连续倒塌对各设计参数的敏感度,包括:梁、柱和支撑的屈服强度,活荷载取值,弹性模型及阻尼比等。应用MonteCarlo模拟,Tornado表分析和一次二阶矩方法确定设计参数的不确定性。分析结果表明,在抗弯框架中,梁屈服强度在各设... 详细信息

研究钢结构建筑连续倒塌对各设计参数的敏感度,包括:梁、柱和支撑的屈服强度,活荷载取值,弹性模型及阻尼比等。应用MonteCarlo模拟,Tornado表分析和一次二阶矩方法确定设计参数的不确定性。分析结果表明,在抗弯框架中,梁屈服强度在各设计参数中影响最大,而在双重系统建筑中,柱屈服强度在各设计参数中影响最大。强度不确定构件的竖向位移敏感度表明,抗弯框架和双重系统建筑的连续倒塌机构因为竖向荷载分布模式不同而完全不同。

关键词：连续倒塌敏感度分析抗弯框架一次二阶矩 Monte Carlo模拟 Tornado表

辣椒中ABA介导的干旱胁迫响应相关基因CaDRT1的鉴定与功能分析

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辣椒杂志 2016年第3期14卷 40-50页

作者： Woonhee Baek Sohee Lim Sung chul lee 刘越孔秋生中央大学生命科学系华中农业大学园艺林学学院

植物时常受到高盐和干旱等各种各样的环境胁迫,因此植物也进化出了各种防御机制以应对胁迫所带来的毒害作用。脱落酸(ABA)是一种植物激素,调控植物的生长发育并对非生物胁迫产生响应。本研究从经ABA处理的甜辣椒(Capsicum annuum)叶片... 详细信息

植物时常受到高盐和干旱等各种各样的环境胁迫,因此植物也进化出了各种防御机制以应对胁迫所带来的毒害作用。脱落酸(ABA)是一种植物激素,调控植物的生长发育并对非生物胁迫产生响应。本研究从经ABA处理的甜辣椒(Capsicum annuum)叶片中鉴定出了一个耐旱基因Ca DRT1(Drought Tolerence 1)。Ca DRT1基因在叶片中的表达受环境胁迫大幅诱导。经ABA处理后,Ca DRT1在辣椒叶片中大量表达,表明Ca DRT1蛋白在非生物胁迫响应中具有着重要功能。通过病毒诱导基因沉默(VIGS)技术沉默Ca DRT1基因后,叶片气孔关闭受限,蒸腾失水量上升,植株受到显著伤害。Ca DRT1过表达(Ca DRT1-OX)的拟南芥在发芽期、幼苗期及成株阶段均呈ABA敏感的表型。此外,Ca DRT1-OX植株呈耐旱表型,其特点是气孔关闭程度高,蒸腾率低,叶片温度高,叶片中干旱应答基因表达量增加。上述结果表明Ca DRT1在ABA介导的干旱胁迫响应中起正向调控的作用。

关键词： ABA CaDRT1 干旱胁迫辣椒病毒诱导基因沉默

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高校体育档案管理存在的问题及对策研究

当代体育科技 2019年第6期9卷 115-115,117页

作者：许章元 Kim Sun Ju lee Joo hyung 韩国国立公州大学韩国32588

高校体育档案管理工作极为重要,事关高校体育事业发展。首先分析高校体育档案管理存在的问题,在此基础上提出相关对策。希望相关措施的提出可进一步促进高校体育档案管理效率的持续提升。

关键词：高校体育档案管理数字化

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韩国城市与区域规划体系发展过程与特点

北京规划建设 2005年第5期 62-64页

作者： Man-hyung lee Chan-Ho Kim 高毅存国立Chungbuk大学都市工程系国立Chungang大学都市工程系

韩国经验:政治与经济因素日本殖民时代结束后,朝鲜陷入了严重的国家分裂与大萧条中,这直接导致了1950年的朝鲜战争,造成150万人伤亡,40%工业设施被毁.基于资本主义的意识形态,当时的韩国总统禁止任何社会主义政治运动,面对社会动荡,他... 详细信息

韩国经验:政治与经济因素日本殖民时代结束后,朝鲜陷入了严重的国家分裂与大萧条中,这直接导致了1950年的朝鲜战争,造成150万人伤亡,40%工业设施被毁.基于资本主义的意识形态,当时的韩国总统禁止任何社会主义政治运动,面对社会动荡,他们没有把精力投入到经济发展中,而是把重点放在维持百姓平稳生计和供应基本生活用品上,因此1960年前根本谈不上城市规划.

关键词：城市规划区域规划韩国特点朝鲜战争社会主义工业设施意识形态资本主义

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MOSFET和肖特基二极管技术的新进展

中国电子商情(基础电子) 2008年第11期 48-50页

作者： Spiro Zefferys Misha Seung lee hyung Mook Choi Vishay公司

集成在单片硅芯片上的新型号MOSFET和肖特基二极管有助于实现较轻负载和较高开关频率的DC-DC转换效率,由Vishay Siliconix开发的名为SkyFET的一项新技术,实现了遍及降压式转换器应用负载范围的更高效率。第一款面市的SkyFET器件是为用... 详细信息

集成在单片硅芯片上的新型号MOSFET和肖特基二极管有助于实现较轻负载和较高开关频率的DC-DC转换效率,由Vishay Siliconix开发的名为SkyFET的一项新技术,实现了遍及降压式转换器应用负载范围的更高效率。第一款面市的SkyFET器件是为用作同步整流器电路的低侧开关而优化的。本文将重点讨论这项技术在DC-DC转换器应用中的优势。

关键词： MOSFET 体二极管沟道轻负载肖特基二极管硅二极管转换器变换器仪表

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