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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： hyun-kyung so Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

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Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun kyung Hwang Ik Jae Park Se Won Seo Jae hyun Park so Jeong Park Jin Young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

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Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1781-1783页

作者： so Jung Kim Jeongeun hyun Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center College of DentistryDankook UniversityCheonanRepublic of Korea

The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTL14 in mitigating the progression of metabolic dysfunction-associated fatty liver disease(MAFLD).1 In this study,Wang et *** the downregulation of METTL14 in hepatocytes from both MAFLD patients and high-fat diet(HFD)-induced MAFLD mouse models,underscoring its pivotal role in maintaining hepatic lipid and redox homeostasis in normal livers.

关键词： liver homeostasis al.

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Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： Jeong hyun Cho Minjae Kim Inchan Yang kyung Tae Park Chang Houn Rhee Hai Woong Park Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

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Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan KIM kyung-hyun CHO Sung-Pil LEE Hui-Ju KIM Yae-Ji JUNG Ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

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Metabolic relationships between marine red algae and algae‑associated bacteria

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Marine Life Science & Technology 2024年第2期6卷 298-314页

作者： kyung hyun Kim Jeong Min Kim Ju Hye Baek Sang Eun Jeong Hocheol Kim Hwan Su Yoon Che Ok Jeon Department of Biological Sciences and Biotechnology Hannam UniversityDaejon 34054Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Republic of Korea

Mutualistic interactions between marine phototrophs and associated bacteria are an important strategy for their success-ful survival in the ocean,but little is known about their metabolic ***,bacterial communities in the algal sphere(AS)and bulk solution(BS)of nine marine red algal cultures were analyzed,and Roseibium and Phycisphaera were identified significantly more abundantly in AS than in *** metabolic features of Roseibium RMAR6-6(isolated and genome-sequenced),Phycisphaera MAG 12(obtained by metagenomic sequencing),and a marine red alga,Porphyridium purpureum CCMP1328(from GenBank),were analyzed ***6-6 has the genetic capability to fix nitrogen and produce B vitamins(B1,B2,B5,B6,B9,and B12),bacterioferritin,dimethylsulfoniopropionate(DMSP),and phenylacetate that may enhance algal growth,whereas MAG 12 may have a limited metabolic capability,not producing vitamins B9 and B12,DMSP,phenylacetate,and siderophores,but with the ability to produce bacitracin,possibly modulating algal *** CCMP1328 lacks the genetic capability to fix nitrogen and produce vitamin B12,DMSP,phenylacetate,and *** was shown that the nitrogen-fixing ability of RMAR6-6 promoted the growth of ***-pureum,and DMSP reduced the oxidative stress of *** metabolic interactions between strain RMAR6-6 and *** CCMP1328 were also investigated by the transcriptomic analyses of their monoculture and *** together,potential metabolic relationships between Roseibium and *** were *** study provides a bet-ter understanding of the metabolic relationships between marine algae and algae-associated bacteria for successful growth.

关键词： Metabolic relationship Marine red algae Symbiotic bacteria Roseibium Phycisphaera Porphyridium

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In-Depth Study of Potential-Based Routing and New Exploration of Its Scheduling Integration

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2891-2911页

作者： Jihoon Sung Yeunwoong kyung Department of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon34141Republic of Korea Division of Information&Communication Engineering Kongju National UniversityCheonan31080Republic of Korea

Industrial wireless mesh networks(WMNs)have been widely deployed in various industrial sectors,providing services such as manufacturing process monitoring,equipment control,and sensor data collection.A notable characteristic of industrial WMNs is their distinct traffic pattern,where the majority of traffic flows originate from mesh nodes and are directed towards mesh *** this context,this paper adopts and revisits a routing algorithm known as ALFA(autonomous load-balancing field-based anycast routing),tailored specifically for anycast(one-to-one-of-many)networking in WMNs,where traffic flows can be served through any one of multiple *** essence,the scheme is a hybrid-type routing strategy that leverages the advantages of both back-pressure routing and geographic ***,its novelty lies in being developed by drawing inspiration from another field,specifically from the movement of charges in an electrostatic potential *** on the previous work,this paper explores further in-depth discussions that were not previously described,including a detailed description of the analogy between an electrostatic system and a WMN system based on precise mapping perspectives derived from intensive analysis,as well as discussions on anycast,numerical methods employed in devising the ALFA scheme,its characteristics,and *** is worth noting that this paper addresses these previously unexplored aspects,representing significant contributions compared to previous *** a completely new exploration,a new scheduling strategy is proposed that is compatible with the routing approach by utilizing the potential-based metric not only in routing but also in *** assigns higher medium access priority to links with a larger potential *** simulation results demonstrate the superior performance of the proposed potential-based joint routing and scheduling scheme across various aspects within industrial WMN scenarios.

关键词： Potential-based routing potential differential scheduling industrial wireless mesh networks

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Long-term outcomes of very low birth weight infants with intraventricular hemorrhage:a nationwide population study from 2011 to 2019

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World Journal of Pediatrics 2024年第7期20卷 692-700页

作者： Joonsik Park sook-hyun Park Yu-ra Kwon so Jin Yoon Joo Hee Lim Jung Ho Han Jeong Eun Shin Ho Seon Eun Min soo Park soon Min Lee Department of Pediatrics Yonsei University College of Medicine211 Eonjuro GangnamguSeoul 06273Republic of Korea

Background Advancements in neonatal care have increased preterm infant survival but paradoxically raised intraventricular hemorrhage(IVH)*** study explores IVH prevalence and long-term outcomes of very low birth weight(VLBW)infants in Korea over a *** Using Korean National Health Insurance data(NHIS,2010-2019),we identified 3372 VLBW infants with IVH among 4,129,808 live ***-related claims data,encompassing diagnostic codes,diagnostic test costs,and administered procedures were sourced from the NHIS *** results of the developmental assessments are categorized into four groups based on standard deviation(SD)*** characteristics and complications were compared among the *** regression models were employed to identify significant changes in the incidence of complications and to calculate odds ratios with corresponding 95%confidence intervals for each risk factor associated with mortality and morbidity in ***-term growth and development were compared between the two groups(years 2010-2013 and 2014-2017).Results IVH prevalence was 12%in VLBW and 16%in extremely low birth weight(ELBW)*** the past decade,IVH rates increased significantly in ELBW infants(P=0.0113),while mortality decreased(P=0.0225).Major improvements in certain neurodevelopmental outcomes and reductions in early morbidities have been observed among VLBW infants with *** percent of the population received surgical treatments such as external ventricular drainage(EVD)or a ventriculoperitoneal(VP)shunt,with the choice of treatment methods remaining consistent over *** IVH with surgical intervention group exhibited higher incidences of delayed development,cerebral palsy,seizure disorder,and growth failure(height,weight,and head circumference)up to 72 months of age(Pso significantly associated with abnormal developmental screening test *** The neurodevelopmental outcomes of infa

关键词： Cerebral intraventricular hemorrhage Developmental Hydrocephalus Mortality Posthemorrhagic ventricular dilatation Surgery

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Spray,droplet evaporation,combustion,and emission characteristics of future transport fuels for compression-ignition engines:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第4期11卷 575-613页

作者： Leang so Khuong Nozomu Hashimoto Osamu Fujita Division of Mechanical and Aerospace Engineering Faculty of EngineeringHokkaido UniversitySapporo 060-8628Japan Faculty of Automotive Engineering National Polytechnic Institute of CambodiaPhnom Penh 120901Cambodia

This review examines the potential of hydrogen,ammonia,and biodiesel as alternative fuels,focusing on spray dynamics,droplet evaporation,combustion,and *** offers superior combustion characteristics but faces challenges in NO_(x)*** like nonpremixed direct injection,increased intake boost pressure,and low-pressure EGR are suggested for robust hydrogen combustion in compression-ignition *** of hydrogen start of injection(soI)and water injection(WI)are identified as effective techniques for reducing NO_(x)*** shows inferior combustion and higher NO_(x)and unburned NH_(3)emissions in the same conditions as conventional fuels with conventional *** ammonia spray and evaporation conditions is significant for optimizing an ammonia-air mixture and minimizing wall impingement and ammonia trap in the crevice,thereby improving combustion and emission *** intake pressure,injection pressure,and EGR rate,employing a turbulent jet,and preheating ammonia improve efficiency and reduce NO_(x)*** ammonia combustion requires the implementation of after-treatment systems such as NH_(3)adsorber and De NO_(x)catalysts to mitigate unburned NH_(3)and NO_(x)*** affects the fuel supply system,combustion,and emission characteristics according to its viscosity and *** injection pressure and blending with volatile fuels enhance spray and *** biodiesel preheating temperatures for the injection pump and injector are crucial for achieving the best pump capacity and spray *** utilizing biodiesel-PODE blends and investigating low-temperature biodiesel combustions,there is potential to improve thermal efficiency and PMNO_(x)***,carbon-neutral fuel adoption should be accelerated to mitigate CO_(2)emissions,highlighting the importance of combustion techniques and emissions reduction strategies.

关键词： Carbon-neutral fuels Spray formation Droplet evaporation Injection strategies Combustion efficiency Emission reduction

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Transparent and Accountable Training Data Sharing in Decentralized Machine Learning Systems

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Computers, Materials & Continua 2024年第6期79卷 3805-3826页

作者： Siwan Noh kyung-hyune Rhee Industrial Science Technology Research Center Pukyong National UniversityBusan48513South Korea Division of Computer Engineering Pukyong National UniversityBusan48513South Korea

In Decentralized Machine Learning(DML)systems,system participants contribute their resources to assist others in developing machine learning *** malicious contributions in DML systems is challenging,which has led to the exploration of blockchain *** leverages its transparency and immutability to record the provenance and reliability of training ***,storing massive datasets or implementing model evaluation processes on smart contracts incurs high computational ***,current research on preventing malicious contributions in DML systems primarily focuses on protecting models from being exploited by workers who contribute incorrect or misleading ***,less attention has been paid to the scenario where malicious requesters intentionally manipulate test data during evaluation to gain an unfair *** paper proposes a transparent and accountable training data sharing method that securely shares data among potentially malicious system ***,we introduce a blockchain-based DML system architecture that supports secure training data sharing through the IPFS ***,we design a blockchain smart contract to transparently split training datasets into training and test datasets,respectively,without involving system *** the system,transparent and accountable training data sharing can be achieved with attribute-based proxy *** demonstrate the security analysis for the system,and conduct experiments on the Ethereum and IPFS platforms to show the feasibility and practicality of the system.

关键词： Decentralized machine learning data accountability dataset sharing

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