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Restenosis of a drug eluting stent on the previous bioresorbable vascular scaffold successfully treated with a drug-coated balloon: A case report

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World Journal of Clinical Cases 2021年第3期9卷 758-763页

作者： hyun Gyung Jang Kyehwan Kim hyun Woong Park Jin-Sin koh Young-Hoon jeong jeong Rang Park MinGyu Kang Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University HospitalJinjuSouth Korea Department of Internal Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalChangwonSouth Korea

BACKGROUND The in-stent restenosis(ISR)rates are reportedly inconsistent despite the increased use of second-generation drug eluting stent(DES).Although bioresorbable vascular scaffold(BVS)have substantial advantages with respect to vascular restoration,the rate of scaffold thrombosis is higher with BVS than with *** treatment strategies have not been established for DES-ISR to *** SUMMARY We report on a case of a 60-year-old man patient with acute coronary *** had a history of ST-segment elevation myocardial infarction associated with very late scaffold thrombosis and treated with a *** angiography revealed significant stenosis,suggesting DES-ISR on the previous *** coherence tomography(OCT)identified a plaque rupture and a disrupted scaffold strut in the neointimal proliferation of *** treat the DES-ISR on the previous BVS,we opted for a drug-coated balloon(DCB)after a balloon angioplasty using a semi-compliant and non-compliant *** patient did not experience adverse cardiovascular events on using a DCB following the use of intensive dual antiplatelet therapy and statin for 24 *** This case highlights the importance of OCT as an imaging modality for characterizing the mechanism of target lesion *** use of a DCB following the administration of optimal pharmacologic therapy may be an optimal strategy for the treatment and prevention of recurrent BVS thrombosis and DES-ISR.

关键词： Bioresorbable vascular scaffold thrombosis In-stent restenosis Drug-coated balloon Optical coherence tomography Intensive dual antiplatelet therapy Case report

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Portable nano probe for micro/nano mechanical scratching and measuring

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 205-209页

作者： Woo-Park jeong Chang-Choi SOO Cho hyun Woo-Lee DEUG Department of Mechanical Design Engineering Chosun University Department of Nano Fusion Technology Pusan National University Department of Nano-mechatronics Engineering Pusan National University

A nano probe system which can measure precise micro parts or optical parts in nanometer range resolution and scratch contact force in mN scale was demonstrated. The nano probe was originally designed for on-machine measuring applications and one kind of contact type measuring probes was designed for miniaturized or microfactory system. It ideally should be of small size and able to measure surface topography in nanometer scale. A commercial capacitive displacement sensor was proposed. It was a new concept in nano probe systems which can measure the displacement of shaft driven by the variation of surface topography. The nano probe mainly consisted of three parts: a capacitive displacement sensor, a porous type air slide and a contact probe part with various tip radiuses. The porous type air slide assured the shaft slided smoothly with controllable normal force in mN scale and had high positioning accuracy. The probe part which was directly in contact with target surface, can be applied to micro/nanoscale scratching as well as the measurement of sample topography by a simple tip change.

关键词：测量探头纳米机械纳米探针电容位移传感器便携式表面形貌测量接触式测头刮擦

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Let-7 miRNA and CDK4 siRNA co-encapsulated in Herceptin-conjugated liposome for breast cancer stem cells

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Asian Journal of Pharmaceutical Sciences 2020年第4期15卷 472-481页

作者： jeong hyun Shin Dae Hwan Shin Jin Seok Kim College of Pharmacy Sookmyung Women’s UniversitySeoul 04310Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea

Recently,breast cancer stem cells(BCSCs)have rapidly emerged as a novel target for the therapy of breast cancer as they play critical roles in tumor growth,maintenance,metastasis,and ***-7 miRNA is known to be downregulated in a variety of cancers,especially BCSCs,whereas CDK4 being overexpressed in human epidermal growth factor receptor 2(HER-2)overexpressing tumor *** this study,let-7 miRNA and CDK4-specific siRNA were chosen as therapeutic agents and co-encapsulated in Herceptinconjugated cationic liposomes for breast cancer *** size,zeta potential,and encapsulation efficacy of mi/siRNA-loaded PEGylated liposome conjugated with Herceptin(Her-PEG-Lipo-mi/siRNA)were 176 nm,28.1 mV,and 99.7%±0.1%,*** cellular uptake(86%)was observed by fluorescence microscopy when SK-BR-3 cells were treated with Her-PEG-Lipo-mi/***,the increased amount of let-7a mRNA and decreased amount of cellular CDK4 mRNA were observed by qRT-PCR when SK-BR-3 cells were treated with Her-PEG-Lipo-mi/siRNA,which was even more so when SK-BR-3 stem cells were used(197 vs 768 times increase for let-7a,62%vs 68%decrease for CDK4).Growth inhibition(65%)andmigration arrest(0.5%)of the cellswere achieved by the treatment of the cells with Her-PEG-Lipo-mi/siRNA,but not withmi/siRNA complex or other *** conclusion,an efficient liposomal delivery system for the combination of miRNA and siRNA to target the BCSCs was developed and could be used as an efficacious therapeuticmodality for breast cancer.

关键词： Let-7 miRNA CDK4 siRNA Liposomes Breast cancer stem cells

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Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 394-400页

作者： Hyemin Seong Joo Yeon jeong Jinhyun Ryu Juyeong Park Yong‑Seop Han hyun-Kyung Cho Seong Jae Kim Jong Moon Park Sang Soo Kang Seong Wook Seo Department of Ophthalmology Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinjuGyeongnam 52727Republic of Korea Department of Ophthalmology Gyeongsang National University Changwon HospitalGyeongsang National UniversityCollege of MedicineChangwon 51472Republic of Korea

AIM: To confirm the changes in proteins related with hypoxia-induced retinal cell death and to assess the effects of resveratrol(Res).METHODS: The therapeutic effect of Res was verified using an ischemic/reperfusion(I/R) model in vivo and a hypoxia modelin retinal ganglion cells(RGCs) in *** of RGCs were confirmed by TUNEL *** expression was confirmed by Western blotting and *** addition, flow cytometric analysis was used to confirm the response in the cell unit to obtain more accurate ***: ErbB2 expression and apoptosis in the ganglion cell layer(GCL) increased after I/R *** of Res rescued I/R-induced ganglion cell death, downregulated apoptosis and ErbB2 protein expression in the *** subsequent in vitro models, Res affects apoptosis by regulating the phosphorylation and expression of mouse double minute 2 homolog(MDM2), along with those of *** results suggest that Res reverses GCL-specific apoptosis via downregulation of ErbB2 in ischemic ***: In light of Res favorable properties, it should be evaluated in the treatment of RGC death and related retinal disease characterized by ErbB2 and MDM2 ***, Res is appropriate therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2.

关键词： ischemia/reperfusion injury hypoxia retinal ganglion cell resveratrol ErbB2

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Lichen Planus Pigmentosus Inversus:Two Case Reports

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International Journal of Dermatology and Venereology 2022年第2期5卷 116-118页

作者： Se Hoon Lee Minah Cho Yu Jin Han Yu Ri Woo Sang hyun Cho jeong Deuk Lee Hei Sung Kim Department of Dermatology Incheon St.Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoulSouth Korea.

Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous *** to its rarity,only a few LPPI cases are *** herein describe two rare cases of *** presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary ***:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural *** axillae and flanks were the most commonly affected areas,followed by the groin and *** half of the female patients had inframammary fold *** shows higher female predominance than Lichen planus *** were fewer cases that lasted more than 3 years compared to ***:LPPI is a rare variant of lichen planus,with a locational characteristic and female ***,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis.

关键词： lichen planus pigmentosus lichen planus pigmentosus inversus

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Unusual presentation of granulomatosis with polyangiitis causing periaortitis and consequent subclavian steal syndrome:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1433-1438页

作者： Uiju Cho Sung-Kyung Kim jeong Min ko Jinyoung Yoo Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Internal Medicine St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Radiology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Granulomatosis with polyangiitis(GPA)is a rare autoimmune disease that involves small-to-medium-sized vessels and forms necrotizing vasculitis with granulomatous *** formation of a large vessel lesion in GPA patients has been scarcely reported,and it can cause confusion in the *** SUMMARY A 27-year-old man presented with mild left-sided pleuritic chest pain that started one year *** imaging study revealed up to 2.5 cm-sized two irregular nodular consolidation nodule in the left lower *** nodules showed central ***,there was a periaortic mass occluding the branching porting of the subclavian *** had positive anti-neutrophil cytoplasmic antibodies(ANCAs),but myeloperoxidase-ANCAs and proteinase 3-ANCAs were *** patient also developed symptoms of subclavian vein syndrome during the *** resection of the lung revealed necrotizing vasculitis,destructive parenchymal abscess and surrounding granuloma,and therefore diagnosed of *** patient started on methotrexate and steroid therapy with a relief of *** Here,we present an unusual manifestation of GPA with periaortitis and consequent subclavian steal syndrome,which has never been previously *** case alerts us that we should include GPA in the differential diagnosis of large vessel vasculitis as well as subclavian steal syndrome.

关键词： Granulomatosis with polyangiitides Wegener granulomatosis Systemic vasculitis Subclavian steal syndrome Periaortitis Case report

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Development of high performance casting analysis software by coupled parallel computation

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China Foundry 2007年第3期4卷 215-219页

作者： Sang hyun CHO jeong Kil CHOI Center For e-Design Korea Institute of Industrial Technology994-32Dongchun-DongYeonsu-GuIncheon406-800Korea

Up to now,so much casting analysis software has been continuing to develop the new access way to real casting processes. Those include the melt flow analysis,heat transfer analysis for solidification calculation,mechanical property predictions and microstructure predictions. These trials were successful to obtain the ideal results comparing with real situations,so that CAE technologies became inevitable to design or develop new casting processes. But for manufacturing fields,CAE technologies are not so frequently being used because of their difficulties in using the software or insufficient computing performances. To introduce CAE technologies to manufacturing field,the high performance analysis is essential to shorten the gap between product designing time and prototyping time. The software code optimization can be helpful,but it is not enough,because the codes developed by software experts are already optimized enough. As an alternative proposal for high performance computations,the parallel computation technologies are eagerly being applied to CAE technologies to make the analysis time shorter. In this research,SMP (Shared Memory Processing) and MPI (Message Passing Interface) (1) methods for parallelization were applied to commercial software "Z-Cast" to calculate the casting processes. In the code parallelizing processes,the network stabilization,core optimization were also carried out under Microsoft Windows platform and their performances and results were compared with those of normal linear analysis codes.

关键词：铸造分析平行计算性能改进铸造过程

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Long-term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants

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Cancer Communications 2023年第10期43卷 1174-1177页

作者： Seogsong jeong Sun Jae Park Minseo Kim Young Jun Park Seulggie Choi Jooyoung Chang Ji Soo Kim Yun Hwan Oh Ahryoung ko Sang Min Park Department of Biomedical Sciences Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Biomedical Informatics CHA University School of MedicineSeongnamSouth Korea Department of Medicine College of MedicineJeonbuk National UniversityJeonjuSouth Korea Medical Research Center Genomic Medicine InstituteSeoul National UniversitySeoulSouth Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea International Healthcare Center Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeongSouth Korea Department of Family Medicine Seoul National University HospitalSeoulSouth Korea

Dear Editor,Antibiotics are considered indispensable in numerous treatments against infectious ***,their over-prescription and widespread use are emerging as important global issues,as they lead to resistant bacteria,reducing the efficacy of antibiotics[1].The defined daily doses per 1,000 habitants per day for antibiotics in South korea is 28,which is much higher than the average of Organization for Economic Co-operation and Development countries[1].In animal studies,antibiotic tigecycline was found to inhibit the proliferation and induce apoptosis of hepatocellular carcinoma(HCC)cells[2].In addition,isoprenoid antibiotic was found to suppress the growth and invasion of HCC by targeting the signal transducer and activator of the transcription 3 signaling cascade[3].Despite evidence of the beneficial effects of antibiotics against HCC,evidence regarding their effects on the longterm development of HCC is *** regarding the incidence of HCC is provided in the Supplementary file.

关键词： doses invasion nationwide

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Stochasticity dominates assembly processes of soil nematode metacommunities on three Asian mountains

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Pedosphere 2023年第2期33卷 331-342页

作者： Shuqi ZOU Jonathan ADAMS Zhi YU Nan LI Dorsaf KERFAHI Binu TRIPATHI Changbae LEE Teng YANG Itumeleng MOROENYANE Xing CHEN Jinsoo KIM hyun jeong KWAK Matthew Chidozie OGWU Sang-Seob LEE Ke DONG Department of Integrative Biotechnology Sungkyunkwan University300 Chuncheon-DongSuwon 16419(Korea) School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210008(China) Key laboratory of Ministry of Education for Environment Change and Resources Use in Beibu Gulf Guangxi Key Laboratory of Earth Surface Processes and Intelligent SimulationNanning Normal University175 East Mingxiu RoadNanning 530001(China) School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601(Korea) korea Polar Research Institute Incheon 21990(Korea) Department of Forestry Environment and SystemsKookmin UniversitySeoul 02707(Korea) State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences71 East Beijing RoadNanjing 210008(China) Institut National Recherche Scientifique Institut Armand-Frappier SantéBiotechnologie531 Boulevard des PrairiesLaval H7V1B7(Canada) College of Life Science and Technology Guangxi University100 Daxue RoadNanning 530004(China) Department of Biological Sciences Kyonggi University154-42 Gwanggyosan-roYeongtong-guSuwon-siGyeonggi-do 16227(Korea) School of Biological Sciences Seoul National University1 Gwanak-roSeoul 08826(Korea)

Nematodes play an important role in ecosystems;however,very little is known about their assembly processes and the factors influencing *** studied nematode communities in bulk soils from three Asian mountain ecosystems to determine the assembly processes of free-living nematode metacommunities and their driving *** each mountain,elevations span a range of climatic conditions with the potential to reveal assembly processes that predominate across multiple biomes.A phylogenetic null modeling framework was used to analyze 18S rRNA gene amplicons to quantify various assembly *** found that phylogenetic turnover between nematode communities on all mountains was dominated by stochastic processes,with“undominated processes”being the most predominant stochastic *** has a significant impact on the relative importance of deterministic and stochastic processes.A variety of climatic and edaphic variables significantly influenced the variations in community assembly processes with elevation,even though their impacts were not consistent between the ***,our results indicate that free-living nematode metacommunities in a wide range of environments are largely structured by stochastic processes rather than by niche-based deterministic processes,suggesting that metacommunities of soil free-living nematodes may respond to climate change in a largely unpredictable way.

关键词： climate change ecological drift elevation gradient environmental stress stochastic process

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Eu^2＋-doped Sr5(PO4)3Br blue-emitting phosphor with high color purity for near-UV-pumped white light-emitting diodes

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Journal of Rare Earths 2018年第9期36卷 917-923页

作者： Zhiwen Gao Shihua Liu Pengfei Sun Jung hyun jeong Ruijin Yu Bin Deng College of Chemistry and Pharmacy Northwest A&F University Yangling 712100 China College of Chemical Biological and Environmental Engineering Xiangnan University Chenzhou 423043 China Department of Physics Pukyong National University Busan 608-737 Republic of Korea

Eu2＋-doped bromophosphateapatite Sr5（PO4）3 Br phosphors were synthesized by the conventional hightemperature solid-state *** crystal structure and luminescence properties of the phosphors,as well as their thermal stability and CIE chromaticity coordinates were systematically *** spectra of Sr5（PO4）3 Br：Eu2＋ exhibit a single blue emission at 450 nm under the excitation of 345 nm,which is ascribed to the 4 f-5 d transition of Eu2＋.The phosphor shows very good thermal stability; The CIE color coordinates are very close to those of BaMgAl10O17：Eu2＋（BAM）.All the properties indicate that the blue-emitting Sr5（PO4）3 Br：Eu2＋ phosphor has potential application in white LEDs.

关键词： Bromophosphate Luminescence EU^2 + ion Rare earths

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