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Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection:A 15-year observational study

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World Journal of Gastroenterology 2022年第36期28卷 5351-5363页

作者： Jae hyun Yoon Sung Kyu Choi Sung Bum Cho Hee Joon Kim Yang Seok ko Chung Hwan Jun Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Gastroenterology and Hepatology Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Surgery Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Surgery Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Surgical resection is one of the most widely used modalities for the treatment of hepatocellular carcinoma(HCC).Early extrahepatic recurrence(EHR)of HCC after surgical resection is considered to be closely associated with poor ***,data regarding risk factors and survival outcomes of early EHR after surgical resection remain *** To investigate the clinical features and risk factors of early EHR and elucidate its association with survival *** From January 2004 to December 2019,we enrolled treatment-naïve patients who were≥18 years and underwent surgical resection for HCC in two tertiary academic *** excluding patients with tumor types other than HCC and/or ineligible data,this retrospective study finally included 779 *** resection of HCC was performed according to the physicians’decisions and the EHR was diagnosed based on contrast-enhanced computed tomography or magnetic resonance imaging,and pathologic confirmation was performed in selected *** Cox regression analysis was performed to identify the variables associated with *** Early EHR within 2 years after surgery was diagnosed in 9.5%of patients during a median followup period of 4.4 *** recurrence-free survival period was 5.2 mo,and the median time to EHR was 8.8 mo in patients with early *** 52.7%of patients with early EHR,EHR occurred as the first recurrence of HCC after surgical *** multivariate analysis,serum albumin100 U/L,surgical margin involvement,venous and/or lymphatic involvement,satellite nodules,tumor necrosis detected by pathology,tumor size≥7 cm,and macrovascular invasion were determined as risk factors associated with early *** sub-categorizing the patients according to the number of risk factors,the rates of both EHR and survival showed a significant correlation with the risk of early ***,multivariate analysis revealed that early E

关键词： Early extrahepatic recurrence Hepatocellular carcinoma Prognosis Surgery Survival

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Enhancing ammonia production rates from electrochemical nitrogen reduction by engineering three-phase boundary with phosphorus-activated Cu catalysts

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Journal of Energy Chemistry 2023年第9期84卷 394-401页

作者： Jeehye Kim Cho Hee Lee Yong hyun Moon Min Hee Lee Eun Hyup Kim Sun Hee Choi Youn jeong Jang Jae Sung Lee School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Pohang Accelerator Laboratory(PAL) Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Electrochemical N_(2) reduction reaction(eNRR) over Cu-based catalysts suffers from an intrinsically low activity of Cu for activation of stable N_(2) molecules and the limited supply of N_(2) to the catalyst due to its low solubility in aqueous ***,we propose phosphorus-activated Cu electrocatalysts to generate electron-deficient Cu sites on the catalyst surface to promote the adsorption of N_(2) *** eNRR system is further modified using a gas diffusion electrode(GDE) coated with polytetrafluoroethylene(PTFE) to form an effective three-phase boundary of liquid water-gas N_(2)-solid catalyst to facilitate easy access of N_(2) to the catalytic *** a result,the new catalyst in the flow-type cell records a Faradaic efficiency of 13.15% and an NH_(3) production rate of 7.69 μg h^(-1) cm^(-2) at-0.2 V_(RHE),which represent 3.56 and 59.2 times increases from those obtained with a pristine Cu electrode in a typical electrolytic *** work represents a successful demonstration of dual modification strategies;catalyst modification and N_(2) supplying system engineering,and the results would provide a useful platform for further developments of electrocatalysts and reaction systems.

关键词： Electrochemical nitrogen reduction reaction Ammonia production Phosphorous modified copper electrodes Gas diffusion electrodes Three-phase boundary PTFE coating

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Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation

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World Journal of Stem Cells 2022年第3期14卷 245-263页

作者： Min-Jung Kim Won Moon jeonghoon Heo Sangwook Lim Seung-hyun Lee Jee-Yeong jeong Sang Joon Lee Department of Biochemistry Cancer Research Institute Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Internal Medicine Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Molecular Biology and Immunology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Radiation Oncology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of General Surgery Kosin University College of MedicineSeogu 49267BusanSouth Korea Department of Ophthalmology Gospel HospitalKosin University College of MedicineSeo-gu 49267BusanSouth Korea

BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to *** concerted efforts,there is no definitive treatment method *** studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are *** We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM *** Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μ*** white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three *** BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in *** The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three *** transplantations of ADSCs delayed the repopulation of BM hematopoietic stem ***-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT *** The results suggested that an optimal amount of MSCs could improve survival rates post-WBI.

关键词： Adipose tissue-derived stem cells Bone marrow suppression Mesenchymal stromal cells Radiation Cell therapy

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Recovery of brachial plexus injury after bronchopleural fistula closure surgery based on electrodiagnostic study:A case report and review of literature

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World Journal of Clinical Cases 2022年第30期10卷 11090-11100页

作者： Young-In Go Da-Sol Kim Gi-Wook Kim Yu Hui Won Sung-Hee Park Myoung-Hwan ko jeong-Hwan Seo Department of Physical Medicine&Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Research Institute of Clinical Medicine of Jeonbuk National University Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Axillary thoracotomy and muscle flap are muscle-and nerve-sparing methods among the surgical approaches to bronchopleural fistula(BPF).However,in patients who are vulnerable to a nerve compression injury,nerve injury may *** this report,we present a unique case in which the brachial plexus(division level),suprascapular,and long thoracic nerve injury occurred after BPF closure surgery in a patient with ankylosing spondylitis and concomitant multiple joint *** SUMMARY A 52-year-old man with a history of ankylosing spondylitis with shoulder joint contractures presented with right arm weakness and sensory impairment immediately after axillary thoracotomy and latissimus dorsi muscle flap surgery for BPF *** the surgery,the patient was positioned in a lateral decubitus position with the right arm hyper-abducted for approximately 6 *** resonance imaging and ultrasound revealed subclavius muscle injury or myositis with brachial plexus(BP)compression and related *** electrodiagnostic study confirmed the presence of BP injury involving the wholedivision level,long thoracic,and suprascapular nerve *** was treated with medication,physical therapy,and ultrasound-guided *** steroid injection at the BP,hydrodissection with 5%dextrose water at the BP and suprascapular nerve,and intra-articular steroid and hyaluronidase injection at the glenohumeral joint were *** postoperative day 194,the pain and arm weakness were resolved,and a follow-up electrodiagnostic study showed marked *** Clinicians should consider the possibilities of multiple nerve injuries in patients with joint contracture,and treat each specific therapeutic target.

关键词： Brachial plexus Electrodiagnosis Physical therapy Surgical flaps Thoracotomy Case report

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Long-primed germinal centres with enduring affinity maturation and clonal migration

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四川生理科学杂志 2022年第9期44卷 1618-1618页

作者： jeong hyun Lee Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology La Jolla CA USA Consortium for HIV/AIDS Vaccine Development The Scripps Research Institute La Jolla CA USA IAVI Neutralizing Antibody Center The Scripps Research Institute La Jolla CA USA Department of Medicine Division of Infectious Diseases and Global Public Health University of California San Diego La Jolla CA USA Department of Immunology and Microbiology The Scripps Research Institute La Jolla CA USA Department of Integrative Structural and Computational Biology The Scripps Research Institute La Jolla CA USA koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA USA Emory National Primate Research Center and Emory Vaccine Center Emory University School of Medicine Atlanta GA USA Ragon Institute of Massachusetts General Hospital Massachusetts Institute of Technology and Harvard University Cambridge MA USA Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA USA Howard Hughes Medical Institute Chevy Chase MD USA Tulane National Primate Research Center Tulane School of Medicine Covington LA USA Department of Surgery Laboratory for AIDS Vaccine Research & Development Duke University Medical Center Duke University Durham NC USA

Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period without further immunization, we demonstrate germinal centre B (BGC) cells that last for at least 6 months. A 186-fold increase in BGC cells was present by week 10 compared with conventional immunization. Single-cell transcriptional profiling showed that both light- and dark-zone germinal centre states were sustained. Antibody somatic hypermutation of BGC cells continued to accumulate throughout the 29-week priming period, with evidence of selective pressure. Env-binding BGC cells were still 49-fold above baseline at 29 weeks, which suggests that they could remain active for even longer periods of time. High titres of HIV-neutralizing antibodies were generated after a single booster immunization. Fully glycosylated HIV trimer protein is a complex antigen, posing considerable immunodominance challenges for B cells1,2. Memory B cells generated under these long priming conditions had higher levels of antibody somatic hypermutation, and both memory B cells and antibodies were more likely to recognize non-immunodominant epitopes. Numerous BGC cell lineage phylogenies spanning more than the 6-month germinal centre period were identified, demonstrating continuous germinal centre activity and selection for at least 191 days with no further antigen exposure. A long-prime, slow-delivery (12 days) immunization approach holds promise for difficult vaccine targets and suggests that patience can have great value for tuning of germinal centres to maximize antibody responses.

关键词： sustained centre holds

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Current Progress on the Geological Record of Microbialites and Microbial Carbonates

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Acta Geologica Sinica(English Edition) 2014年第1期88卷 260-275页

作者： CHEN Jitao LEE jeong-hyun Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences School of Earth and Environmental Sciences Seoul National University

This paper reviews the current progress and problems in the study of microbialites and microbial carbonates. Microbialites and microbial carbonates, formed during growth of microbes by their calcification and binding of detrital sediment, have recently become one of the most popular geological topics. They occur throughout the entire geological history, and bear important theoretical and economic significances due to their complex structures and formative processes. Microbialites are in place benthic microbial buildups, whereas microbial carbonates can be classified into two categories： stabilized microbial carbonates（i.e., carbonate microbialites, such as stromatolites and thrombolites） and mobilized microbial carbonates（i.e., microbial carbonate grains, such as oncoids and microbial lumps）. Various texture, structures, and morphologies of microbialites and microbial carbonates hamper the systematic description and classification. Moreover, complex calcification pathways and diagenetic modifications further obscure the origin of some microbialites and microbial carbonates. Recent findings of abundant sponge spicules in previously identified ＂microbialites＂ challenge the traditional views about the origins of these ＂microbialites＂ and their implications to reef evolution. Microbialites and microbial carbonates did not always flourish in the aftermath of extinction events, which, together with other evidences, suggests that they are affected not only by metazoans but also by other geological factors. Their growth, development, and demise are also closely related to sea-level changes, due to their dependence on water depth, clarity, nutrient, and sunlight. Detailed studies on microbialites and microbial carbonates throughout geological history would certainly help understand causes and effects of major geological events as well as the coevolution of life and environment.

关键词： microbialite microbial carbonate reef calcification calcimicrobe

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Effects of Polymeric Stabilizers on the Synthesis of Gold Nanoparticles

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Journal of Materials Science & Technology 2014年第2期30卷 107-111页

作者： Eun Jung Kim jeong hyun Yeum Jin hyun Choi Department of Advanced Organic Materials Science and Engineering Kyungpook National University Department of Bio-fibers and materials Science Kyungpook National University

Gold nanoparticles （AuNPs） stabilized with sodium alginate （SA）, glycol chitosan （GC）, polyvinyl alcohol （PVA）, and polyethyleneimine （PEI） were synthesized in aqueous solutions at room temperature. Different sizes and size distributions of AuNPs were obtained according to the polymeric stabilizers. The mean particle diameters of AuNPs synthesized with GC and PVA as stabilizers were about 5.1 and 5.3 nm, respectively, while those of AuNPs stabilized with SA and PEI were 8.4 and 10.8 nm, respectively. When SA was used, relatively large particles aggregated to form large clusters. In the case of GC, a number of small particles built up large clusters. When PVA was used, the size and the number of nanoperticles were estimated small with a low weight content of Au. For this reason, the PVA-stabilized AuNPs formed clusters with a small hydrodynamic size. The AuNPs synthesized in the aqueous solution of PEI without a reducing agent, sodium borohydride, were uniform in size and formed the smallest nanoclusters （67.4 nm）. In this case, the highest Au content was obtained. Sufficiently grown nanoparticles with a high Au content and a limited hydrodynamic size are considered to be suitable for a variety of applications.

关键词： Gold nanoparticles Sodium alginate Glycol chitosan Polyvinyl alcohol Polyethyleneimine

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Development of Ubiquitous Simulation Service Structure Based on High Performance Computing Technologies

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Journal of Materials Science & Technology 2008年第3期24卷 374-378页

作者： Sang-hyun CHO jeong-Kil CHOI Center For e-Design KITECH7-47Songdo-DongYeonsu-Ku

The simulation field became essential in designing or developing new casting products and in improving manufacturing processes within limited time, because it can help us to simulate the nature of processing, so that developers can make ideal casting designs. To take the prior occupation at commercial simulation market, so many development groups in the world are doing their every effort. They already reported successful stories in manufacturing fields by developing and providing the high performance simulation technologies for multipurpose. But they all run at powerful desk-side computers by well-trained experts mainly, so that it is hard to diffuse the scientific designing concept to newcomers in casting field. To overcome upcoming problems in scientific casting designs, we utilized information technologies and full-matured hardware backbones to spread out the effective and scientific casting design mind, and they all were integrated into Simulation Portal on the web. It professes scientific casting design on the NET including ubiquitous access way represented by ＂Anyone, Anytime, Anywhere＂ concept for casting designs.

关键词： Parallel computation Message passing interface (MPI) Shared memory processing (SMP) Clustering Ubiquitous

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Fibrillary gelation and dedoping of PEDOT:PSS fibers for interdigitated organic electrochemical transistors and circuits

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npj Flexible Electronics 2022年第1期6卷 330-340页

作者： Young Jin Jo Soo Young Kim jeong Hun hyun Byeonghak Park Seunghwan Choy Gyan Raj koirala Tae-il Kim School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Biomedical Institute for Convergence(BICS) Sungkyunkwan University(SKKU)Suwon 16419Korea

As one of conducting polymers,PEDOT:PSS,is commonly used in organic electronics,especially for bioelectronics due to its advantages such as high electrical and ionic conductivity,solution-processability and *** bioelectronics with the PEDOT:PSS requires advanced techniques to obtain physical/chemical modification of the PEDOT:PSS for improved performance and various *** satisfy these demands,fibrillary gelation of PEDOT:PSS by injection to choline acetate,an ionic liquid,with a constant flow rate was used in this study to make a conductive fiber and improve characteristics of PEDOT:*** fibers by fibrillary gelation showed enhanced electrical conductivity of about 400 S cm^(-1) and volumetric capacitance of about 154 F cm^(−3) which would be strongly beneficial to be utilized for organic electrochemical transistors(OECTs),resulting in a high transconductance of 19 mS in a ***,dedoping of the conductive fibers by PEI(polyethyleneimine)enabled the creation of enhancement-mode *** inverters were then fabricated by connecting depletion and enhancement-mode *** results demonstrate that these conductive fibers and electronic-textiles are suitable candidates for applications in bio-integrated electronics.

关键词： fibers doping digit

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Stick-and-play system based on interfacial adhesion control enhanced by micro/nanostructures

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Nano Research 2021年第9期14卷 3143-3158页

作者： Jung II Yoo Seung hyun Kim Heung Cho ko School of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea

The evolution of membrane-type electronics has facilitated the development of stick-and-play systems,which confer diverse electrical functions to various planar or arbitrary curvilinear *** stick-and-play concept is based on the development of thin electronic devices in a printable format and their subsequent transfer to target *** development of this technology requires control of the interfacial adhesion of the electronic prints for retrieval from a carrier and transfer to the target ***,we discuss the transfer printing for membrane-type electronics,starting from an overview of materials available for flexible substrates,transfer printing of electronic prints for retrieval,and assembly for further ***,we explain the stick-and-play concept based on fabricated membrane-type electronics;"stick" and “play"refer to the transfer of electronic devices and the performance of their electronic functions,*** particular,we broadly survey various methods based on micro/nanostructures,including gecko-inspired,interlocking,cephalopod-sucker-inspired,and cilia structures,which can be employed to stick-and-play systems for enhancing interfacial adhesion with complex target surfaces under dynamic and wet ***,we highlight the stick-and-play system application of micro/nanostructures for skin-attachable biomedical electronics,e-textiles,and environmental monitoring electronics.

关键词： transfer printing interfacial adhesion flexible electronics stick-and-play system bioinspired adhesive

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