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Light-stabilized FHA2 suppresses miRNA biogenesis through interactions with DCL1 and HYL1

Molecular Plant 2021年第4期14卷 647-663页

作者： Seung jun Park Suk Won Choi Gu Min kim Christian Moller hyun-Sook Pai Seong Wook Yang Department of Systems Biology College of Life Science and BiotechnologyYonsei UniversitySeoul 120749Korea EDepartment of Systems Biology Institute of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Korea Department of Plant and Environnental Sciences Faculty of ScienceUniversity of CopenhagenThorvaldsensvei 40DK-1871 FrederiksbergCopenhagenDenmark Pohang University of Science and Technology(POSTECH) 77 Cheongam-RoNam-GuPohangGyeongbuk37673.Korea These authors contributed equally to this article.

The precise regulation of microRNA(miRNA)biogenesis is crucial for plant development,which requires core microprocessors and many fine tuners to coordinate their miRNA processing activity/specificity in fluctuating cellular *** de-etiolation,light triggers a dramatic accumulation of core microprocessors and primary miRNAs(pri-miRNAs)but decreases pri-miRNA processing activity,resulting in relatively constant miRNA *** mechanisms underlying these seemingly contradictory regulatory changes remain *** this study,we identified forkhead-associated domain 2(FHA2)as a light-stabilized suppressor of miRNA *** found that FHA2 deficiency increased the level of mature miRNAs,accompanied by a reduction in pri-miRNAs and target *** assays showed that FHA2 associates with the core microprocessors DCL1,HYL1,and SE,forming a complex to suppress their pri-miRNA processing *** analyses revealed that FHA2 promotes HYL1 binding but inhibits the binding of DCL1-PAZ-RNase-RNA-binding domains(DCL1-PRR)to miRNAs,whereas FHA2 does not directly bind to these ***,we found that FHA2 protein is unstable in the dark but stabilized by light during ***,disruption of FH A led to defects in light-triggered changes in miRNA expression and reduced the survival rate of deetiolated seedlings after prolonged light ***,these data suggest that FHA2 is a novel light-stabilized suppressor of miRNA biogenesis and plays a role in fine-tuning miRNA processing during de-etiolation.

关键词： miRNA biogenesis Suppressor of the microprocessor miRNA-biogenetic inconsistency

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Visible light communication based on space-division multiple access optical beamforming

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Chinese Optics Letters 2014年第12期12卷 9-12页

作者： Sung-Man kim hyun-jun Lee Department of Electronic Engineering Kyungsung UniversityBusan 608-736South Korea

We propose and demonstrate a visible light communication （VLC） scheme based on space-division multiple access （SDMA） optical beamforming to accommodate multiple user devices in the VLC based on optical beamforming. SDMA optical bealnforming is a technique which separates light-emitting diode light spa- tially and focuses each part on different target devices simultaneously. We show the experimental results of the VLC signal amplitudes, the optical power densities, and the bit-error rate performance as a function of transmission distance before and after the SDMA optical beamforming. The results show that the VLC signal amplitudes and optical power densities are improved by 8-2 and 3.8- 5 dB, respectively, with the help of SDMA optical beamforming.

关键词： VLC SDMA Visible light communication based on space-division multiple access optical beamforming

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Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee hyun-Pyo Choi Jang-Hoon kim jun-Won kim Da-Un jung Ji-Ho Shin jung-Taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

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Boost Up the Mechanical and Electrical Property of CNT Fibers by Governing Lyotropic Liquid Crystalline Mesophases with Aramid Polymers for Robust Lightweight Wiring Applications

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Advanced Fiber Materials 2023年第2期5卷 514-526页

作者： Ki‑hyun Ryu Jeong‑Gil kim Dongju Lee Seo Gyun kim Bon‑Cheol Ku jun Yeon Hwang Kwang‑Un Jeong Nam Dong kim Dae‑Yoon kim Functional Composite Materials Research Center Korea Institute of Science and TechnologyWanju 55324Republic of Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju 55324Republic of Korea Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

Monofilament type of polyaromatic amide(PA)and carbon nanotube(CNT)composite fibers is presented.A concept of a lyotropic liquid crystal(LLC)constructed via a spontaneous self-assembly is introduced to mitigate the extremely low com-patibility between PA and *** approaches provide an effective co-processing route of PA and CNT simultaneously to fabricate the uniform,continuous,and reliable composite fibers through a ***,the addition of a small amount PA into the dope solution of CNT governs the LLC mesophase not only in a spinneret stage but also in a coagulant ***,the developed PA/CNT composite fibers have the high uniaxial orientational order and the close interfacial packing compared to the pure CNT *** PA/CNT composite fibers achieve the outstanding tensile strength,electrical conductivity,and electrochemical response,while maintaining a *** also exhibit the chemical,mechanical,and thermal *** of these advantages can make flexible,sewable,and washable PA/CNT composite fibers ideal nanocomposite materials for use in next-generation information and energy transporting system by replacing conventional metal electrical conductors.

关键词： Carbon nanotube Aramid polymer Liquid crystal Composite fiber Electrical wire

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Efficient Remote Identification for Drone Swarms

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Computers, Materials & Continua 2023年第9期76卷 2937-2958页

作者： Kang-Moon Seo Jane kim Soojin Lee jun-WooKwon Seung-hyun Seo The Department of Electronic&Electrical Engineering Graduate SchoolHanyang UniversityAnsanKorea School of Electrical Engineering Hanyang University ERICAAnsanKorea

With the advancement of unmanned aerial vehicle(UAV)technology,the market for drones and the cooperation of many drones are *** swarms move together in multiple regions to perform their tasks.A Ground Control Server(GCS)located in each region identifies drone swarmmembers to prevent unauthorized drones from *** on drone identification have been actively conducted,but existing studies did not consider multiple drone identification ***,developing a secure and effective identification mechanism for drone swarms is *** suggested a novel approach for the remote identification of drone *** an efficient identification process between the drone swarm and the GCS,each Reader drone in the region collects the identification information of the drone swarmand submits it to the GCS for *** proposed identification protocol reduces the verification time for a drone swarm by utilizing batch verification to verify numerous drones in a drone *** prove the security and correctness of the proposed protocol,we conducted a formal security verification using ProVerif,an automatic cryptographic protocol *** also implemented a non-flying drone swarmprototype usingmultiple Raspberry Pis to evaluate the proposed protocol’s computational overhead and *** showed simulation results regarding various drone simulation scenarios.

关键词： Drone remote identification drone swarms multi-drone authentication

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Effect of dexamethasone injection into Zusanli(ST 36) acupoint on ovalbumin-induced allergic rhinitis

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Journal of Traditional Chinese Medicine 2019年第3期39卷 307-314页

作者： Na-Ra Han Seung-jun Han Phil-Dong Moon Sungwei Hong Hyeongjin kim Yanhua Li hyung-Min kim hyun-Ja Jeong Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Korean Medicine Graduate School of Wonkwang University Iksan 54538 Republic of Korea Department of Pharmacology Graduate School Kyung Hee University Seoul 02447Republic of Korea Department of Clinical Korean Medicine Graduate School Kyung Hee University Seoul 02447 Republic of Korea Department of Food Science & Technology and Research Institute for Basic Science Hoseo UniversityChungnam 31499 Republic of Korea

OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(***)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)***:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control *** hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(*** group),while three groups received *** at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,*** symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th *** isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing *** weight was measured using an electronic *** levels of IgE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent *** serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde *** blot analysis was performed on nasal mucosal tissue ***:*** significantly reduced the rubbing score,spleen weight,serum IgE,and serum histamine in OVA-sensitized *** significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized *** significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-l

关键词： Dexamethasone Point ST36 (Zusanli) Pharmaceutical research Acupuncture Rhinitis,allergic Ovalbumin Thymic stromal lymphopoietin

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A modified,simple technique for internal limiting membrane free flap transplantation in macular hole surgery:the Peel-PFCL-Peel technique

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1636-1638页

作者： hyun Goo Kang Jae Yong Han Jae Won jun Min kim Department of Ophthalmology Institute of Vision ResearchGangnam Severance HospitalYonsei University College of Medicine211 EonjuroGangnam-guSeoul 06273Republic of Korea

Dear Editor,We would like to introduce a simple but modified variant perfluorocarbon liquid(PFCL)-assisted technique,namely the"Peel-PFCL-Peel"technique,which overcomes these difficulties while improving manipulation ... 详细信息

关键词： modified limiting overcome

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Transverse myelitis caused by herpes zoster following COVID-19 vaccination:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1419-1425页

作者： Su-Yeon Cho Bo-hyun Jang jun-Won Seo Suk-Whee kim Kyung-Joon Lim hyun-Young Lee Dong-Joon kim Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Internal Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun UniversityCollege of MedicineGwangju 61453South Korea

BACKGROUND Transverse myelitis(TM)is characterized by sudden lower extremity progressive weakness and sensory impairment,and most patients have a history of advanced viral infection symptoms.A variety of disorders can cause TM in association with viral or nonviral infection,vascular,neoplasia,collagen vascular,and iatrogenic,such as *** has become common through the global implementation against coronavirus disease 2019(COVID-19)and reported complications like herpes zoster(HZ)activation has *** SUMMARY This is a 68-year-old woman who developed multiple pustules and scabs at the T6-T9 dermatome site 1 wk after vaccination with the COVID-19 vaccine(Oxford/AstraZeneca([ChAdOx1S{recombinant}]).The patient had a paraplegia aggravation 3 wk after HZ symptoms *** magnetic resonance imaging(MRI)showed transverse myelitis at the T6–T9 *** was acyclovir with steroids combined with physical *** neurological function was slowly restored by Day *** HZ developed after COVID-19 vaccination,which may lead to more severe ***,HZ treatment itself should not be *** neurological complications worsen after appropriate management,an immediate diagnostic procedure,such as magnetic resonance imaging and laboratory tests,will start and should treat the neurological complications.

关键词： Herpes zoster Transverse myelitis Paraplegia COVID-19 Vaccination Case report

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Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： Daebeom Park Ho-Sung Lee jun Hyuk Kang Seon-Myeong kim Jeong-Ryeol Gong Kwang-hyun Cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

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Development of a 3D subcutaneous construct containing insulin-producing beta cells using bioprinting

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Bio-Design and Manufacturing 2022年第2期5卷 265-276页

作者： Chi B.Ahn Ji-hyun Lee Joo H.kim Tae H.kim Hee-Sook jun Kuk H.Son Jin W.Lee Department of Molecular Medicine College of MedicineGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea Department of Health Sciences and Technology GAIHSTGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea College of Pharmacy Gachon University191Hambangmoe-roYeonsu-kuIncheonRepublic of Korea Department Thoracic and Cardiovascular Surgery Gachon University Gil Medical CenterCollege of MedicineGachon University21Namdong-daero 774 beon-gilNamdong-guIncheonRepublic of Korea

Type 1 diabetes is caused by insulin deficiency due to the loss of beta cells in the islets of *** severe cases,islet transplantation into the portal vein is ***,due to the loss of transplanted islets and the failure of islet function,the 5-year insulin independence rate of these patients is<50%.In this study,we developed a long-term,insulin-secreting,3 Dbioprinted construct implanted subcutaneously with the aim of preventing islet *** bioprinted construct was fabricated by the multi-layer bioprinting of beta-cell(mouse insulinoma-6:MIN-6)-encapsulated alginate bioink and poly(caprolactone)biodegradable polymer.A glucose response assay revealed that the bioprinted constructs proliferated and released insulin normally during the 4-week in vitro *** MIN-6 generated clusters with a diameter of 100-200μm,similar to the original pancreatic islets in the *** an in vivo study using type 1 diabetes mice,animals implanted with bioprinted constructs showed three times higher insulin secretion and controlled glucose levels at 8 weeks after *** the implanted,bioprinted constructs had a positive effect on insulin secretion in the experimental animals,the survival rate of the implanted group(75%)was three times higher than that of the non-implanted group(25%).The results suggest that the proposed,3 D-bioprinted,subcutaneous construct can be a better alternative to portal vein islet transplantation.

关键词： 3D bioprinting Subcutaneous construct Type 1 diabetes Insulin Beta cells

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