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Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho Lee Jeong june Choi Joo Hye Sim Younmin Shin Seung-Joon Oh Ji-Hyang Gu hyun ju ha Dong Hwi Jeon Eun-jung Lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

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Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo ha Hyo-Young JEONG ju Hun LEE hyun-jung CHUNG Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology

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Fatal rhabdomyolysis and disseminated intravascular coagulation after total knee arthroplasty under spinal anesthesia:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1349-1356页

作者： Dae Hun Yun Eun ha Suk Wan ju Eun Hyoung Seo hyun Kang Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Rhabdomyolysis develops as a result of skeletal muscle cell collapse from leakage of the intracellular contents into *** severe cases,it can be associated with acute kidney injury and disseminated intravascular coagulation,leading to life threatening *** can occur in the perioperative period from various etiologies but is rarely induced by tourniquet use during orthopedic *** SUMMARY A 77-year-old male underwent right total knee arthroplasty using a tourniquet under spinal *** 24 h after surgery,he was found in a drowsy mental state and manifested features of severe rhabdomyolysis,including fever,hypotension,oliguria,high creatine kinase,myoglobinuria,and disseminated intravascular *** supportive care,cardiac arrest developed abruptly,and the patient was not able to be *** Severe rhabdomyolysis and disseminated intravascular coagulation can develop from surgical tourniquet,requiring prompt,aggressive treatments to save the patient.

关键词： Rhabdomyolysis Total knee arthroplasty Tourniquet Disseminated intravascular coagulation Case report

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Massive hemothorax following internal jugular vein catheterization under ultrasound guidance:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5776-5782页

作者： hyun Kang Soo Young Cho Eun ha Suk Wan ju Joon Yong Choi Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Hemothorax is a rare but life-threatening complication of central venous *** reports suggest that ultrasound guidance may reduce complications however,it does not guarantee safety CASE SUMMARY A 75-year-old male patient was admitted for laparoscopic radical *** ultrasound guidance,right internal jugular vein catheterization was successfully achieved after failure to aspirate blood from the catheter in the first *** hypotension developed after surgical positioning and persisted until the end of the operation,lasting for about 4 *** the recovery room,a massive hemothorax was identified on chest radiography and computed *** patient recovered following chest tube drainage of 1.6 L *** Hemothorax must be suspected when unexplained hemodynamic instability develops after central venous catheterization despite ultrasound *** the proper use of ultrasound is important.

关键词： Central venous catheterization Hemothorax Ultrasound guidance Internal jugular vein Case report

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Effect of Length Scale Tuning of Background Error in WRF-3DVAR System on Assimilation of High-Resolution Surface Data for Heavy Rainfall Simulation

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Advances in Atmospheric Sciences 2012年第6期29卷 1142-1158页

作者： Ji-hyun ha Dong-Kyou LEE Atmospheric Sciences Program School of Earth and Environmental SciencesSeoul National UniversitySeoul 151-747Korea

We investigated the impact of tuning the length scale of the background error covariance in the Weather Research and Forecasting （WRF） three-dimensional variational assimilation （3DVAR） system. In particular, we studied the effect of this parameter on the assimilation of high-resolution surface data for heavy rainfall forecasts associated with mesoscale convective systems over the Korean Peninsula. In the assimilation of high-resolution surface data, the National Meteorological Center method tended to exaggerate the length scale that determined the shape and extent to which observed information spreads out. In this study, we used the difference between observation and background data to tune the length scale in the assimilation of high-resolution surface data. The resulting assimilation clearly showed that the analysis with the tuned length scale was able to reproduce the small-scale features of the ideal field effectively. We also investigated the effect of a double-iteration method with two different length scales, representing large and small-length scales in the WRF-3DVAR. This method reflected the large and small-scale features of observed information in the model fields. The quantitative accuracy of the precipitation forecast using this double iteration with two different length scales for heavy rainfall was high; results were in good agreement with observations in terms of the maximum rainfall amount and equitable threat scores. The improved forecast in the experiment resulted from the development of well-identified mesoscale convective systems by intensified low-level winds and their consequent convergence near the rainfall area.

关键词： WRF 3DVAR tuning surface data heavy rainfall

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Copper telluride with manipulated carrier concentrations for high-performance solid-state thermoelectrics

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Journal of Materials Science & Technology 2022年第34期129卷 190-195页

作者： hyun ju Dabin Park Minsu Kim Jooheon Kim G.W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Chemical Engineering&Materials Science Chung-Ang UniversitySeoul 06974Republic of Korea Department of Intelligent Energy and Industry Graduate SchoolChung-Ang UniversitySeoul 06974Republic of Korea Department of Advance Materials Engineering Chung-Ang UniversityAnseong 17546Republic of Korea

This study proposed a strategy for effectively diminishing the carrier concentration in Cu_(2)Te by introducing graphene sheets,Based on thermoelectric property measurements and single parabolic band modeling,the incorporated graphene effectively reduced the carrier concentration,not only enhancing the thermoelectric performance of the Cu_(2)Te/graphene composite but also substantially improving its figure of merit up to ~1.47 at 1000 K,which is 268% higher than that of pristine Cu_(2)Te,This study gives an insight into the control of carrier concentration and thermoelectric properties in Cu_(2)Te,and it could be extended to other copper chalcogenides for excellent thermoelectrics.

关键词： Thermoelectric Copper telluride Graphene Carrier concentration Single parabolic band model

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Effects of compressive stress on the nonlinear electromechanical behavior of ferroelectric ceramics

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Science China(Technological Sciences) 2006年第1期49卷 29-37页

作者： LEE jung-ju KIM hyun Cheol Department of Mechanical Engineering KAIST Taejon 305-701 Korea

The effects of compressive stress parallel and perpendicular to the polar axis of PZT ceramics on the nonlinear electromechanical behavior of the materials has been experimentally studied. A domain-switching model that divides each 180° switching to two successive 90° switching is proposed to explain these effects. In the case of stress parallel to the polar axis, domain switching in the ceramics is approximately axisymmetric and can be simulated by an analytical model. While in the case of stress perpendicular to the polar axis, domain switching is three-dimensional and cannot be simplified. The simulated re-sults that match the experiments well show the validity of the proposed domain-switching model.

关键词： ferroelectric ceramics, domain switching, electromechanical, PZT.

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Effect of a seasonal diffuse pollution migration on natural organic matter behavior in a stratified dam reservoir

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Journal of Environmental Sciences 2010年第6期22卷 908-914页

作者： Soon ju Yu Jae Yil Lee Sung Ryong ha National Institute of Environmental Research Department of Urban Engineering Chungbuk National University

This article aims to describe the influence of diffuse pollution on the temporal and spatial characteristics of natural organic matter （NOM） in a stratified dam reservoir, the Daecheong Dam, on the basis of intensive observation results and the dynamic water quality simulation using CE-QUAL-W2. Turbidity is regarded as a comprehensive representation of allochothonous organic matter from diffuse sources in storm season because the turbidity concentration showed reasonable significance in a statistical correlation with the UV absorbance at 254 nm and total phosphorus. CE-QUAL-W2 simulation results showed good consistency with the observed data in terms of dissolved organic matter （DOM） including refractory dissolved organic carbon （RDOC） and labile DOC and also well explained the internal movement of constituents and stratification phenomenon in the reservoir. Instead turbidity and NOM were related well in the upper region of the reservoir according to flow distance, gradually as changing to dissolved form of organic matter, RDOM affected organic matter concentration of reservoir water quality compared to turbidity. To control the increase of soluble organic matters in the dam reservoir, appropriate dam water discharge gate operation provided effective measurement. Because of the gate operation let avoid the accumulation of organic matter within a dam reservoir by shorten of turbid regime retention time.

关键词： CE-QUQL-W2 natural organic matter stratified dam reservoir turbidity flow

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Effect of Radiant Spectral Characteristics on Performance of a Near-Infra-Red Heating Module

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Journal of Thermal Science 2011年第6期20卷 510-515页

作者： ju-hyun Kim Won-Taek Choi Minsub han School of Mechanical System Engineering University of Incheon Araytech IncheonKorea

We simulated the heat transfer phenomena of the heating module that is primarily based on the radiant energy in the near-infra-red(NIR) *** the module,the power emitted by the lamp filament is distributed to the lamp glass,reflector,and the target medium,which are cooled by an air *** radiant heat transfer is simulated by using the ray-tracing scheme,in which the spectral characteristics of the emission and the materials are *** heat transport from the lamp glass to the cooling air is analyzed by using the finite volume *** the lamp-filament temperature rises in the range of 3000-3400K,the NIR radiant power on the target medium ***,the lamp-glass temperature also rises,and the proportion of the NIR power to the entire radiation has a peak in the temperature *** spectral distributions of the absorbed energies in all the components in the module are highly non-uniform,and a monochromatic model of the radiant heat transfer may result in a significant discrepancy.

关键词： Computational Fluid Dynamics(CFD) Curing Drying Coating process

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Repurposing ibrutinib:therapeutic effects and implications for translational approaches in Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2194-2195页

作者： hyun-ju Lee Hyang-Sook Hoe Department of Neural Development and Disease Korea Brain Research Institute(KBRI)DaeguSouth Korea Department of Brain and Cognitive Sciences Daegu Gyeongbuk Institute of Science&TechnologyDaegu 42988South Korea

Alzheimer’s disease(AD)is the most prevalent neurodegenerative disease,and the number of patients with AD is estimated to double by 2060(Alzheimer’s Association,2022).The AD mortality rate has increased by 145%over the last decade,the largest increase among the ten leading causes of death in the US(Alzheimer’s Association,2022).

关键词： Alzheimer mortality therapeutic

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