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Interface properties and phase formation between surface coated SKD61 and aluminum alloys

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中国有色金属学会会刊：英文版 2009年第4期19卷 875-878页

作者： Se-Weon CHOI Young-Chan KIM Se-Hun CHANG Ik-hyun OH Joon-sik PARK Chang-Seog KANG Automotive Components Center Korea Institute of Industrial Technology Division of Advanced Materials Engineering Hanbat National University

The intermediate phase formation and surface protection effects between SKD61 die mold alloys and aluminum alloys were investigated during a simulated die-casting *** surface coatings of SKD61 alloy were carried out via Si pack cementation coatings at 900 ℃ for 10 h and the ε-FeSi phase *** the coated SKD61 alloy was dipped in the liquid aluminum alloy(ALDC12),the surface coated SKD61 alloys showed better surface properties compared with uncoated SKD61 alloys,i.e.,the intermediate phases(FeSiAl compound) were not produced for the coated SKD61 *** coating layer of ε-FeSi served as a diffusion barrier for the formation of FeSiAl compounds.

关键词：表面涂层铝合金接口特性表面合金涂层表面保护合金生产化合物中间相

SnO2@Co3O4 hollow nano-spheres for a Li-ion battery anode with extraordinary performance

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Nano Research 2014年第8期7卷 1128-1136页

作者： Won-sik Kim Yoon Hwa Hong-Chan Kim Jong-hyun Choi Hun-Joon Sohn Seong-Hyeon Hong Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National University Seoul151-744 Republic of Korea

SnO2@Co3O4 hollow nano-spheres have been prepared using the template-based sol-gel coating technique and their electrochemical performance as an anode for lithium-ion battery （LIB） was investigated. The size of synthesized hollow spheres was about 50 nm with the shell thickness of 7-8 nm. The fabricated SnO2@Co3O4 hollow nano-sphere electrode exhibited an extraordinary reversible capacity （962 mAh-g-1 after 100 cycles at 100 mA-g-1）, good cyclability, and high rate capability, which was attributed to the Co-enhanced reversibility of the Li20 reduction reaction during cycling.

关键词： hollow sphere lithium-ion battery anode SnO2 Co3O4

Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation

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World Journal of Gastroenterology 2014年第34期20卷 12350-12354页

作者： Sun-Hye ko Chul-hyun Lim Jae-Young Kim Seung Hun Kang Myong Ki Baeg hyun Jin Oh Division of Endocrinology and Metabolism Department of Internal MedicineCollege of MedicineThe Catholic UniversitySeoul 137-701South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Colonoscopic screening has been reported to reduce deaths from colorectal *** bowel preparation is essential for this and safety is an important issue in choosing the *** glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium ***,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel *** waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance *** serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH *** thyroid and adrenal functions were *** were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH *** was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels ***-up visits showed the patient to have a normal sodium level without neurologic *** case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms.

关键词： Inappropriate antidiuretic hormone syndrome Colonoscopy Polyethyelene glycol Hyponatremia Seizure

Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats

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World Journal of Gastroenterology 2008年第5期14卷 731-736页

作者： Jun-Ho La Tae-sik Sung hyun-Ju Kim Tae-Wan Kim Tong Mook Kang Il-Suk Yang Department of Physiology College of Veterinary Medicine SeoulNational University Seoul 151-742 Republic of Korea Department of Physiology College of VeterinaryMedicine Kyungpuk National University Daegu 702-701Republic of Korea Department of Physiology SungkyunkwanUniversity School of Medicine Suwon 440-746 Republic ofKorea

AIM:To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. METHODS:We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. RESULTS:Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 μg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 μg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. CONCLUSION:These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis.

关键词： Corticotropin releasing hormone Visceral hypersensitivity Colitis

Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA

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Molecular Plant 2017年第2期10卷 223-243页

作者： Dhinesh Kumar Ritesh Kumar Dongwon Baek Tae-Kyung hyun Woo sik Chung Dae-Jin Yun Jae-Yean Kim Division of Applied Life Sciences Plant Molecular Biology and Biotechnology Research Center Gyeongsang National University Jinju 660-701 Korea Department of Industrial Plant Science and Technology Conege of Agricultural Life and Environmental Sciences Chungbuk National University Cheongju 28644Korea These authors contributed equally to this article.

Abscisic acid （ABA） is a major phytohormone involved in important stress-related and developmental plant processes. Membrane-delimited ABA signal transduction plays an important role in early ABA signaling, but the molecular mechanisms connecting core signaling components to the plasma membrane remain un- clear. Plants have evolved a large number of receptor-like kinases （RLKs） to modulate diverse biological processes by perceiving extracellular stimuli and activating downstream signaling responses. In this study, a putative leucine-rich repeat-RLK gene named RECEPTOR DEAD KINASE1 （AtRDK1） was identified and characterized in Arabidopsis thaliana. RDK1 promoter-GUS analysis revealed that RDK1 is expressed ubiq- uitously in the various tissues in Arabidopsis, and its expression is mainly induced by ABA. In the presence of ABA, RDKl-deficient rdkl-1 and rdkl-2 lines showed significant resistance in cotyledon greening and root growth, whereas RDKl-overexpressing lines showed enhanced sensitivity. Consistently, the expres- sion of ABA-responsive genes was significantly downregulated in rdkl mutant seedlings, which were also hypersensitive to drought stress with increased water loss. Interestingly, RDK1 was found to be an atypical kinase localized to the plasma membrane and did not require its kinase activity during ABA-mediated inhi- bition of seedling development. Accordingly, RDK1 interacted in the plasma membrane with type 2C protein phosphatase ABSClSIC ACID INSENSITIVE1 （ABI1）; this interaction was further enhanced by exogenous application of ABA, suggesting that RDKl-mediated recruitment of ABI1 onto the plasma membrane is important for ABA signaling. Taken together, these results reveal an important role for RDK1 in plant responses to abiotic stress conditions in an ABA-dependent manner.

关键词： ABA abiotic stress Arabidopsis atypical kinases protein phosphatases receptor-like kinases

The optimal timing of post-prostate biopsy magnetic resonance imaging to guide nerve-sparing surgery

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Asian Journal of Andrology 2014年第2期16卷 280-284,I0010页

作者： Young Hwii ko Phil hyun Song Ki Hak Moon Hee Chang Jung Jun Cheon Deuk Jae Sung Department of Urology Yeuflgnam University School of Medicine Daegu Korea Department of Urology Korea University School of Medicine Seoul Korea Department of Radiology Korea University School of Medicine Seoul Korea

The goal of our study was to evaluate the impact of the interval between prostate biopsy and magnetic resonance imaging （MRI） on the accuracy of simple tumor localization, which is essential information that enables nerve-sparing surgery. We also sought to determine the optimal timing of a post-biopsy MRI, A total of 184 patients who had undergone MRI before radical prostatectomy at an institution without a predetermined schedule for MRI after a prostate biopsy were enrolled. The mean interval from the biopsy to the MRI was 30.8 ± 18.6days. The accuracy of the MRI for simplified tumor location （right, left, bilateral and none） was 44.6%. In the group with discordant pathologic and MRI findings, the most common reason recorded was ＇MRI predicted a unilateral lesion, but pathology revealed bilateral lesions＇（58.3%）, followed by ＇MRI predicted no lesion, but pathology revealed the presence of a lesion＇（32.0%）. Multivariable analysis showed that the discordant group had a shorter interval （25.0 ± 14.3 vs 38.1 ± 20.6days, P 〈 0.01） preceding the MRI and a higher rate of hemorrhage as observed by MRI （80.4% vs 54.8%, P 〈 0.01） in comparison with the accordant group. In receiver operating characteristics analysis, the area under the curve of the MRI interval in accurate prediction of the tumor location was 0.707 （P 〈 0.001）. At the MRI interval＇s cutoff of 28.5days, the sensitivity was 73.2% and the specificity was 63.7%. When the MRI was performed within 28days, the accumulated accuracy was only 26.1% （23/88）; however, when it was performed after 28days, the reversely accumulated accuracy was 61.5% （59/96）. These data support a waiting period of at least 4weeks after a biopsy before performing an MRI for the purposes of surgical refinement.

关键词： magnetic resonance imaging nerve preservation prostate biopsy radical prostatectomy

Totally laparoscopic total gastrectomy using the modified overlap method and conventional open total gastrectomy:A comparative study

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World Journal of Gastroenterology 2021年第18期27卷 2193-2204页

作者： Chang Seok ko Nam Ryong Choi Byung sik Kim Jeong Hwan Yook Min-Ju Kim Beom Su Kim Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although several methods of totally laparoscopic total gastrectomy(TLTG)have been *** best anastomosis technique for LTG has not been *** To investigate the effectiveness and surgical outcomes of TLTG using the modified overlap method compared with open total gastrectomy(OTG)using the circular stapled *** We performed 151 and 131 surgeries using TLTG with the modified overlap method and OTG for gastric cancer between March 2012 and December *** and oncological outcomes were compared between groups using propensity score *** addition,we analyzed the risk factors associated with postoperative *** Patients who underwent TLTG were discharged earlier than those who underwent OTG[TLTG(9.62±5.32)vs OTG(13.51±10.67),P<0.05].Time to first flatus and soft diet were significantly shorter in TLTG *** pain scores at all postoperative periods and administration of opioids were significantly lower in the TLTG group than in the OTG *** significant difference in early,late and esophagojejunostomy(EJ)-related complications or 5-year recurrence free and overall survival between *** analysis demonstrated that body mass index[odds ratio(OR),1.824;95%confidence interval(CI):1.029-3.234,P=0.040]and American Society of Anaesthesiologists(ASA)score(OR,3.154;95%CI:1.084-9.174,P=0.035)were independent risk factors of early ***,age was associated with≥3 Clavien-Dindo classification and EJrelated *** Although TLTG with the modified overlap method showed similar complication rate and oncological outcome with OTG,it yields lower pain score,earlier bowel recovery,and *** should perform total gastrectomy cautiously and delicately in patients with obesity,high ASA scores,and older ages.

关键词： Laparoscopic surgery Gastrectomy Anastomosis Stomach neoplasms Totally laparoscopic total gastrectomy

Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis

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World Journal of Gastroenterology 2003年第12期9卷 2791-2795页

作者： Jun-Ho La Tae-Wan Kim Tae-sik Sung Jeoung-Woo Kang hyun-Ju Kim ⅠI-Suk Yang Department of Physiology College of Veterinary MedicineSeoul National UniversitySeoulRepublic of Korea

AIM:Irritable bowel syndrome(IBS)is a functional bowel disorder characterized by visceral hypersensitivity and altered bowel *** is increasing evidence suggesting the role of inflammation in the pathogenesis of IBS,which addresses the possibility that formerly established rat model of colitis could be used as an IBS model after the inflammation subsided. METHODS:Colitis was induced by intracolonic instillation of 4% acetic acid in male Sprague-Dawley *** extent of inflammation was assessed by histological examination and myeloperoxidase(MPO)activity *** subsidence of colitis,the rats were subjected to rectal distension and restraint stress,then the abdominal withdrawal reflex and the number of stress-induced fecal output were measured, respectively. RESULTS:At 2 days post-induction of colitis,the colon showed characteristic inflammatory changes in histology and 8-fold increase in MPO *** 7 days post-induction of colitis,the histological features and MPO activity returned to *** rats at 7 days post-induction of colitis showed hypersensitive response to rectal distension without an accompaning change in rectal compliance,and defecated more stools than control animals when under ***: These results concur largely with the characteristic features of IBS, visceral hypersensitivity and altered defecation pattern in the absence of detectable disease, suggesting that this animal model is a methodologically convenient and useful model for studying a subset of IBS.

关键词： Acetic Acid Animals Biological Markers Colitis Disease Models, Animal Inflammation Irritable Bowel Syndrome Male Pain Peroxidase Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't

Construction of tantalum/poly(ether imide)coatings on magnesium implants with both corrosion protection and osseointegration properties

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Bioactive Materials 2021年第4期6卷 1189-1200页

作者： Kwang-Hee Cheon Cheonil Park Min-Ho Kang In-Gu Kang Min-Kyu Lee hyun Lee Hyoun-Ee Kim hyun-Do Jung Tae-sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheonGyeonggi-doRepublic of Korea Institute of Health Science Research Korea UniversitySeoul02841Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangjuRepublic of Korea

Poly(ether imide)(PEI)has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium(Mg),a potential candidate of biodegradable orthopedic implant ***,its innate hydrophobic property causes insufficient osteoblast affinity and a lack of ***,we modify the physical and chemical properties of a PEI-coated Mg implant.A plasma immersion ion implantation technique is combined with direct current(DC)magnetron sputtering to introduce biologically compatible tantalum(Ta)onto the surface of the PEI *** PEI-coating layer is not damaged during this process owing to the extremely short processing time(30 s),retaining its high corrosion protection property and adhesion *** Ta-implanted layer(roughly 10-nm-thick)on the topmost PEI surface generates long-term surface hydrophilicity and favorable surface conditions for pre-osteoblasts to adhere,proliferate,and ***,in a rabbit femur study,the Ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration *** results indicate that Ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications.

关键词： Magnesium Tantalum Poly(ether imide) Bio-functionalized coating Biodegradable orthopedic implants