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Applications of scaffolds:Tools for enhancing the immunomodulation of mesenchymal stromal cells

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BIOCELL 2022年第6期46卷 1439-1443页

作者： OK-HYEON kim EUN RAN kim JUN hyunG PARK hyun JUNG LEE Department of Anatomy and Cell Biology College of MedicineChung-Ang UniversitySeoul06974South Korea Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974South Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteCollege of MedicineYonsei UniversitySeoul03722South Korea

Exogenously delivered mesenchymal stromal cells(MSCs)are therapeutically beneficial owing to their paracrine effect;they secrete various cytokines,nucleic acids,and *** bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions(both structurally and functionally).Various scaffolds mimic the natural extracellular matrix(ECM)using both natural and synthetic polymers,providing favorable environments for MSC proliferation and *** on material properties,either topographically or elastically structured scaffolds can be ***-dimensional scaffolds have tunable substrate rigidities and structures,aiding MSC *** ECM-derived hydrogels are similar to the natural ECM,thus improving the paracrine effects of ***,we discuss recent research on the application of scaffolds to maximize the immunomodulatory function of MSCs.

关键词： Extracellular matrix(ECM) Immunomodulation Mesenchymal stromal cells(MSCs) Scaffolds Stem cell niche

Locked nucleic acid real-time polymerase chain reaction method identifying two polymorphisms of hepatitis B virus genotype C2 infections,rt269L and rt269I

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World Journal of Gastroenterology 2023年第11期29卷 1721-1734页

作者： Kijeong kim Yu-Min Choi Dong hyun kim Junghwa Jang Won Hyeok Choe Bum-Joon kim Department of Microbiology College of MedicineChung-Ang UniversitySeoul 06974South Korea Department of Microbiology and Immunology College of MedicineSeoul National UniversitySeoul 03080South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Biomedical Sciences College of MedicineSeoul National UniversitySeoul 03080South Korea Liver Research Institute College of MedicineSeoul National UniversitySeoul 03080South Korea Seoul National University Medical Research Center Seoul 03080South Korea

BACKGROUND The presence of two distinct hepatitis B virus(HBV)Pol RT polymorphisms,rt269L and rt269I,could contribute to the unique clinical or virological phenotype of HBV genotype ***,a simple and sensitive method capable of identifying both types in chronic hepatitis B(CHB)patients infected with genotype C2 should be *** To develop a novel simple and sensitive locked nucleic acid(LNA)-real timepolymerase chain reaction(RT-PCR)method capable of identifying two rt269 types in CHB genotype C2 *** We designed proper primer and probe sets for LNA-RT-PCR for the separation of rt269 *** synthesized DNAs of the wild type and variant forms,melting temperature analysis,detection sensitivity,and endpoint genotyping for LNA-RT-PCR were *** developed LNA-RT-PCR method was applied to a total of 94 CHB patients of genotype C2 for the identification of two rt269 polymorphisms,and these results were compared with those obtained by a direct sequencing *** The LNA-RT-PCR method could identify two rt269L and rt269I polymorphisms of three genotypes,two rt269L types[‘L1’(WT)and‘L2’]and one rt269I type(‘I’)in single(63 samples,72.4%)or mixed forms(24 samples,27.6%)in 87(92.6%sensitivity)of 94 samples from Korean CHB *** the results were compared with those obtained by the direct sequencing protocol,the LNA-RT-PCR method showed the same results in all but one of 87 positive detected samples(98.9%specificity).CONCLUSION The newly developed LNA-RT-PCR method could identify two rt269 polymorphisms,rt269L and rt269I,in CHB patients with genotype C2 *** method could be effectively used for the understanding of disease progression in genotype C2 endemic areas.

关键词： Hepatitis B virus Genotype C2 Polymerase rt269 Locked nucleic acid-real time-polymerase chain reaction Chronic hepatitis B

Rational Design of LDH/Zn_(2)SnO_(4) Heterostructures for Efficient Mineralization of Toluene Through Boosted Interfacial Charge Separation

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Energy & Environmental Materials 2023年第1期6卷 317-324页

作者： Ben Lei Wen Cui Peng Chen Ruimin Chen Yanjuan Sun Ki-hyun kim Fan Dong Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China Department of Civil and Environmental Engineering Hanyang University222 Wangsimni-RoSeoul 04763Korea State Centre for International Cooperation on Designer Low carbon and Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

It is crucial to efficiently separate and transport photo-induced charge carriers for the effective implementation of photocatalysis toward environmental remediation.A rational design strategy is proposed to validate such proposition through the construction of an interfacial structure in the form of LDH/Zn_(2)SnO_(4) heterostructures in this *** interfacial charge transfer on LDH/Zn_(2)SnO_(4) is greatly promoted via the unique charge transfer pathway,as characterized by transient photocurrent responses,X-ray photoelectron spectroscopy,electron paramagnetic resonance spectrum,and photoluminescence *** such,it contributes to the generation of reactive oxygen species(ROS)and the activation of reactants for the mineralization of *** to the in situ DRIFTS spectra analysis,the accumulation of benzoic acid takes place possibly through the partial oxidation of the methyl group on toluene at the interface of the LDH/Zn 2 SnO 4 *** process can greatly promote the photocatalytic oxidation of toluene with the enhanced ring-opening *** LDH/Zn 2 SnO 4 is thus demonstrated as superior photocatalyst against toluene(removal efficiency of 89.5%;mineralization of 83.1%;and quantum efficiency of 4.55×10^(−6) molecules/photon).As such,the performance of this composite far exceeds that of their individual components(e.g.,P25,pure Mg-Al LDH,or Zn_(2)SnO_(4)).This study is expected to offer a new path to the interfacial charge transfer mechanism based on the design of highly efficient photocatalysts for air purification.

关键词： heterostructure interfacial charge transfer photocatalysis toluene degradation

Precise photoelectrochemical tuning of semiconductor microdisk lasers

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Advanced Photonics 2023年第5期5卷 68-76页

作者： Debarghya Sarkar Paul HDannenberg Nicola Martino Kwon-Hyeon kim Yue Wu Seok-hyun Yun Harvard Medical School BostonMassachusettsUnited States Massachusetts General Hospital Wellman Center for PhotomedicineBostonMassachusettsUnited States Massachusetts Institute of Technology Harvard-MIT Health Sciences and TechnologyCambridgeMassachusettsUnited States

Micro-and nanodisk lasers have emerged as promising optical sources and probes for on-chip and free-space ***,the randomness in disk diameter introduced by standard nanofabrication makes it challenging to obtain deterministic *** address this,we developed a photoelectrochemical(PEC)etching-based technique that enables us to precisely tune the lasing wavelength with subnanometer *** examined the PEC mechanism and compound semiconductor etching rate in diluted sulfuric acid *** this technique,we produced microlasers on a chip and isolated particles with distinct lasing *** precisely tuned disk lasers were then used to tag cells in *** results demonstrate that this scalable technique can be used to produce groups of lasers with precise emission wavelengths for various nanophotonic and biomedical applications.

关键词： microdisk lasers semiconductor precision lasing photoelectrochemical etching laser particle nanophotonics

Installing a molecular truss beam stabilizes MOF structures

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npj Computational Materials 2022年第1期8卷 1110-1118页

作者： Hong Ki kim Jong-Yeong Jung Gyumin Kang Mu-hyun Baik Eun-Young Choi Department of Chemistry Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science(IBS)Daejeon34141Republic of Korea Korea Science Academy of KAIST 105-47 Baegyanggwanmun-roBusanjin-guBusan47162Republic of Korea

Enhancing the stability and durability of metal-organic frameworks(MOFs)is vital for practical applications because many promising MOF materials suffer from phase transitions and/or structural decompositions with humidity being a particularly damaging *** mechanical engineering,the frame of buildings and furniture can be stabilized significantly by installing a truss *** the same principle,we functionalized the organic component of MOF-5 to contain a carbazole moiety that can act as a molecular truss beam by reaching across the corner and forming a stableπ–πinteraction with a phenyl group on the edge position of the *** structural support enhanced the stability of the MOF substantially,allowing the designed MOF to maintain compositional integrity under steam conditions at 90℃for~5 *** unmodified MOF-5 shows clear signs of structural collapse after~1 h.

关键词： beam moiety durability

A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon pyo Choi Seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park hyun Young kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

Abnormal Behavior Detection Using Deep-Learning-Based Video Data Structuring

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Intelligent Automation & Soft Computing 2023年第8期37卷 2371-2386页

作者： Min-Jeong kim Byeong-Uk Jeon hyun Yoo Kyungyong Chung Department of Computer Science Kyonggi UniversitySuwon-si16227Gyeonggi-doKorea Contents Convergence Software Research Institute Kyonggi UniversitySuwon-si16227Gyeonggi-doKorea Division of AI Computer Science and Engineering Kyonggi UniversitySuwon-si16227Gyeonggi-doKorea

With the increasing number of digital devices generating a vast amount of video data,the recognition of abnormal image patterns has become more ***,it is necessary to develop a method that achieves this task using object and behavior information within video *** methods for detecting abnormal behaviors only focus on simple motions,therefore they cannot determine the overall behavior occurring throughout a *** this study,an abnormal behavior detection method that uses deep learning(DL)-based video-data structuring is *** and motions are first extracted from continuous images by combining existing DL-based image analysis *** weight of the continuous data pattern is then analyzed through data structuring to classify the overall *** performance of the proposed method was evaluated using varying parameter settings,such as the size of the action clip and interval between action *** model achieved an accuracy of 0.9817,indicating excellent ***,we conclude that the proposed data structuring method is useful in detecting and classifying abnormal behaviors.

关键词： Deep learning object detection abnormal behavior recognition classification data structuring

Congenital ovarian anomaly manifesting as extra tissue connection between the two ovaries:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9318-9322页

作者： Myeong Gyun Choi Jong Woon kim Yoon Ha kim A Mi kim Tae Young kim hyun Kyung Ryu Department of Obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Ovarian anomalies except for uni-or bilateral streak gonads are *** present a rare case of an ovarian anomaly in which both ovaries were connected by extra *** SUMMARY A 32-year-old,primipara with a twin pregnancy at 36 weeks of gestation was admitted to the hospital with severe *** underwent emergency cesarean section owing to persistent headache,blurred vision,and general *** a peritoneal incision,a thin rectangular-shaped tissue was seen in front of the *** delivery,the extra tissue was removed;no other anomalies were reported in either the ovaries or *** results of the removed tissue disclosed a well-vascularized loose stromal tissue with few follicles and scattered luteinized *** this case,to prevent pelvic adhesion or intestinal obstruction resulting from volvulus,strangulation,and torsion,the extra tissue was *** We report a case of a rare ovarian anomaly where both ovaries were connected by extra *** the extra tissue extends to the abdominal cavity,it should be removed to prevent pelvic adhesion or abdominal complications including intestinal volvulus,strangulation,and torsion.

关键词： Connected ovaries Extra tissue Ovarian anomaly Case report

Amorphous silica fiber matrix biomaterials:An analysis of material synthesis and characterization for tissue engineering

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Bioactive Materials 2023年第1期19卷 155-166页

作者： hyun S.kim Sangamesh G.Kumbar Syam P.Nukavarapu Department of Biomedical Engineering University of ConnecticutStorrsCTUSA Department of Material Science and Engineering University of ConnecticutStorrsCTUSA Department of Orthopaedic Surgery University of Connecticut HealthFarmingtonCTUSA

Silica biomaterials including Bioglass offer great biocompatibility and bioactivity but fail to provide pore and degradation features needed for tissue *** we report on the synthesis and characterization of novel amorphous silica fiber matrices to overcome these *** silica fibers were fused by sintering to produce porous *** effects of sacrificial polymer additives such as polyvinyl alcohol(PVA)and cellulose fibers(CF)on the sintering process were also *** resulting matrices formed between sintering temperatures of 1,350-1,550◦C retained their fiber *** matrices presented pores in the range of 50-200μm while higher sintering temperatures resulted in increased pore *** addition to silica significantly reduced the pore diameter and porosity compared with silica matrices with or without the addition of *** PVA additive morphologically appeared to fuse the silica fibers to a greater extent and resulted in significantly higher compressive modulus and strength than the rest of the matrices *** matrices lost roughly 30%of their original mass in an in vitro degradation study over 40 *** matrices absorbed 500 wt%of water and did not change in their overall morphology,size,or shape with *** fiber matrices supported human mesenchymal stem cell adhesion,proliferation,and mineralized matrix *** silica fiber biomaterials/matrices reported here are biodegradable and porous and closely resemble the native extracellular matrix structure and water absorption *** the methodology reported here to alter matrix properties may lead to a variety of tissue engineering,implant,and drug delivery applications.

关键词： Silica biomaterial Porous matrix ECM-Like fibrous structure Biodegradable Water absorption