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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun kang Dong Ho Lee Dong hyun Oh Hyuk Yoon Cheol Min Shin Young Soo Park Nayoung Kim hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： Daebeom Park Ho-Sung Lee Jun Hyuk kang Seon-Myeong Kim Jeong-Ryeol Gong Kwang-hyun Cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

Simultaneous robot-assisted approach in a super-elderly patient with urothelial carcinoma and synchronous contralateral renal cell carcinoma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7153-7162页

作者： Ji kang Yun Si hyun Kim Woong Bin Kim Hee Kyung Kim Sang Wook Lee Department of Urology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584South Korea Department of Urology Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151South Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584South Korea

BACKGROUND It is rare for urothelial and renal cell carcinomas to coexist in the same patient,and even rarer for them to be detected *** of this rarity,a standard treatment has not been established and studies about overall survival are ***,physicians must modify treatments according to the individual’s situation and the stage of each *** recent years,with advances in the instruments and techniques,minimal invasive robotic surgeries have become available for advanced-stage or high-risk *** SUMMARY An 85-year-old woman with a medical history of hypertension and hyperlipidemia visited our *** had visited her local hospital complaining of intermittent,painless,gross hematuria that had started 3 mo *** computed tomography,a right renal mass and left proximal ureteral mass with hydronephrosis were found *** decided to perform robot-assisted surgery on both sides during one *** renal function and kidney loading,right partial nephrectomy was performed first,followed by left nephroureterectomy with bladder cuff *** the 6-mo follow-up,no specific symptoms were reported and dialysis was not *** were no unusual findings in the imaging study,and regular follow-up and imaging studies are *** This case report assessed the feasibility of simultaneous minimal invasive robotic surgery as an alternative to conventional open or laparoscopic surgery.

关键词： Robot surgical procedure Renal cell carcinoma Transitional cell carcinoma Minimally invasive surgical procedures Case report

Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第27期22卷 6127-6134页

作者： Kwang Il Kim Hye Kyung Chung Ju Hui Park Yong Jin Lee Joo hyun kang Molecular Imaging Research Center Korea Institute of Radiological and Medical Sciences Korea Drug Development Platform using Radio-Isotope Korea Institute of Radiological and Medical Sciences

Hepatocellular carcinoma (HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene’s expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumor-specific reporter gene expression driven by an alpha-fetoprotein (AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment.

关键词： Alpha-fetoprotein Hepatocellular carcinoma Molecular imaging Reporter gene Tumor-specific enhancer/promoter

Hybrid Friction Stir Welding of High-carbon Steel

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Journal of Materials Science & Technology 2011年第2期27卷 127-130页

作者： Don-hyun Choi Chang-Yong Lee Byung-Wook Ahn Jung-hyun Choi Yun-Mo Yeon Keun Song Seung-Gab Hong Won-Bae Lee Ki-Bong kang Seung-Boo Jung School of Advanced Materials Science and Engineering Sungkyunkwan University 300 Cheoncheon-dongJangan-guSuwonGyeonggi-do 440-746South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology 335 GwahangnoYuseong-guDaejeon 305-701South Korea Department of Advanced Materials Application Suwon Science College 9-10Botong-liJeongnam-myeonHwasungGyeonggi-do 445-742South Korea Technical Research Lab POSCO Corp.Goedong-dongNam-guPohangGyeongbuk790-785South Korea

A high-carbon steel joint,SK5（0.84 wt% C）,was successfully welded by friction stir welding（FSW）,both without and with a gas torch,in order to control the cooling rate during *** welding,the weld zone comprised gray and black regions,corresponding to microstructural variation：a martensite structure and a duplex structure of ferrite and cementite,*** volume fraction of the martensite structure and the Vickers hardness in the welds were decreased with the using of the gas torch,which was related with the lower cooling rate.

关键词： Friction stir welding High-carbon steel Transformation Martensite

Seroepidemiology of echovirus 30 in Korean children

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World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： Joo Young Lee Yumi Seo Ui Yoon Choi Jong-hyun Kim Jin Han kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology

Emerging role of vitamin D in colorectal cancer

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World Journal of Gastrointestinal Oncology 2011年第8期3卷 123-127页

作者： Wonmo kang Sujin Lee Eunyi Jeon Kook-hyun Kim Jun-Hyeog Jang Department of Biochemistry School of Medicine Inha University Incheon 400-712 South Korea Department of Internal Medicine College of Medicine CHA University Gumi 730-040 South Korea

Colorectal cancer is a common cancer and the fourth leading cause of death in Korea. The incidence and mortality of colorectal cancer varies according to risk factors, such as age, family history, genetic history, food habits, and physical activities. Some studies have focused on the association between vitamin D and colorectal cancer. Today, there is growing evidence that high vitamin D intake and a plasma level of 25(OH)D3 reduce the incidence of colorectal cancer by modifying cancer angiogenesis, cell apoptosis, differentiation, and proliferation. Taken together, these results suggest that vitamin D supplementation alone, or in combination with anti-cancer agents, might reduce the incidence of colorectal cancer. In this review, we discuss the function and mechanism of vitamin D including the effect of vitamin D on colorectal cancer.

关键词： Colorectal cancer Vitamin D Vitamin D receptor 25-hydroxyvitamin D 1,25(OH)2D3

Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats

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World Journal of Gastroenterology 2008年第5期14卷 731-736页

作者： Jun-Ho La Tae-Sik Sung hyun-Ju Kim Tae-Wan Kim Tong Mook kang Il-Suk Yang Department of Physiology College of Veterinary Medicine SeoulNational University Seoul 151-742 Republic of Korea Department of Physiology College of VeterinaryMedicine Kyungpuk National University Daegu 702-701Republic of Korea Department of Physiology SungkyunkwanUniversity School of Medicine Suwon 440-746 Republic ofKorea

AIM:To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. METHODS:We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. RESULTS:Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 μg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 μg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. CONCLUSION:These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis.

关键词： Corticotropin releasing hormone Visceral hypersensitivity Colitis

Exploring the experimental study and density functional theory calculations of symmetric and asymmetric chalcogen atoms interacted molybdenum dichalcogenides for lithium-ion batteries

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Journal of Materials Science & Technology 2023年第31期162卷 44-56页

作者： Dhanasekaran Vikraman Sajjad Hussain Zeesham Abbas K.Karuppasamy Woo-Seok kang P.Santhoshkumar A.Kathalingam Jongwan Jung hyun-Seok Kim Division of Electronics and Electrical Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Hybrid Materials Center(HMC) Sejong UniversitySeoul 05006Republic of Korea Millimeter-wave Innovation Technology(MINT)Research Center Dongguk University-SeoulSeoul 04620Republic of Korea

Two-dimensional asymmetric chalcogen atoms attached to Janus nanoparticles have fascinated research attention owing to their distinctive properties and characteristics for various *** paper proposed a facile synthesis to produce efficient molybdenum-based symmetric and asymmetric chalcogens bounded by X Mo X and TeMo X ***,the fabricated X Mo X and TeMo X nanostruc-tures were employed as anodes for lithiumion batteries(LIBs).Assembled LIBs using TeMoS and TeMoSe Janus anodes achieved 2610 and 2073 mAh g^(-1)reversible capacity at 0.1 A g^(-1),respectively for the halfcell configuration,which is outstanding performance compared with previous *** rate capability performances at 0.1-20 A g^(-1)and exceptional cycling solidity confirmed high charge and discharge capacities for TeMo X Janus lithium-ion battery *** addition,the full cell device with TeMoS//LiCoO_(2)configuration explored the discharge capacity of 1605 mAh g^(-1)at 0.1 A g^(-1)which suggests their excellent electrochemical *** density functional theory approximations established the significance of assembled symmetric and asymmetric chalcogen atoms interacted with X Mo X and TeMo X anode materials for ***,the present investigation supports a new approach to creating two-dimensional materials based on asymmetric chalcogen atoms with core metal to effectively increase desirable energy storage characteristics.

关键词： TeMoS TeMoSe Janus Li-ion battery

Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1499-1505页

作者： Sungbae Moon hyun Wook Ryoo Jae Yun Ahn Jung Bae Park kang Suk Seo Sang Do Shin Kyoung Jun Song kang hyun Lee In Sool Yoo Jin Seong Cho hyun Ho Ryu Tae Oh Jeong Seok Ran Yeom Young Taek Kim Sung Ok Hong Department of Emergency Medicine School of MedicineKyungpook National University Daegu 700-721 Korea Department of Emergency Medicine College of MedicineSeoul National University Seoul 110-799 Korea Department of Emergency Medicine Wonju College of Medicine Yonsei University Wonju Gangwon-do 220-701Korea Department of Emergency Medicine School of MedicineChungnam National University Daejeon 301-747 Korea Department of Emergency Medicine Gachon University Gil Medical Center Incheon 406-799 Korea Department of Emergency Medicine School of MedicineChonnam National University Gwangju 501-746 Korea Department of Emergency Medicine School of MedicineChonbuk National University Jeonju Jeollabuk-do 561-180Korea Department of Emergency Medicine School of MedicinePusan National University Busan 602-739 Korea Korean Centers for Disease Control & Prevention Cheongiu Chungcheongbuk-do 361-951 Korea

AIM：To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS： A cross-sectional,multi-center,observational *** with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were *** data were prospectively collected between March and September 2010 using a *** injuries that occurred during risky sports were examined by gender and ***,the rate of open globe injuries that occurred with and without protective eyewear was examined for each *** variables were compared using Student＇s t-test and categorical variables were compared using Chi-square ***： A total of 446 patients had sports-related eye ***（10-19 years old） and young adults（20-29 years old） had the most eye *** injuries accounted for 0.2% of Emergency Department *** was the most common cause of sports-related eye injuries,followed by soccer and *** gear was worn by 9.4% of all *** that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of *** proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and ***： Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear *** in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was *** athletes should be educated on and provided with protective eyewear and policies protective gear use should be *** older adults,eye protection should be encouraged,especially during hiking.

关键词： athletic injuries eye injuries protective devices sports.