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Expression of E-cadherin and α-catenin in a varicocele-induced infertility rat model

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Asian Journal of Andrology 2011年第3期13卷 470-475,514页

作者： Hong koo Ha hyun Jun Park Nam cheol Park Department of Urology Pusan National University School of Medicine Busan 602739 Korea Medical Research Institute Pusan National University Hospital Busan 602739 Korea

The roles of E-cadherin and α-catenin were evaluated in the development of varicocele-induced infertility. Analysis of the association between the expression of E-cadherinla-catenin and clinical/pathological parameters was performed. Thirty lO-week-old male rats （experimental group） were used for the experiments; the left renal vein was ligated to form a varicocele. The abdomen was incised in 30 rats （control group） and no procedure was performed on 10 rats （baseline group）. The weights of the left testis, serum reactive oxygen species （ROS）, testosterone, luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and degenerative changes in the seminiferous tubules after 4 and 8 weeks were recorded. The expression of E-cadherin and α-catenin was evaluated by immunohistochemical （IHC） staining and Western blot analysis. The ROS increased in the 8-week experimental group, compared with the baseline and control groups （P〈0.001 for both）. Additionally, FSH significantly increased in the 4- and 8-week experimental group compared with the control groups （P= 0.013 and P= 0.032, respectively）. The ratio of degenerative changes in the seminiferous tubules of the experimental groups increased. The IHC staining showed that the expression of E-cadherin and a-catenin decreased in the 4- and 8-week experimental groups. Similar to the IHC staining, the experimental group had decreased reactivity on Western blot analysis. The expression of E-cadherin and a-catenin was significantly associated with the ROS and degenerative changes in the seminiferous tubules. The results of this study suggest that damage to the blood-testis barrier （BTB） is associated with varicocele-induced male infertility, and that ROS may cause damage to the BTB.

关键词： α-catenin blood-testis barrier E-cadherin varicocele infertility

Contrast in Fluid M etallogeny between the Tianmashan Au-S Deposit and the Datuanshan Cu Deposit in Tongling,Anhui Province

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Acta Geologica Sinica(English Edition) 2003年第1期77卷 116-124页

作者： LEE hyun koo Depatment of Geology Chungnam National University 220 Kungdong Yuseong Ku Taejon 305-764 Republic of Korea

A comprehensive contrast of ore-forming geological background and ore-forming fluid features, especially fluid ore-forming processes, has been performed between the Tianmashan and the Datuanshan ore deposits in Tongling, Anhui Province. The major reasons for the formation of the stratabound skarn Au-S ore deposit in Tianmashan and the stratabound skarn Cu ore deposit in Datuanshan are analyzed in accordance with this contrast. The magmatic pluton in Tianmashan is rich in Au and poor in Cu, but that in Datuanshan is rich in Cu and Au. The wallrock strata in Tianmashan contain Au-bearing pyrite layers with some organic substance but those in Datuanshan contain no such layers. Moreover, the ore-forming fluids in Tianmashan are dominantly magmatic ones at the oxide and sulfide stages, but those with high content of Cu in Datuanshan are mainly groundwater fluids. In addition, differences in compositional evolution and physicochemical condition variation of the ore-forming fluids result in gradual dispersion

关键词： fluid inclusion fluid ore-forming process contrast in fluid metallogeny Au-S ore deposit Cu ore deposit magmatic fluid groundwater fluid Tongling Anhui Province

Ungraded Matrix Factorizations as Mirrors of Non-orientable Lagrangians

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Acta Mathematica Sinica,English Series 2024年第1期40卷 26-42页

作者： Lino AMORIM cheol-hyun CHO Department of Mathematics Kansas State University138 Cardwell Hall1228 N.17th StreetManhattanKS 66506USA Department of Mathematical Sciences Research Institute of MathematicsSeoul National UniversitySan 56-1ShinrimdongGwanakguSeoul 47907South Korea

We introduce the notion of ungraded matrix factorization as a mirror of non-orientable Lagrangian *** ungraded matrix factorization of a polynomial W,with coefficients in a field of characteristic 2,is a square matrix Q of polynomial entries satisfying Q^(2)=W·*** then show that non-orientable Lagrangians correspond to ungraded matrix factorizations under the localized mirror functor and illustrate this construction in a few *** main example is the Lagrangian submanifold RP^(2)⊂CP^(2)and its mirror ungraded matrix factorization,which we construct and *** particular,we prove a version of Homological Mirror Symmetry in this setting.

关键词： Mirror symmetry non-orientable Lagrangian submanifold matrix factorization

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Effects of compressive stress on the nonlinear electromechanical behavior of ferroelectric ceramics

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Science China(Technological Sciences) 2006年第1期49卷 29-37页

作者： LEE Jung-Ju KIM hyun cheol Department of Mechanical Engineering KAIST Taejon 305-701 Korea

The effects of compressive stress parallel and perpendicular to the polar axis of PZT ceramics on the nonlinear electromechanical behavior of the materials has been experimentally studied. A domain-switching model that divides each 180° switching to two successive 90° switching is proposed to explain these effects. In the case of stress parallel to the polar axis, domain switching in the ceramics is approximately axisymmetric and can be simulated by an analytical model. While in the case of stress perpendicular to the polar axis, domain switching is three-dimensional and cannot be simplified. The simulated re-sults that match the experiments well show the validity of the proposed domain-switching model.

关键词： ferroelectric ceramics, domain switching, electromechanical, PZT.

Exploring the relationship between rarity and price of profile picture NFT:A formal concept analysis on the BAYC NFT collection

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Blockchain(Research and Applications) 2024年第2期5卷 140-150页

作者： Heejung Lee Geun-cheol Lee Hoon-Young koo School of Interdisciplinary Industrial Studies Hanyang University222 Wangsimni-roSeongdong-guSeoul04763Republic of Korea College of Business Administration Konkuk University120 Neungdong-roGwangjin-guSeoul05029Republic of Korea School of Business Chungnam National University99 Daehak-roYuseong-guDaejeon34134Republic of Korea

Non-fungible token(NFT)is a digital asset whose ownership can be validated and controlled via blockchain *** NFT market is a rapidly growing field,and the rarity of NFT is an essential factor that affects its price,as scarcity leads to higher *** study focuses on the BAYC NFT collection,which is a successful and representative collection of profile picture NFT,and analyzes how rarity affects NFT *** paper investigates the relationship between the rarity and price of the BAYC NFT collection using formal concept analysis(FCA)*** results show that rarity is a major factor influencing the price of NFT and the effect is more apparent in the medium rarity *** rarity is very high or very low,other factors become significant determinants,such as the uniqueness and appeal of NFT,and even the naturalness of NFT *** research highlights the importance of considering rarity when assessing NFT and underscores the need for a comprehensive evaluation of NFT *** study also provides valuable insights into the NFT market and can be useful for NFT investors,creators,and ***,the usefulness of FCA as a tool for quantifying NFT rarity and evaluating NFT price was demonstrated.

关键词： NFT valuation Formal concept analysis Rarity

Effect of pre-deformation on precipitation behavior of AZ80 alloy:Comparison of slip-and twinning-dominant deformation

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Journal of Magnesium and Alloys 2024年第9期12卷 3616-3630页

作者： hyun Ji Kim Sang cheol Jin Sumi Jo Sung Hyuk Park Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Graduate School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

This study investigates the effect of the deformation mode on the precipitation behavior of an extruded Mg-8.0Al-0.5Zn-0.2Mn(AZ80)*** alloy samples are compared after the application of 3.5%tension and 3.5%compression along the extrusion direction to induce slip-dominant and twinning-dominant deformation modes,*** pre-compressed(PC)sample,which contained numerous{10-12}tension twins,has a reduced grain size and a higher internal strain than the pre-tensioned(PT)sample,which is attributed to the inherent internal strain that occurs during the formation and growth of the *** a result,the precipitation behavior of the PC sample is accelerated,leading to its short peak aging time of 32 h,which is lower than those of the PT and as-extruded samples(48 and 100 h,respectively).Furthermore,fine continuous precipitates(CPs)rapidly form within the{10-12}twins,contributing to the enhanced *** precipitates(DPs),which have a hardness comparable to the CP-containing twinned regions,in the PC sample experience less coarsening during aging than those in the PT sample due to growth inhibition by the{10-12}***,the{10-12}twins generated under the twinning-dominant deformation condition lead to enhanced precipitation behaviors,including the preferential formation and refinement of CPs and the suppressed coarsening of ***,pre-deformation that occurs{10-12}twinning exhibits more pronounced effects on precipitation acceleration and microstructural modification than slip-inducing pre-deformation.

关键词： AZ80 alloy Slip Twinning Precipitation Hardness

Influence of undissolved second-phase particles on dynamic recrystallization behavior of Mg–7Sn–1Al–1Zn alloy during low-and high-temperature extrusions

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Journal of Materials Science & Technology 2021年第12期71卷 87-97页

作者： hyun Ji Kim Sang-cheol Jin Jae-Gil Jung Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon51508Republic of Korea

This study investigates the effects of fine and coarse undissolved particles in a billet of the Mg–7 Sn–1 Al–1 Zn(TAZ711)alloy on the dynamic recrystallization(DRX)behavior during hot extrusion at low and high temperatures and the resultant microstructure and mechanical properties of the *** this end,partially homogenized(PH)and fully homogenized(FH)billets are extruded at temperatures of250 and 450°*** PH billet contains fine and coarse undissolved Mg_(2) Sn particles in the interdendritic region and along the grain boundaries,*** fine particles(<1μm in size)retard DRX during extrusion at 250°C via the Zener pinning effect,and this retardation causes a decrease in the area fraction of dynamically recrystallized(DRXed)grains of the extruded *** addition,the inhomogeneous distribution of fine particles in the PH billet leads to the formation of a bimodal DRXed grain structure with excessively grown grains in particle-scarce *** contrast,in the FH billet,numerous nanosized Mg_(2) Sn precipitates are formed throughout the material during extrusion at 250°C,which,in turn,leads to the formation of small,uniform DRXed grains by the grain-boundary pinning effect of the *** the PH billet is extruded at the high temperature of 450°C,the retardation effect of the fine particles on DRX is weakened by their dissolution in theα-Mg matrix and the increased extent of thermally activated grain-boundary *** contrast,the coarse Mg_(2) Sn particles in the billet promote DRX during extrusion through the particle-stimulated nucleation phenomenon,which results in an increase in the area fraction of DRXed *** both low and high extrusion temperatures,the extruded material fabricated using the PH billet,which contains both fine and coarse undissolved particles,has a lower tensile strength than that fabricated using the FH billet,which is virtually devoid of second-phase *** lower strength of the former is attributed mai

关键词： Mg–Sn alloy Second-phase particle Extrusion Homogenization Dynamic recrystallization

Predictors of pain resolution after varicocelectomy for painful varicocele

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Asian Journal of Andrology 2011年第5期13卷 754-758页

作者： hyun Jun Park Seung Soo Lee Nam cheol Park Department of Urology Pusan National University School of MedicineMedical Research InstitutePusan National University.Busan 602-739Korea

Varioocelectomny is a management option for patients with painful varicocele. In this study, we assessed the effectiveness of varicocelectomy for painful varicocele and examined the factors that might be predictive of outcome. All patients who underwent a varicocelectomy for pain between February 2007 and July 2009 were includecL A review of patient medical records was conducted; patient age,body mass index （BMI）, uede, iocatien of the vericocele, tasticular volume, duration and quality of the pain （dull, draaing, throbbing or sharp） and surgical technique （ingulnal versus subinguinal） were documented. All parameters were compared with the rasolution of pain （complete, partial or failure）. We followed up on 53 of 104 patients （51.0%）. Complete postopanntive resolution of pain was reported by 28 patients （52.8%）, whereas 22 （41.5%） reported partial resolution, Only three patients （5.7%） mpaded failure. No relationship was observed between postoperative pain resolution and age, BMI, grade of varicoceio, location of varicocele, ipsilateral testicular, quality of pain or surgical technique. The duration of pain before surllery was the only factor that correlated with postopaative pain resolution （univariate, P=-0.004; multivariate, P=0.002）. Our rasults indicatethat varicocelectomy isan effective treatmentfar painful varicocele in properly selected patients, and that duration of pain before surgery may be predictive of outcome.

关键词： duration pain testis vadcocele vadcocelectemy

Current status and challenges for cell-cultured milk technology: a systematic review

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1778-1792页

作者： Hyuk cheol Kwon hyun Su Jung Vahinika Kothuri Sung Gu Han Department of Food Science and Biotechnology of Animal Resources Konkuk UniversitySeoulRepublic of Korea

Cellular agriculture is an innovative technology for manufacturing sustainable agricultural products as an alternative to traditional *** most cellular agriculture is predominantly centered on the production of cultured meat,there is a growing demand for an understanding of the production techniques involved in dairy products within cellular *** review focuses on the current status of cellular agriculture in the dairy sector and technical challenges for cell-cultured milk *** agriculture technology in the dairy sector has been classified into fermentation-based and animal cell culture-based cellular ***,various companies synthesize milk components through precision fermentation ***,several startup companies are pursuing animal cell-based technology,driven by public concerns regarding genetically modified organisms in precision fermentation ***,this review offers an up-to-date exploration of animal cell-based cellular agriculture to produce milk components,specifically emphasizing the structural,functional,and productive aspects of mammary epithelial cells,providing new information for industry and academia.

关键词： Cell culture system Cell-cultured milk Mammary epithelial cells Precision fermentation