检索结果-南通市图书馆

Hemorrhagic hemangioma in the liver:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第23期21卷 7326-7330页

作者： Jeong Min Kim Woo Jin Chung Byoung Kuk Jang Jae Seok Hwang Yong hoon Kim Jung Hyeok kwon Mi Sun Choi Department of Internal Medicine Keimyung University School of Medicine Department of Hepatobiliary Surgery Keimyung University School of Medicine Department of Radiology Keimyung University School of Medicine Department of Pathology Keimyung University School of Medicine

Hemangioma is the most common type of benign tumor that arises in the liver. Although rupture and hemorrhage of hepatic hemangioma are rare complications, they can be the cause of mortality. The authors report a case of hemorrhagic hepatic hemangioma: in a 54-yearold woman who was admitted with epigastric *** had taken oral contraceptives several weeks *** results of a blood examination were normal. An abdominal computed tomography scan revealed a tumor in hepatic segment 4, and a hemorrhage inside the cystic mass was suspected. The mass was removed laparoscopically to confirm the tumor properties and control the hemorrhage. The pathologic findings of the resected mass were consistent with hepatic hemangioma with intratumoral hemorrhage. The patient was discharged 8 d after the surgery, without further complications or complaints, and the patient's condition was found to have improved during follow-up.

关键词： Hemangioma Liver Hemorrhage Tumor Complication

Endoscopic transcystic stent placement for an intrahepatic abscess due to gallbladder perforation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第9期13卷 1458-1459页

作者： Myung Soo Kang Do Hyun Park Ki Du kwon Jeong hoon Park Suck-Ho Lee Hong-Soo Kim Sang-Heum Park Sun-Joo Kim Division of Gastroenterology Department of Internal MedicineSoon Chun Hyang University Cheonan HospitalCheonan Korea

Perforation of the gallbladder with cholecystohepatic communication is a rare cause of liver abscess. Because it is a rare entity, the treatment modality has not been fully established. We report for the first time a patient with an intrahepatic abscess due to gallbladder perforation successfully treated by endoscopic stent placement into the gallbladder who had a poor response to continuous percutaneous drainage.

关键词： Liver abscess Gallbladder perforation Endoscopic stent placement Cholecystohepatic communication

Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multiinstitutional analysis (KROG 19-04)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第6期19卷 931-944页

作者： Sung Uk Lee Jinsil Seong Tae Hyun Kim Jung Ho Im Woo Chul Kim Kyubo Kim Hae Jin Park Tae Gyu Kim Youngkyong Kim Bae kwon Jeong Jin Hee Kim Byoung hyuck Kim Taek-Keun Nam Center for Proton Therapy and Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyang 10408Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13497Korea Department of Radiation Oncology Inha University HospitalInha University School of MedicineIncheon 22332Korea Department of Radiation Oncology Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985Korea Department of Radiation Oncology Hanyang University Medical CenterHanyang University College of MedicineSeoul 04763Korea Department of Radiation Oncology Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Korea Department of Radiation Oncology Kyung Hee University HospitalKyung Hee University College of MedicineSeoul 02447Korea Department of Radiation Oncology Gyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Korea Department of Radiation Oncology Dongsan Medical CenterKeimyung University School of MedicineDaegu 41931Korea Department of Radiation Oncology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University College of MedicineHwasun 58128Korea

Objective:The effectiveness of adjuvant treatments for resected gallbladder carcinoma(GBC)has remained unclear due to lack of randomized controlled trials;thus,the aim of present study was to evaluate the role of adjuvant treatments,including chemoradiotherapy(CRT)and/or chemotherapy(CTx),in patients with resected ***:A total of 733 GBC patients who received curative-intent surgical resection were identified in a multi-institutional *** 733 patients,372(50.8%)did not receive adjuvant treatment,whereas 215(29.3%)and 146(19.9%)received adjuvant CTx and CRT,*** locoregional recurrence-free survival(LRFS),recurrence-free survival(RFS),and overall survival(OS)of the adjuvant treatment groups were compared according to tumor stage(stage II *** III–IV).Results:In stage II disease(n=381),the 5-year LRFS,RFS,and OS were not significantly different among the no-adjuvant therapy,CTx,and CRT groups,and positive resection margin,presence of perineural invasion,and Nx classification were consistently associated with worse LRFS,RFS,and OS in the multivariate analysis(P<0.05).For stage III–IV(n=352),the CRT group had significantly higher 5-year LRFS,RFS,and OS than the no-adjuvant therapy and CTx groups(67.8%,45.2%,and 56.9%;37.9%,28.8%,and 35.4%;and 45.0%,30.0%,and 45.7%,respectively)(P<0.05).Conclusions:CRT has value as adjuvant treatment for resected GBC with stage III–IV *** study is needed for stage II disease with high-risk features.

关键词： Gallbladder cancer adjuvant treatment chemoradiotherapy locoregional recurrence-free survival overall survival

Glucose metabolism and neurogenesis in the gerbil hippocampus after transient forebrain ischemia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第8期11卷 1254-1259页

作者： Dae Young Yoo kwon Young Lee Joon Ha Park Hyo Young Jung Jong Whi Kim Yeo Sung Yoon Moo-Ho Won Jung hoon Choi In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary Medicine and Institute of Veterinary ScienceKangwon National University Department of Neurobiology School of MedicineKangwon National University

Recent evidence exists that glucose transporter 3（GLUT3） plays an important role in the energy metabolism in the *** previous studies have been conducted using focal or hypoxic ischemia models and have focused on changes in GLUT3 expression based on protein and m RNA levels rather than tissue *** the present study,we observed change in GLUT3 immunoreactivity in the adult gerbil hippocampus at various time points after 5 minutes of transient forebrain *** the sham-operated group,GLUT3 immunoreactivity in the hippocampal CA1 region was weak,in the pyramidal cells of the CA1 region increased in a time-dependent fashion 24 hours after ischemia,and in the hippocampal CA1 region decreased significantly between 2 and 5 days after ischemia,with high level of GLUT3 immunoreactivity observed in the CA1 region 10 days after *** a double immunofluorescence study using GLUT3 and glial-fibrillary acidic protein（GFAP）,we observed strong GLUT3 immunoreactivity in the ***3 immunoreactivity increased after ischemia and peaked 7 days in the dentate gyrus after ischemia/*** a double immunofluorescence study using GLUT3 and doublecortin（DCX）,we observed low level of GLUT3 immunoreactivity in the differentiated neuroblasts of the subgranular zone of the dentate gyrus after ***3 immunoreactivity in the sham-operated group was mainly detected in the subgranular zone of the dentate *** results suggest that the increase in GLUT3 immunoreactivity may be a compensatory mechanism to modulate glucose level in the hippocampal CA1 region and to promote adult neurogenesis in the dentate gyrus.

关键词： nerve regeneration transient forebrain ischemia glucose transporter 3 pyramidal cells astrocytes neuroblasts neural regeneration

In-situ formation of MOF derived mesoporous Co3N/amorphous N-doped carbon nanocubes as an efficient electrocatalytic oxygen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第7期12卷 1605-1611页

作者： Bong Kyun Kang Seo Young Im Jooyoung Lee Sung hoon Kwag Seok Bin kwon SintayehuNibret Tiruneh Min-Jun Kim Jung Ho Kim Woo Seok Yang Byungkwon Lim Dae Ho Yoon Nano Materials and Components Research Center Korea Electronics Technology InstituteSeongnam 463-816Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University Suwon 440-746Republic of Korea Advanced Materials & Processing Center Institute for Advanced Engineering (IAE)Yongin 175-28Republic of Korea Australian Institute for Innovative Materials (AIIM) University of WollongongSquires WayNorth Wollongong NSW 2500Australia Department of Advanced Materials Engineering for Information and Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do17104Republic of Korea

The suitable materials,metal nitrides,are a promising class of electrocatalyst materials for a highly efficient oxygen evolution reaction (OER) because they exhibit superior intrinsic conductivity and have higher sustainability than oxide-based *** our knowledge,for the first time,we report a designable synthesis of three-dimensional (3D) and mesoporous Co3N@ amorphous N-doped carbon (AN-C) nanocubes (NCs) with well-controlled open-framework structures via monodispersed Co3[Co(CN)6]2 Prussian blue analogue (PBA) NC precursors using in situ nitridation and calcination ***3N@AN-C NCs (2 h) demonstrate better OER activity with a remarkably low Tafel plot (69.6 mV-dec-1),low overpotential of 280 mV at a current density of 10 ***,excellent cycling stability in alkaline electrolytes was exhibited without morphological changes and voltage elevations,superior to most reported hierarchical structures of transition-metal nitride *** presented strategy for synergy effects of metal-organic frameworks (MOFs)-derived transition-metal nitrides-carbon hybrid nanostructures provides prospects for developing high-performance and advanced electrocatalyst materials.

关键词： transition-metal nitride metal organic framework mesoporous oxygen evaluation reaction alkaline water electrolysis

Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2018年第6期24卷 460-466页

作者： kwon-Yeon Weon Min Gi Kim Soyoung Shin Tae Hwan Kim Sang hoon Joo Eunsook Ma Seok Won Jeong Sun Dong Yoo Yu Seok Youn Beom Soo Shin College of Pharmacy Catholic University of Daegu School of Pharmacy Sungkyunkwan University College of Pharmacy Wonkwang University

Objective： To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib （Iressae） and the oriental medications Guipi Decoction （归脾汤, GPD, Guibi-tang in Korean） and Bawu Decoction （八物汤, BWD, Palmul-tang in Korean）. Methods： Methylceliulose （MC, control）, GPD （1,200 mg/kg）, or BWD （6,000 mg/kg） was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefitinib （10 mg/kg） was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments. To examine the effects of the multiple doses of the herbal medicines, gefltinib （10 mg/kg） was orally administered following 7 consecutive days of the administration of MC or each herbal medicine. The plasma concentrations of gefitinib were determined with liquid chromatography-tandem mass spectrometry assay. The plasma concentration-time profiles of gefitinib were analyzed with a noncompartmental analysis. Results： Gefitinib was rapidly absorbed and showed a mono- exponential decline with an elimination half-life of 3.7-4.1 h. The pharmacokinetics of gefitinib was not affected by GPD pretreatment. However, a significantly lower maximum plasma concentration （Crux, P〈0.05） and area under the curve （P〈0.05）, and a delayed time to reach Cmax （Tmax, P〈0.01） were observed in both single- and multiple- dose BWD-pretreated rats compared with the control rats. Conclusions： BWD and not GPD might delay and interfere with gefitinib absorption. Further evaluations of the clinical significance of these findings are needed.

关键词： herb-drug interaction pharmacokinetics gefitinib Guipi Decoction Bawu Decoction

Small cell carcinoma of the liver and biliary tract without jaundice

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第44期19卷 8146-8150页

作者： Jae-Min Jo Yoo-Kyung Cho Chang-Lim Hyun Kyoung-Hee Han Ji-Young Rhee Jung-Mi kwon Woo-Kun Kim Sang-hoon Han Department of Internal Medicine Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing Province South Korea Department of Pathology Jeju National University Hospital Jeju-si 890-716 Jeju Self-Governing ProvinceSouth Korea Jeju National University School of Medicine Jeju-si 890-716 Jeju Self-Governing Province South Korea

An 80-year-old woman presenting with chest pain was found to have a large,lobulated soft tissue mass in the liver and nearby tissues on abdominal computed tomography(CT).The tumor had invaded the common hepatic artery and main portal *** developed 4 wk later,at which point,a pancreas and biliary CT scan revealed a large mass in the right lobe of the liver and a hilar duct obstruction,which was found to be a small cell *** its rarity,liver and bile duct small cell carcinoma should be considered in the differential diagnosis of atypical chest pain without jaundice.

关键词： Extrapulmonary small cell carcinoma Jaundice Liver mass Bile duct mass Neuroendocrine tumor

Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第34期21卷 9887-9899页

作者： Jung Ho Kim You-Jin Hwang Sang hoon Han Young Eun Lee Saerom Kim Yoon Jae Kim Jae Hee Cho Kwang An kwon Ju Hyun Kim Se-Hee Kim Department of Internal Medicine Gachon University Gil Medical Center Division of Biological Science Gachon University of Medicine and Science Department of Internal Medicine Jeju National University School of Medicine Gachon Medical Research Institute Gachon University Gil Medical Center

AIM:To elucidate the effects of dexamethasone on hypoxia-induced epithelial-to-mesenchymal transition(EMT) in colon ***:Human colon cancer HCT116 and HT29 cells were exposed to normoxic(21%) and hypoxic(1%) conditions. First,the effect of dexamethasone on cell viability was examined by MTT cell proliferation assay. In order to measure the expression levels of EMT markers(Snail,Slug,Twist,E-cadherin,and integrin αVβ6) and hypoxia-related genes [Hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF)] by dexamethasone,quantitative real-time polymerase chain reaction and western blot analysis were performed. Furthermore,the morphological changes of colon cancer cells and the expression pattern of E-cadherin by dexamethasone were detected through immunocytochemistry. Finally,the effects of dexamethasone on the invasiveness and migration of colon cancer cells were elucidated using matrigel invasion,migration,and wound healing migration ***:Under hypoxia,dexamethasone treatment inhibited HIF-1α protein level and its downstream gene,VEGF m RNA level in the colon cancer cell lines,HCT116 and HT29. In addition,the presence of dexamethasone down-regulated the m RNA levels of hypoxia-induced Snail,Slug,and Twist,all transcriptional factors of EMT,as well as hypoxia-induced integrin αVβ6 protein level,a well-known EMT marker for colon cancer cells. Furthermore,reduced E-cadherin in hypoxic condition was found to be recoverable by treating with dexamethasone in both colon cancer cell lines. Similarly,under hypoxic conditions,dexamethasone restored the growth pattern and morphological phenotype reminiscent of colon cancer cells grown under normoxic conditions; dexamethasone blocked the migration and invasion of both colorectal cancer cell lines in ***:Our study suggested that dexamethasone has inhibitory effects on cell migration and invasion by suppressing EMT of colon cancer cell lines in hypoxic condition.

关键词： Dexamethasone Colon cancer Hypoxia Hypoxia-inducib

Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm Sun-Young Jang Se hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-Seon Lee Kyuseok Kim Soon-Kyeong kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 02447Republic of Korea BioNanocomposite Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea College of Korean Medicine Kyung Hee UniversitySeoul 02447Republic of Korea Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju 52828Republic of Korea Department of Anatomy&Information Sciences College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea

Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut *** has been proven to be effective in reducing AD symptoms without serious adverse events,but its underlying mechanism is not completely *** purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut *** AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11)***-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and *** microbiota was profiled using 16S rRNA gene sequencing from fecal *** Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed byβ-diversity indices and analysis of *** beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated ***,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the *** attenuated these abnormalities,which was gut *** Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new perspective for non-pharmacological strategies for

关键词： Atopic dermatitis Acupuncture Gut microbiota Intestinal barrier function