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It is necessary to exam bottom and top slide smears of EUS-FNA for pancreatic cancer

Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 553-558页

作者： Jong-chanb Lee Haeryoung kim hyoung woo kim Jongchan Lee Kyu-hyun Paik Jingu Kang Jin-Hyeok Hwang Jaihwan kim Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Pathology Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine Chungbuk National University College of Medicine Chungbuk National University Hospital Department of Internal Medicine The Catholic University of Korea Daejeon St. Mary’s Hospital Department of Internal Medicine Kangdong Sacred Heart Hospital of Hallym University Medical Center

Background: Despite many reports on the diagnostic yield of cytology from endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA), inter-slide differences are unknown. This prospective study aimed to compare diagnostic yield and cellular characteristics of bottom slides(BS) and top slides(TS) from EUSFNA cytology performed without an on-site cytopathologist. Methods: In patients with suspected pancreatic cancer on previous imaging explorations, a single endoscopist performed EUS-FNA and obtained 2 sets of cytology slide(8 BS and 8 TS), 1 cellblock slide, and 1 biopsy slide. Both slide sets were randomly assigned. A cytopathologist with more than 10 years of expertise in pancreatic cytopathology blindly inspected and compared two slide sets. Results: In total, 73 specimens [42 head(57.5%), 16 body(21.9%), and 15 tail(20.5%)] were acquired for final analysis. Seventy-one cases were finally diagnosed with pancreatic cancer. The sensitivity and specificity of BS were 80.3% and 100.0%; and of TS 78.9% and 100.0%, respectively. In analyzing inter-slide difference, 66 cases(90.4%) showed consistent results between BS and TS. However, seven(9.6%) were positive only in one slide sets(4 BS and 3 TS). The proportions of specimens more than moderate and high cellularity were 75.3% and 60.3% in both slide sets( P > 0.99), and the proportion of artifact-free sets were 50.7%, and 52.1% for the BS and TS, respectively( P = 0.869). Conclusions: Although BS and TS exhibited highly consistent diagnostic yields in cytologic smears from EUS-FNA, the proportion of inter-slide discordance is clinically considerable. Both slide sets need to be examined if there is no on-site cytopathologist.

关键词： Endoscopic ultrasound-guided fine-needle aspiration Pancreatic neoplasm Cytology

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In vitro Cyto and Blood Compatibility of Titanium Containing Diamond-Like Carbon Prepared by Hybrid Sputtering Method

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Plasma Science and Technology 2012年第9期14卷 829-836页

作者： Krishnasamy NAVANEETHA PANDIYARAJ Jan HEEG Andreas LAMPKA Fabian JUNGE Torsten BARFELS Marion WIENECKE Young Ha RHEE hyoung woo kim Department of Physics Sri Shakthi Institute of Engineering and Technology Institute of Surface and Thin Film Technology Hochschule WismarGermany Department of Microbiology College of Bioscience&BiotechnologyChungnam National University

In recent years, diamond-like carbon films （DLC） have been given more attention in research in the biomedical industry due to their potential application as surface coating on biomedical materials such as metals and polymer substrates. There are many ways to prepare metal containing DLC films deposited on polymeric film substrates, such as coatings from car- bonaceous precursors and some means that incorporate other elements. In this study, we in- vestigated both the surface and biocompatible properties of titanium containing DLC （Ti-DLC） films. The Ti-DLC films were prepared on the surface of poly （ethylene terephthalate）（PET） film as a function of the deposition power level using reactive sputtering technique. The films＇ hydrophilicity was studied by contact angle and surface energy tests. Their surface morphology was studied by scanning electron microscopy （SEM） and atomic force microscopy （AFM）. Their elemental chemical composition was analyzed using energy dispersive X-spectra （EDX） and X-ray photoelectron spectroscopy （XPS）. Their blood and cell compatibility was studied by in vitro tests, including tests on platelet adhesion, thrombus formation, whole blood clotting time and osteoblast cell compatibility. Significant changes in the morphological and chemical composition of the Ti-DLC films were observed and found to be a function of the deposition level. These morphological and chemical changes reduced the interfacial tension between Ti-DLC and blood proteins as well as resisted the adhesion and activation of platelets on the surface of the Ti-DLC films. The cell compatibility results exhibited significant growth of osteoblast cells on the surface of Ti incorporated DLC film compared with that of DLC film surface.

关键词： Ti-DLC hybrid reactive sputtering technique surface analysis cyto and blood compatibility

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Advanced Burst Mode Control to Reduce the Standby Power of Flyback Converter

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Engineering（科研） 2013年第1期5卷 137-141页

作者： Min-Sung kim hyoung-woo kim Ji-Hye Jang Ki-Hyun kim Department of Electronic Engineering Changwon National University Changwon Republic of Korea Power Semiconductor Research Center Korea Electrotechnology Research Institute 28-1 Sungju-Dong Sungsan-Gu Changwon 642-120 Republic of Korea

This paper we proposed advanced burst mode control technique to reduce the standby power consumption of the switch mode power supply (SMPS). To reduce the standby power consumption, most of the converter use burst mode or skip mode control technique. However Conventional standby mode control techniques have some problems such as audible noise and poor regulation. In proposed techniques, basically, the burst mode control technique is employed to reduce the fundamental switching frequency while limiting the peak drain current. But, in proposed technique, to improve the regulation characteristic, burst period of the proposed technique is shorter than that of the conventional burst mode technique. And also, to reduce the switching loss increase due to the short burst period, burst switching signal of the proposed technique is partially skipped. By using proposed advanced burst mode control technique, calculated standby power is 0.695W while standby power of the conventional burst mode control is 1.014W.

关键词： Standby power Flyback converter PWM IC SMPS

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叶酸受体阳性肿瘤靶向显像剂同型99Tcm和188Re标记的叶酸-甘氨酸-甘氨酸-半胱氨酸-谷氨酸的临床前研究

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中华核医学与分子影像杂志 2017年第7期37卷 444-444页

作者：唐军 woo hyoung kim Chang Guhn kim Myoung Hyoun kim Dae-Weung kim Cho Rong Park Ji Yong Park Yun-Sang Lee Hyewon Youn Keon wook Kang Jae Min Jeong June-Key Chung 苏州大学附属第二医院核医学科 Department of Nuclear Medicine Seoul National University Hospital Department of Nuclear Medicine Institute of Wonkwang Medical ScienceWonkwang University School of Medicine

目的制备同型的~(（99）Tcm和~(（188）Re标记的叶酸-甘氨酸-甘氨酸-半胱氨酸-谷氨酸（叶酸-GGCE）,并通过小鼠肿瘤模型评价其用于叶酸受体（FR）靶向分子显像的可行性。方法采用固相肽合成法合成叶酸-GGCE,并用99Tcm或188Re标记。放化... 详细信息

目的制备同型的~(（99）Tcm和~(（188）Re标记的叶酸-甘氨酸-甘氨酸-半胱氨酸-谷氨酸（叶酸-GGCE）,并通过小鼠肿瘤模型评价其用于叶酸受体（FR）靶向分子显像的可行性。方法采用固相肽合成法合成叶酸-GGCE,并用99Tcm或188Re标记。放化纯测定采用放射性高效液相色谱法。99Tcm-叶酸-GGCE的生物分布研究在同时注射或不注射过量的游离叶酸的情况下完成,小鼠肿瘤模型分别为荷FR阳性的KB细胞模型和荷FR阴性的HT1080细胞模型。188Re-叶酸-GGCE的生物分布研究在荷KB细胞小鼠肿瘤模型上完成。静脉注射99Tcm-叶酸-GGCE后,采集2种小鼠肿瘤模型的系列平面图像。小鼠肿瘤模型注射99Tcm-叶酸-GGCE或188Re-叶酸-GGCE（同时注射或不注射过量的游离叶酸）后,进行系列microSPECT/CT图像采集。结果99Tcm和188Re标记的叶酸-GGCE的标记率和标记后4 h内的放化纯均>95%。荷KB细胞模型在注射99Tcm-叶酸-GGCE后1、2、4 h,其肿瘤组织的放射性摄取值分别为16.4、23.2和17.6%ID/g,如果同时注射过量的叶酸,肿瘤组织的摄取可被抑制97.4%。注射后4 h,肿瘤与血液、肝、肺、肌肉和肾的T/NT比值分别是54.3、25.2、38.3、97.8和0.3。荷KB细胞模型在注射188Re-叶酸-GGCE后2、4、8、16 h,其肿瘤组织的放射性摄取值分别为17.4、21.7、24.1和15.6%ID/g。注射后8 h,肿瘤与血液、肝、肺、肌肉和肾的T/NT比值分别是126.8、21.9、54.8、80.3和0.4。注射99Tcm或188Re标记的叶酸-GGCE后,系列平面图像和microSPECT/CT图像均见KB细胞肿瘤组织的放射性摄取较高,肿瘤显像清晰。肿瘤对显像剂的摄取在同时注射过量叶酸时可被完全抑制。结论同型99Tcm和188Re标记的叶酸-GGCE可被FR阳性肿瘤高摄取,且T/NT比值较高。2种显像剂均具有良好的靶向能力,在FR阳性肿瘤的诊断和疗效观察中有一定的应用价值。

关键词：叶酸受体肿瘤 99Tcm 188Re SPECT/CT

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Bacteriophage cocktail supplementation improves growth performance,gut microbiome and production traits in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1339-1350页

作者： Santi Devi Upadhaya Je Min Ahn Jae hyoung Cho Jin Young kim Dae Kyung Kang Sung woo kim Hyeun Bum kim In Ho kim Department of Animal Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea Department of Animal Science North Carolina State University116 Polk HallBox 7621120 W Broughton DrRaleighNC 27695USA

Background:Effective antibiotic alternatives are urgently needed in the poultry industry to control disease *** therapy mainly utilizes lytic phages to kill their respective bacterial hosts and can be an attractive solution to combating the emergence of antibiotic resistance in ***:Five hundred and four,one-day-old broilers(Ross 308)were allotted to 1 of 4 treatment groups in a completely randomized *** consisted of CON(basal diet),PC(CON+0.025%Avilamax®),BP 0.05(CON+0.05%bacteriophage),and BP 0.10(CON+0.10%bacteriophage).Results:A significant linear effect on body weight gain(BWG)was observed during days 1–7,days 22–35,and cumulatively in bacteriophage(BP)supplemented *** BWG tended to be higher(P=0.08)and the feed intake(FI)was increased(P=0.017)in the PC group over CON group.A greater(P=0.016)BWG and trends in increased FI(P=0.06)were observed in the experiment in birds fed PC than CON *** the genus level,the relative abundance of Lactobacillus was decreased in PC(65.28%),while it was similar in BP 0.05 and BP 0.10(90.65%,86.72%)compared to CON(90.19%).At the species level,the relative abundance of Lactobacillus salivarus was higher in BP 0.05(40.15%)and BP 0.10(38.58%)compared to the CON(20.04%)and PC(18.05%).A linear reduction in the weight of bursa of Fabricius(P=0.022)and spleen(P=0.052)was observed in birds fed graded level of BP and an increase(P=0.059)in the weight of gizzard was observed in birds fed PC over BP *** and quadratic responses were observed in redness of breast muscle color in birds fed graded level of ***:The inclusion of the 0.05%and 0.1%BP cocktail linearly improved broiler weight during the first 7 days,22–35 days and cumulatively,whereas 0.05%BP addition was sufficient for supporting immune organs,bursa and spleen as well as enhancing gut microbiome,indicating the efficacy of 0.05%BP as a substitute antibiotic growth promoter in broiler diets.

关键词： Bacteriophage Broiler chickens Gut microbiome Performance

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Silica-quaternary ammonium “Fixed-Quat” nanofilm coated fiberglass mesh for water disinfection and harmful algal blooms control

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Journal of Environmental Sciences 2019年第8期31卷 213-224页

作者： Daniela Diaz Jared Church Mikaeel Young Keug Tae kim Jungsu Park Yun Bin Hwang Swadeshmukul Santra woo hyoung Lee Department of Civil Environmental and Construction Engineering University of Central Florida NanoScience Technology Center University of Central Florida Burnett School of Biomedical Sciences University of Central Florida Department of Environmental & Energy Engineering Suwon University K-water Institute Korea Water Resources Corporation Department of Material Science and Engineering 4000 Central Florida Blvd University of Central Florida Department of Chemistry 4111 Libra Drive University of Central Florida

Intensification of pollution loading worldwide has promoted an escalation of different types of disease-causing microorganisms, such as harmful algal blooms(HABs), instigating detrimental impacts on the quality of receiving surface waters. Formation of unwanted disinfection by-products(DBPs) resulting from conventional disinfection technologies reveals the need for the development of new sustainable alternatives. Quaternary Ammonium Compounds(QACs) are cationic surfactants widely known for their effective biocidal properties at the ppm level. In this study, a novel silica-based antimicrobial nanofilm was developed using a composite of silica-modified QAC(Fixed-Quat) and applied to a fiberglass mesh as an active surface via sol–gel technique. The synthesized Fixed-Quat nanocoating was found to be effective against E. coli with an inactivation rate of 1.3 × 10^(-3) log reduction/cm min. The Fixed-Quat coated fiberglass mesh also demonstrated successful control of Microcystis aeruginosa with more than 99% inactivation after 10 hr of *** developed antimicrobial mesh was also evaluated with wild-type microalgal species collected in a water body experiencing HABs, obtaining a 97% removal efficiency. Overall,the silica-functionalized Fixed-Quat nanocoating showed promising antimicrobial properties for water disinfection and HABs control, while decreasing concerns related to DBPs formation and the possible release of toxic nanomaterials into the environment.

关键词： Fiberglass mesh HAB mitigation Nanocoating Quaternary ammonium compounds(QACs) Silica-functionalization Water disinfection

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On-screen fingerprint sensor with optically and electrically tailored transparent electrode patterns for use on high-resolution mobile displays

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Microsystems & Nanoengineering 2020年第1期6卷 243-254页

作者： Hyun-Joon kim-Lee Seog woo Hong Dong Kyun kim Jinmyoung kim Hong Suk kim Seok-Whan Chung Eun-hyoung Cho Hae-Sung kim Byung-Kyu Lee Device Research Center Samsung Advanced Institute of Technology130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 443-803Republic of Korea

In this study,a mutual capacitive-type on-screen fingerprint sensor,which can recognize fingerprints on a display screen to provide smartphones with full-screen displays with a minimal bezel area,is ***-screen fingerprint sensors are fabricated using an indium tin oxide transparent conductor with a sheet resistance of~10Ω/*** a transmittance of~94%(~86% with the substrate effect)in the visible wavelength range,and assembled onto a display *** at this high transmittance,the electrodes can degrade the display quality when they are placed on the *** interference between periodic display pixel arrays and sensor patterns can lead to the *** is necessary to find an appropriate sensor pattern that minimizes the Moirepattern,while maintaining the signal *** search for appropriate patterns,a numerical calculation is carried out over wide ranges of pitches and rotation *** range is narrowed for an experimental evaluation,which is used to finally determine the sensor *** the selected sensor pitches are too small to detect capacitance variations,three unit patterns are electrically connected to obtain a unit block generating a larger *** applying the selected sensor pattern and circuit driving by block,fingerprint sensing on a display is demonstrated with a prototype built on a commercial smartphone.

关键词： transparent pattern smart

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A surgical technique using the gastroepiploic vein for portal inflow restoration in living donor liver transplantation in a patient with diffuse portomesenteric thrombosis

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Hepatobiliary & Pancreatic Diseases International 2023年第5期22卷 537-540页

作者： Sang-Hoon kim Deok-Bog Moon woo-hyoung Kang Dong-Hwan Jung Sung-Gyu Lee Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical Center and University of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea

Portal vein thrombosis(PVT)is no longer a definitive contraindication in liver transplants(LTs)[1].Complex vascular reconstructions such as cavoportal hemitransposition(CPHT)[2–5],renoportal anastomosis(RPA)[6,7],and use of sizable collaterals(pericholedochal varix[8,9],coronary vein,peripancreatic or perigastroesophageal varices[10],right superior colic vein[11],ileocolic vein[12],and left gastric vein[13]),or combined liverpancreas-small bowel transplant[14]are required for portal inflow in patients with total portosplenomesenteric thrombosis.

关键词： thrombosis anastomosis portal

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Contrast evaluation methods for natural color images in display systems: within- and cross-content evaluations

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第11期12卷 897-909页

作者： Choon-woo kim School of Information and Communication Engineering Inha University

Contrast evaluation can be used as a criterion to evaluate performance of contrast enhancement algorithms and to compare contrast capability of display systems. This paper deals with contrast evaluation models for natural color images. Two separate models are defined for within- and cross-content evaluations. The former is to differentiate the perceived contrast of the images with the same content. The latter is to discriminate the differences in contrast among the images with different contents. Perception mechanisms are quite different for within- and cross-content evaluations. Local contrast plays an important role in within-content evaluation. In contrast, global contrast dominates the contrast perception for cross-content evaluation. Results of human visual experiments show that the proposed evaluation models outperform previous methods for both within- and cross-content evaluations.

关键词： Contrast evaluation Global contrast Local contrast Within content Cross content Statistical significance

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Laparoscopic partial cystectomy with mucosal stripping of extraluminal duodenal duplication cysts

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World Journal of Gastroenterology 2014年第4期20卷 1123-1126页

作者： Jeik Byun hyoung-Min Oh Soo-Hong kim Hyun-Young kim Sung-Eun Jung Kwi-Won Park woo-Sun kim Department of Pediatric Surgery Seoul National University Children’s Hospital Department of Radiology Seoul National University Hospital

Duodenal duplication cysts are rare congenital *** duplication should be considered in the differential diagnosis of patients who present with abdominal symptoms with cystic structures neighboring the ***,we present an 8-year-old girl with a duodenal duplication cyst treated with partial cystectomy with mucosal stripping performed *** surgery can be considered as a treatment option for duodenal duplication cysts,especially in extraluminal locations.

关键词： Duodenal duplication cyst Laparoscopic surgery Partial cystectomy Extraluminal situation Children

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