检索结果-南通市图书馆

Hepatobiliary Surgery and Nutrition 2024年第1期13卷 115-118页

作者： Bo Kyung Koo dong hyeon lee Jeong Hwan Park Won Kim Division of Endocrinology Department of Internal MedicineBoramae Medical CenterSeoulRepublic of Korea Department of Internal Medicine Seoul National University College of MedicineSeoulRepublic of Korea Division of Gastroenterology and Hepatology Department of Internal MedicineBoramae Medical CenterSeoulRepublic of Korea Department of Pathology Boramae Medical CenterSeoulRepublic of Korea

Advanced fibrosis determines the prognosis of nonalcoholic fatty liver disease(NAFLD);therefore,accurate risk-prediction for advanced fibrosis is fundamental in the management of NAFLD(1).Targeted screening for advanced fibrosis in high-risk populations,such as those with type 2 diabetes,obesity with metabolic complications,a family history of cirrhosis,or significant alcohol use is recommended for implementing early intervention to prevent future adverse hepatic outcomes of NAFLD(2,3).Non-invasive tests including fibrosis-4 index(FIB-4)and liver stiffness measurement(LSM)are recommended to identify individuals at a higher risk of liver-related events(1,2).In addition to clinical classifications,such as FIB-4;genetic information provides further stratification for liver-related outcomes(4).

关键词： Nonalcoholic fatty liver disease(NAFLD) cirrhosis PNPLA3-rs738409

Investigation into charge carrier dynamics in organic light-emitting diodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research Energy 2024年第2期3卷 39-46页

作者： dong-Guang Zheng hyeon-dong lee Gyeong Won lee dong-Soo Shin Jeongwon Kim Jong-In Shim Zhiqun Lin Tae-Woo lee dong Ha Kim Information Engineering College Hangzhou Dianzi UniversityHangzhou 311305China Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Photonics and Nanoelectronics Hanyang University ERICA55 Hanyangdeahak-roSangnok-guAnsanGyeonggi 15588Republic of Korea Department of Chemistry and Nanoscience Ewha Womans University52Ewhayeodae-gilSeodaemun-guSeoul 03760Republic of Korea Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore School of Chemical and Biological Engineering Institute of Engineering ResearchResearch Institute of Advanced MaterialsSoft FoundrySeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Basic Sciences Research Institute(Priority Research Institute) Ewha Womans UniversitySeoul 03760Republic of Korea Nanobio∙Energy Materials Center(National Research Facilities and Equipment Center) Ewha Womans UniversitySeoul 03760Republic of Korea

Organic light-emitting diodes(OLEDs)have demonstrated remarkable advancements in both device lifetime and luminous ***,insufficient operation lifetime due to device degradation remains a major hurdle,especially for brighter *** the degradation mechanisms of OLEDs due to the degradation of functional materials and the formation of defects in device architectures continues to be a significant ***,we evaluate the degradation characteristics by scrutinizing the electrical and optical properties,as well as analyzing the charge carrier dynamics in pristine and aged states of phosphorescent OLEDs(PhOLEDs).We show that degradation mechanisms in PhOLEDs can be elucidated in terms of the ideality factors of current and luminance in pristine and aged device *** consistent shifts in distinct ideality factors across various states points out that the device degradation is attributed to the deterioration of the guest material,***-light-emitting phosphorescent ***,the incongruity in ideality factor changes between the two states indicates that the degradation results from the deterioration of non-light-emitting *** characterization experiments provide further evidence that this degradation is primarily attributed to the deterioration of CBP-host *** thorough understanding of degradation mechanisms established in this study can contribute to realizing the highly reliable PhOLEDs with a long lifetime.

关键词： organic light-emitting diodes ideality factor carrier transport processes degradation mechanism

Pathological findings following radical prostatectomy in patients who are candidates for active surveillance： impact of varying PSA levels

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第6期13卷 838-841页

作者： dong Il Kang Thomas L. Jang Jeongyun Jeong Eun Young Choi Kelly Johnson dong hyeon lee Wun-Jae Kim Isaac Yi Kim Section of Urologic Oncology and Dean and Betty Gallo Prostate Cancer The Cancer Institute of New Jersey Robert Wood Johnson Medical School New Brunswick NJ 08903 USA Department of Urology Inje University Medical School Busan 614-735 Korea Department of Urology Ewha Womans University Seoul 158-710 Korea Department of Urology Chungbuk National University College of Medicine Cheongju 361-711 Korea

Active surveillance is an acceptable treatment option in men with a low-risk prostate cancer. In the present study, we have retrospectively reviewed the outcomes of 509 men who fit the criteria for active surveillance but selected radical prostatectomy. Then, the impact of varying prostate-specific antigen （PSA） levels on the risk of upstaging and upgrading in these patients was assessed. Pathological characteristics of patients who fulfilled the inclusion criteria under three active surveillance criteria--those of the University of California-San Francisco, the National Cancer Institute and the European Association of Urology--were examined. The proportion of men who were deemed candidates for active surveillance but were subsequently upstaged or upgraded was determined. Of 509 patients, 186 （36.5%）, 132 （25.9%） and 88 （17.3%） men fulfilled the active surveillance criteria, respectively. Upgrading （Gleason scores 7-10） ranged from 32.8% to 38.6%, while upstaging （≥ pT3） ranged from 10.2% to 12.5%, depending on the three active surveillance criteria. After a median follow-up of 24 months, three patients developed a biochemical recurrence. When the impact of varying PSA levels was examined using a test for trend analysis in the context of PSA for each protocol, rates of upstaging were lower in men with PSA 〈4 ng m1-1. However, there was no impact of varying PSA levels on upgrading. In conclusion, commonly used active surveillance protocols carry the risks of upgrading and upstaging. More reliable and accurate markers are needed to better stratify the risks of men who are appropriate candidates for active surveillance.

关键词： prostatectomy prostate-specific antigen prostatic neoplasm risk

Atomically Adjustable Rhodium Catalyst Synthesis with Outstanding Mass Activity via Surface-Li mi ted Cation Exchange

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第2期7卷 83-92页

作者： Hak hyeon lee dong Su Kim Swagotom Sarker Ji Hoon Choi Ho Seong lee Hyung Koun Cho Department of Advanced Materials Science&Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-doSeoul 16419Korea Department of Advanced Materials Science&Engineering Kyungpook National University80Daehak-roBuk-guDaegu 41566Korea

Rh has been widely studied as a catalyst for the promising hydrazine oxidation reaction that can replace oxygen evolution reactions for boosting hydrogen production from hydrazine-containing *** Rh being expensive,only a few studies have examined its electrocatalytic mass ***,surface-limited cation exchange and electrochemical activation processes are designed to remarkably enhance the mass activity of *** atoms were readily replaced at the Ni sites on the surface of NiOOH electrodes by cation exchange,and the resulting RhOOH compounds were activated by the electrochemical reduction *** cation exchange-derived Rh catalysts exhibited particle sizes not exceeding 2 nm without agglomeration,indicating a decrease in the number of inactive inner Rh ***,an improved mass activity of 30 A mg_(Rh)^(-1)was achieved at 0.4 V versus reversible hydrogen ***,the two-electrode system employing the same CE-derived Rh electrodes achieved overall hydrazine splitting over 36 h at a stable low *** proposed surface-limited CE process is an effective method for reducing inactive atoms of expensive noble metal catalysts.

关键词： cation exchange synthesis electrochemical metallization hydrazine oxidation reaction mass activity rhodium catalyst

Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho Jung-Hwan Yoon Jeong-ju Yoo Minjong lee dong hyeon lee Eun Ju Cho Jeong-Hoon lee Su Jong Yu Yoon Jun Kim Chung Yong Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： Kyu-Sang Park Pyo-Jin Sin dong hyeon lee Seung-Kuy Cha Min-Jeong Kim Na-Hyun Kim Soon-Koo Baik Seong-Woo Jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

Depolarization mitigated in ferroelectric Hf_(0.5)Zr_(0.5)O_(2)ultrathin films(<5 nm)on Si substrate by interface engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2024年第3期13卷 282-292页

作者： Se Hyun Kim Younghwan lee dong Hyun lee Geun hyeong Park Hyun Woo Jeong Kun Yang Yong hyeon Cho Young Yong Kim Min Hyuk Park Department of Materials Science and Engineering College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Advanced Materials College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Pohang Accelerator Laboratory Pohang University of Science&TechnologyPohang 790784Republic of Korea

(Hf,Zr)O_(2)offers considerable potential for next-generation semiconductor devices owing to its nonvolatile spontaneous polarization at the ***,scaling this material to sub-5 nm thickness poses several challenges,including the formation of an interfacial layer and high trap *** particular,a low-k SiO_(2)interfacial layer is naturally formed when(Hf,Zr)O_(2)films are directly grown on a Si substrate,leading to high depolarization fields and rapid reduction of the remanent *** address these issues,we conducted a study to significantly improve ferroelectricity and switching endurance of(Hf,Zr)O_(2)films with sub-5 nm thicknesses by inserting a TiO_(2)interfacial *** deposition of a Ti film prior to Hf_(0.5)Zr_(0.5)O_(2)film deposition resulted in a high-k TiO_(2)interfacial layer and prevented the direct contact of Hf_(0.5)Zr_(0.5)O_(2)with *** findings show that the high-k TiO_(2)interfacial layer can reduce the SiO_(2)/Si interface trap density and the depolarization field,resulting in a switchable polarization of 60.2μC/cm^(2)for a 5 nm thick Hf_(0.5)Zr_(0.5)O_(2)***,we propose that inserting a high-k TiO_(2)interfacial layer between the Hf_(0.5)Zr_(0.5)O_(2)film and the Si substrate may offer a promising solution to enhancing the ferroelectricity and reliability of(Hf,Zr)O_(2)grown on the Si substrate and can pave the way for next-generation semiconductor devices with improved performance.

关键词： ferroelectric charge trapping hafnia depolarization

Development of vehicle-recognition method on water surfaces using LiDAR data:SPD^(2)(spherically stratified point projection with diameter and distance)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第6期36卷 95-104页

作者： Eon-ho lee hyeon Jun Jeon Jinwoo Choi Hyun-Taek Choi Sejin lee The Department of Mechanical Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea Ocean System Engineering Research Division Korea Research Institute of Ships and Ocean Engineering(KRISO)Daejeon 34103Republic of Korea The Division of Mechanical&Automotive Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea

Swarm robot systems are an important application of autonomous unmanned surface vehicles on water *** monitoring natural environments and conducting security activities within a certain range using a surface vehicle,the swarm robot system is more efficient than the operation of a single object as the former can reduce cost and save *** is necessary to detect adjacent surface obstacles robustly to operate a cluster of unmanned surface *** this purpose,a LiDAR(light detection and ranging)sensor is used as it can simultaneously obtain 3D information for all directions,relatively robustly and accurately,irrespective of the surrounding environmental *** the GPS(global-positioning-system)error range exists,obtaining measurements of the surface-vessel position can still ensure stability during platoon *** this study,a three-layer convolutional neural network is applied to classify types of surface *** aim of this approach is to redefine the sparse 3D point cloud data as 2D image data with a connotative meaning and subsequently utilize this transformed data for object classification ***,we have proposed a descriptor that converts the 3D point cloud data into 2D image *** use this descriptor effectively,it is necessary to perform a clustering operation that separates the point clouds for each *** developed voxel-based clustering for the point cloud ***,using the descriptor,3D point cloud data can be converted into a 2D feature image,and the converted 2D image is provided as an input value to the *** intend to verify the validity of the proposed 3D point cloud feature descriptor by using experimental data in the ***,we explore the feasibility of real-time object classification within this framework.

关键词： Object classification Clustering 3D point cloud data LiDAR(light detection and ranging) Surface vehicle

Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第5期20卷 451-460页

作者： Tae hyeon Kim Hyeri lee Selin Woo Hayeon lee Jaeyu Park Guillaume Fond Laurent Boyer Jong Woo Hahn Jiseung Kang dong Keon Yon Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Center for Digital Health Medical Science Research InstituteKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea CEReSS-Health Service Research and Quality of Life Center Assistance Publique des Hôpitaux de MarseilleAix-Marseille UniversityMarseilleFrance Department of Pediatrics Seoul National University College of MedicineSeoulSouth Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnamSouth Korea Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital14913th StreetRoom 4140CharlestownBostonMAUSA Division of Sleep Medicine Harvard Medical SchoolBostonMAUSA Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-roDongdaemun-guSeoul02447South Korea Department of Precision Medicine Kyung Hee University College of MedicineSeoulSouth Korea

Background Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome(SIDS)effects is *** investigated the risk and protective factors related to *** We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related ***/MEDLINE,Embase,EBSCO,and Google Scholar were searched from inception until January 18,*** extraction,quality assessment,and certainty of evidence were assessed by using A Measurement Tool Assessment Systematic Reviews 2 following PRISMA *** to observational evidence,credibility was graded and classified by class and quality of evidence(CE;convincing,highly suggestive,suggestive,weak,or not significant).Our study protocol was registered with PROSPERO(CRD42023458696).The risk and protective factors related to SIDS are presented as equivalent odds ratios(eORs).Results We identified eight original meta-analyses,including 152 original articles,covering 12 unique risk and protective factors for SIDS across 21 countries/regions and five *** risk factors,including prenatal drug exposure[eOR=7.84(95%CI=4.81–12.79),CE=highly suggestive],prenatal opioid exposure[9.55(95%CI=4.87–18.72),CE=suggestive],prenatal methadone exposure[9.52(95%CI=3.34–27.10),CE=weak],prenatal cocaine exposure[4.38(95%CI=1.95–9.86),CE=weak],prenatal maternal smoking[2.25(95%CI=1.95–2.60),CE=highly suggestive],postnatal maternal smoking[1.97(95%CI=1.75–2.22),CE=weak],bed sharing[2.89(95%CI=1.81–4.60),CE=weak],and infants found with heads covered by bedclothes after last sleep[11.01(95%CI=5.40–22.45),CE=suggestive],were *** the other hand,three protective factors,namely,breastfeeding[0.57(95%CI=0.39–0.83),CE=non-significant],supine sleeping position[0.48(95%CI=0.37–0.63),CE=suggestive],and pacifier use[0.44(95%CI=0.30–0.65),CE=weak],were also *** Based on the evidence,we propose several risk and protecti

关键词： Infant Protective factor Risk factor Sudden infant death syndrome Umbrella review

Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim dong Guk Kang hyeon Gyu lee Yen Hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling