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One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients

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Journal of Geriatric Cardiology 2013年第3期10卷 235-241页

作者： Yeon Pyo Yoo Ki-Woon Kang hyeon soo yoon Jin Cheol Myung Yu Jeong Choi Won Ho Kim Sang Hyun Park Kyung Tae Jung Myung Ho Jeong Division of Cardiology Hyosung General Hospital 162-90 Sandang dong Chungju 360-802 South Korea Division of Cardiology Eulji University Hospital Eulji University School of Medicine 1306 Dunsan dong Seogu Daejeon 302-120 South Korea Division of Cardiology Worker`s Compensation&Welfare Service Hospital 833 Gaejok-ro Daejeon 306-060 South Korea Division of Cardiology Chunman National University Hospital 42 Jaebong-ro Kwangju 501-757 South Korea

Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up.

关键词： Acute myocardial infarction Cardiogenic shock Elderly patients

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Predictive modeling of critical temperatures in magnesium compounds using transfer learning

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Journal of Magnesium and Alloys 2024年第4期12卷 1540-1553页

作者： Surjeet Kumar Russlan Jaafreh Subhajit Dutta Jung hyeon Yoo Santiago Pereznieto Kotiba Hamad Dae Ho yoon School of Advanced Materials Science&Engineering Sungkyunkwan University Suwon 16419Republic of Korea

This study presents a transfer learning approach for discovering potential Mg-based superconductors utilizing a comprehensive target dataset.Initially,a large source dataset(Bandgap dataset)comprising approximately∼75k compounds is utilized for pretraining,followed by fine-tuning with a smaller Critical Temperature(T_(c))dataset containing∼300 compounds.Comparatively,there is a significant improvement in the performance of the transfer learning model over the traditional deep learning(DL)model in predicting Tc.Subsequently,the transfer learning model is applied to predict the properties of approximately 150k compounds.Predictions are validated computationally using density functional theory(DFT)calculations based on lattice dynamics-related theory.Moreover,to demonstrate the extended predictive capability of the transfer learning model for new materials,a pool of virtual compounds derived from prototype crystal structures from the Materials Project(MP)database is generated.T_(c) predictions are obtained for∼3600 virtual compounds,which underwent screening for electroneutrality and thermodynamic stability.An Extra Trees-based model is trained to utilize E_(hull)values to obtain thermodynamically stable materials,employing a dataset containing Ehull values for approximately 150k materials for training.Materials with Ehull values exceeding 5 meV/atom were filtered out,resulting in a refined list of potential Mg-based superconductors.This study showcases the effectiveness of transfer learning in predicting superconducting properties and highlights its potential for accelerating the discovery of Mg-based materials in the field of superconductivity.

关键词： Superconductivity Critical temperature Transfer learning Crystal structure features Thermodynamic stability

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Transparent high-performance piezoceramics through pressureless sintering

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Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-Lim Yu Woo-Seok Kang Ju-hyeon Lee Temesgen Tadeyos Zate Young-Jin Lee Bo-Kun Koo Dong-Jin Shin Min-soo Kim soon-Jong Jeong Young Ghyu Ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer applications.There has been a consistent demand for transparent piezoelectric materials for optoelectrical applications.Therefore,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric materials.Nonetheless,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial applicability.Therefore,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline ceramics.In this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)ceramics.By utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/N.This material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural fields.However,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising cost.Furthermore,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in cattle.In this point of view,electroporation in embryos has been risen as an alternative.Results First,editing efficiency of our electroporation methods were tested for embryos.Presence of mutation on embryo was confirmed by T7E1 assay.With first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,respectively.In case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for BLG.Afterwards,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep sequencing.Thirteen recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double KO.Ten surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both genes.Conclusions These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively applied.Finally,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

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Investigation into charge carrier dynamics in organic light-emitting diodes

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Nano Research Energy 2024年第2期3卷 39-46页

作者： Dong-Guang Zheng hyeon-Dong Lee Gyeong Won Lee Dong-soo Shin Jeongwon Kim Jong-In Shim Zhiqun Lin Tae-Woo Lee Dong Ha Kim Information Engineering College Hangzhou Dianzi UniversityHangzhou 311305China Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Photonics and Nanoelectronics Hanyang University ERICA55 Hanyangdeahak-roSangnok-guAnsanGyeonggi 15588Republic of Korea Department of Chemistry and Nanoscience Ewha Womans University52Ewhayeodae-gilSeodaemun-guSeoul 03760Republic of Korea Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore School of Chemical and Biological Engineering Institute of Engineering ResearchResearch Institute of Advanced MaterialsSoft FoundrySeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Basic Sciences Research Institute(Priority Research Institute) Ewha Womans UniversitySeoul 03760Republic of Korea Nanobio∙Energy Materials Center(National Research Facilities and Equipment Center) Ewha Womans UniversitySeoul 03760Republic of Korea

Organic light-emitting diodes(OLEDs)have demonstrated remarkable advancements in both device lifetime and luminous efficiency.However,insufficient operation lifetime due to device degradation remains a major hurdle,especially for brighter devices.Understanding the degradation mechanisms of OLEDs due to the degradation of functional materials and the formation of defects in device architectures continues to be a significant challenge.Herein,we evaluate the degradation characteristics by scrutinizing the electrical and optical properties,as well as analyzing the charge carrier dynamics in pristine and aged states of phosphorescent OLEDs(PhOLEDs).We show that degradation mechanisms in PhOLEDs can be elucidated in terms of the ideality factors of current and luminance in pristine and aged device states.The consistent shifts in distinct ideality factors across various states points out that the device degradation is attributed to the deterioration of the guest material,i.***.green-light-emitting phosphorescent material.Conversely,the incongruity in ideality factor changes between the two states indicates that the degradation results from the deterioration of non-light-emitting material.Subsequent characterization experiments provide further evidence that this degradation is primarily attributed to the deterioration of CBP-host material.The thorough understanding of degradation mechanisms established in this study can contribute to realizing the highly reliable PhOLEDs with a long lifetime.

关键词： organic light-emitting diodes ideality factor carrier transport processes degradation mechanism

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Highly Flexible Fabrics/Epoxy Composites with Hybrid Carbon Nanofillers for Absorption-Dominated Electromagnetic Interference Shielding

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Nano-Micro Letters 2022年第11期14卷 307-323页

作者： Jong-Hoon Lee yoon-Sub Kim Hea-Jin Ru Seul-Yi Lee soo-Jin Park Department of Chemistry Inha University100 InharoIncheon 22212Korea Korea Architecture Safety Testing and Research Institute(KASTI) 88 Gasan Digital 1-roSeoul 08590Korea

Epoxy-based nano-composites can be ideal electromagnetic interference(EMI)-shielding materials owing to their lightness,chemical inertness,and mechanical durability.However,poor conductivity and brittleness of the epoxy resin are challenges for fast-growing portable and flexible EMI-shielding applications,such as smart wristband,medical cloth,aerospace,and military equipment.In this study,we explored hybrid nanofillers of single-walled carbon nanotubes(SWCNT)/reduced graphene oxide(rGO)as conductive inks and polyester fabrics(PFs)as a substrate for flexible EMI-shielding composites.The highest electrical conductivity and fracture toughness of the SWCNT/rGO/PF/epoxy composites were 30.2 S m^(−1)and 38.5 MPa m^(1/2),which are~270 and 65%enhancement over those of the composites without SWCNTs,respectively.Excellent mechanical durability was demonstrated by stable electrical conductivity retention during 1000 cycles of bending test.An EMI-shielding effectiveness of~41 dB in the X-band frequency of 8.2-12.4 GHz with a thickness of 0.6 mm was obtained with an EM absorption-dominant behavior over a 0.7 absorption coefficient.These results are attributed to the hierarchical architecture of the macroscale PF skeleton and nanoscale SWCNT/rGO networks,leading to superior EMI-shielding performance.We believe that this approach provides highly flexible and robust EMI-shielding composites for next-generation wearable electronic devices.

关键词： Conductive polymer composites Fracture toughness Flexible composites Absorption-dominated electromagnetic interference shielding

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Reconstruction of the lower back wound with delayed infection after spinal surgery:A case report

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世界临床病例杂志 2023年第27期11卷 6646-6652页

作者： DoWon Kim sooA Lim SuRak Eo Jung soo yoon Department of Plastic and Reconstructive Surgery DongGuk University Ilsan HospitalGoyang 10326South Korea

BACKGROUND Orthopedic surgeries after device implantation are susceptible to infections and may require device removal in the worst cases.For this reason,many efforts are being made to control infections after spinal surgery;however,the number of infec-tion cases is increasing owing to the increasing number of elderly citizens.CASE SUMMARY A 75-year-old male with a chronic spinal defect due to previous spine surgery underwent reconstruction using a perforator-based island flap.After bursectomy and confirmation that there was no connection with the deep tissue,reconstruction was performed.However,wound disruption occurred with abscess formation on postoperative day 29,which led to an imaging workup revealing delayed deep tissue infection.CONCLUSION Infection is one of the most common causes of surgical wound dehiscence and is associated with devastating results if not controlled promptly and definitively.Surgeons should always suspect delayed infections when reconstructing chronic soft tissue defects.

关键词： Surgical wound dehiscence Surgical wound infection Lumbar spine Complications Abscess Case report

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Congenital retinal macrovessel with intracranial venous malformation in a pediatric patient: a case report

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1214-1216页

作者： hyeon Jin Park sook Hyun yoon sook Young Kim Donghun Lee Department of Ophthalmology Daegu Catholic University School of MedicineDaegu 42472Republic of Korea

Dear Editor,Congenital retinal macrovessel (CRM) is defined as an abnormal large retinal vessel that encircles the foveal avascular zone (FAZ).Since the first description of a large aberrant vessel crossing the macula by Mauthnerin 1868,there have been several case reports about CRM.And recently,Pichi et alreported clinical manifestations and multimodal retinal imaging of 49 eyes with CRM.In their study,they had identified an association between macrovessel in the retina and venous anomalies of the brain and they emphasized the importance of systemic workups including brain magnetic resonance imaging (MRI).

关键词： venous Congenital malformation

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A new analytical approach for identifying market contagion

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Financial Innovation 2022年第1期8卷 1097-1131页

作者： Hee soo Lee Tae yoon Kim Department of Business Administration Sejong University209 Neungdong-ro Gwangjin-guSeoul 05006Korea Department of Statistics Keimyung University1095 Dalgubeol-daeroDaegu 704-701Korea.

This study proposed a new analytical approach to identify the excessive comovement of two markets as contagion.This goal is achieved by linking latent-factor and single-equation error correction models and evaluating the breaks in the short-and long-term relationships and correlatedness in the linked model.The results demonstrated that a short-term relationship representing the market speed ratio between two markets plays a key role in contagion dynamics.When a long-term relationship or correlatedness is broken(comovement change)due to a break in the short-term relationship(market speed ratio),contagion is highly likely and should be formally declared.Bayesian posterior probabilities were calculated to determine the cause.Furthermore,this study applied this analytical Bayesian approach to empirically test the contagion effects of the U.S.stock market during the global financial crisis between 2007 and 2009 using 22 developed equity markets.

关键词： Contagion test Market integration Bayesian approach Comovement Market speed ratio

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Recurred forehead osteoma disseminated after previous osteoma excision:A case report

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World Journal of Clinical Cases 2023年第31期11卷 7684-7689页

作者： Dong Yun Lee sooA Lim Jung soo yoon SuRak Eo Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Forehead osteoma is a commonly encountered benign facial bone tumor.Endoscopic excision of benign forehead masses is widely performed.Here,we report a rare case of recurrent forehead osteoma that disseminated after a previous osteoma excision.CASE SUMMARY A 54-year-old female patient had previously undergone endoscopic removal of a single forehead osteoma at 30 years of age.However,she had a recurrent osteoma around the same site and underwent another endoscopic resection at 40 years of age.During her first visit to our outpatient clinic,she presented with a cobblestone-like irregular surface on the forehead and a 3D facial bone computed tomography scan revealed a widely ragged surface of the inoculated osteoma on the outer table of the frontal bone.Under general anesthesia,we performed a radical complete excision of the disseminated osteoma through a bicoronal incision using an osteotome,chisel,mallet,and rasping.We hypothesized that the recurrence may have been caused by the inoculation of residual osteoma remnants from the previous procedure.Craniofacial surgeons should be cautious when removing osteoma particles,particularly when using an endoscopic approach.CONCLUSION To prevent recurrence,it is essential to conduct additional meticulous burring and a thorough inspection of the surface after copious irrigation.

关键词： Recurred osteoma Inoculation Dissemination Bicoronal approach Craniofacial Case report

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