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Electrochemical Studies on Uranyl nitrate Complexes in 1-Alkyl-3-Methylimidazolium nitrate Ionic Liquids

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Electrochemical Studies on Uranyl Nitrate Complexes in 1-Alk...

老年人群血清25-羟维生素D水平和CYP1A1,CYP1B1基因多态性对血压的交互作用

作者： S.kim n.Ohta Y.Morita n.Asanuma K.Takao Y.Ikeda Japan Atomic Energy Agency Tokai-muraNaka-gunIbaraki 319-1195Japan Research Laboratory for nuclear Reactors Tokyo Institute of Technology2-12-1-N1-34 O-okayamaMeguro-kuTokyo 152-8550 Japan Department of Energy Science and Engineering School of EngineeringTokai University 1117 KitakanameHiratsuka-shiKanagawa 259-1292 Japan

InTRODUCTIOn:Ionic liquids(ILs) have been paid attention as environmentally benign media,because ILs have attractive properties such as thermal stability,nonflammability, high ionic conductivity,and wide electrochemical potential *** the nuclear industry field,ILs are expected to be used as reaction media in the reprocessing processes and the radioactive waste treatments, i.e.,media for pyro-reprocessing,liquid-liquid extraction,electrodeposition,and so *** study was performed to obtain basic data on electro-

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中华高血压杂志 2014年第12期22卷 1199-1199页

作者： Park hy kim JH Bae S Choi YY Park JY Hong YC 刘莉叶鹏

高血压和维生素D缺乏在全球普遍流行,尤其是老年人群。考虑到基因-环境对疾病发展的影响,研究人员评估某些细胞色素P450基因多态性与维生素D水平对血压的影响。方法：研究人员测定535名≥60岁个体的血清25-羟基维生素D[serum25-hydroxyv... 详细信息

高血压和维生素D缺乏在全球普遍流行,尤其是老年人群。考虑到基因-环境对疾病发展的影响,研究人员评估某些细胞色素P450基因多态性与维生素D水平对血压的影响。方法：研究人员测定535名≥60岁个体的血清25-羟基维生素D[serum25-hydroxyvitamin D,25（OH）D]和血压水平,同时测定淋巴细胞DnA中CYP1A1和CYP1B1的单核苷酸基因多态性（single—nucleotide polymorphisms，SnP），统计学应用重复测量分析。

关键词： CYP1A1,CYP1B1 基因多态性细胞色素交互作用单核苷酸重复测量负相关协同作用遗传变异 DnA

Design and evaluation of nicorandil extended-release tablet

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 108-113页

作者： Ju-Young kim Chun-Woong Park Beom-Jin Lee Eun-Seok Park Yun-Seok Rhee College of Pharmacy Woosuk UniversityWanju-gun 565-701Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 361-763Republic of Korea College of Pharmacy Ajou UniversitySuwon 443-749Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440-746Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Gyeongsang National UniversityJinju 660-701Republic of Korea

The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

关键词： nicorandil In vitro In vivo Pharmacokinetic Extended-release

FUZZY REGRESSIOn MODEL TO PREDICT THE BEAD GEOMETRY In THE ROBOTIC WELDInG PROCESS

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Acta Metallurgica Sinica(English Letters) 2007年第6期20卷 391-397页

作者： B.S. Sung I.S. kim Y. Xue H.H. kim Y.H. Cha Department of Material Engineering Chosun University 375 Seosul-Dong Dong-GuGwangju 501-759 Korea Department of Mechanical Engineering Mokpo National University 61 Dorim-riChungkye-Myun Muan-Gun Jconnam 534-729 Korea Department of Mechanical Engineering Chosun University 375 Seosul-Dong Dong-GuGwangju 501-759 Korea

Recently, there has been a rapid development in computer technology, which has in turn led to develop the fully robotic welding system using artificial intelligence （AI） technology. However, the robotic welding system has not been achieved due to difficulties of the mathematical model and sensor technologies. The possibilities of the fuzzy regression method to predict the bead geometry, such as bead width, bead height, bead penetration and bead area in the robotic GMA （gas metal arc） welding process is presented. The approach, a well-known method to deal with the problems with a high degree of fuzziness, is used to build the relationship between four process variables and the four quality characteristics, respectively. Using these models, the proper prediction of the process variables for obtaining the optimal bead geometry can be determined.

关键词： robotic arc welding bead geometry fuzzy regression modelwelding quality

Growth of single crystals in the (na_(1/2)Bi_(1/2))TiO_(3)-(Sr_(1-x)Ca_(x))TiO_(3) system by solid state crystal growth

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Journal of Advanced Ceramics 2021年第5期10卷 973-990页

作者： Phan Gia LE Huyen Tran TRAn Jong-Sook LEE John G.FISHER Hwang-Pill kim Wook JO Won-Jin MOOnC School of Materials Science and Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea Korea Basic Science Institute Gwangju Center77 Yongbong-roBuk-guGwangju 61186Republic of Korea

Ceramics based on(na_(1/2)B_(1/2))TiO_(3) are promising candidates for actuator applications because of large strains generated by an electric field-induced phase *** example,the(1-x)(na_(1/2)Bi_(1/2))TiO_(3)-xSrTiO_(3) system exhibits a morphotropic phase boundary at x=0.2-0.3,leading to high values of inverse piezoelectric constant d_(33),which can be further improved by the use of single *** our previous work,single crystals of (na_(1/2)B_(1/2))TiO_(3)-SrTiO_(3) and (na_(1/2)Bi_(1/2))TiO_(3)-TiO_(3) were grown by the solid state crystal growth *** in the(nai/2Bi/2)TiO3-SrTiO3 system was sluggish whereas the (na_(1/2)B_(1/2))TiO_(3)-CaTiO_(3) single crystals grew *** the present work,0.8(na_(1/2)Bi_(1/2))Ti0_(3)-0.2(Sr_(1-x)Ca_(x))Ti0_(3) single crystals(with x=0.0,0.1,0.2,0.3,0.4)were produced by the solid state crystal growth technique in an attempt to improve crystal growth *** dependence of mean matrix grain size,single crystal growth distance,and electrical properties on the Ca concentration was investigated in *** investigations indicated that at x=0.3 the matrix grain growth was suppressed and the driving force for single crystal growth was *** Sr with Ca increased the shoulder temperature T_(s) and temperature of maximum relative permittivity T_(max),causing a decrease in inverse piezoelectric properties and a change from normal to incipient ferroelectric behavior.

关键词： (na_(1/2)Bi_(1/2))TiO_(3) lead-free piezoelectric single crystal microstructure electrical properties

Super-anti-freezing,tough and adhesive titanium carbide and L-ornithine-enhanced hydrogels

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生物质资源与工程(英文) 2023年第2期8卷 136-145页

作者： Zhangkang Li Jamie LeBlanc Hitendra Kumar Hongguang Zhang Weijun Yang Xiao He Qingye Lu Jeffrey Van Humbeck Keekyoung kim Jinguang Hu Department of Biomedical Engineering University of CalgaryCalgaryUniversity Drive NWCalgaryAB T2N 1N4Canada Department of Chemistry University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Department of Mechanical and Manufacturing Engineering University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Pathology and Laboratory Medicine Cumming School of EngineeringUniversity of CalgaryHospital Drive NWT2N 4N1AlbertaCanada Department of Chemical and Petroleum Engineering University of CalgaryUniversity Drive NWCalgary T2N 1N4AlbertaCanada Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China

hydrogels are highly porous three-dimensional crosslinked polymer networks consisting of hy-drophilic polymers,employed most practically in medicine and industry,often as *** hydrogels suffer limitations in their mechanical properties,such as tensile and com-pression,and freeze at sub-zero temperatures,which compromise their ability as useful *** this study,the incorporation of L-ornithine-based zwitterionic monomer(OZM),titanium carbide(MXene),and glycerol within polyacrylamide hydrogels was used to prepare a novel polyacrylamide/polyL-ornithine-based zwitterion/MXene(PAM/Porn/MXene)hydrogel to im-prove the mechanical,adhesion,and anti-freezing properties of pure polyacrylamide *** study also analyzed the mechanical strength(tensile and compression),adhesion,and anti-freezing properties of a novel PAM/Porn/MXene hydrogel at 1%,4%,and 10%MXene concen-trations to establish to what extent the conductive MXene material enhanced these properties and concluded that the tensile and compressive properties improved linearly with the increase in the concentrations of MXene,adhesion decreased with the increased MXene concentrations,and syn-ergistic interaction between MXene and OZM significantly improved the anti-freezing properties up to-80°C.

关键词： Super-anti-freezing Tough Adhesive L-ornithine MXene

Development of PLGA micro-and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 86-94页

作者： Jiafu Cao Jin-Seok Choi Murtada A.Oshi Juho Lee nurhasni Hasan Jihy.n kim Jin-Wook Yoo College of Pharmacy Pusan National UniversityBusan 46241South Korea Department of Medical Management Chodang UniversityMuan-gun 58530South Korea College of nanoscience&nanotechnology Pusan National UniversityBusan 46241South Korea

Particle shape has been recognized as one of the key properties of nanoparticles in biomedical applications including targeted drug *** ability of shape-engineered particles depends largely on targeting ligands conjugated on the particle ***,poor capacity for surface ligand conjugation remains a problem in anisotropic nanoparticles made with biodegradable polymers such as *** this study,we prepared anisotropic PLGA nanoparticles with abundant conjugatable surface functional groups by a film stretching-based fabrication method with poly(ethylene-alt-maleic acid)(PEMA).Scanning electron microscopy images showed that microrods and nanorods were successfully fabricated by the PEMA-based film stretching *** presence of surface carboxylic acid groups was confirmed by confocal microscopy and zeta potential *** the improved film-stretching method,the amount of protein conjugated to the surface of nanorods was increased ***-conjugated,nanorods fabricated by the improved method exhibited higher binding and internalization than unmodified ***,the PEMA-based film-stretching system presented in this study would be a promising fabrication method for non-spherical biodegradable polymeric micro-and nanoparticles with high capacity of surface modifications for enhanced targeted delivery.

关键词： Particle shape PLGA nanoparticles Film-stretching method Surface modification Targeted drug delivery

Characteristic Dermatologic Changes in the Condition of Skin after Ultrasonic Stimulation in Healthy Korean Men

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 195-206页

作者： So-Jung kim Seung-Min Yang Ju-hy.n kim Jeong-Uk Lee Mee-Young kim Lim-Kyu Lee Byoung-Sun Park Won-Deok Lee Ji-Woong noh Yong-Sub Shin Doo-Ho kim Il-hy.n kim Junghwan kim Laboratory of Health Science & nanophysiotherapy Department of Physical Therapy Graduate School Yongin University Yongin Republic of Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan Republic of Korea Department of Physical Therapy College of Health Science Honam University Gwangsan-gu Republic of Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Power Plant Yeongwol-gun Republic of Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin Republic of Korea

The aim of our study was to recognize different skin conditions of the face and neck using six biophysical parameters and to show the changes after the application of ultrasonic stimulation (US). We assessed the differences in the sebum, moisture, pores, wrinkles, pigmentation, and elasticity of the skin in the face and neck regions. A total of 30 healthy men in their 20s were enrolled. We used a skin diagnosis meter to assess the state of the skin. The sebum and pores of the face were more significant than in the neck. The amount of moisture in the U-zone was significantly higher than in other areas. Statistical differences were found between the pre-and post-measure-ment values in the sebum, moisture, wrinkles and pigmentation. Wrinkles and pigmentation were positively correlated. Our data showed that the changes in skin condition are associated with external stimulants. The effect of US on skin may differ depending on the part of the body, and some biophysical properties of skin vary depending on the location on the body.

关键词： Ultrasonic Stimulation Korean Men Skin

Analysis of Interferential Current Therapy-Induced Skin Changes in Healthy Korean Men

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natural Science 2018年第11期10卷 436-447页

作者： So-Jung kim Seung-Min Yang Ju-hy.n kim Jeong-Uk Lee Mee-Young kim Lim-Kyu Lee Byoung-Sun Park Won-Deok Lee Ji-Woong noh Yong-Sub Shin Doo-Ho kim Il-hy.n kim Kong-Sook noh Junghwan kim Laboratory of Health Science & nanophysiotherapy Department of Physical Therapy Graduate School Yongin Uni-versity Yongin-si Republic of Korea Department of Physical Therapy College of Health Welfare Wonkwang Health Science University Iksan-si Republic of Korea Department of Physical Therapy College of Health Science Honam University Gwangju-si Republic of Korea The Team of Safety and Quality Management Yeongwol Combined Cycle Power Plant Division Korea Southern Pow-er Plant Yeongwol-gun Republic of Korea Department of Physical Therapy College of Public Health & Welfare Yongin University Yongin-si Republic of Korea

We examined the changes in numerous skin conditions before and after the ap-plication of interferential current therapy to various regions of healthy male bodies. In this study, we assessed the differences in the skin’s sebum, moisture levels, pores, wrinkles, pigmentation, and elasticity on the shoulders, lower back, and the knees of Korean males in their 20s. A total of 30 healthy males were in-cluded in the study. We used a skin diagnosis meter as a device for measuring the state of the skin. A statistical difference was found when comparing the pre- and post-measurement values in regards to the moisture levels, wrinkles, and pig-mentation. In the correlation analysis results, the sebum and pigmentation, moisture levels and wrinkles, moisture levels and pigmentation, and moisture levels and elasticity were all positively correlated, respectively. The results of this study partially suggest that a change in skin condition is associated with ex-ternal stimulation. The study also found that the effects of the application of in-terferential current therapy on the various skin conditions may differ depending on the region of the body that the application is conducted as well.

关键词： Interferential Current Therapy Korean Men Skin