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Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

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Journal of Renewable Materials 2024年第1期12卷 29-43页

作者： Thean Heng Tan Najihah Mohd Hashim Wageeh Abdulhadi Yehya Dabdawb Mochamad Zakki Fahmi hwei voon lee Nanotechnology&Catalysis Research Center(NANOCAT) Universiti MalayaKuala Lumpur50603Malaysia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversiti MalayaKuala Lumpur50603Malaysia Department of Chemistry Faculty of Science and TechnologyUniversitas AirlanggaCampus CMulyorejoSurabaya60115Indonesia

The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose(NCC)as a potential drug delivery system for targeting folate receptor-positive cancer *** FA-functionalized NCCs were synthesized through a series of chemical reactions,resulting in nanoparticles with favorable properties for biomedical *** microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor ***,these nanoparticles possessed a negative surface charge,enhancing their stability and repelling potential *** binding specificity of FA-functionalized NCCs to folate receptor-positive cancer cells was demonstrated through various *** free folic acid inhibition assay showed approximately 30%decrease in the binding of functionalized NCCs in the presence of just 5 mM free FA,confirming their selectivity for folate receptor-positive *** microscopy further validated this specificity,as only cancer cells displayed significant binding of functionalized ***,biocompatibility tests revealed that both NCCs and FA-functionalized NCCs had minimal effects on red blood cells,and they did not induce erythrocyte ***,cell viability assays demonstrated functionalized NCCs have selective cytotoxicity against colorectal cancer cells HT-29 and SW-620(68%–88%cell viability)while sparing noncancerous colon cells CCD-18Co(81%–97%cell viability).In summary,FA-functionalized NCCs exhibit promising characteristics for targeted drug delivery in cancer *** biocompatibility,stability,and selective cytotoxicity make them an attractive option for delivering therapeutic agents to folate receptor-positive cancer cells,potentially improving the effectiveness of cancer treatments while minimizing harm to healthy tissues.

关键词： Agricultural wastes sustainable nanocarrier blood biocompatibility folic acid receptor drug delivery system nanomedicine

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Review of Cellulose Smart Material: Biomass Conversion Process and Progress on Cellulose-Based Electroactive Paper

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Journal of Renewable Materials 2018年第1期6卷 1-25页

作者： S.H.Hassan lee hwei voon T.S.Velayutham Lindong Zhai Hyun Chan Kim Jaehwan Kim Nanotechnology and Catalysis Research Center(NanoCat) Institute of Postgraduate StudiesUniversity of Malaya50603 Kuala LumpurMalaysia Low Dimensional Materials Research Center Department of PhysicsFaculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia Department of Mechanical Engineering Inha UniversityIncheon 22212South Korea

Cellulose is a renewable biomass material and natural polymer which is abundantly available on Earth,and includes agricultural wastes,forestry residues,and woody *** excellent and smart characteristics of cellulose materials,such as lightweight,biocompatibility,biodegradability,high mechanical strength/stiffness and low thermal expansibility,have made cellulose a highpotential material for various industry *** has recently been discovered as a smart material in the electroactive polymers family which carries the name of cellulose-based electroactive paper(EAPap).The shear piezoelectricity in cellulose polymers is able to induce large displacement output,low actuation voltage,and low power consumption in the application of biomimetic sensors/actuators and electromechanical *** present study provides an overview of biomass pretreatment from various lignocellulosic cellulose(LC)resources and nanocellulose production via TEMPO-mediated oxidation reaction,followed by the production of different types of EAPap versus its performance,and lastly the applications of EAPap in different areas and ***,LC biomass consists mainly of cellulose having a small content of hemicelluloses and lignins which form a defensive inner structure against the degradation of plant cell ***,selective approaches are discussed to ensure proper extraction of cellulosic fibers from complex biomass for further minimization to *** addition,a comprehensive review of the development of cellulose-based EAPap as well as fabrication,characterization,performance enhancement and applications of EAPap devices are discussed herein.

关键词： Biomass pretreatment nanocellulose renewable materials smart materials actuators

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Correct diagnosis and successful treatment for pericardial effusion due to toothpick injury: A case report and literature review

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World Journal of Gastroenterology 2007年第31期13卷 4278-4281页

作者： Yu-Yin Liu Chun-Nan Yeh Hsiang-Lin lee Yi-Yin Jan Jeng-hwei Tseng Ji-Tseng Fang Department of Surgery Chang Gung Memorial Hospital ChangGung University Taiwan China Department of Radiology Chang GungMemorial Hospital Chang Gung University Taiwan China Department of Internal Medicine Chang GungMemorial Hospital Chang Gung University Taiwan China

We reported a 55-year-old man who suffered from chest pain and dyspnea on exertion for two weeks associated with night sweating, general malaise, poor appetite, and body weight loss. Physical examination revealed friction rub with distant heart sound, bilateral clear breathing sound, no abdomen tenderness, and normal bowel sound. Subsequent chest X-ray revealed cardiomegaly and cardiac echo showed massive pericardial and pleural effusion with normal left ventricular function. Constrictive pericarditis was diagnosed based on clinical information. Tuberculosis (TB), malignancy, autoimmune disease, infection, hypothyroidism, and idiopathic could be the causes but excluded by further study. High-resolution lung CT scan after reconstruction revealed a moderate amount pericardial effusion with possible superimposed infection. Thickness of pericardium and left lobe liver abscess were found. A straight tubular structure about 6 cm in length transverses the lateral segment of liver to pericardial space and unknown foreign body was suspected. Laparotomy was performed, 6.5 cm toothpick was found through the liver into pericardium. Post-operative course was uneventful and he discharged one week later. The patient could not remember swallowing the toothpick before. He had no chest pain and dyspnea on exertion during a 6-mo follow-up period.

关键词： Toothpick injury Pericardial effusion Laparotomy

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Is Wound Complication a Deterrent to Lateral Extensile Approach in Calcaneus Fracture?

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Open Journal of Orthopedics 2019年第8期9卷 180-189页

作者： Leow voon Chin lee Jie Ying Mohamad Izani Hospital Raja Permaisuri Bainun Ipoh Malaysia

Introduction: The lateral extensile approach has been a widely accepted surgical approach in treatment of intraarticular calcaneal fracture. It provides good exposure for fixation by correcting the hindfoot varus, fracture reduction and restores calcaneal height but it has a high wound complication rate. Methods and materials: 36 intraarticular calcaneal fractures (Sanders II, III and IV) treated using the lateral extensile approach in 34 patients presenting between 2015 and 2018 were retrospectively reviewed. Wound complication in the early stage (day 1 to day 3), intermediate (2 weeks) and late (6 weeks) were documented. Results: We found early (Day 1 - Day 3) infection rate of 5.6%, intermediate (2 weeks) at 17.6% and late wound complication (6 weeks) at 2.9%. Conclusion: Lateral expansile approach is a reliable surgical exposure for fracture reduction of calcaneal fractures with acceptable wound related complication rate. Minimally invasive techniques and the sinus tarsi approach are being used for less comminuted fractures, but those techniques are technically more demanding. Smoking, long duration of surgery and soft tissue handling also play a role in increasing wound complication rates.

关键词： Wound Complications Calcaneal Fracture Lateral Extensile Approach

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The impact of urological resection and reconstruction on patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

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Asian Journal of Urology 2018年第3期5卷 194-198页

作者： Grace hwei Ching Tan Nicholas B.Shannon Claramae Shulyn Chia Lui Shiong lee Khee Chee Soo Melissa Ching Ching Teo Division of Surgical Oncology National Cancer Centre SingaporeSingapore Duke-NUS Medical School Singapore Department of Urology Singapore General HospitalSingapore

Objective:Cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)are increasingly being used to treat peritoneal *** resections and reconstruction(URR)are occasionally performed during the *** aim to evaluate the impact of these procedures on peri-operative outcomes of CRS and HIPEC ***:A retrospective review of a prospectively maintained database of all patients who underwent CRS-HIPEC from April 2001 to February 2016 was *** between patients who had surgery involving,and not involving URR were *** outcomes were the rate of major complications and the duration of stay in the intensive care unit(ICU)and *** outcomes were that of overall survival(OS)and prognostic factors that would indicate a need for ***:A total of 214 CRS-HIPEC were performed,21 of which involved a *** clinical characteristics did not vary between the groups(URR *** URR).Urological resections comprised of 52%bladder resections,24%ureteric resections,and 24%involving both bladder and ureteric *** bladder defects were closed primarily while ureteric reconstructions consisted of two end-to-end anastomoses,one ureto-uretostomy,five direct implantations into the bladder and three boari *** were more frequently required in patients with colorectal peritoneal disease(p Z 0.029),but was not associated with previous pelvic surgery(76%vs.54%,p Z 0.065).Patients with URR did not suffer more serious complications(14%vs.24%,p Z 0.42).ICU(2.2 days vs.1.4 days,p Z 0.51)and hospital stays(18 days vs.25 days,p Z 0.094)were not significantly *** a URR did not affect OS(p Z 0.99),but was associated with increased operation time(570 min vs.490 min,p Z 0.046).Conclusion:While concomitant URR were associated with an increase in operation time,there were no significant differences in postoperative complications or *** with colorectal peritoneal metastases a

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis Urological procedures Urological reconstruction

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Mixed-Ligand Ni(Ⅱ), Co(Ⅱ) and Fe(Ⅱ) Complexes as Catalysts for Esterification of Biomass-Derived Levulinic Acid with Polyol and in Situ Reduction via Hydrogenation with NaBH_(4)

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Journal of Renewable Materials 2019年第8期7卷 731-748页

作者： Md.Anwar Hossain lee hwei voon Nanotechnology&Catalysis Research Centre(NanoCat) Level 3Block AInstitute of Postgraduate StudiesUniversity of MalayaKuala Lumpur 50603Malaysia Department of Chemistry Rajshahi University of Engineering&TechnologyRajshahi 6204Bangladesh

Synthesizing polyol-based ester from biomass feedstocks for the preparation of biolubricant overcomes the dependence on petroleum oil *** biomass-derived bio-oil is an alternative for the production of polyol ester,upgrading is essential prior to use as *** acid(LA),obtained from bio-oil was applied for the catalytic esterification with two polyols,e.g.,trimethylolpropane(TMP)and pentaerythritol(PE),in the presence of mixed-ligand Ni(Ⅱ),Co(Ⅱ),and Fe(Ⅱ)complexes as *** mixed-ligand coordination complexes with empirical formula;[Ni(Phe)(Bpy)Cl].H2O,[Co(Phe)(Bpy)Cl].H2O,and[Fe(Phe)(Tyr)Cl].H2O were synthesized by the reaction of ligands[L-phenylalanine(Phe),4,4'-bipyridine(Bpy),and L-tyrosine(Tyr)]with metal chloride salts and characterized by elemental analysis,magnetic susceptibility,FTIR,TGA/DTA,powder-XRD,and SEM *** study aims to investigate the catalytic activities of the complexes via esterification reaction of levulinic acid with trimethylolpropane and *** addition,these catalysts were further employed for the in situ hydrogenation of levulinate esters via NaBH_(4) at room temperature upon ***,the iron(Ⅱ)complex was more potential,exhibiting its efficiency as a homogeneous catalyst for esterification-hydrogenation reaction for synthesizing ester-based oils.

关键词： Biomass esterification-hydrogenation mixed-ligand complex NaBH_(4) reduction

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黄斑色素光学密度、中央黄斑厚度与体重指数的关系（英文）

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国际眼科杂志 2019年第5期19卷 709-713页

作者： lee Hong Nien Fazliana Ismail Rafidah Sudarno Angela Loo voon Pei Visvaraja Subrayan 马来西亚大学医疗中心眼科马来西亚吉隆坡59100 Tunku Abdul Rahman大学医学部马来西亚吉隆坡蕉赖43000

目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用SD Cirrus OCT测... 详细信息

目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用SD Cirrus OCT测量中央黄斑厚度。记录所有眼MPOD和OCT信息。使用Microsoft~?Excel,SPSS和R进行数据分析。结果:MPOD和中央黄斑厚度之间呈明显正相关(r=0.42,P<0.01)。同时,MPOD和BMI之间呈明显负相关(r=-0.23,P<0.01)。结论:研究得出,MPOD和中央黄斑厚度之间呈明显正相关。还需要进一步研究中央凹的详细结构及其与MPOD的关系。研究发现了MPOD与BMI之间呈明显正相关,且得出BMI的降低可能会增加黄斑色素的密度,这有助于预防年龄相关性黄斑变性(ARMD)。

关键词：黄斑色素光学密度体重指数中央黄斑厚度

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Effect of Microwave Power and Clamping Pressure on the Microwave Welding of Polypropylene Using Silicon Carbide Nanowhiskers as Microwave Susceptor

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Chinese Journal of Polymer Science 2022年第11期40卷 1466-1481页

作者： Phey Yee Foong Chun Hong voon Bee Ying Lim Pei Leng Teh Mohd Afendi Bin Rojan Nor Azizah Parmin Subash C.B.Gopinath Mohd Khairuddin Md Arshad Foo Wah Low Savisha Mahalingam Abreeza Manap Ruslinda A.Rahim Uda Hashim Institute of Nano Electronic Engineering Universiti Malaysia PerlisSeriabKangarPerlis01000Malaysia Faculty of Chemical Engineering Technology Universiti Malaysia PerlisJejawiPerlis Arau02600Malaysia Faculty of Mechanical Engineering Technology Universiti Malaysia PerlisPauhPerlis Arau02600Malaysia Department of Electrical&Electronic Engineering Lee Kong Chian Faculty of Engineering&ScienceUniversiti Tunku Abdul RahmanBandar Sungai LongKajangSelangor43000Malaysia Institute of Sustainable Energy Universiti Tenaga NasionalJalan IKRAM-UNITENKajangSelangor43000Malaysia

Due to their excellent dielectric properties and the rapid response to microwave irradiation,silicon carbide nanowhiskers(SiCNWs)were employed as microwave susceptor in this study to absorb microwave and locally melt the surrounding polypropylene(PP)substrates for the joining of PP *** welded joint is formed after the melted PP was cooled and *** than microwave susceptor,SiCNWs also acted as the nanofillers in strengthening the welded joint through the formation of SiCNWs reinforced PP nanocomposite at the interface of PP ***,the effect of microwave power on the microwave welding of PP substrates using SiCNWs as susceptor was studied and *** was found that the tensile strength and modulus of elasticity of the welded joint improved as microwave power ***,it deteriorates the flexibility of the welded joint as high stiffness SiCNWs were incorporated deeper into the PP matrix which restricted the PP chain *** from microwave power,clamping pressure is also critical in determining the mechanical properties of a welded *** compared to unclamped welded joint,the tensile strength,modulus of elasticity and flexibility of welded joint subjected to clamping pressure improved ***,the tensile strength of welded joint increased when the clamping pressure was increased from P1 to P3,but decreased when the clamping pressure was further increased to P4 due to the occurrence of flashing at welded *** formation mechanism of SiCNWs reinforced PP welded joint was also proposed in this *** to conventional welding,this welding process is easy,straightforward and is able to produce welded joint with outstanding mechanical properties via precise controlling of the processing ***,microwave welding is thought to offer an option for the joining of thermoplastics and other applications.

关键词： Microwave welding Silicon carbide Nanowhiskers Joining Susceptor

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马来西亚大学对外汉语学习者汉语语言态度调查研究

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科教文汇 2015年第36期 32-34页

作者：李冰玲曹文富马来西亚理科大学马来西亚槟城11800

本研究主要探讨马来西亚大学对外汉语学习者汉语语言态度。研究内容包括学习者对汉语的感性与理性认知、情感还有行为。笔者应用调查问卷的方法进行研究,对马来西亚理科大学110位不同性别、年龄与族群对外汉语学习者的汉语语言态度进行... 详细信息

本研究主要探讨马来西亚大学对外汉语学习者汉语语言态度。研究内容包括学习者对汉语的感性与理性认知、情感还有行为。笔者应用调查问卷的方法进行研究,对马来西亚理科大学110位不同性别、年龄与族群对外汉语学习者的汉语语言态度进行抽样调查与分析。研究发现,学习者对语言的理性认知会影响行为选择,而行为选择与情感也有一定的关系,即:如果学习者学习动机越具功利性,学习态度就会更加积极,而学习态度越积极的学习者对于汉语和中华文化的喜爱会更加强烈。

关键词：对外汉语教学心理学语言态度理性与感性认知行为情感

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磺胺噻唑與痢疾噬菌體對福氏痢疾桿菌的協同制菌作用

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微生物学报 1958年第2期 237-241页

作者：李萍徐世德彭永范山东医学院微生物学教研组安徽医学院微生物学教研组

S.T.舆痢疾噬菌體配合於试管内作用於福氏痢疾菌时,可使噬菌體的溶菌力价及S.T.的制菌力皆增高,明显地抑制了再生菌生长。 S.T.浓度愈高协同制菌作用较强,但此差别并不显著,数菌株无差别或反之。噬菌體的稀释度愈高则其协同作用愈弱,反... 详细信息

S.T.舆痢疾噬菌體配合於试管内作用於福氏痢疾菌时,可使噬菌體的溶菌力价及S.T.的制菌力皆增高,明显地抑制了再生菌生长。 S.T.浓度愈高协同制菌作用较强,但此差别并不显著,数菌株无差别或反之。噬菌體的稀释度愈高则其协同作用愈弱,反之则强。

关键词：痢疾菌磺胺磺胺类药制菌作用溶菌

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