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Predictability of polygenic risk score for progression to dementia and its interaction with APOEε4 in mild cognitive impairment

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Translational Neurodegeneration 2021年第3期10卷 412-420页

作者： Jung‑Min Pyun Young Ho Park Keon‑Joo Lee SangYun kim Andrew J.Saykin Kwangsik Nho Department of Neurology Uijeongbu Eulji Medical CenterEulji UniversityUijeongbuRepublic of Korea Department of Neurology Seoul National University Bundang Hospital and Seoul National University College of Medi‑cineSeongnamRepublic of Korea Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease CenterIndiana University School of MedicineIndianapolisINUSA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisINUSA Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisINUSA.

Background:The combinatorial efect of multiple genetic factors calculated as a polygenic risk score(PRS)has been studied to predict disease progression to Alzheimer’s disease(AD)from mild cognitive impairment(MCI).Previous studies have investigated the performance of PRS in the prediction of disease progression to AD by including and excluding single nucleotide polymorphisms within the region surrounding the APOE *** studies may have missed the APOE genotype-specifc predictability of PRS for disease progression to ***:We analyzed 732 MCI from the Alzheimer’s Disease Neuroimaging Initiative cohort,including those who progressed to AD within 5 years post-baseline(n=270)and remained stable as MCI(n=462).The predictability of PRS including and excluding the APOE region(PRS_(+APOE) and PRS_(−APOE))on the conversion to AD and its interaction with the APOEε4 carrier status were assessed using Cox regression ***:PRS_(+APOE)(hazard ratio[HR]1.468,95%CI 1.335-1.615)and PRS_(−APOE)(HR 1.293,95%CI 1.157-1.445)were both associated with a signifcantly increased risk of MCI progression to *** interaction between PRS_(+APOE) and APOEε4 carrier status was signifcant with a P-value of *** association of PRSs with the progression risk was stronger in APOEε4 non-carriers(PRS_(+APOE):HR 1.710,95%CI 1.244-2.351;PRS_(−APOE):HR 1.429,95%CI 1.182-1.728)than in APOEε4 carriers(PRS_(+APOE):HR 1.167,95%CI 1.005-1.355;PRS_(−APOE):HR 1.172,95%CI 1.020-1.346).Conclusions:PRS could predict the conversion of MCI to dementia with a stronger association in APOEε4 noncarriers than APOEε4 *** indicates PRS as a potential genetic predictor particularly for MCI with no APOEε4 alleles.

关键词： Polygenic risk score Mild cognitive impairment Alzheimer’s disease Disease progression APOEε4

Development of a Hybrid Best Management Practice System for Control of Agricultural Nonpoint Water Pollution

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Journal of Agricultural Chemistry and Environment 2014年第4期3卷 161-168页

作者： Minyoung kim Seounghee kim Sangbong Lee Yongho Cho National Academy of Agricultural Science Rural Development Administration Jeonju City Republic of Korea

Agricultural drainage ditches play an important role in removing surplus water;however, these can also potentially act as major conduits of agricultural nonpoint source pollutants, including sediment, nitrogen, and phosphorus. A supplementary hybrid system to limit such pollution was developed in this study;this consists of biodegradable fiber check dams, used in combination with a synthetic polymer (Polyacrylamide, PAM). An open channel experiment was conducted to optimize the design of the hybrid system, taking into account a variety of physical and hydraulic conditions. Subsequent field application of the hybrid system improved runoff water quality, such as 10.0% to 98.3% reduction for suspended solids, 25.2% to 98.4% reduction for turbidity, 21.1% to 91.1% increase for BOD, 19.2% to 75.4% increase for COD, 21.0% to 73.3% reduction for T-N, 5.9% to 91.2% reduction for T-P and 35.7% to 97.6% reduction for fecal coliforms. This clearly showed that this hybrid system could play a significant role in supplementing conventional best management practices.

关键词： Biodegradable Check Dam (BCD) Flocculation Nonpoint Source (NPS) Pollution Sedimentation Synthetic Polymer

Quantum dots-labeled polymeric scaffolds for in vivo tracking of degradation and tissue formation

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Bioactive Materials 2022年第10期7卷 285-292页

作者： Kun Hee Sim Seyed Mohammand Mir Sophia Jelke Solaiman Tarafder Jinho kim Chang H.Lee Regenerative Engineering Laboratory Center for Dental and Craniofacial ResearchColumbia University Irving Medical Center630 West 168th StreetVC12-211New YorkNY10032USA Department of Biomedical Engineering Stevens Institute of TechnologyHobokenNJ07030USA

The inevitable gap between in vitro and in vivo degradation rate of biomaterials has been a challenging factor in the optimal designing of scaffold’s degradation to be balanced with new tissue *** enable non-/minimum-invasive tracking of in vivo scaffold degradation,chemical modifications have been applied to label polymers with fluorescent ***,the previous approaches may have limited expandability due to complicated synthesis ***,we introduce a simple and efficient method to fluorescence labeling of polymeric scaffolds via blending with near-infrared(NIR)quantum dots(QDs),semiconductor nanocrystals with superior optical ***-labeled,3D-printed PCL scaffolds showed promising efficiency and reliability in quantitative measurement of degradation using a custom-built fiber-optic imaging ***,QDs-PCL scaffolds showed neither cytotoxicity nor secondary labeling of adjacent ***-PCL scaffolds also supported the engineering of fibrous,cartilaginous,and osteogenic tissues from mesenchymal stem/progenitor cells(MSCs).In addition,QDs-PCL enabled a distinction between newly forming tissue and the remaining mass of scaffolds through multi-channel ***,our findings suggest a simple and efficient QDs-labeling of PCL scaffolds and minimally invasive imaging modality that shows significant potential to enable in vivo tracking of scaffold degradation as well as new tissue formation.

关键词： Key terms:quantum dots Polycaprolactone Tissue engineering In vivo tracking Degradation

Updates in the management of cranial dural arteriovenous fistula

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Stroke & Vascular Neurology 2020年第1期5卷 50-58页

作者： Humain Baharvahdat Yinn Cher Ooi Wi Jin kim Ashkan Mowla Alexander L Coon Geoffrey P Colby Neurosurgery Ronald Reagan UCLA Medical CenterLos AngelesCaliforniaUSA Neurointerventional Radiology UCLALos AngelesCaliforniaUSA Western Neuro Carondelet Health NetworkTucsonArizonaUSA

Dural arteriovenous fistula(dAVF)accounts for approximately 10%of all intracranial vascular *** they can be benign lesions,the presence of retrograde venous drainage and cortical venous reflux makes the natural course of these lesions aggressive high risk of haemorrhage,neurological injury and *** treatment is often the first line of treatment for *** transarterial and transvenous approaches are used to cure *** selection of treatment approach depends on the angioarchitecture of the dAVF,the location,the direction of venous *** and,to a lesser extent,stereotactic radiosurgery are used when endovascular approaches are impossible or unsuccessful.

关键词： Surgery arterial treatment

Dirac Coupled Channel Analyses of Proton Inelastic Scatterings from s-d Shell Nuclei

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Journal of Applied Mathematics and Physics 2015年第4期3卷 443-448页

作者： Sugie Shim Moon-Won kim Young-You kim Physics Department Kongju National University Gonjusi Republic of Korea

Proton inelastic scatterings from several s-d shell nuclei are analyzed using optical potential model and collective model in Dirac coupled channel formalism. The optical potential parameters obtained phenomenologically for the scatterings from the s-d shell nuclei are compared with each other for systematic Dirac analysis. Dirac equations are reduced to the second-order differential equations in order to obtain the Schroedinger equivalent effective central and spin-orbit optical potentials, and the surface-peaked phenomena are observed at the real effective central potentials for the scatterings from 22Ne, 20Ne and 24Mg. By analyzing the obtained effective spin-orbit potentials, it is confirmed that the spin-orbit interaction is a surface-peaked interaction. The first-order rotational collective models are used to describe the low-lying excited states of the ground state rotational bands in the s-d shell deformed nuclei, and the obtained deformation parameters are analyzed by comparing with each other, and compared with those obtained by using the nonrelativistic calculations. The obtained deformation parameters of Dirac phenomenological calculations for the s-d shell nuclei are found to agree pretty well with those of the nonrelativistic calculations using the same Woods-Saxon potential shape, even though the theoretical bases are quite different.

关键词： Dirac Coupled Channel Analyses Optical Potential Model Proton Inelastic Scattering Collective Model

Ultrathin ZnS nanosheet/carbon nanotube hybrid electrode for high-performance flexible all-solid-state supercapacitor

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Nano Research 2017年第8期10卷 2570-2583页

作者： Xiaoyi Hou Tao Peng Jinbing Cheng Qiuhong Yu Rongjie Luo Yang Lu Xianming Liu Jang-Kyo kim Jun He Yongsong Luo School of Physics and Electronic Engineering Xinyang Normal University Xinyang 464000 China Key Laboratory of Advanced Micro/Nano Functional Materials Xinyang Normal University Xinyang 464000 China College of Chemistry and Chemical Engineering Luoyang Normal University Luoyang 471022 China Department of Mechanical and Aerospace Engineering Hang Kong University of Science and Technology Clear Water Bay Kowloon Hang Kong China National Center for Nanoscience and Technology Beijing 100190 China

Flexible and easily reconfigurable supercapacitors show great promise for application in wearable electronics. In this study, multiwall C nanotubes （CNTs） decorated with hierarchical ultrathin zinc sulfide （ZnS） nanosheets （ZnS@CNT） are synthesized via a facile method. The resulting ZnS@CNT electrode, which delivers a high specific capacitance of 347.3 F·g^-1 and an excellent cycling stability, can function as a high-performance electrode for a flexible all-solid-state supercapacitor using a polymer gel electrolyte. Our device exhibits a remarkable specific capacitance of 159.6 F·g^-1, a high energy density of 22.3 W·h·kg^-1, and a power density of 5 kW·kg^-1 It also has high electrochemical performance even under bending or twisting. The all-solid-state supercapacitors can be easily integrated in series to power different commercial light-emitting diodes without an external bias voltage.

关键词： multiwall C nanotubes decorated with hierarchical ultrathin zinc sulfide nanosheets(ZnS@CNT) ultrathin nanosheet flexible synergistic supercapacitor

Study of the Unsteady Condensation of Moist Air in Shock Tube

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Journal of Thermal Science 2004年第3期13卷 235-244页

作者： S.-C. BAEK S.-B. KWON H.-D. kim T. SETOGUCHI S. MATSUO Department of Mechanical Engineering Kyungpook National University 1370 Sankyuk-dong Daegu 702-701 Korea School of Mechanical Engineering Andong National University Songchun-dong Andong 760-749 Korea Department of Mechanical System Engineering Saga University 1 Honjo Saga 840-8502 Japan

The major flow physics of the unsteady condensation in the subsonic flows induced by the unsteady expansion waves in shock tube was studied in this paper. The unsteady condensation phenomenon was analyzed by using the two-dimensional, unsteady, Navier-Stokes equations, which were fully coupled with a droplet growth equation. The third-order TVD MUSCL scheme was applied to solve the governing equation systems. The computational results were compared with the previous experimental data. The time-dependent behavior of unsteady condensation of moist air in shock tube was investigated in details. The results show that the major characteristics of the unsteady condensation phenomenon in shock tube are very different from those in the supersonic wind tunnels.

关键词： shock tube shock wave expansion wave unsteady flow compressible flow unsteady condensation

Mass-forming ischemic colitis that mimics colon cancer

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Chinese Medical Journal 2020年第10期133卷 1253-1254页

作者： Ho Seung kim Fozan Sauri Jae Hyun Kang Nam Kyu kim Division of Colorectal Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoul 03722Korea.

To the Editor:Rarely,ischemic colitis can also mimic a carcinoma during colonoscopy and on computed tomography(CT)*** colonoscopy,an ulceration,a submucosal mass,and a narrowed colon segment with an ulcerated mucosa have all been described as mimicking this kind of *** reports have documented this type of mass-forming ischemic colitis variant.[1-4]Here,we described two patients with ischemic colitis who presented with lesions mimicking colon cancer.

关键词： colon cancer. colitis

Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

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中国有色金属学会会刊：英文版 2009年第B9期19卷 164-170页

作者： Tae-Jin JE Kang-Won LEE Sang-Cheon PARK Jae-Gu kim Doo-Sun CHOI Kyoung-Taik PARK Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟