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Glial cells in the center of future ischemic stroke treatments

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Neural Regeneration Research 2022年第12期17卷 2659-2660页

作者： Ivóh.hernández Maria Josépérez-Álvarez Genomic Instability Group Spanish National Cancer Research Centre(CNIO)MadridSpain Departamento de Biología(Fisiología Animal)Facultad de Ciencias Universidad Autónoma de Madridand Instituto de Biología Molecular-CBMSOUAM/CSICMadridSpain

In the last century,increasing knowledge about glial cells has revealed their importance in brain physiology and disease and an exciting potential target for new therapeutic interventions(hernández et al.,2021).Ischemic stroke is the most common of all types of *** the second leading cause of disability and mortality,ischemic stroke is a serious socio-economic burden *** it has been strongly associated with aging,during 2020 COVID-19 emerged as a new risk factor for ischemic stroke in younger patients(Cagnazzo et al.,2021).The only therapy or intervention currently available for humans is early reperfusion after the onset of the first ***,due to the high risk of brain hemorrhage,these treatments are suitable for only a small percentage of ***,reperfusion does not prevent post-injury neurodegeneration,hence the importance of finding new therapeutic alternatives to ameliorate ischemic damage and improve post-stroke quality of life.

关键词： mortality treatment younger

An Intelligent Multi-robot path planning in a Dynamic Environment Using Improved Gravitational Search Algorithm

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International Journal of Automation and computing 2021年第6期18卷 1032-1044页

作者： p.K.Das h.S.Behera p.K.Jena B.K.panigrahi Department of Computer Sceime and Engineering and Information TechnologyVeer Surendra Sai University of TechnologyBurlaOdishaIndia Departmet of Mechanical Engineering Veer Surendra Sai University of TechnologyBurlaOdishaIndia Departmet of Electrical Engineering Indian Institute of TechnologyDelhiIndia

This paper proposes a new methodology to optimize trajectory of the path for multi-robots using improved gravitational search algorithm(IGSA) in clutter environment. Classical GSA has been improved in this paper based on the communication and memory characteristics of particle swarm optimization(pSO). IGSA technique is incorporated into the multi-robot system in a dynamic framework, which will provide robust performance, self-deterministic cooperation, and coping with an inhospitable environment. The robots in the team make independent decisions, coordinate, and cooperate with each other to accomplish a common goal using the developed IGSA. A path planning scheme has been developed using IGSA to optimally obtain the succeeding positions of the robots from the existing position in the proposed environment. Finally, the analytical and experimental results of the multi-robot path planning were compared with those obtained by IGSA, GSA and differential evolution(DE) in a similar environment. The simulation and the Khepera environment result show outperforms of IGSA as compared to GSA and DE with respect to the average total trajectory path deviation, average uncovered trajectory target distance and energy optimization in terms of rotation.

关键词： Gravitational search algorithm multi-robot path planning average total trajectory path deviation average uncovered trajectory target distance average path length

Effect of Selenium on Aflatoxin hepatocarcinogenesis in the Rat

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Biomedical and Environmental Sciences 1990年第1期3卷 65-80页

作者： BORIS h.RUEBNER DENNIS p. h. hSIEh Department of pathology Department of Environmental Toxicology University of California Davis California 95616

The effects of selenium (Na_2SeO_3) on aflatoxin B_1 (AFB_1)-induced hepatic neoplasia were studied in the rat. putative preneoplastic foci and nodules composed of basophilic, eosinophilic, and clear cells developed early. Basophilic foci were seen first; in the later stages basophilic and eosinophilic nodules predominated. At each stage the AFB_1 + Se groups showed fewer and smaller foci and nodules than the AFB_1 -Se group. The number of foci in the AFB_1 + 3 ppm Se group and their mean area were smaller than those in the 6 ppm Se + AFB_1 group. At the end of the experiment hepatocellular carcinoma (hCC) was found in 11/18 rats (61%) of the AFB_1-Se group. hCC was not found in either of the groups given AFB_1 +Se. We conclude that Se had an inhibitory effect on the initiation and promotion stages of AFB_1-induced preneoplastic foci and nodules. Se also prevented progression of these nodules to hCC even after cessation of AFB_1 administration. The inhibitory effect of Se at 3 ppm was greater than at 6 ppm. The 6 ppm Se group also showed evidence of toxicity. 1990 Academic ***.

关键词： Effect of Selenium on Aflatoxin hepatocarcinogenesis in the Rat

Neutronic analysis of Indian helium-cooled solid breeder tritium breeding module for testing in ITER

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plasma Science and Technology 2022年第6期24卷 189-195页

作者： h L SWAMI Deepak ShARMA C DANANI p ChAUDhARI R SRINIVASAN Rajesh KUMAR Institute for plasma Research Gandhinagar 382428India homi Bhabha National Institute AnushaktinagarMumbai 400094India

India has proposed the helium-cooled solid breeder blanket concept as a tritium breeding module to be tested in *** module has lithium titanate for tritium breeding and beryllium for neutron *** also enhances tritium breeding.A design for the module is prepared for detailed *** analysis is performed to assess the tritium breeding rate,neutron distribution,and heat distribution in the *** tritium production distribution in submodules is evaluated to support the tritium transport *** tritium breeding density in the radial direction of the module is also assessed for further optimization of the *** heat deposition profile of the entire module is generated to support the heat removal circuit *** estimated neutron spectrum in the radial direction also provides a more in-depth picture of the nuclear interactions inside the material *** total tritium produced in the hCSB module is around 13.87 mg per full day of operation of ITER,considering the 400 s ON time and 1400 s dwell *** estimated nuclear heat load on the entire module is around 474 kW,which will be removed by the high-pressure helium cooling *** heat deposition in the test blanket model(TBM)is huge(around 9 GJ)for an entire day of operation of ITER,which demonstrates the scale of power that can be produced through a fusion reactor *** per the Brayton cycle,it is equivalent to 3.6 GJ of electrical *** terms of power production,this would be around 1655 MWh *** evaluation is carried out using the MCNp5 Monte Carlo radiation transport code and FEDNL 2.1 nuclear cross section *** hCSB TBM neutronic performance demonstrates the tritium production capability and high heat deposition.

关键词： hCSB TBM tritium nuclear heat ITER

Approximate solutions of Klein-Gordon equation with improved Manning-Rosen potential in D-dimensions using SUSYQM

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Chinese physics B 2014年第12期23卷 38-43页

作者： A.N.Ikot h.hassanabadi h.p.Obong Y.E.Chad Umoren C.N.Isonguyo B.h.Yazarloo Department of physics University of Port HarcourtChoba P M B5323 Port Harcourt Nigeria Department of Basic Sciences Shahrood Branch Islamic Azad UniversityShahrood Iran Theoretical physics Group Department of Physics University of Uyo-NigeriaNigeria

In this paper, we present solutions of the Klein–Gordon equation for the improved Manning–Rosen potential for arbitrary l state in d-dimensions using the supersymmetric shape invariance method. We obtained the energy levels and the corresponding wave functions expressed in terms of Jacobi polynomial in a closed form for arbitrary l state. We also calculate the oscillator strength for the potential.

关键词： Klein–Gordon equation improved Manning–Rosen potential supersymmetric quantum mechanics(SUSYQM)

An empirical examination of investor sentiment and stock market volatility: evidence from India

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Financial Innovation 2020年第1期6卷 667-681页

作者： haritha p h Abdul Rishad Central University of Kerala KasaragodIndia Central University of himachal pradesh DharamsalaHimachal PradeshIndia

Understanding the irrational sentiments of the market participants is necessary for making good investment *** the recent academic effort to examine the role of investors’sentiments in market dynamics,there is a lack of consensus in delineating the structural aspect of market *** research is an attempt to address this *** study explores the role of irrational investors’sentiments in determining stock market *** employing monthly data on market-related implicit indices,we constructed an irrational sentiment index using principal component *** sentiment index was modelled in the GARCh and Granger causality framework to analyse its contribution to *** results showed that irrational sentiment significantly causes excess market ***,the study indicates that the asymmetrical aspects of an inefficient market contribute to excess volatility and *** findings are crucial for retail investors as well as portfolio managers seeking to make an optimum portfolio to maximise profits.

关键词： Investor sentiment Stock market volatility principal component analysis GARCh Granger causality test

power management unit chip design for automobile active-matrix organic light-emitting diode display module

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Journal of Central South University 2009年第4期16卷 621-628页

作者： KIM J h pARK J h KIM J h CAO T V LEE T Y BAN h J YANG K KIM h G hA p B KIM Y h Department of Electronic Engineering Changwon National University 9 Sarim-Dong Changwon 641-773 Korea Denso pS Electronics Corporation 47 Seongsan-Dong Changwon 641-315 Korea

A power management unit （pMU） chip supplying dual panel supply voltage, which has a low electro-magnetic interference （EMI） characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The pMU chip is designed with MagnaChip＇s 0.25 μ high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SpICE simulation is done.

关键词： DC-DC converter AMOLED charge pumping power management unit (pMU) dual panel supply voltage

InAs/InAsSb Avalanche photodiode (ApD) for applicaions in long-wavelength infrared region

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Optoelectronics Letters 2008年第5期4卷 342-346页

作者： p.K.Maurya h.Agarwal A.Singh p.Chakrabarti Center for Research in Microelectronics Department of Electronics EngineeringInstitute of TechnologyBanaras Hindu UniversityVaranasi-221005India

A generic numerical model of a long-wavelength Avalanche photodiode （ApD） based on narrow bandgap semiconductor InAsSb on InAs substrate is reported for the first time. This model has been applied for theoretical characterization of a proposed N^＋ InAS/p-InAsSb avalanche photodiode structure for possible application in 2-5 μm wavelength region. The parameters such as gain, excess noise factor and their trade-off with variation of doping concentration and bias voltage have been estimated for the ApD taking into account history-dependent theory of avalanche multiplication process, The LWIR ApD is expected to fred application in optical gas sensor and in future generation of optical communication system.

关键词：长波长紫外线区域雪崩二极管数字模型

Effect of Indian Medium Coking Coal on Coke Quality in Non-recovery Stamp Charged Coke Oven

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Journal of Iron and Steel Research International 2014年第7期21卷 673-678页

作者： h.p.Tiwari p.K.Banerjee V.K.Saxena S.K.haldar Raw Material and Coke Making Research Group Research and Development DivisionTata Steel Ltd.Jamshedpur 831001JharkhandIndia Department of Chemical Engineering Indian School of Mines Coke plants Tata Steel Ltd.Jamshedpur 831001JharkhandIndia

The maximum possibility of utilizing the Indian coking coals and inferior grade coking coal for producing metallurgical coke through non-recovery stamp charging tech_nology was investigated. Indian indigenous coals contained low percent of vitrinite （〈50%） and higher content of ash （〉15%） compared to imported coking coal. Therefore, the selection of appropriate proportion of different types of coals was a major challenge for coke makers. Coal blend selection criterion based on a single coefficient, named as composite coking potential （CCp）, was developed. The use of increased proportion of semi-soft coal （crucible swelling number of 2.5） and high ash （≥15%） indigenous coal in the range of 20%- 35% and 20%-65% respectively in the blends resulted in good quality of coke. plant data of a non recovery coke oven were used for developing and validating the model. The results showed that the coke strength after reaction （CSR） varied in the range of 63.7%-67.7% and the M40 value was between 81.8 and 89.3 in both the cases.

关键词： Indian coking coal imported coking coal CCp CSR M40 non-recovery stamp charged coke making