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World Journal of Gastroenterology 2006年第33期12卷 5379-5383页

作者： Halil Eken Hayrettin Ozturk Hulya Ozturk huseyin buyukbayram Mardin Children Hospital Department of Pediatric Surgery Diyarbakir Turkey Abanty Izzet Baysal University Medical School Departments of Pediatric Surgery Bolu Turkey Diyarbakir Children Hospital Department of Pediatric Surgery Diyarbakir Turkey Dicle University Medical School Departments of Pathology Diyarbakir Turkey

AIM: To evaluate the effects of dexamethasone on liver damage in rats with bile duct ligation. METHODS: A total of 40 male Sprague-Dawley rats, weighing 165-205 g, were used in this study. Group 1 (sham-control, n = 10) rats underwent laparotomy alone and the bile duct was just dissected from the surrounding tissue. Group 2 rats (untreated, n = 10) were subjected to bile duct ligation (BDL) and no drug was applied. Group 3 rats (low-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. Group 4 rats (high-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. At the end of the two-week period, biochemical and histological evaluations were processed. RESULTS: The mean serum bilirubin and liver enzyme levels signifi cantly decreased, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) values were significantly increased in low-dose dexa and high-dose dexa groups when compared to the untreated group. The histopathological score was significantly less in the low-dose and high-dose dexa groups compared to the untreated rats. In the low-dose dexa group, moderate liver damage was seen, while mild liver damage was observed in the high-dose dexa group. CONCLUSION: Corticosteroids reduced liver damage produced by bile duct obstruction. However, the histopathological score was not signifi cantly lower in the high-dose corticosteroid group as compared to the low-dose group. Thus, low-dose corticosteroid provides asignifi cant reduction of liver damage without increased side effects, while high dose is associated not with lower fi brosis but with increased side effects.

关键词：地塞米松肝脏损伤胆管结扎小鼠动物实验

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Interaction of L-Arginine-methyl ester and Sonic hedgehog in liver ischemia-reperfusion injury in the rats

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World Journal of Gastroenterology 2007年第28期13卷 3841-3846页

作者： Mehmet Cudi Tuncer Hayrettin Ozturk huseyin buyukbayram Hulya Ozturk Dicle University Medical SchoolDepartments of AnatomyDiyarbakirTurkey Abanty Izzet Baysal University Medical SchoolDepartments of Pediatric SurgeryBoluTurkey Dicle University Medical SchoolDepartments of PathologyDiyarbakirTurkey Izzet Baysal Obstetric and Children Hospital Department of Pediatric SurgeryBoluTurkey

AIM: To investigate the role of Sonic hedgehog (Shh) on the course of liver ischemia and reperfusion (I/R) in rats, and the interaction between treatment with nitric oxide donor L-Arginine-methyl ester (L-Arg) and up-regulation of Shh expression. METHODS: A total of 30 male Sprague-Dawley rats weighing 220-240 g were used in this study. Sham-control group (G1, n = 10): a sham operation was performed (except for liver I/R). I/R-untreated group (G2, n = 10): rats underwent liver ischemia for 1 h followed by reperfusion for 45 min. I/R-L-Arg group (G3, n = 10): after performing the same surgical procedure as in group 2, animals were treated with L-Arg. Liver tissues were taken for determination of malondialdehyde (MDA) levels, and biochemical and histological evaluations were made. RESULTS: Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and γ-glutamyltranspeptidase (GGT) activities were higher in group 2 than in group 3. MDA values and the hepatic injury score decreased in the L-Arg treated group compared to the I/R-untreated group. In group 2, the hepatocytes were swollen with marked vacuolization. Group 3 rats showed well-preserved liver parenchyma, with hepatocytes extending from the central vein. The morphology of the hepatocytes and the sinusoidal structures was normal, without any signs of congestion. Mild Shh positive immunostaining was detected in group 2 animals. The expression of immunoreactive cells was increased markedly in liver tissue from I/R-L-Arg ***: Our findings suggest that Shh molecules are critical factors in the pathophysiology of inflammatory liver injury induced by I/R. In addition, NO plays an important role in the immunohistochemical expression of these molecules.

关键词：局部缺血再灌注肝损伤 L-精氨酸甲酯

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Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

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World Journal of Gastroenterology 2008年第46期14卷 7101-7106页

作者： Ercan Gedik Sadullah Girgin Hayrettin Ozturk Basra Deniz Obay Hulya Ozturk huseyin buyukbayram Department of General Surgery Medical SchoolDicle University Department of Pediatric Surgery Medical SchoolAbant Izzet Baysal University Department of Physiology Medical SchoolDicle University Department of Pediatric Surgery Medical SchoolDuzce University Department of Pathology Medical SchoolDicle University

AIM:To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreat- ed with resveratrol (10 μmol/L,iv). Liver tissues wweerre obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase ,and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusion-related liver injury.

关键词：肝损伤肝缺血氧化应激力临床医学

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Pseudoxantoma elasticum,as a repetitive upper gastrointestinal hemorrhage cause in a pregnant woman

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World Journal of Gastroenterology 2007年第28期13卷 3897-3899页

作者： Vedat Goral Dogan Demir Yekta Tuzun Ugur Keklikci huseyin buyukbayram Kadim Bayan Asur Uyar Department of Gastroenterology Dicle University School of MedicineDiyarbakirTurkey Department of Family Medicine Dicle University School of MedicineDiyarbakirTurkey Department of Ophtalmology Dicle University School of MedicineDiyarbakirTurkey Department of Pathology Dicle University School of MedicineDiyarbakirTurkey Department of Radiology Dicle University School of MedicineDiyarbakirTurkey

Pseudoxantoma elasticum is a rare, hereditary, multisystemic disease affecting the skin, eye, and cardiovascular system. A twenty-eight-year-old female has presented to emergency unit with the complaint of gastrointestinal hemorrhage. This patient, who had been monitored in the gastroenterology clinic more than 10 times in the past 8 years, noted a repetitive hemorrhage during her previous pregnancy in her history. The examination of the patient revealed the following signs and symptoms: atrophy in the epithelium of the retina pigment; typical angioid streaks and peau d'orange finding in the fundus; thinning of the retinal nerve fiber in OCT (optic coherence tomography); bilateral and reticular papillary lesions with yellowish-color in the neck region (plucked chicken appearance); presence of bleeding foci in fundus; and nephrocalcinosis in kidneys. In light of these symptoms, the patient was diagnosed with pseudoxantoma elasticum. Skin biopsy confirmed the pseudoxantoma elasticum diagnose. PXE is an uncommon, hereditary disease. Early diagnosis of pseudoxantoma elasticum cases, is important for minimalizing systemic complications and informing the other family members through genetic counseling.

关键词：孕妇上消化道出血胃肠疾病症状

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