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H pylori iceA alleles are disease-specific virulence factors

World Journal of Gastroenterology 2007年第18期13卷 2581-2585页

作者： Vildan Caner Mustafa Yilmaz Nadir Yonetci Sevil Zencir Nedim Karagenc Ilknur Kaleli huseyin bagci Department of Medical Biology School of Medicine Pamukkale University 20020 Kinikli Denizli Turkey Department of Gastroenterology School of Medicine Pamukkale University 20020 Kinikli Denizli Turkey Department of Microbiology and Clinical Microbiology School of Medicine Pamukkale University 20020 Kinikli Denizli Turkey

AIM： To characterize and compare genotype profiles of H pylori strains isolated from patients with chronic gastritis and duodenal ulcer in western part of Turkey. METHODS： A total of 46 patients [30 chronic gastritis （CG） and 16 duodenal ulcer （DU）] who had undergone endoscopy because of dyspeptic complaints were studied. The antral biopsy specimens were evaluated for the presence of Hpylori by rapid urease test and culture, and the genotype profiles were determined by real-time PCR. RESULTS： The cagA gene was observed in 43 （93.5%） isolates. The vacA s1m2 genotype was the predominant subtype, found in 63.3% and 68.7% of isolates in patients with CG and DU, respectively. Twenty （66.6%） isolates from patients with CG were iceA2 positive while the iceA1 was predominant in those with DU （68.8%）. In terms of the association of the ice,4 alleles to other genes, both alleles were significantly associated with the cagA vacA slm2 genotype. CONCLUSION： The prevalent circulating genotypes in CG and DU were cagA vacA slm2 iceA2 and cagA vacA slm2 iceA1 genotype, respectively. It was found that cagA vacA slm2 genotype seems to be common virulence factors in both CG and DU while iceA alleles show specificity for gastroduodenal pathologies in this study.

关键词： Hpylori Virulence genes Culture Real-timePCR

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