检索结果-南通市图书馆

SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients

引用

World Journal of Gastrointestinal Oncology 2019年第8期11卷 589-598页

作者： Landry E Nfonsam Jana Jandova hunter c jecius Pamela N Omesiete Valentine N Nfonsam Department of Genetics Children’s Hospital of Eastern OntarioOttawaOntario K1H 8L1Canada Department of Surgery University of ArizonaTucsonAZ 85724United States

BAcKGROUND colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of *** affects 1.2 million people around the world and is responsible for about 0.6 million deaths every *** decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(creted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon ***4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient *** SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of california Santa cruz cancer Browser *** SFRP4 was found to be co-expressed with the EMT-linked markers cDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and ***4 expression negatively correlated with the EMTlinked suppressors cLDN4,cLDN7,TJP3,MUc1,and *** expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon ***,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).cONcLUSION considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy.

关键词： Secreted frizzled-related protein 4 Epithelial mesenchymal transition colon cancer Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

引用

Asian Journal of Andrology 2008年第1期10卷 14-22页

作者： Travis D. Strong Milena A. Gebska Arthur L. Bumett hunter c. champion Trinity J. Bivalacqua The Brady Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA Division of cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 USA

Erectile dysfunction （ED） commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 （PDE-5） inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.

关键词： erectile dysfunction endothelial-specific gene endothelial dysfunction gene therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

引用

International Journal of Oral Science 2020年第3期12卷 199-208页

作者： Mohit Sharma Felipe Paiva Fonseca Keith D.hunter Raghu Radhakrishnan Department of Oral Pathology Sudha Rustagi College of Dental Sciences and ResearchFaridabadHaryanaIndia Department of Oral Surgery and Pathology School of DentistryFederal University of Minas GeraisBelo HorizonteMGBrazil Academic Unit of Oral and Maxillofacial Medicine and Pathology School of Clinical DentistryUniversity of SheffieldClaremont CrescentSheffieldUK Department of Oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnatakaIndia

The integrity of the basal stem cell layer is critical for epithelial *** this paper,we review the expression of oral mucosal stem cell markers(OM-ScMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OScc)to understand the role of basal cells in potentiating cancer stem cell behaviour in *** the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal *** vacillating expression patterns of OM-ScMs confirm the role of keratins 5,14,19,cD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYc,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and *** downregulation of OM-ScMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

关键词： epithelium malignant mucosal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rural implementation of the perioperative surgical home:A case-control study

引用

World Journal of Orthopedics 2023年第3期14卷 123-135页

作者： Srinivasan Sridhar Amy Mouat-hunter Bernadette Mccrory center for Health Outcomes and Policy Evaluation College of Public HealthThe Ohio State UniversityColumbusOH 43210United States Preanesthesia clinic Bozeman HealthBozemanMT 59715United States Mechanical and Industrial Engineering Montana State UniversityBozemanMT 59715United States

BAcKGROUND Perioperative surgical home(PSH)is a novel patient-centric surgical system developed by American Society of Anesthesiologist to improve outcomes and patient *** has proven success in large urban health centers by reducing surgery cancellation,operating room time,length of stay(LOS),and readmission ***,only limited studies have assessed the impact of PSH on surgical outcomes in rural *** To evaluate the newly implemented PSH system at a community hospital by comparing the surgical outcomes using a longitudinal case-control *** The research study was conducted at an 83-bed,licensed level-III trauma rural community hospital.A total of 3096 TJR procedures were collected retrospectively between January 2016 and December 2021 and were categorized as PSH and non-PSH cohorts(n=2305).To evaluate the importance of PSH in the rural surgical system,a case-control study was performed to compare TJR surgical outcomes(LOS,discharge disposition,and 90-d readmission)of the PSH cohort against two control cohorts[control-1 PSH(c1-PSH)(n=1413)and control-2 PSH(c2-PSH)(n=892)].Statistical tests including chi-square test or Fischer’s exact test were performed for categorical variables and Mann-Whitney test or Student’s t-test were performed for continuous *** general linear models(Poisson regression and binomial logistic regression)were performed to fit adjusted *** The LOS was significantly shorter in PSH cohort compared to two control cohorts(median PSH=34 h,c1-PSH=53 h,c2-PSH=35 h)(P valuecohort had lower percentages of discharges to other facilities(PSH=3.5%,c1-PSH=15.5%,c2-PSH=6.7%)(P valuecal difference observed in 90-d readmission between control and PSH ***,the PSH implementation reduced the 90-d readmission percentage(PSH=4.7%,c1-PSH=6.1%,c2-PSH=3.6%)lower than the national average 30-d readmission percentage which is 5.5%.The PSH system was effecti

关键词： Perioperative surgical home Rural medicine case-control study Total joint replacements Health equity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease

引用

World Journal of Gastroenterology 2009年第10期15卷 1209-1218页

作者： courtney S Schaffert Michael J Duryee carlos D hunter Bartlett c Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele Department of Internal Medicine University of Nebraska Medical Center 986350 Nebraska Medical Center Omaha NE 68198-6350 United States Veterans Administration Alcohol Research center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States Department of Pathology and Microbiology University of Nebraska Medical Center 986495 Nebraska Medical Center Omaha NE 68198-6495 United States

The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.

关键词： Alcoholic liver disease Inflammation Fibrosis Sinusoidal liver endothelial cells Kupffer cells Hepatocyte Stellate cells Precision cut liver slices

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mastering the power of self-hypnosis : a practical guide to self-empowerment

引用

2011年

作者： hunter c. Roy

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

FtsH4 protease controls biogenesis of the PSII complex by dual regulation of high light-inducible proteins

引用

Plant communications 2023年第1期4卷 272-286页

作者： Vendula Krynická Petra Skotnicová Philip J.Jackson Samuel Barnett Jianfeng Yu Anna Wysocka Radek Kaña Mark J.Dickman Peter J.Nixon c.Neil hunter Josef Komenda The czech Academy of Sciences Institute of MicrobiologyCentre AlgatechNovohradská 23737901 TreboñCzech Republic Plants Photosynthesis and SoilSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK Department of chemical and Biological Engineering University of SheffieldSheffield S13JDUK Sir Ernst chain Building-Wolfson Laboratories Department of Life SciencesSouth Kensington CampusImperial College LondonLondon SW72AZUK Faculty of Science University of South Bohemia37005 Ceské BudějoviceCzech Republic

FtsH proteases are membrane-embedded proteolytic complexes important for protein quality control and regulation of various physiological processes in bacteria,mitochondria,and *** most cyanobacteria,the model species Synechocystis *** 6803 contains four FtsH homologs,FtsH1–***1–FtsH3 form two hetero-oligomeric complexes,FtsH1/3 and FtsH2/3,which play a pivotal role in acclimation to nutrient deficiency and photosystem Ⅱ quality control,***4 differs from the other three homologs by the formation of a homo-oligomeric complex,and together with Arabidopsis thaliana AtFtsH7/9 orthologs,it has been assigned to another phylogenetic group of unknown *** results exclude the possibility that Synechocystis FtsH4 structurally or functionally substitutes for the missing or non-functional FtsH2 subunit in the FtsH2/3 ***,we demonstrate that FtsH4 is involved in the biogenesis of photosystem Ⅱ by dual regulation of high light-inducible proteins(Hlips).FtsH4 positively regulates expression of Hlips shortly after high light exposure but is also responsible for Hlip removal under conditions when their elevated levels are no longer *** provide experimental support for Hlips as proteolytic substrates of *** labeling of FtsH4 enabled us to assess its localization using advanced microscopic *** show that FtsH4 complexes are concentrated in well-defined membrane regions at the inner and outer periphery of the thylakoid *** on the identification of proteins that co-purified with the tagged FtsH4,we speculate that FtsH4 concentrates in special compartments in which the biogenesis of photosynthetic complexes takes place.

关键词： thylakoid photosystemⅡbiogenesis FtsH4 high light-inducible protein proteolysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Impact of Systemic Factors on Iran-Gulf Arab Relations

引用

International Relations and Diplomacy 2020年第11期8卷 461-474页

作者： Shireen hunter Georgetown University WashingtonD.C.USA

Since the Persian Gulf Arab states became independent in the 1960s and the 1970s,their relations with Iran have been mostly *** particular,since the 1979 Islamic Revolution in Iran,relations with the Persian Gulf Arab states have *** and geographic imbalances,often clashing ideologies and world views,diverging security interest,competition for regional influence,plus ethnic and sectarian differences between Iran and the Arabs,have been responsible for the fraught state of Iran-Gulf Arab ***,systemic factors both at international and regional levels,have also deeply affected these *** the regional level,the Israel factor and the evolving nature of intra-Arab politics have been especially *** the international level,the character of the international political system,especially the balance of power among its key actors,plus the policies of the major international players have had the greatest *** pattern is likely to continue in future as well.

关键词： Iran Gcc Relations Systemic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factors associated with concussion-symptom knowledge and attitudes toward concussion care seeking in a national survey of parents of middle-school children in the US

引用

Journal of Sport and Health Science 2021年第2期10卷 113-121页

作者： Zachary Y.Kerr Aliza K.Nedimyer Melissa c.Kay Avinash chandran Paula Gildner K.hunter Byrd Juliet K.Haarbauer-Krupa Johna K.Register-Mihalik Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNC 27599-8700USA Matthew Gfeller Sport-Related Traumatic Brain Injury Research center University of North CarolinaChapel HillNC 27599-8700USA Injury Prevention Research center University of North CarolinaChapel HillNC 27510USA Human Movement Science curriculum University of North CarolinaChapel HillNC 27599-8700USA School of Health Professions University of Southern MississippiHattiesburgMS 39406USA Datalys center for Sports Injury Research and Prevention IndianapolisIN 46202USA National center for Injury Prevention and control Centers for Disease Control and PreventionAtlantaGA 30341USA

Background:Developing appropriate concussion prevention and management paradigms in middle school(MS)settings requires understanding parents’general levels of concussion-related knowledge and *** study examined factors associated with concussion-symptom knowledge and care-seeking attitudes among parents of MS children(aged 10-15 years).Methods:A panel of 1224 randomly selected ***,aged ≥18 years and identifying as parents of MS children,completed an online questionnaire capturing parental and child *** parents’concussion-symptom knowledge was measured using 25 questions,with possible answers being“yes”,“maybe”,and“no”.correct answers earned 2 points,“maybe”answers earned 1 point,and incorrect answers earned 0 point(range:0-50;higher scores=better knowledge).concussion care-seeking attitudes were also collected using five 7-point scale items(range:5-35;higher scores=more positive attitudes).Multivariable ordinal logistic regression models identified predictors of higher *** met proportional odds *** odds ratios(aORs)with 95%confidence intervals(95%cIs)(excluding 1.00)were deemed statistically ***:Median scores were 39(interquartile range:32-44)for symptom knowledge and 32(interquartile range:28-35)for care-seeking *** multivariable models,odds of better symptom knowledge were higher in women ***(aOR=2.28;95%cI:1.71-3.05),white/non-Hispanics *** racial or ethnic groups(aOR=1.88;95%cI:1.42-2.49),higher parental age(10-year-increase aOR=1.47;95%cI:1.26-1.71),and greater competitiveness(10%-scale-increase aOR=1.24;95%cI:1.13-1.36).Odds of more positive care-seeking attitudes were higher in white/non-Hispanics *** racial or ethnic groups(aOR=1.45;95%cI:1.06-1.99)and in older parental age(10-year-increase aOR=1.24;95%cI:1.05-1.47).conclusion:characteristics of middle school children’s parents(e.g.,sex,race or ethnicity,age)are associated with their concussion-symptom knowle

关键词： Pediatrics Traumatic brain injury Youth

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

comparative transcriptome analysis of thiamethoxam susceptible and resistant Asian citrus psyllid,Diaphorina citri(Hemiptera:Liviidae),using RNA-sequencing

引用

Insect Science 2021年第6期28卷 1708-1720页

作者： Xue Dong chen Surendra Neupane Torrence A.Gill hunter Gossett Kirsten S.Pelz-Stelinski Lukasz L.Stelinski Entomology and Nematology Department University of FloridaCitrus Research and Education Center700 Experiment station RdLake AlfredFL 33850USA Biology Department Chowan UniversityOne University PlaceMurfreesboroNC 27855USA

Asian citrus psyllid,Diaphorina citri Kuwayama(Hemiptera:Liviidae),transmits the causal pathogen of huanglongbing and is a global pest of *** populations exhibit resistance to multiple insecticide modes of action in areas where these chemicals have been *** performed genome-wide transcriptional analysis for two field populations of ***(Wauchula and Lake Alfred,Florida,USA)that exhibit 1300-fold resistance to the neonicotinoid insecticide,thiamethoxam,and compared it to that of susceptible psyllids collected from the same area and without imposed *** Lake Alfred population responded to insecticide resistance by up-regulation of 240 genes and down-regulation of 148 *** Wauchula population exhibited similar patterns to the Lake Alfred population with up-regulation of 253 genes and down-regulation of 115 *** Ontology annotation associated with cellular processes,cell,and catalytic activity were assigned to differentially expressed genes(DEGs).The DEGs from Lake Alfred and Wauchula populations were mapped to Kyoto Encyclopedia of Gene and Genomes pathways and implicated enrichment of metabolic pathways,oxidative phosphorylation,extracellular matrix-receptor interaction,terpenoid backbone biosynthesis,and insect hormone biosynthesis in the resistant populations,lip-regulation of 60s ribo-somal proteins,UDP-gluscoyltransferases,cytochrome c oxidases,and cYP and ABc transporters among thiamethoxam-resistant *** implicates a broad array of novel and conventionally understood resistance mechanisms.

关键词： cuticle genes enzymatic activity neonicotinoid resistance transcriptomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：