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高龄妇女孕期管理专家共识

中华围产医学杂志 2024年第6期27卷 441-449页

作者：中华医学会围产医学分会中华医学会妇产科学分会产科学组漆洪波赵扬玉杨慧霞王岚杨静不详重庆医科大学附属妇女儿童医院妇产科重庆401147 北京大学第三医院妇产科北京100191 北京大学第一医院妇产生殖医学中心北京100034 重庆医科大学附属妇女儿童医院北京大学第三医院

随着高龄孕产妇比例的逐年上升,妊娠相关风险日益凸显。为提升我国高龄妇女的孕期管理水平,中华医学会围产医学分会联合中华医学会妇产科学分会产科学组结合国内外已经发表的高龄孕产妇相关研究证据和共识,经过国内专家多次的深入讨论,... 详细信息

随着高龄孕产妇比例的逐年上升,妊娠相关风险日益凸显。为提升我国高龄妇女的孕期管理水平,中华医学会围产医学分会联合中华医学会妇产科学分会产科学组结合国内外已经发表的高龄孕产妇相关研究证据和共识,经过国内专家多次的深入讨论,共同制定了“高龄妇女孕期管理专家共识”。本共识包括了高龄孕妇的定义、孕前准备、产前诊断、围产期并发症防治、终止妊娠的时机和方式以及围分娩期管理等关键问题,旨在为产科医师提供规范化的高龄孕产妇管理指南,进而提升高龄孕产妇的母婴保健水平。

关键词：高龄孕期管理实践指南

Advances in probing single biomolecules: From DNA bases to glycans

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Interdisciplinary Materials 2023年第4期2卷 511-528页

作者： Baofei Hou Teng Zhang huixia yang Xu Han Liwei Liu Linfei Li Cesare Grazioli Xu Wu Nan Jiang Yeliang Wang MIIT Key Laboratory for Low-Dimensional Quantum Structure and Devices School of Integrated Circuits and ElectronicsBeijing Institute of TechnologyBeijingChina Department of Chemistry University of Illinois ChicagoChicagoIllinoisUSA IOM-CNR Istituto Officina dei MaterialiTriesteItaly

Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental *** the various imaging techniques available for biomolecules and their assembled nanostructures,scanning probe microscopy(SPM)provides a powerful and nondestructive imaging *** is unique in visualizing intrinsically disordered biomolecules at the nanometer scale(e.g.,glycans).This review highlights recent achievements in studying biomolecules using SPM technique,focusing on DNA bases,amino acids,proteins,and *** atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure–property ***-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

关键词： atomic-scale probing biomolecules scanning probe microscopy structure visualization

Two-phase smooth particle hydrodynamics modeling of air-water interface in aerated flows

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Science China(Technological Sciences) 2017年第3期60卷 479-490页

作者： yang huixia LI Ran LIN PengZhi WAN Hang FENG JingJie College of Civil Engineering Guizhou University State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

Abstracted/indexed in:Science Citation Index,Science Citation Index Expanded(SciSearch),Journal Citation Reports/Science Edition,SCOPUS,INSPEC,Zentralblatt Math,Chemical Abstracts Service(CAS),Google Scholar,CSA,Academic OneFile,Current Contents/Engineering,Computing and Technology,Earthquake Engineering Abstracts,EI-Compendex,Gale,OCLC,SCImago,Summon by ProQuest Supervised by Chinese Academy of

关键词： aerated flow dam break density difference hydraulic jump interface smoothed particle hydrodynamics

Gestational weight gain and risk of gestational diabetes mellitus among Chinese women

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Chinese Medical Journal 2014年第7期127卷 1255-1260页

作者： Liu Zheng Ao Deng yang huixia Wang Yan Department of Child Adolescent and Women's Health School of Public Health Peking University Beijing 100191 China Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China

Background Gestational diabetes mellitus （GDM） is a common complication during pregnancy,and gestational weight gain is one of the major and modifiable risk *** study aims to estimate the relationship between the rate of gestational weight gain before diagnosis of GDM and the subsequent risk of *** A case-control study was conducted with 90 GDM cases and 165 women in the control group from May 2012 to August 2012 at Peking University First Affiliated *** was diagnosed according to the standards issued by the Ministry of Health of China in *** plasma glucose levels,weights,and covariate data of the women were obtained based on medical *** analysis and unconditional Logistic regression model were used to estimate the *** After adjusting for age at delivery,parity,and pre-pregnancy body mass index,the risk of GDM increased with increasing rates of gestational weight *** with the lower rate of gestational weight gain （less than 0.28 kg per week）,a rate of weight gain of 0.28 kg per week or more was associated with increased risk of GDM （odds ratio：2.03; 95％ confidence interval：1.15 to 3.59）.The association between the rate of gestational weight gain and GDM was primarily attributed to the increased weight gain in the first *** High rates of gestational weight gain,particular during early pregnancy,may increase a woman＇s risk of GDM.

关键词： gestational diabetes mellitus gestational weight gain case-control study

Conservative Treatment of Fetal Goitrous Hypothyroidism Due to Thyroglobulin Mutations:A Case Report and Literature Review

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Maternal-Fetal Medicine 2023年第3期5卷 182-186页

作者： Shiping Liu Wei Bai Ying Gao Chunyan Shi Lixin Fan Junya Chen Jian Shi Weije Sun Xinlin Hou huixia yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Pediatrics Peking University First HospitalBeijing 100034China Department of Endocrinology Peking University First HospitalBeijing 100034China Department of Ultrasound Peking University First HospitalBeijing 100034China

With the advances in fetal medicine,there will be more cases of congenital hypothyroidism(CH)diagnosed in the fetal ***,there is no consensus on the management *** present a successful case of conservatively managed fetal goitrous hypothyroidism due to compound heterozygous TG *** was observed in a fetus at 23 weeks of *** there was no evidence of transplacental passage of antithyroid antibody and drugs,iodine overload,and iodine deficiency,the fetus was highly suspected to have *** the potential risks of amniocentesis/cordocentesis,and lack of available parenteral levothyroxine in China,the fetus was closely monitored thereafter.A male neonate was delivered vaginally without complications at 39 weeks of *** verified severe hypothyroidism in the infant and immediately initiated levothyroxine *** growth and mental development were normal at the age of 8 ***-exome sequencing showed that the neonate had two compound heterozygous mutations in the TG *** also performed a literature review of the prognosis of postnatal treatment of CH due to TG mutations and the result showed that postnatal treatment of CH due to TG mutations has a favorable ***,further prospective studies are warranted to verify this conclusion.

关键词： Thyroglobulin Gene mutations Fetal hypothyroidism

Incidence and factors influencing postpartum bacterial vaginosis： a controlled study

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Chinese Medical Journal 2014年第3期127卷 586-587页

作者： Zhang Dai Mi Lan yang huixia Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China

Vaginitis is a common infectious disease often associated with abnormal vaginal *** studies have shown that abnormal vaginal flora often cause bacterial vaginosis （BV）,a risk factor of preterm ***,BV is a concern in pregnant *** now,few studies have focused on changes in vaginal flora in postpartum *** et al1 identified BV as a risk factor for post-cesarean ***,yang et al2 found that the incidence of BV is higher in postpartum women than in nonpregnant *** study measured the incidence of BV in postpartum patients and the factors influencing the disparity in *** study was designed to identify whether BV drug therapy is necessary in postpartum ***：bacterial vaginosis; postpartum

关键词： bacterial vaginosis postpartum

栉风沐雨,薪火相传:《中华围产医学杂志》的25个春秋

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中华围产医学杂志 2023年第11期26卷 881-885页

作者：杨慧霞北京大学第一医院妇产科北京100034

2023年11月是“中国围产保健之母”严仁英先生诞辰110周年,2023年也是中华医学会围产医学分会创建35周年及《中华围产医学杂志》创刊25周年,本文回顾了我国围产医学发展之路以及本刊在学术引领方面的工作及成绩,重点从妊娠期高血糖管理... 详细信息

2023年11月是“中国围产保健之母”严仁英先生诞辰110周年,2023年也是中华医学会围产医学分会创建35周年及《中华围产医学杂志》创刊25周年,本文回顾了我国围产医学发展之路以及本刊在学术引领方面的工作及成绩,重点从妊娠期高血糖管理促进母婴两代人全生命周期健康,以及提高胎盘植入性疾病的早识别和综合处理能力两方面,提出杂志未来应更加关注有关“预防胜于治疗”,以及围孕期干预对母婴远期健康的研究报道,以促进并实现从生命早期着手预防成年期疾病的发生。

关键词：期刊(主题) 出版围产医学回顾性研究

Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China

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Chinese Medical Journal 2022年第6期135卷 665-671页

作者： Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang huixia yang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics Tianjin Central Obstetrics and Gynecology HospitalTianjin 300199China Department of Obstetrics Jinan Maternal and Child Health HospitalJinanShandong 250000China Department of Obstetrics Dalian Maternity HospitalDalianLiaoning 116033China Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Obstetrics Shenzhen Peking University HospitalShenzhenGuangdong 518036China Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Huazhong University of Science and TechnologyWuhanHubei 430030China Department of Obstetrics and Gynecology Suzhou Jiulong Hospital Affiliated to Shanghai Jiaotong UniversitySuzhouJiangsu 320571China Department of Obstetrics Affiliated Hospital of Inner Mongolia Medical UniversityHuhhotInner Mongolia 010050China Department of Obstetrics and Gynecology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Epidemiology Branch Division of Intramural Population Health ResearchEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMD 20817USA

Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM *** was shown that a history of GDM was significantly associated with a higher maternal risk for GDM *** incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in *** aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in ***:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research *** participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed *** participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were ***:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of *** are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal ***,it seems

关键词： Gestational diabetes mellitus Recurrence Risk factors Multipara Primipara

病例03(2024):产后溶血性尿毒综合征1例

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中华围产医学杂志 2024年第4期27卷 322-327页

作者：杨红英冯烨李东言魏玉梅赫英东张广意任志菲常聪慧赵静周福德李楠耿妍王文生王茫桔丁欢田娜马淑琴孙伟杰杨慧霞北京大学第一医院宁夏妇女儿童医院(宁夏回族自治区妇幼保健院)产科银川750011 北京大学第一医院妇产生殖医学中心北京100034 北京大学第一医院肾内科北京100034 北京大学第一医院重症医学科北京100034 北京大学第一医院风湿免疫科北京100034 北京大学第一医院血液科北京100034 宁夏医科大学总医院重症医学科银川750011 宁夏医科大学总医院肾内科银川750011 宁夏医科大学总医院产科银川750011

本文报告了1例足月妊娠因重度子痫前期行剖宫产,术后出现产后溶血性尿毒综合征(postpartum hemolytic uremic syndrome,pHUS)的病例。患者孕39周因重度子痫前期在北京大学第一医院宁夏妇女儿童医院行急诊剖宫产,术后即刻发生微血管病性... 详细信息

本文报告了1例足月妊娠因重度子痫前期行剖宫产,术后出现产后溶血性尿毒综合征(postpartum hemolytic uremic syndrome,pHUS)的病例。患者孕39周因重度子痫前期在北京大学第一医院宁夏妇女儿童医院行急诊剖宫产,术后即刻发生微血管病性溶血性贫血、血小板减少、乳酸脱氢酶升高、肝功能异常(转氨酶及胆红素升高)、肾功能异常(少尿、血尿及肌酐进行性升高)。经多学科会诊,考虑重度子痫前期并发pHUS,需行血液透析及血浆置换治疗,转诊至宁夏医科大学总医院。经血液透析及血浆置换治疗,患者病情好转出院。出院后定期肾内科随诊,肾功能术后1个月恢复正常。

关键词：产后溶血性尿毒综合征重度子痫前期 HELLP综合征妊娠