检索结果-南通市图书馆

Journal of Modern Power Systems and Clean Energy 2017年第2期5卷 177-186页

作者： Wenxia LIU Shuya NIU huiting xu State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

In this paper, a cost-benefit analysis based optimal planning model of battery energy storage system(BESS) in active distribution system(ADS) is established considering a new BESS operation strategy. Reliability improvement benefit of BESS is considered and a numerical calculation method based on expectation is proposed for simple and convenient calculation of system reliability improvement with BESS in planning phase. Decision variables include both configuration variables and operation strategy control variables. In order to prevent the interaction between two types of variables and enhance global search ability, intelligent single particle optimizer(ISPO) is adopted to optimize this model. Case studies on a modified IEEE benchmark system verified the performance of the proposed operation strategy and optimal planning model of BESS.

关键词： Battery energy storage system Cost-benefit analysis Reliability improvement benefit Operation strategy Intelligent single particle optimizer

TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第1期40卷 17-34页

作者： Siying Qu Shengfeng Hu huiting xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng Wang Xi Huang Center for Infection and Immunity and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China The State Key Laboratory of Respiratory Disease Guangdong Provincial Key Laboratory of Allergy and Clinical ImmunologyThe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Division of Nephrology Department of Medicinethe Fifth Affliated Hospital of Sun Yat-sen UniversityZhuhai 519000China

Multiple sclerosis(MS)is a neuroinflammatory demyelinating disease,mediated by pathogenic T helper 17(Th17)***,the therapeutic effect is accompa-nied by the fluctuation of the proportion and function of Th17 cells,which prompted us to find the key regulator of Th17 differentiation in ***,we demonstrated that the triggering receptor expressed on myeloid cells 2(TREM-2),a modulator of pattern recognition receptors on innate immune cells,was highly expressed on pathogenic CD4-positive T lymphocyte(CD4^(+)T)cells in both patients with MS and experimental autoimmune encephalomyelitis(EAE)mouse *** knockout of Trem-2 in CD4^(+)T cells significantly alleviated the disease activity and reduced Th17 cell infiltration,activation,differentiation,and inflammatory cytokine production and secretion in EAE ***,with Trem-2 knockout in vivo experiments and in vitro inhibitor assays,the TREM-2/zeta-chain associated protein kinase 70(ZAP70)/signal transducer and activator of transcription 3(STAT3)signal axis was essential for Th17 activation and differentiation in EAE *** conclusion,TREM-2 is a key regulator of pathogenic Th17 in EAE mice,and this sheds new light on the potential of this therapeutic target for MS.

关键词： Multiple sclerosis Experimental autoimmune encephalomyelitis T helper 17 Triggering receptor expressed on myeloid cells 2

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

考虑电压控制成本的分布式电源优化配置

电网技术 2016年第10期40卷 2998-3005页

作者：刘文霞徐慧婷新能源与电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

大量间歇性分布式电源并网对电网规划与运行提出了新的挑战。为达到经济成本和分布式电源接纳能力的最佳平衡,提出一种考虑电压控制成本以及电压控制效果的主动配电网一体化规划新方法。首先,分析分散式与集中式电压调整的调压特点,建... 详细信息

大量间歇性分布式电源并网对电网规划与运行提出了新的挑战。为达到经济成本和分布式电源接纳能力的最佳平衡,提出一种考虑电压控制成本以及电压控制效果的主动配电网一体化规划新方法。首先,分析分散式与集中式电压调整的调压特点,建立不同调压系统的技术框架、调压策略和经济成本模型;然后,建立以年综合成本最小、清洁能源发电占比最大为目标函数,以电压合格、总费用合理等为约束条件的规划模型,并运用多目标差分进化算法进行求解。以并有分布式电源的IEEE 33节点配电网系统为算例,仿真优化中计及了电压的实时控制,仿真结果验证了所提模型和算法的有效性和实用性,能在保证电压合格的情况下改善配电网经济效益,并提高接纳分布式电源的能力。

关键词：分布式电源电压控制主动配电网一体化规划

Inhibition of Ku80 by RNAi enhances the radiosensitivity of cervical carcinoma cell line SiHa

在线全文

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2007年第3期6卷 285-289页

作者： Liang Zhuang Shiying Yu Xiaoyuan Huang Huihua Xiong huiting xu Cancer Center Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China

Objective： To study the radiosensitivity of SiHa cells with Ku80 inhibition by RNAi. Methods： pKu80-siRNA and pNeg-siRNA were constructed and then transfected into SiHa cells. Western blot and RT-PCR were applied to measure the expression of Ku80. After 10 Gy irradiation with 6 MV X-ray, cells were harvested at 20 h, 28 h and 48 h, and analyzed by flow cytometry for apoptosis rate. The SF2 and α, β values of cells were acquired by clone formation array. Results： Two stable transfection cell clones SiHa/Ku80-siRNA and SiHa/Neg-siRNA were screened from the pKu80-siRNA and pNeg-siRNA transfected cells. Western blot and RT-PCR indicated that the expression of Ku80 was suppressed by the Ku80-siRNA, The apoptosis rates of SiHa/Ku80-siRNA were higher than control cells at 28 h and 48 h after X-ray irradiation （P 〈 0.05）. The SF2 value of SiHa/Ku80-siRNA （0.422） was lower than that of SiHa/Neg-siRNA cells （0.587） or untransfected cells （0.583）, and the a value of SiHa/Ku80-siRNA was 0.295 ± 0.016, higher than that of SiHa/Neg-siRNA （0.176 ± 0.010） or control cells （0.188 ± 0.011）. Conclusion： Inhibition of Ku80 could enhance the radiosensitivity of SiHa, which showed that Ku80 could be a good target for molecular therapy.

关键词： Ku80 RNA interference cervical carcinoma SiHa radiosensitivity

在线全文

学校读者我要写书评

暂无评论

TPL主导下的生鲜电商三级供应链决策分析

工业工程 2022年第1期25卷 75-82页

作者：徐慧婷厦门城市职业学院商贸系福建厦门361000

研究由TPL、生鲜电商、生鲜产品供应商组成的三级供应链系统,其中生鲜农产品的市场需求受网上零售价格、安全追溯系统可用性、新鲜度的影响。在TPL主导下,运用Stackelberg博弈模型,分析生鲜电商、生鲜产品供应商不同领导权下的最优决策... 详细信息

研究由TPL、生鲜电商、生鲜产品供应商组成的三级供应链系统,其中生鲜农产品的市场需求受网上零售价格、安全追溯系统可用性、新鲜度的影响。在TPL主导下,运用Stackelberg博弈模型,分析生鲜电商、生鲜产品供应商不同领导权下的最优决策和最大利润,得出以下结论:生鲜产品供应商作为第二领导下的TPL利润、安全追溯系统可用性、保鲜水平、市场需求均大于其作为第三领导时的情形;不同领导权对供应链企业的利润也会产生影响,利润偏向于领导权大的一方。然而不管哪种决策模型,其供应链利润均小于集中决策下的情形。

关键词：博弈论供应链决策生鲜电商三级供应链权利结构

Effects of p38 MAPK inhibitor on the rat pain behavior and proinflammatory cytokines in a metastatic bone cancer pain model

在线全文

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2008年第3期7卷 154-158页

作者： Cuiju Tang Shiying Yu Min Zhang Rui Jiang Na Li huiting xu Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Oncology The Affiliated Nanjing First Hospital Nanjing Medical University Nanjing 210006 China Hubei Medical Association Wuhan 430064 China

Objective： To observe the effects of p38 mitogen activated protein kinase （MAPK） inhibitor SB203580 by intrathecal injection on the pain behavior and the spinal proinflammatory cytokines in a rat model of bone cancer pain induced by breast cancer cells. Methods： Eleven rats were used to establish the models of bone cancer pain, six rats were treated by intrathecal SB203580 injection, and the other 5 were as the controls. The paw withdrawal latency （PWL）, histology and the spinal levels of IL-1β and TNF-α were detected. Results： All the 11 rats presented evident bone destruction and thermal hyperalgesia after intra-tibial injection of breast cancer cells. No effect of SB203580 on the bone destruction was observed. However, following intrathecal injection of SB203580, the left PWLs （12.12± 1.26 s at 16 days and 12.99 ± 1.65 s at 19 days） were significant higher than that of controls （9.05 ± 1.08 s at 16 days and 8.55 ± 1.60 s at 19 days）, P 〈 0.05. Meanwhile, inkathecal injection of SB203580 evidently reduced the levels of spinal IL-1β and TNF-α. Conclusion： Intrathecal injection of SB203580 in a rat model of bone cancer pain cannot prevent the tibial destruction but significantly depress the thermalgia sensitivity, which might result from inhibiting inkacellular p38 MAPK signaling transduction, and thereby reducing the release of the proinflammatory cytokines.

关键词： p38 MAPK inhibitor bone cancer pain thermal hyperalgesia proinflammatory cytokine

计及多维不确定性影响的配电信息物理系统优化规划方法

在线全文

学校读者我要写书评

暂无评论

中国电机工程学报 2017年第24期37卷 7205-7215页

作者：刘文霞徐慧婷陈晔刘宗歧新能源与电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

配电信息物理系统(cyber physical distribution system,CPDS)与主动配电系统具有内在一致性,该融合系统的多维不确定性、深度耦合性使其规划问题更为复杂。文中基于配电信息物理系统在规划中的耦合特性分析,建立计及电压控制功能及通... 详细信息

配电信息物理系统(cyber physical distribution system,CPDS)与主动配电系统具有内在一致性,该融合系统的多维不确定性、深度耦合性使其规划问题更为复杂。文中基于配电信息物理系统在规划中的耦合特性分析,建立计及电压控制功能及通信系统随机故障的CPDS规划模型,提出考虑信息系统随机失效和控制失效的CPDS规划框架,通过优化方案形成和方案概率约束指标评价相结合的融合过程进行求解。以分布式光伏并网且具备电压控制功能的改进IEEE-33节点配电系统为例进行仿真验证,验证所提模型和算法的有效性和实用性,并探讨控制参数、光伏渗透率对配置方案和信息系统随机故障对电压合格概率指标的影响,为配电信息物理系统的规划和改进措施提出建议。

关键词：配电信息物理系统电压控制规划随机故障

在线全文

学校读者我要写书评

暂无评论

基于功能离子液体促进的有机反应研究进展

有机化学 2016年第10期36卷 2353-2367页

作者：徐慧婷张超怀陈钢沈润溥应安国绍兴文理学院化学化工学院绍兴312000 台州学院医药化工学院台州318000

离子液体作为绿色溶剂和催化剂,具有低挥发性,优良的热稳定性、溶解性以及可回收等优点,近年来广泛应用于有机合成领域中,在提高反应速率,反应选择性等方面发挥了巨大作用.综述了离子液体作为催化剂或溶剂在传统有机合成反应中的最新研... 详细信息

离子液体作为绿色溶剂和催化剂,具有低挥发性,优良的热稳定性、溶解性以及可回收等优点,近年来广泛应用于有机合成领域中,在提高反应速率,反应选择性等方面发挥了巨大作用.综述了离子液体作为催化剂或溶剂在传统有机合成反应中的最新研究成果,包括Baylis-Hillman反应、Michael加成反应、氧化还原反应、Knoevenagel缩合反应、Aldol缩合反应、Diels-Alder反应、Heck偶联反应、Suzuki反应、不对称反应、Biginelli反应、Mannich反应、Hantzsch多组分反应.分析离子液体结构对反应催化性能的影响,探讨其反应机理,为开发新型结构可调性功能离子液体打下基础.

关键词：功能离子液体有机合成构效关系绿色化学重复使用

一维链状氢键型甘氨酸超分子化合物[(Gly)^(+)/_(2)(18-crown-6)_(2)(MnCl4)^(2‒)]的合成、结构及介电性质

在线全文

学校读者我要写书评

暂无评论

高等学校化学学报 2021年第3期42卷 691-699页

作者：王乐秦刘磊刘洋任丽徐慧婷刘尊奇新疆农业大学化学工程学院乌鲁木齐830052

以甘氨酸(Gly)、18-冠醚-6、二氯化锰(MnCl_(2))和盐酸为原料,通过蒸发法获得一种新型相变一维链状氢键型甘氨酸超分子化合物[(Gly)^(+)/_(2)(18-crown-6)_(2)(MnCl4)^(2‒)](1).通过元素分析、变温X射线单晶衍射和介电测试等手段对其进... 详细信息

以甘氨酸(Gly)、18-冠醚-6、二氯化锰(MnCl_(2))和盐酸为原料,通过蒸发法获得一种新型相变一维链状氢键型甘氨酸超分子化合物[(Gly)^(+)/_(2)(18-crown-6)_(2)(MnCl4)^(2‒)](1).通过元素分析、变温X射线单晶衍射和介电测试等手段对其进行了表征和解析.实验结果表明,该晶体属于单斜晶系,空间群从P2_(1)/c(100 K)转化为C2/c(293 K).随着温度升高,[MnCl_(4)]^(2‒)呈现无序状态的共棱双四面体结构.质子化甘氨酸分子和分子内羟基(—OH)发生动态摆动,引起O—H…Cl型一维氢键链产生明显伸缩运动,导致化合物1在一定温度范围内出现结构相变及介电异常.

关键词：氢键分子摆动金属配合物结构相变阶梯状介电

在线全文

学校读者我要写书评

暂无评论

P2P网络借贷成功率影响因素研究

西安石油大学学报（社会科学版） 2017年第6期26卷 40-45页

作者：徐慧婷厦门城市职业学院商贸系福建厦门361009

以美国最大的P2P网络借贷平台Prosper为例,采用二元logistic回归模型建立网络借贷模型,研究借贷成功率的影响因素及其相对重要程度。结果表明,影响借款成功率的各因素排名为:投标总数、竞标时间、每月还款金额、借款利率、借款期限、信... 详细信息

以美国最大的P2P网络借贷平台Prosper为例,采用二元logistic回归模型建立网络借贷模型,研究借贷成功率的影响因素及其相对重要程度。结果表明,影响借款成功率的各因素排名为:投标总数、竞标时间、每月还款金额、借款利率、借款期限、信用评级、有无房产、加入群组、负债/收入比、借款用途、借款金额、照片认证。在研究结论的基础上,提出了P2P网贷平台借贷成功率的具体建议。

关键词： P2P网络借贷借贷成功率 Logistic模型