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Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide

Acta Pharmaceutica Sinica B 2024年第2期14卷 881-892页

作者： Zhiwu Tong Xiahong Xie huiming Ge Ruihua Jiao Tingting wang Xincun wang Wenying Zhuang Gang Hu Renxiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

Peptides are a particular molecule class with inherent attributes of some small-molecule drugs and macromolecular biologics,thereby inspiring continuous searches for peptides with therapeutic and/or agrochemical ***,the success rate is decreasing,presumably because many interesting but less-abundant peptides are so scarce or labile that they are likely‘overlooked’during the characterization ***,we present the biochemical characterization and druggability improvement of an unprecedented minor fungal RiPP(ribosomally synthesized and post-translationally modified peptide),named acalitide,by taking the relevant advantages of metabolomics approach and disulfide-bridged substructure which is more frequently imprinted in the marketed peptide drug *** is biosynthetically unique in the macrotricyclization via two disulfide bridges and a protease(AcaB)-catalyzed lactamization of AcaA,an unprecedented precursor *** a biosynthetic logic was successfully re-edited for its sample supply renewal to facilitate the identification of the in vitro and in vivo antiparkinsonian efficacy of acalitide which was further confirmed safe and rendered brain-targetable by the liposome encapsulation *** together,the work updates the mining strategy and biosynthetic complexity of RiPPs to unravel an antiparkinsonian drug candidate valuable for combating Parkinson’s disease that is globally prevailing in an alarming manner.

关键词： Fungal RiPPs Biosynthesis Macrocyclic peptide Acalitide Antiparkinsonian

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Two-layer autonomous intelligence dynamic trajectory planning method based on shield-tunnel ring-geology interactions

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Underground Space 2024年第6期19卷 227-250页

作者： Min Hu Bingjian Wu huiming Wu Liefeng Pei SILC Business School Shanghai UniversityShanghai 201800China SHU-SUCG Research Centre for Building Industrialization Shanghai 201800China Shanghai Tunnel Engineering Co. Ltd.Shanghai 200032China

To solve the problem that current attitude planning methods do not fully consider the interaction and constraints among the shield,segmental tunnel ring,and geology,and cannot adapt to the changes in the actual engineering environment,or provide feasible long-term and short-term attitude planning,this paper proposes autonomous intelligent dynamic trajectory planning(AI-DTP)to provide tunnel ring and centimeter-layer planning targets for a self-driving shield to meet long-term accuracy and short-term ***-DTP introduces the Frenet coordinate system to solve the problem of inconsistent spatial representation of tunnel data,segmental tunnel ring location,and surrounding geological conditions,designs the long short-term memory attitude prediction model to accurately predict shield attitude change trend based on shield,tunnel,and geology,and uses a heuristic algorithm for trajectory ***-DTP provides ring-layer and centimeter-layer planning objectives that meet the needs of long-term accuracy and short-term correction of shield attitude *** the Hangzhou-Shaoxing Intercity Railroad Tunnel Project in China,the‘‘Zhiyu”shield equipped with the AI-DTP system was faster and more accurate than the manually controlled shield,with a smoother process and better quality of the completed tunnel.

关键词： Shield tunnel Trajectory planning Attitude control Self-driving Machine learning

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Cyclic-delay time-reversal space-time block codes for single-carrier transmission with frequency-domain decision-feedback equalization

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Science China(Information Sciences) 2011年第9期54卷 1905-1915页

作者： FENG Ang,YIN QinYe & wang huiming MOE Key Laboratory for Intelligent Networks and Network Security,Xi’an Jiaotong University,Xi’an 710049,China MOE Key Laboratory for Intelligent Networks and Network Security Xi’an Jiaotong University Xi’an China

Transmit diversity is an important multiple-input multiple-output (MIMO) approach to improve the transmission reliability;however,it is usually designed with maximum-likelihood *** this paper,we investigate a simple transceiver structure for single-carrier MIMO systems,in which the cyclic-delay time-reversal space-time block code (CDTR-STBC) is employed at the transmitter,and the frequency-domain decision-feedback equalization (FD-DFE) is used at the *** separate the transmit antennas into two groups,and then,encode the groups by STBC and cyclically delay the data streams within each *** processing can mitigate the impact of error-propagation and reduce the signal-to-noise ratio (SNR) loss when FD-DFE is employed,in which SNR is defined as the ratio of the received signal power over the noise power at each receive *** support our proposal,this paper also provides the performance analysis of *** is shown that the proposed scheme can achieve full diversity and full transmission rate for a MIMO system employing arbitrary ***,it has considerable performance improvement over the existing schemes.

关键词： single-carrier frequency-domain equalization cyclic delay space-time block code diversity order

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普萘洛尔通过长链非编码RNA核旁丛组装转录本1靶向微小RNA-194-5p调控血管瘤内皮细胞增殖

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中华实验外科杂志 2024年第8期41卷 1716-1720页

作者：王慧明徐伟立胡志刚安雯婷李萌马亚贞孙驰河北医科大学第二医院小儿外科石家庄050004 河北医科大学第二医院普外科石家庄050004 河北医科大学第二医院中心实验室石家庄050004

目的探讨普萘洛尔通过长链非编码RNA核旁丛组装转录本1(lncRNA NEAT1)靶向微小RNA(miR)-194-5p调控血管瘤内皮细胞(HemECs)增殖的作用。方法收集2021年3月至2022年8月在河北医科大学第二医院小儿外科手术切除的血管瘤标本20例,根据Mulli... 详细信息

目的探讨普萘洛尔通过长链非编码RNA核旁丛组装转录本1(lncRNA NEAT1)靶向微小RNA(miR)-194-5p调控血管瘤内皮细胞(HemECs)增殖的作用。方法收集2021年3月至2022年8月在河北医科大学第二医院小儿外科手术切除的血管瘤标本20例,根据Mulliken标准分为增生期组和消退期组。采用实时定量反转录聚合酶链反应(RT-qPCR)方法检测两组瘤体中NEAT1和miR-194-5p水平。制备HemECs,细胞计数试剂盒(CCK-8)试验检测敲低和过表达NEAT1对HemECs增殖影响。双荧光素酶酶报告基因实验及RT-qPCR验证miR-194-5p与NEAT1之间的相互作用。不同浓度普萘洛尔给药后,CCK-8试验检测细胞活性,5-乙炔基-2’脱氧尿嘧啶核苷(EdU)法检测细胞增殖,RT-qPCR方法检测NEAT1和miR-194-5p水平。两组间比较采用独立样本t检验进行分析,多组间比较采用单因素方差分析和重复测量方差分析,采用Spearman分析确定各指标间相关性。结果RT-qPCR结果显示增生期血管瘤NEAT1表达高于退化期血管瘤(17.43±5.38比8.82±3.70,t=4.176,P<0.01);而增生期血管瘤miR-194-5p表达低于退化期血管瘤(0.28±0.11比0.41±0.11,t=2.692,P<0.01)。CKK-8检测结果显示,si-NEAT1组细胞活性低于si-NC组(0.86±0.05比1.11±0.03,t=7.794,P<0.01);OE-NEAT1组细胞活性高于OE-NC组(1.33±0.01比1.11±0.05,t=8.072,P<0.05)。Si-NEAT1组miR-194-5p表达水平高于si-NC组(2.88±0.33比1.14±0.47,t=5.206,P<0.01);OE-NEAT1组miR-194-5p表达水平低于OE-NC组(0.43±0.06比1.24±0.11,t=10.830,P<0.01)。双荧光素酶报告基因实验结果显示miR-194-5p和NEAT1-WT共转染组荧光素酶活性高于miR-NC和NEAT1-WT共转染组(0.35±0.05比0.65±0.04,t=5.273,P<0.01)。OE-NEAT1+普萘洛尔组细胞EdU染色阳性细胞率显著低于OE-NEAT1组和OE-NC组(35.97±1.09比69.66±2.85、51.89±1.09,F=65.100,P<0.01),OE-NEAT1+普萘洛尔组NEAT1、miR-194-5p表达量均与OE-NEAT1组比较,差异有统计学意义(1.63±0.30比3.94±0.50,t=6.851,P<0.01;0.86±0.26比0.37±0.03,t=3.213,P<0.05)。结论普萘洛尔可通过NEAT1靶向miR-194-5p调节HemECs增殖,NEAT1可能作为婴幼儿血管瘤分子治疗的潜在靶点。

关键词：普萘洛尔长链非编码RNA 微小RNA 血管瘤内皮细胞增殖

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Cooperative communications when collaborators are not synchronized

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Chinese Science Bulletin 2011年第27期56卷 2984-2984页

作者： huiming wang XiangGen Xia

A basic challenge for future wireless communication systems is the contradiction between the fast growing demand for high speed wireless communications and the limited electromagnetic wave frequency spectrum. The multiple-input multiple-output (MIMO) technique with space-time coding (STC) is recognized as a promising scheme for the next-generation of high speed wireless communication systems. This is mainly because of its capability of providing spatial diversity to combat fading in wireless channels and increasing the capacity

关键词：高速无线通信同步作者协作无线通信系统多输入多输出电磁波频谱空时编码

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Insight into the Permeability and Microstructure Evolution Mechanism of the Sliding Zone Soil: A Case Study from the Huangtupo Landslide, Three Gorges Reservoir, China

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Journal of Earth Science 2024年第3期35卷 941-954页

作者： Qianyun wang huiming Tang Pengju An Kun Fang Junrong Zhang Minghao Miao Qingwen Tan Lei Huang Shengming Hu Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan 430074China Faculty of Engineering China University of GeosciencesWuhan 430074China Institute of Rock Mechanics Ningbo UniversityNingbo 315211China National and Provincial Joint Engineering Laboratory for the Hydraulic Engineering Safety and Efficient Utilization of Water Resources of Poyang Lake Basin Nanchang Institute of TechnologyNanchang 330099China

A large number of laboratory investigations related to the permeability have been conducted on the sliding *** little attention has been paid to the particular sliding zones of the slideprone Badong ***,we experimentally investigate the permeability nature and the mechanism of seepage in the viscous sliding zone of the Huangtupo *** seepage tests have been performed first with consideration of six dry densities and thirteen hydraulic gradients,in conjunction with the mercury intrusion porosimetry test and scanning electron microscopy test for the microstructure analysis after *** results show that seepage in the sliding zone soil does not follow Darcy’s Law,since there is a threshold hydraulic gradient(i0)below which no flow is observed and a critical hydraulic gradient(icr)over which the hydraulic conductivity(K)tends to be *** percentage of bound water could be responsible for the occurrence of i0 and ***,pore size distributions(PSD)less than 0.6µm and between 10 and 90µm exhibit positive and negative correlations with the i0,respectively,indicating that the i0 is related to the *** mechanism accounting for this result is that pore water pressure forces fine clay particles into the surrounding large pores and converts arranged particles to discretely distributed ones,thereby weakening the connectivity of *** seepages in the sliding zones behave differently from that in the sliding mass and sliding bed in response to the permeability.

关键词： reservoir landslides sliding zone soil permeability microstructure seepage.

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人工噪声策略的临界信噪比和功率分配研究

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通信学报 2019年第6期40卷 66-73页

作者：邓浩王慧明河南大学物理与电子学院河南开封450004 西安交通大学电子与信息工程学院陕西西安710049

给出了多输入单输出窃听链路中人工噪声策略安全性能的统一分析。通过对私密信号和人工噪声之间最优功率分配的研究,发现人工噪声策略不是在所有情况下都能有效提升系统的安全性,同时给出了人工噪声工作的临界信噪比。此外,基于保密速... 详细信息

给出了多输入单输出窃听链路中人工噪声策略安全性能的统一分析。通过对私密信号和人工噪声之间最优功率分配的研究,发现人工噪声策略不是在所有情况下都能有效提升系统的安全性,同时给出了人工噪声工作的临界信噪比。此外,基于保密速率的下界得出了适应任意信噪比的功率分配表达式,据此推导出了未知窃听用户统计信道信息情况下的功率分配结果。仿真结果显示,相对于平均功率分配策略,所提功率分配方案可以有效增大系统的保密速率。

关键词：物理层安全人工噪声保密速率最优功率分配

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Enhancing source domain availability through data and feature transfer learning for building power load forecasting

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Building Simulation 2024年第4期17卷 625-638页

作者： Fanyue Qian Yingjun Ruan huiming Lu Hua Meng Tingting Xu College of Mechanical and Energy Engineering Tongji UniversityShanghai200092China United Automotive Electronic Systems Co. LtdShanghai201206China

During the initial phases of operation following the construction or renovation of existing buildings,the availability of historical power usage data is limited,which leads to lower accuracy in load forecasting and hinders normal ***,by transferring load data from similar buildings,it is possible to enhance forecasting ***,indiscriminately expanding all source domain data to the target domain is highly likely to result in negative transfer *** study explores the feasibility of utilizing similar buildings(source domains)in transfer learning by implementing and comparing two distinct forms of multi-source transfer ***,this study focuses on the Higashita area in Kitakyushu City,Japan,as the research *** buildings that exhibit the highest similarity to the target buildings within this area were selected for ***,the two-stage TrAdaBoost.R^(2) algorithm is used for multi-source transfer learning,and its transfer effect is ***,the application effects of instance-based(IBMTL)and feature-based(FBMTL)multi-source transfer learning are compared,which explained the effect of the source domain data on the forecasting accuracy in different transfer *** results show that combining the two-stage TrAdaBoost.R^(2) algorithm with multi-source data can reduce the CV-RMSE by 7.23%compared to a single-source domain,and the accuracy improvement is *** the same time,multi-source transfer learning,which is based on instance,can better supplement the integrity of the target domain data and has a higher forecasting ***,IBMTL tends to retain effective data associations and FBMTL shows higher forecasting *** findings of this study,which include the verification of real-life algorithm application and source domain availability,can serve as a theoretical reference for implementing transfer learning in load forecasting.

关键词： building power load multi-source transfer learning two-stage TrAdaBoost.R2 source domain availability

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Experimental investigation on shear strength deterioration at the interface between different rock types under cyclic loading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3063-3079页

作者： Qiong Wu Zhiqi Liu huiming Tang Liangqing wang Xiaoxue Huo Zhen Cui Shiyu Li Bo Zhang Zhiwei Lin Faculty of Engineering China University of GeosciencesWuhan430074China Guangxi Fangchenggang Beitou Environmental Protection Water Co. Ltd.Fangchenggang538021China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The shear strength deterioration of bedding planes between different rock types induced by cyclic loading is vital to reasonably evaluate the stability of soft and hard interbedded bedding rock slopes under earthquake;however,rare work has been devoted to this subject due to lack of *** this study,experimental investigations on shear strength weakening of discontinuities with different joint wall material(DDJM)under cyclic loading were conducted by taking the interface between siltstone and mudstone in the Shaba slope of Yunnan Province,China as research objects.A total of 99 pairs of similar material samples of DDJM(81 pairs)and discontinuities with identical joint wall material(DIJM)(18 pairs)were fabricated by inserting plates,engraved with typical surface morphology obtained by performing three-dimensional laser scanning on natural DDJMs sampled from field,into mold *** shear tests were conducted on these samples to study their shear strength changes with the cyclic number considering the effects of normal stress,joint surface morphology,shear displacement amplitude and shear *** results indicate that the shear stress *** displacement curves under each shear cycle and the peak shear strength *** number curves of the studied DDJMs are between those of DIJMs with siltstone and mudstone,while closer to those of DIJMs with *** peak shear strengths of DDJMs exhibit an initial rapid decline followed by a gradual decrease with the cyclic number and the decrease rate varies from 6%to 55.9%for samples with varied surface morphology under different testing *** normal stress,joint surface morphology,shear displacement amplitude and shear rate collectively influence the shear strength deterioration of DDJM under cyclic shear loading,with the degree of influence being greater for larger normal stress,rougher surface morphology,larger shear displacement amplitude and faster shear rate.

关键词： Discontinuities with different joint wall material(DDJM) Discontinuities with identical joint wall material(DIJM) Cyclic shear test Shear strength deterioration Joint surface morphology Shear displacement amplitude Shear rate Normal stress

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考虑微观变形特征的水凝胶均匀和非均匀溶胀分析及其影响参数研究

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力学学报 2021年第2期53卷 437-447,I0003页

作者：刘岩王惠明浙江大学工程力学系杭州310027 浙江省软体机器人与智能器件研究重点实验室杭州310027

本文给出考虑微观变形的水凝胶溶胀的分析模型,该模型假设构成聚合物网络的单链受到由于周围链的作用而产生类似圆管状的约束,并且认为每个单链变形与网络变形之间存在非仿射关系.利用该模型分析了凝胶在自由溶胀情形,预拉伸凝胶单一方... 详细信息

本文给出考虑微观变形的水凝胶溶胀的分析模型,该模型假设构成聚合物网络的单链受到由于周围链的作用而产生类似圆管状的约束,并且认为每个单链变形与网络变形之间存在非仿射关系.利用该模型分析了凝胶在自由溶胀情形,预拉伸凝胶单一方向溶胀情形以及具有刚性核的球形凝胶溶胀至平衡状态情形的变形特征.研究表明,对于自由溶胀的均匀变形情形,水凝胶微观单链与宏观网络的变形相一致,伸长率随链段数的增加而增大,随单链密度的增大而减小.伸长率也会随有效圆管几何参数数值的增大而增大,但是当外部溶剂压力达到一定数值以后单链的圆管约束对凝胶溶胀变形影响逐渐减小.在单一方向溶胀状态下,预拉伸凝胶会出现微观单链和宏观网络伸长率相等的溶胀平衡状态,此时约束应力等于零.具有刚性核的球形凝胶溶胀至平衡状态时产生径向和环向伸长率不相等的非均匀球对称变形.在刚性核的附近,单链和网络的径向伸长率均大于自由溶胀状态伸长率.在远离刚性核的位置,单链和网络的伸长率均接近自由溶胀状态的伸长率.网络渗透压随有效圆管几何参数数值的增大而降低,溶剂分子体积分数则随有效圆管几何参数数值的增大而增大.所建立的分析模型可以模拟凝胶溶胀导致的微观单链变形.

关键词：水凝胶均匀溶胀非均匀溶胀非仿射微观变形

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